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Fusion gene ID: 19495 |
FusionGeneSummary for LAS1L_SDC3 |
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Fusion gene information | Fusion gene name: LAS1L_SDC3 | Fusion gene ID: 19495 | Hgene | Tgene | Gene symbol | LAS1L | SDC3 | Gene ID | 81887 | 9672 |
Gene name | LAS1 like, ribosome biogenesis factor | syndecan 3 | |
Synonyms | Las1-like|WTS|dJ475B7.2 | SDCN|SYND3 | |
Cytomap | Xq12 | 1p35.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ribosomal biogenesis protein LAS1Lprotein LAS1 homolog | syndecan-3N-syndecansyndecan neural typesyndecan proteoglycan 3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9Y4W2 | O75056 | |
Ensembl transtripts involved in fusion gene | ENST00000374807, ENST00000374811, ENST00000374804, ENST00000312391, | ENST00000336798, ENST00000339394, ENST00000471567, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 8 X 5=320 |
# samples | 2 | 11 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(11/320*10)=-1.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LAS1L [Title/Abstract] AND SDC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF935530 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000374807 | ENST00000336798 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-intron | ENST00000374807 | ENST00000339394 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-intron | ENST00000374807 | ENST00000471567 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-3UTR | ENST00000374811 | ENST00000336798 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-intron | ENST00000374811 | ENST00000339394 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-intron | ENST00000374811 | ENST00000471567 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-3UTR | ENST00000374804 | ENST00000336798 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-intron | ENST00000374804 | ENST00000339394 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-intron | ENST00000374804 | ENST00000471567 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-3UTR | ENST00000312391 | ENST00000336798 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-intron | ENST00000312391 | ENST00000339394 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
intron-intron | ENST00000312391 | ENST00000471567 | LAS1L | chrX | 64739256 | + | SDC3 | chr1 | 31345192 | + |
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FusionProtFeatures for LAS1L_SDC3 |
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Hgene | Tgene |
LAS1L | SDC3 |
Involved in the biogenesis of the 60S ribosomal subunit.Required for maturation of the 28S rRNA. Functions as a componentof the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMCcomplex is recruited to ZNF148 by methylated CHTOP, leading todesumoylation of ZNF148 and subsequent transactivation of ZNF148target genes. {ECO:0000269|PubMed:20647540,ECO:0000269|PubMed:22872859}. | Cell surface proteoglycan that may bear heparan sulfate(By similarity). May have a role in the organization of cell shapeby affecting the actin cytoskeleton, possibly by transferringsignals from the cell surface in a sugar-dependent mechanism.{ECO:0000250, ECO:0000269|PubMed:11527150}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LAS1L_SDC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LAS1L_SDC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LAS1L_SDC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LAS1L_SDC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |