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Fusion gene ID: 19494 |
FusionGeneSummary for LAS1L_MSN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LAS1L_MSN | Fusion gene ID: 19494 | Hgene | Tgene | Gene symbol | LAS1L | MSN | Gene ID | 81887 | 4478 |
| Gene name | LAS1 like, ribosome biogenesis factor | moesin | |
| Synonyms | Las1-like|WTS|dJ475B7.2 | HEL70|IMD50 | |
| Cytomap | Xq12 | Xq12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ribosomal biogenesis protein LAS1Lprotein LAS1 homolog | moesinepididymis luminal protein 70membrane-organizing extension spike protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9Y4W2 | P26038 | |
| Ensembl transtripts involved in fusion gene | ENST00000374807, ENST00000374811, ENST00000374804, ENST00000312391, | ENST00000609205, ENST00000360270, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 2=72 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LAS1L [Title/Abstract] AND MSN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MSN | GO:0001771 | immunological synapse formation | 27405666 |
| Tgene | MSN | GO:0042098 | T cell proliferation | 27405666 |
| Tgene | MSN | GO:0070489 | T cell aggregation | 27405666 |
| Tgene | MSN | GO:0071394 | cellular response to testosterone stimulus | 24065547 |
| Tgene | MSN | GO:0072678 | T cell migration | 27405666 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-CZ-5468-01A | LAS1L | chrX | 64751237 | - | MSN | chrX | 64820542 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000374807 | ENST00000609205 | LAS1L | chrX | 64751237 | - | MSN | chrX | 64820542 | + |
| 5CDS-intron | ENST00000374807 | ENST00000360270 | LAS1L | chrX | 64751237 | - | MSN | chrX | 64820542 | + |
| 5CDS-intron | ENST00000374811 | ENST00000609205 | LAS1L | chrX | 64751237 | - | MSN | chrX | 64820542 | + |
| 5CDS-intron | ENST00000374811 | ENST00000360270 | LAS1L | chrX | 64751237 | - | MSN | chrX | 64820542 | + |
| 5CDS-intron | ENST00000374804 | ENST00000609205 | LAS1L | chrX | 64751237 | - | MSN | chrX | 64820542 | + |
| 5CDS-intron | ENST00000374804 | ENST00000360270 | LAS1L | chrX | 64751237 | - | MSN | chrX | 64820542 | + |
| 5CDS-intron | ENST00000312391 | ENST00000609205 | LAS1L | chrX | 64751237 | - | MSN | chrX | 64820542 | + |
| 5CDS-intron | ENST00000312391 | ENST00000360270 | LAS1L | chrX | 64751237 | - | MSN | chrX | 64820542 | + |
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FusionProtFeatures for LAS1L_MSN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LAS1L | MSN |
| Involved in the biogenesis of the 60S ribosomal subunit.Required for maturation of the 28S rRNA. Functions as a componentof the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMCcomplex is recruited to ZNF148 by methylated CHTOP, leading todesumoylation of ZNF148 and subsequent transactivation of ZNF148target genes. {ECO:0000269|PubMed:20647540,ECO:0000269|PubMed:22872859}. | Probably involved in connections of major cytoskeletalstructures to the plasma membrane. May inhibit herpes simplexvirus 1 infection at an early stage. Plays a role in regulatingthe proliferation, migration, and adhesion of human lymphoid cellsand participates in immunologic synapse formation(PubMed:27405666). {ECO:0000269|PubMed:21549406,ECO:0000269|PubMed:27405666}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LAS1L_MSN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LAS1L_MSN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LAS1L | PNKP, PELP1, UBC, SMARCAD1, SIRT7, CUL3, CAND1, TEX10, BARD1, ECT2, MDC1, CBX6, IPO5, NOL9, SENP3, WDR18, SOX2, PASK, CEP250, CUL7, OBSL1, RNF2, BMI1, SUMO2, NTRK1, IFI16, XPO1, RPL10, NES, CDC5L, ZNF746, RAF1, FOXA1 | MSN | TSC1, HLA-B, BID, TNFRSF10B, EZR, FADD, FASLG, MAPK8, FAS, RHOA, ARHGDIA, CASP10, CASP8, TNFRSF1A, MSN, ICAM3, NCF1, NCF4, VCAM1, SLC9A3R1, SELL, SPN, SPTAN1, CD46, ICAM2, CD44, SELPLG, H2AFX, ELAVL1, SIRT7, ISG15, TERF1, BRCA1, CDK2, HADHA, GTF3C4, SRCAP, S100A16, FN1, ITGA4, ICAM1, CD81, IGSF8, CDK11B, MAPK10, ASNS, CAPN2, DHX15, GINS3, GSS, HSPA5, AHCY, ATIC, DCPS, FH, NAE1, PDIA4, PFAS, PTMA, STK24, TATDN1, TUBB3, VCL, NSFL1C, PAFAH1B1, PAFAH1B2, PAPSS1, PDHA1, PPP1R2, RAP1GDS1, ABCE1, TSPAN33, VPS11, ACAA2, AKR1B1, CALR, CALU, CD2AP, CTNNB1, EIF5AL1, ENO1, ENO2, FABP5, FAXC, FKBP2, HNRNPA1, HSD17B10, HSPA4, HSPA4L, HSPE1, HSPH1, ISYNA1, JUP, LCP1, DUT, GDI1, HSPB1, IMPA2, ME1, NOTCH2, P4HB, PGD, PGK1, PGK2, PLS1, PLS3, RCN1, STIP1, TAGLN2, TKT, UCHL3, WDR1, EWSR1, MYH9, PTPN1, MYO19, TRIM15, MCM2, U2AF2, SMURF1, CDC73, MISP, MRPL12 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LAS1L_MSN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LAS1L_MSN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MSN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | MSN | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Tgene | MSN | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | MSN | C3495559 | Juvenile arthritis | 1 | CTD_human |
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