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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19485

FusionGeneSummary for LARP7_LARP7

check button Fusion gene summary
Fusion gene informationFusion gene name: LARP7_LARP7
Fusion gene ID: 19485
HgeneTgene
Gene symbol

LARP7

LARP7

Gene ID

51574

51574

Gene nameLa ribonucleoprotein domain family member 7La ribonucleoprotein domain family member 7
SynonymsALAZS|HDCMA18P|PIP7SALAZS|HDCMA18P|PIP7S
Cytomap

4q25

4q25

Type of geneprotein-codingprotein-coding
Descriptionla-related protein 7P-TEFb-interaction protein for 7SK stabilityla-related protein 7P-TEFb-interaction protein for 7SK stability
Modification date2018052220180522
UniProtAcc

Q4G0J3

Q4G0J3

Ensembl transtripts involved in fusion geneENST00000344442, ENST00000509061, 
ENST00000324052, ENST00000503898, 
ENST00000344442, ENST00000509061, 
ENST00000324052, ENST00000503898, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 3=75
# samples 45
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LARP7 [Title/Abstract] AND LARP7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI565516LARP7chr4

113568393

-LARP7chr4

113568921

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344442ENST00000344442LARP7chr4

113568393

-LARP7chr4

113568921

-
In-frameENST00000344442ENST00000509061LARP7chr4

113568393

-LARP7chr4

113568921

-
In-frameENST00000344442ENST00000324052LARP7chr4

113568393

-LARP7chr4

113568921

-
5CDS-intronENST00000344442ENST00000503898LARP7chr4

113568393

-LARP7chr4

113568921

-
In-frameENST00000509061ENST00000344442LARP7chr4

113568393

-LARP7chr4

113568921

-
In-frameENST00000509061ENST00000509061LARP7chr4

113568393

-LARP7chr4

113568921

-
In-frameENST00000509061ENST00000324052LARP7chr4

113568393

-LARP7chr4

113568921

-
5CDS-intronENST00000509061ENST00000503898LARP7chr4

113568393

-LARP7chr4

113568921

-
In-frameENST00000324052ENST00000344442LARP7chr4

113568393

-LARP7chr4

113568921

-
In-frameENST00000324052ENST00000509061LARP7chr4

113568393

-LARP7chr4

113568921

-
In-frameENST00000324052ENST00000324052LARP7chr4

113568393

-LARP7chr4

113568921

-
5CDS-intronENST00000324052ENST00000503898LARP7chr4

113568393

-LARP7chr4

113568921

-
intron-3CDSENST00000503898ENST00000344442LARP7chr4

113568393

-LARP7chr4

113568921

-
intron-3CDSENST00000503898ENST00000509061LARP7chr4

113568393

-LARP7chr4

113568921

-
intron-3CDSENST00000503898ENST00000324052LARP7chr4

113568393

-LARP7chr4

113568921

-
intron-intronENST00000503898ENST00000503898LARP7chr4

113568393

-LARP7chr4

113568921

-

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FusionProtFeatures for LARP7_LARP7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARP7

Q4G0J3

LARP7

Q4G0J3

Negative transcriptional regulator of polymerase IIgenes, acting by means of the 7SK RNP system. Within the 7SK RNPcomplex, the positive transcription elongation factor b (P-TEFb)is sequestered in an inactive form, preventing RNA polymerase IIphosphorylation and subsequent transcriptional elongation.{ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18483487}. Negative transcriptional regulator of polymerase IIgenes, acting by means of the 7SK RNP system. Within the 7SK RNPcomplex, the positive transcription elongation factor b (P-TEFb)is sequestered in an inactive form, preventing RNA polymerase IIphosphorylation and subsequent transcriptional elongation.{ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18483487}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LARP7_LARP7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LARP7_LARP7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LARP7_LARP7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LARP7_LARP7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLARP7C3714756Intellectual Disability1CTD_human
TgeneLARP7C3714756Intellectual Disability1CTD_human