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Fusion gene ID: 19484 |
FusionGeneSummary for LARP7_ALPK1 |
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Fusion gene information | Fusion gene name: LARP7_ALPK1 | Fusion gene ID: 19484 | Hgene | Tgene | Gene symbol | LARP7 | ALPK1 | Gene ID | 51574 | 80216 |
Gene name | La ribonucleoprotein domain family member 7 | alpha kinase 1 | |
Synonyms | ALAZS|HDCMA18P|PIP7S | 8430410J10Rik|LAK | |
Cytomap | 4q25 | 4q25 | |
Type of gene | protein-coding | protein-coding | |
Description | la-related protein 7P-TEFb-interaction protein for 7SK stability | alpha-protein kinase 1chromosome 4 kinaselymphocyte alpha-kinaselymphocyte alpha-protein kinase | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q4G0J3 | Q96QP1 | |
Ensembl transtripts involved in fusion gene | ENST00000344442, ENST00000509061, ENST00000324052, ENST00000503898, | ENST00000458497, ENST00000177648, ENST00000504176, ENST00000505912, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 3 X 3=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LARP7 [Title/Abstract] AND ALPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A09N-01A | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000344442 | ENST00000458497 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3CDS | ENST00000344442 | ENST00000177648 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3CDS | ENST00000344442 | ENST00000504176 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3UTR | ENST00000344442 | ENST00000505912 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3CDS | ENST00000509061 | ENST00000458497 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3CDS | ENST00000509061 | ENST00000177648 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3CDS | ENST00000509061 | ENST00000504176 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3UTR | ENST00000509061 | ENST00000505912 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
5UTR-3CDS | ENST00000324052 | ENST00000458497 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
5UTR-3CDS | ENST00000324052 | ENST00000177648 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
5UTR-3CDS | ENST00000324052 | ENST00000504176 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
5UTR-3UTR | ENST00000324052 | ENST00000505912 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3CDS | ENST00000503898 | ENST00000458497 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3CDS | ENST00000503898 | ENST00000177648 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3CDS | ENST00000503898 | ENST00000504176 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
intron-3UTR | ENST00000503898 | ENST00000505912 | LARP7 | chr4 | 113558759 | + | ALPK1 | chr4 | 113332983 | + |
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FusionProtFeatures for LARP7_ALPK1 |
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Hgene | Tgene |
LARP7 | ALPK1 |
Negative transcriptional regulator of polymerase IIgenes, acting by means of the 7SK RNP system. Within the 7SK RNPcomplex, the positive transcription elongation factor b (P-TEFb)is sequestered in an inactive form, preventing RNA polymerase IIphosphorylation and subsequent transcriptional elongation.{ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18483487}. | Kinase that recognizes phosphorylation sites in whichthe surrounding peptides have an alpha-helical conformation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LARP7_ALPK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LARP7_ALPK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LARP7 | MEPCE, CDK9, HNRNPA1, TERF1, TERF2, PRPF40A, SIRT7, CAND1, APP, BARD1, PAXIP1, CSNK2A1, RPS16, RN7SK, HEXIM1, CCNT1, JMJD6, BRCC3, CD2AP, HDAC1, SPAG9, HNRNPR, HUWE1, MTA2, NR3C1, RABEP2, RPP25, TRIM28, TSC22D1, VCPIP1, LIN28A, LIN28B, AFF1, RNF2, SIRT6, HIST1H1A, NOL12, TRA2A, RPL6, NIFK, RPS2, RPSA, ZC3H3, RPS8, ZC3H8, FBL, LUC7L2, NTRK1, SSB, IFI16, MED4, ORC1, AURKA, FOXL2, HEXIM2, SART3, SNRNP70, ZCRB1, E4F1 | ALPK1 | MYC, HSP90AA1, ALOXE3, XPO1, SCGB1D2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LARP7_ALPK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LARP7_ALPK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LARP7 | C3714756 | Intellectual Disability | 1 | CTD_human |