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Fusion gene ID: 19463 |
FusionGeneSummary for LARP1B_TAF7 |
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Fusion gene information | Fusion gene name: LARP1B_TAF7 | Fusion gene ID: 19463 | Hgene | Tgene | Gene symbol | LARP1B | TAF7 | Gene ID | 55132 | 6879 |
Gene name | La ribonucleoprotein domain family member 1B | TATA-box binding protein associated factor 7 | |
Synonyms | LARP2 | TAF2F|TAFII55 | |
Cytomap | 4q28.2 | 5q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | la-related protein 1BLa ribonucleoprotein domain family, member 2la-related protein 2 | transcription initiation factor TFIID subunit 7RNA polymerase II TBP-associated factor subunit FTAF(II)55TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDaTAFII-55TATA box binding protein (TBP)-associated factor, RNA poly | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q659C4 | Q15545 | |
Ensembl transtripts involved in fusion gene | ENST00000326639, ENST00000264584, ENST00000441387, ENST00000354456, ENST00000506199, ENST00000512292, ENST00000394288, ENST00000432347, ENST00000427266, | ENST00000313368, | |
Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 2 X 2 X 1=4 |
# samples | 9 | 3 | |
** MAII score | log2(9/126*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/4*10)=2.90689059560852 | |
Context | PubMed: LARP1B [Title/Abstract] AND TAF7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TAF7 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11592977|16407123|18391197 |
Tgene | TAF7 | GO:0006352 | DNA-templated transcription, initiation | 9603525 |
Tgene | TAF7 | GO:0006366 | transcription by RNA polymerase II | 7824954 |
Tgene | TAF7 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 9603525|16407123 |
Tgene | TAF7 | GO:0006469 | negative regulation of protein kinase activity | 18391197 |
Tgene | TAF7 | GO:0035067 | negative regulation of histone acetylation | 11592977 |
Tgene | TAF7 | GO:0045892 | negative regulation of transcription, DNA-templated | 11592977|16407123|18391197 |
Tgene | TAF7 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12676957 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE185469 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000326639 | ENST00000313368 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
intron-3CDS | ENST00000264584 | ENST00000313368 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
intron-3CDS | ENST00000441387 | ENST00000313368 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
intron-3CDS | ENST00000354456 | ENST00000313368 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
intron-3CDS | ENST00000506199 | ENST00000313368 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
intron-3CDS | ENST00000512292 | ENST00000313368 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
intron-3CDS | ENST00000394288 | ENST00000313368 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
intron-3CDS | ENST00000432347 | ENST00000313368 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
intron-3CDS | ENST00000427266 | ENST00000313368 | LARP1B | chr4 | 129087525 | - | TAF7 | chr5 | 140699233 | - |
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FusionProtFeatures for LARP1B_TAF7 |
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Hgene | Tgene |
LARP1B | TAF7 |
Functions as a component of the DNA-binding generaltranscription factor complex TFIID, a multimeric protein complexthat plays a central role in mediating promoter responses tovarious activators and repressors. Present in both of thepreviously described TFIID species which either lack or containTAFII30 (TFIID alpha and TFIID beta respectively).{ECO:0000269|PubMed:10438527}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LARP1B_TAF7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LARP1B_TAF7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LARP1B_TAF7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LARP1B_TAF7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |