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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19460

FusionGeneSummary for LARP1B_FBLN1

check button Fusion gene summary
Fusion gene informationFusion gene name: LARP1B_FBLN1
Fusion gene ID: 19460
HgeneTgene
Gene symbol

LARP1B

FBLN1

Gene ID

55132

2192

Gene nameLa ribonucleoprotein domain family member 1Bfibulin 1
SynonymsLARP2FBLN|FIBL1
Cytomap

4q28.2

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionla-related protein 1BLa ribonucleoprotein domain family, member 2la-related protein 2fibulin-1
Modification date2018051920180522
UniProtAcc

Q659C4

P23142

Ensembl transtripts involved in fusion geneENST00000326639, ENST00000264584, 
ENST00000441387, ENST00000354456, 
ENST00000506199, ENST00000512292, 
ENST00000394288, ENST00000432347, 
ENST00000427266, 
ENST00000348697, 
ENST00000402984, ENST00000262722, 
ENST00000327858, ENST00000442170, 
ENST00000340923, ENST00000476366, 
Fusion gene scores* DoF score6 X 7 X 3=12612 X 11 X 7=924
# samples 913
** MAII scorelog2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/924*10)=-2.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LARP1B [Title/Abstract] AND FBLN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFBLN1

GO:0001933

negative regulation of protein phosphorylation

11792823

TgeneFBLN1

GO:0007162

negative regulation of cell adhesion

11792823

TgeneFBLN1

GO:0007229

integrin-mediated signaling pathway

11792823

TgeneFBLN1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11792823

TgeneFBLN1

GO:0072378

blood coagulation, fibrin clot formation

7642629

TgeneFBLN1

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

11792823

TgeneFBLN1

GO:2000146

negative regulation of cell motility

11792823

TgeneFBLN1

GO:2000647

negative regulation of stem cell proliferation

11238726


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF873944LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000326639ENST00000348697LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000326639ENST00000402984LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000326639ENST00000262722LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000326639ENST00000327858LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000326639ENST00000442170LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000326639ENST00000340923LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000326639ENST00000476366LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000264584ENST00000348697LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000264584ENST00000402984LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000264584ENST00000262722LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000264584ENST00000327858LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000264584ENST00000442170LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000264584ENST00000340923LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000264584ENST00000476366LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000441387ENST00000348697LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000441387ENST00000402984LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000441387ENST00000262722LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000441387ENST00000327858LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000441387ENST00000442170LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000441387ENST00000340923LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000441387ENST00000476366LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5UTR-intronENST00000354456ENST00000348697LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5UTR-intronENST00000354456ENST00000402984LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5UTR-intronENST00000354456ENST00000262722LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5UTR-intronENST00000354456ENST00000327858LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5UTR-intronENST00000354456ENST00000442170LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5UTR-intronENST00000354456ENST00000340923LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5UTR-intronENST00000354456ENST00000476366LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
intron-intronENST00000506199ENST00000348697LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
intron-intronENST00000506199ENST00000402984LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
intron-intronENST00000506199ENST00000262722LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
intron-intronENST00000506199ENST00000327858LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
intron-intronENST00000506199ENST00000442170LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
intron-intronENST00000506199ENST00000340923LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
intron-intronENST00000506199ENST00000476366LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000512292ENST00000348697LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000512292ENST00000402984LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000512292ENST00000262722LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000512292ENST00000327858LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000512292ENST00000442170LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000512292ENST00000340923LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000512292ENST00000476366LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000394288ENST00000348697LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000394288ENST00000402984LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000394288ENST00000262722LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000394288ENST00000327858LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000394288ENST00000442170LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000394288ENST00000340923LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000394288ENST00000476366LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000432347ENST00000348697LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000432347ENST00000402984LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000432347ENST00000262722LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000432347ENST00000327858LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000432347ENST00000442170LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000432347ENST00000340923LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000432347ENST00000476366LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000427266ENST00000348697LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000427266ENST00000402984LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000427266ENST00000262722LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000427266ENST00000327858LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000427266ENST00000442170LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000427266ENST00000340923LARP1Bchr4

128999075

-FBLN1chr22

45929052

-
5CDS-intronENST00000427266ENST00000476366LARP1Bchr4

128999075

-FBLN1chr22

45929052

-

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FusionProtFeatures for LARP1B_FBLN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARP1B

Q659C4

FBLN1

P23142


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LARP1B_FBLN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LARP1B_FBLN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LARP1B_FBLN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LARP1B_FBLN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFBLN1C0014175Endometriosis1CTD_human
TgeneFBLN1C0033578Prostatic Neoplasms1CTD_human