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Fusion gene ID: 19460 |
FusionGeneSummary for LARP1B_FBLN1 |
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Fusion gene information | Fusion gene name: LARP1B_FBLN1 | Fusion gene ID: 19460 | Hgene | Tgene | Gene symbol | LARP1B | FBLN1 | Gene ID | 55132 | 2192 |
Gene name | La ribonucleoprotein domain family member 1B | fibulin 1 | |
Synonyms | LARP2 | FBLN|FIBL1 | |
Cytomap | 4q28.2 | 22q13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | la-related protein 1BLa ribonucleoprotein domain family, member 2la-related protein 2 | fibulin-1 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q659C4 | P23142 | |
Ensembl transtripts involved in fusion gene | ENST00000326639, ENST00000264584, ENST00000441387, ENST00000354456, ENST00000506199, ENST00000512292, ENST00000394288, ENST00000432347, ENST00000427266, | ENST00000348697, ENST00000402984, ENST00000262722, ENST00000327858, ENST00000442170, ENST00000340923, ENST00000476366, | |
Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 12 X 11 X 7=924 |
# samples | 9 | 13 | |
** MAII score | log2(9/126*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/924*10)=-2.8293812283876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LARP1B [Title/Abstract] AND FBLN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FBLN1 | GO:0001933 | negative regulation of protein phosphorylation | 11792823 |
Tgene | FBLN1 | GO:0007162 | negative regulation of cell adhesion | 11792823 |
Tgene | FBLN1 | GO:0007229 | integrin-mediated signaling pathway | 11792823 |
Tgene | FBLN1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 11792823 |
Tgene | FBLN1 | GO:0072378 | blood coagulation, fibrin clot formation | 7642629 |
Tgene | FBLN1 | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 11792823 |
Tgene | FBLN1 | GO:2000146 | negative regulation of cell motility | 11792823 |
Tgene | FBLN1 | GO:2000647 | negative regulation of stem cell proliferation | 11238726 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF873944 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000326639 | ENST00000348697 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000326639 | ENST00000402984 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000326639 | ENST00000262722 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000326639 | ENST00000327858 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000326639 | ENST00000442170 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000326639 | ENST00000340923 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000326639 | ENST00000476366 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000264584 | ENST00000348697 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000264584 | ENST00000402984 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000264584 | ENST00000262722 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000264584 | ENST00000327858 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000264584 | ENST00000442170 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000264584 | ENST00000340923 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000264584 | ENST00000476366 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000441387 | ENST00000348697 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000441387 | ENST00000402984 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000441387 | ENST00000262722 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000441387 | ENST00000327858 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000441387 | ENST00000442170 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000441387 | ENST00000340923 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000441387 | ENST00000476366 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5UTR-intron | ENST00000354456 | ENST00000348697 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5UTR-intron | ENST00000354456 | ENST00000402984 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5UTR-intron | ENST00000354456 | ENST00000262722 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5UTR-intron | ENST00000354456 | ENST00000327858 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5UTR-intron | ENST00000354456 | ENST00000442170 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5UTR-intron | ENST00000354456 | ENST00000340923 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5UTR-intron | ENST00000354456 | ENST00000476366 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
intron-intron | ENST00000506199 | ENST00000348697 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
intron-intron | ENST00000506199 | ENST00000402984 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
intron-intron | ENST00000506199 | ENST00000262722 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
intron-intron | ENST00000506199 | ENST00000327858 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
intron-intron | ENST00000506199 | ENST00000442170 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
intron-intron | ENST00000506199 | ENST00000340923 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
intron-intron | ENST00000506199 | ENST00000476366 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000512292 | ENST00000348697 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000512292 | ENST00000402984 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000512292 | ENST00000262722 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000512292 | ENST00000327858 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000512292 | ENST00000442170 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000512292 | ENST00000340923 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000512292 | ENST00000476366 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000394288 | ENST00000348697 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000394288 | ENST00000402984 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000394288 | ENST00000262722 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000394288 | ENST00000327858 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000394288 | ENST00000442170 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000394288 | ENST00000340923 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000394288 | ENST00000476366 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000432347 | ENST00000348697 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000432347 | ENST00000402984 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000432347 | ENST00000262722 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000432347 | ENST00000327858 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000432347 | ENST00000442170 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000432347 | ENST00000340923 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000432347 | ENST00000476366 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000427266 | ENST00000348697 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000427266 | ENST00000402984 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000427266 | ENST00000262722 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000427266 | ENST00000327858 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000427266 | ENST00000442170 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000427266 | ENST00000340923 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
5CDS-intron | ENST00000427266 | ENST00000476366 | LARP1B | chr4 | 128999075 | - | FBLN1 | chr22 | 45929052 | - |
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FusionProtFeatures for LARP1B_FBLN1 |
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Hgene | Tgene |
LARP1B | FBLN1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LARP1B_FBLN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LARP1B_FBLN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LARP1B_FBLN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LARP1B_FBLN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FBLN1 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | FBLN1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |