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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19459

FusionGeneSummary for LARP1B_C4orf29

check button Fusion gene summary
Fusion gene informationFusion gene name: LARP1B_C4orf29
Fusion gene ID: 19459
HgeneTgene
Gene symbol

LARP1B

C4orf29

Gene ID

55132

80167

Gene nameLa ribonucleoprotein domain family member 1Babhydrolase domain containing 18
SynonymsLARP2C4orf29
Cytomap

4q28.2

4q28.2

Type of geneprotein-codingprotein-coding
Descriptionla-related protein 1BLa ribonucleoprotein domain family, member 2la-related protein 2protein ABHD18abhydrolase domain-containing protein 18alpha/beta hydrolase domain-containing protein 18
Modification date2018051920180519
UniProtAcc

Q659C4

Ensembl transtripts involved in fusion geneENST00000326639, ENST00000264584, 
ENST00000441387, ENST00000354456, 
ENST00000506199, ENST00000512292, 
ENST00000394288, ENST00000432347, 
ENST00000427266, 
ENST00000398965, 
ENST00000444616, ENST00000388795, 
Fusion gene scores* DoF score6 X 7 X 3=1261 X 1 X 1=1
# samples 91
** MAII scorelog2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: LARP1B [Title/Abstract] AND C4orf29 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-A9SP-01ALARP1Bchr4

129012667

+C4orf29chr4

128956917

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000326639ENST00000398965LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000326639ENST00000444616LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000326639ENST00000388795LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000264584ENST00000398965LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000264584ENST00000444616LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000264584ENST00000388795LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000441387ENST00000398965LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000441387ENST00000444616LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000441387ENST00000388795LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5UTR-intronENST00000354456ENST00000398965LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5UTR-intronENST00000354456ENST00000444616LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5UTR-intronENST00000354456ENST00000388795LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
intron-intronENST00000506199ENST00000398965LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
intron-intronENST00000506199ENST00000444616LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
intron-intronENST00000506199ENST00000388795LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000512292ENST00000398965LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000512292ENST00000444616LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000512292ENST00000388795LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000394288ENST00000398965LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000394288ENST00000444616LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000394288ENST00000388795LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000432347ENST00000398965LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000432347ENST00000444616LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000432347ENST00000388795LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000427266ENST00000398965LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000427266ENST00000444616LARP1Bchr4

129012667

+C4orf29chr4

128956917

+
5CDS-intronENST00000427266ENST00000388795LARP1Bchr4

129012667

+C4orf29chr4

128956917

+

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FusionProtFeatures for LARP1B_C4orf29


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARP1B

Q659C4

C4orf29

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LARP1B_C4orf29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LARP1B_C4orf29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LARP1BELAVL1, CUL3, APP, UBC, POLR2J, KIF2A, TRIM69, CCNI2, TRA2A, NIFK, RPS2, ZC3H3, HNRNPA1, LUC7L2, CCNG1, POC1A, GSPT2, LARP1, ELAVL2, CDX1, DGCR8, H2AFX, APOBEC3D, WDR46, HIST1H1E, SNRNP70C4orf29SELO, VSIG4, HSPD1, IMPDH1, C1orf85, PDCD1, BPNT1, MGAT5B, LAMP2, YBEY, CD79A, SLC2A12, APLNR, TOR1AIP2, PRIMPOL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LARP1B_C4orf29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LARP1B_C4orf29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource