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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19458

FusionGeneSummary for LARP1B_BTG3

check button Fusion gene summary
Fusion gene informationFusion gene name: LARP1B_BTG3
Fusion gene ID: 19458
HgeneTgene
Gene symbol

LARP1B

BTG3

Gene ID

55132

10950

Gene nameLa ribonucleoprotein domain family member 1BBTG anti-proliferation factor 3
SynonymsLARP2ANA|ANA/BTG3|APRO4|TOB5|TOB55|TOFA
Cytomap

4q28.2

21q21.1

Type of geneprotein-codingprotein-coding
Descriptionla-related protein 1BLa ribonucleoprotein domain family, member 2la-related protein 2protein BTG3B-cell translocation gene 3BTG family member 3abundant in neuroepithelium area proteinprotein Tob5
Modification date2018051920180527
UniProtAcc

Q659C4

Q14201

Ensembl transtripts involved in fusion geneENST00000326639, ENST00000264584, 
ENST00000441387, ENST00000354456, 
ENST00000506199, ENST00000512292, 
ENST00000394288, ENST00000432347, 
ENST00000427266, 		ENST00000339775, 
ENST00000348354, ENST00000464058, 
Fusion gene scores* DoF score6 X 7 X 3=1263 X 3 X 2=18
# samples 93
** MAII scorelog2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LARP1B [Title/Abstract] AND BTG3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBTG3

GO:0045930

negative regulation of mitotic cell cycle

9632145


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX107631LARP1Bchr4

129003378

+BTG3chr21

18966628

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000326639ENST00000339775LARP1Bchr4

129003378

+BTG3chr21

18966628

-
Frame-shiftENST00000326639ENST00000348354LARP1Bchr4

129003378

+BTG3chr21

18966628

-
5CDS-intronENST00000326639ENST00000464058LARP1Bchr4

129003378

+BTG3chr21

18966628

-
intron-3CDSENST00000264584ENST00000339775LARP1Bchr4

129003378

+BTG3chr21

18966628

-
intron-3CDSENST00000264584ENST00000348354LARP1Bchr4

129003378

+BTG3chr21

18966628

-
intron-intronENST00000264584ENST00000464058LARP1Bchr4

129003378

+BTG3chr21

18966628

-
In-frameENST00000441387ENST00000339775LARP1Bchr4

129003378

+BTG3chr21

18966628

-
Frame-shiftENST00000441387ENST00000348354LARP1Bchr4

129003378

+BTG3chr21

18966628

-
5CDS-intronENST00000441387ENST00000464058LARP1Bchr4

129003378

+BTG3chr21

18966628

-
5UTR-3CDSENST00000354456ENST00000339775LARP1Bchr4

129003378

+BTG3chr21

18966628

-
5UTR-3CDSENST00000354456ENST00000348354LARP1Bchr4

129003378

+BTG3chr21

18966628

-
5UTR-intronENST00000354456ENST00000464058LARP1Bchr4

129003378

+BTG3chr21

18966628

-
intron-3CDSENST00000506199ENST00000339775LARP1Bchr4

129003378

+BTG3chr21

18966628

-
intron-3CDSENST00000506199ENST00000348354LARP1Bchr4

129003378

+BTG3chr21

18966628

-
intron-intronENST00000506199ENST00000464058LARP1Bchr4

129003378

+BTG3chr21

18966628

-
In-frameENST00000512292ENST00000339775LARP1Bchr4

129003378

+BTG3chr21

18966628

-
Frame-shiftENST00000512292ENST00000348354LARP1Bchr4

129003378

+BTG3chr21

18966628

-
5CDS-intronENST00000512292ENST00000464058LARP1Bchr4

129003378

+BTG3chr21

18966628

-
In-frameENST00000394288ENST00000339775LARP1Bchr4

129003378

+BTG3chr21

18966628

-
Frame-shiftENST00000394288ENST00000348354LARP1Bchr4

129003378

+BTG3chr21

18966628

-
5CDS-intronENST00000394288ENST00000464058LARP1Bchr4

129003378

+BTG3chr21

18966628

-
In-frameENST00000432347ENST00000339775LARP1Bchr4

129003378

+BTG3chr21

18966628

-
Frame-shiftENST00000432347ENST00000348354LARP1Bchr4

129003378

+BTG3chr21

18966628

-
5CDS-intronENST00000432347ENST00000464058LARP1Bchr4

129003378

+BTG3chr21

18966628

-
In-frameENST00000427266ENST00000339775LARP1Bchr4

129003378

+BTG3chr21

18966628

-
Frame-shiftENST00000427266ENST00000348354LARP1Bchr4

129003378

+BTG3chr21

18966628

-
5CDS-intronENST00000427266ENST00000464058LARP1Bchr4

129003378

+BTG3chr21

18966628

-

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FusionProtFeatures for LARP1B_BTG3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARP1B

Q659C4

BTG3

Q14201

Overexpression impairs serum-induced cell cycleprogression from the G0/G1 to S phase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LARP1B_BTG3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LARP1B_ENST00000326639_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0aa

>In-frame_LARP1B_ENST00000441387_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0aa

>In-frame_LARP1B_ENST00000512292_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0aa

>In-frame_LARP1B_ENST00000394288_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0aa

>In-frame_LARP1B_ENST00000432347_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0aa

>In-frame_LARP1B_ENST00000427266_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LARP1B_ENST00000326639_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000441387_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000512292_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000394288_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000432347_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000427266_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_LARP1B_ENST00000326639_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000441387_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000512292_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000394288_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000432347_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt

>In-frame_LARP1B_ENST00000427266_chr4_129003378_+_BTG3_ENST00000339775_chr21_18966628_-_0nt


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FusionGenePPI for LARP1B_BTG3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LARP1B_BTG3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LARP1B_BTG3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBTG3C0007134Renal Cell Carcinoma1CTD_human
TgeneBTG3C3495559Juvenile arthritis1CTD_human