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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 19446

FusionGeneSummary for LAPTM4A_SDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: LAPTM4A_SDC1
Fusion gene ID: 19446
HgeneTgene
Gene symbol

LAPTM4A

SDC1

Gene ID

9741

6382

Gene namelysosomal protein transmembrane 4 alphasyndecan 1
SynonymsHUMORF13|LAPTM4|MBNT|MtrpCD138|SDC|SYND1|syndecan
Cytomap

2p24.1

2p24.1

Type of geneprotein-codingprotein-coding
Descriptionlysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transportersyndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1
Modification date2018052320180527
UniProtAcc

Q15012

P18827

Ensembl transtripts involved in fusion geneENST00000175091, ENST00000254351, 
ENST00000381150, ENST00000403076, 
ENST00000482879, 
Fusion gene scores* DoF score7 X 6 X 4=1684 X 3 X 2=24
# samples 74
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LAPTM4A [Title/Abstract] AND SDC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AC-A6IW-01ALAPTM4Achr2

20251171

-SDC1chr2

20405185

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000175091ENST00000254351LAPTM4Achr2

20251171

-SDC1chr2

20405185

-
In-frameENST00000175091ENST00000381150LAPTM4Achr2

20251171

-SDC1chr2

20405185

-
In-frameENST00000175091ENST00000403076LAPTM4Achr2

20251171

-SDC1chr2

20405185

-
5CDS-5UTRENST00000175091ENST00000482879LAPTM4Achr2

20251171

-SDC1chr2

20405185

-

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FusionProtFeatures for LAPTM4A_SDC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAPTM4A

Q15012

SDC1

P18827

May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}. Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSDC1chr2:20251171chr2:20405185ENST00000254351-0523_25422311Topological domainExtracellular
TgeneSDC1chr2:20251171chr2:20405185ENST00000254351-05276_31022311Topological domainCytoplasmic
TgeneSDC1chr2:20251171chr2:20405185ENST00000381150-1623_25422311Topological domainExtracellular
TgeneSDC1chr2:20251171chr2:20405185ENST00000381150-16276_31022311Topological domainCytoplasmic
TgeneSDC1chr2:20251171chr2:20405185ENST00000254351-05255_27522311TransmembraneHelical
TgeneSDC1chr2:20251171chr2:20405185ENST00000381150-16255_27522311TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAPTM4Achr2:20251171chr2:20405185ENST00000175091-17226_22937234Compositional biasNote=Poly-Pro
HgeneLAPTM4Achr2:20251171chr2:20405185ENST00000175091-17108_12837234TransmembraneHelical
HgeneLAPTM4Achr2:20251171chr2:20405185ENST00000175091-17160_18037234TransmembraneHelical
HgeneLAPTM4Achr2:20251171chr2:20405185ENST00000175091-1729_4937234TransmembraneHelical
HgeneLAPTM4Achr2:20251171chr2:20405185ENST00000175091-1782_10237234TransmembraneHelical


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FusionGeneSequence for LAPTM4A_SDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000254351_chr2_20405185_-_326aa
MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIP
TSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETS
TPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGG

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000381150_chr2_20405185_-_326aa
MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIP
TSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETS
TPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGG

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000403076_chr2_20405185_-_185aa
MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIP
TSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPVHFVSW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000254351_chr2_20405185_-_978nt
ATGGTGTCCATGAGTTTCAAGCGGAACCGCAGTGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATC
ATCCTGGGGACCTGGTACATGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCC
GGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCC
ACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTA
GTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCAT
CTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCA
ACCCCTGCAGGACCCAGCCAAGCTGACCTTCACACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGA
GCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTCTGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTG
GAGCCTGACCGCCGGAACCAGTCCCCAGTGGATCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGG
GTCATTGCCGGAGGCCTCGTGGGGCTCATCTTTGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGC

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000381150_chr2_20405185_-_978nt
ATGGTGTCCATGAGTTTCAAGCGGAACCGCAGTGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATC
ATCCTGGGGACCTGGTACATGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCC
GGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCC
ACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTA
GTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCAT
CTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCA
ACCCCTGCAGGACCCAGCCAAGCTGACCTTCACACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGA
GCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTCTGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTG
GAGCCTGACCGCCGGAACCAGTCCCCAGTGGATCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGG
GTCATTGCCGGAGGCCTCGTGGGGCTCATCTTTGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGC

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000403076_chr2_20405185_-_555nt
ATGGTGTCCATGAGTTTCAAGCGGAACCGCAGTGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATC
ATCCTGGGGACCTGGTACATGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCC
GGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCC
ACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTA
GTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCAT
CTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGTCCACTTTGTTTCGTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000254351_chr2_20405185_-_3455nt
ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA
TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT
GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG
AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG
CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG
GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG
TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGCAAATTGTGGC
TACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCAC
CTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTAC
AGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGC
CCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCA
GGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCA
CACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGAGCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTC
TGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTGGAGCCTGACCGCCGGAACCAGTCCCCAGTGGA
TCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGGGTCATTGCCGGAGGCCTCGTGGGGCTCATCTT
TGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGG
CGGGGCCTACCAGAAGCCCACCAAACAGGAGGAATTCTATGCCTGACGCGGGAGCCATGCGCCCCCTCCGCCCTGCCACTCACTAGGCCC
CCACTTGCCTCTTCCTTGAAGAACTGCAGGCCCTGGCCTCCCCTGCCACCAGGCCACCTCCCCAGCATTCCAGCCCCTCTGGTCGCTCCT
GCCCACGGAGTCGTGGGGTGTGCTGGGAGCTCCACTCTGCTTCTCTGACTTCTGCCTGGAGACTTAGGGCACCAGGGGTTTCTCGCATAG
GACCTTTCCACCACAGCCAGCACCTGGCATCGCACCATTCTGACTCGGTTTCTCCAAACTGAAGCAGCCTCTCCCCAGGTCCAGCTCTGG
AGGGGAGGGGGATCCGACTGCTTTGGACCTAAATGGCCTCATGTGGCTGGAAGATCCTGCGGGTGGGGCTTGGGGCTCACACACCTGTAG
CACTTACTGGTAGGACCAAGCATCTTGGGGGGGTGGCCGCTGAGTGGCAGGGGACAGGAGTCCACTTTGTTTCGTGGGGAGGTCTAATCT
AGATATCGACTTGTTTTTGCACATGTTTCCTCTAGTTCTTTGTTCATAGCCCAGTAGACCTTGTTACTTCTGAGGTAAGTTAAGTAAGTT
GATTCGGTATCCCCCCATCTTGCTTCCCTAATCTATGGTCGGGAGACAGCATCAGGGTTAAGAAGACTTTTTTTTTTTTTTTTTAAACTA
GGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTGTGTTGTCTCTTGAGTTTGTCGCTCATGTGTGCAACAGGGTATGGACTA
TCTGTCTGGTGGCCCCGTTTCTGGTGGTCTGTTGGCAGGCTGGCCAGTCCAGGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTGC
CTGTGTCCATGCGCTCAGGGCCATGCTGAGGCCTGGGCCGCTGCCACGTTGGAGAAGCCCGTGTGAGAAGTGAATGCTGGGACTCAGCCT
TCAGACAGAGAGGACTGTAGGGAGGGCGGCAGGGGCCTGGAGATCCTCCTGCAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGGG
GCTGCTTCCTCCTGGAAATTGACGAGGGGTGTCTTGGGCAGAGCTGGCTCTGAGCGCCTCCATCCAAGGCCAGGTTCTCCGTTAGCTCCT
GTGGCCCCACCCTGGGCCCTGGGCTGGAATCAGGAATATTTTCCAAAGAGTGATAGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCAA
TGGGTTTTTCCCTGTACAGTAGATTTTCCAAATGTAATAAACTTTAATATAAAGTAGTCCTGTGAATGCCACTGCCTTCGCTTCTTGCCT
CTGTGCTGTGTGTGACGTGACCGGACTTTTCTGCAAACACCAACATGTTGGGAAACTTGGCTCGAATCTCTGTGCCTTCGTCTTTCCCAT
GGGGAGGGATTCTGGTTCCAGGGTCCCTCTGTGTATTTGCTTTTTTGTTTTGGCTGAAATTCTCCTGGAGGTCGGTAGGTTCAGCCAAGG
TTTTATAAGGCTGATGTCAATTTCTGTGTTGCCAAGCTCCAAGCCCCATCTTCTAAATGGCAAAGGAAGGTGGATGGCCCCAGCACAGCT
TGACCTGAGGCTGTGGTCACAGCGGAGGTGTGGAGCCGAGGCCTACCCCGCAGACACCTTGGACATCCTCCTCCCACCCGGCTGCAGAGG
CCAGAGGCCCCCAGCCCAGGGCTCCTGCACTTACTTGCTTATTTGACAACGTTTCAGCGACTCCGTTGGCCACTCCGAGAGGTGGGCCAG
TCTGTGGATCAGAGATGCACCACCAAGCCAAGGGAACCTGTGTCCGGTATTCGATACTGCGACTTTCTGCCTGGAGTGTATGACTGCACA
TGACTCGGGGGTGGGGAAAGGGGTCGGCTGACCATGCTCATCTGCTGGTCCGTGGGACGGTGCCCAAGCCAGAGGCTGGGTTCATTTGTG

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000381150_chr2_20405185_-_3453nt
ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA
TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT
GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG
AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG
CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG
GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG
TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGCAAATTGTGGC
TACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCAC
CTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTAC
AGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGC
CCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCA
GGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCA
CACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGAGCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTC
TGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTGGAGCCTGACCGCCGGAACCAGTCCCCAGTGGA
TCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGGGTCATTGCCGGAGGCCTCGTGGGGCTCATCTT
TGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGG
CGGGGCCTACCAGAAGCCCACCAAACAGGAGGAATTCTATGCCTGACGCGGGAGCCATGCGCCCCCTCCGCCCTGCCACTCACTAGGCCC
CCACTTGCCTCTTCCTTGAAGAACTGCAGGCCCTGGCCTCCCCTGCCACCAGGCCACCTCCCCAGCATTCCAGCCCCTCTGGTCGCTCCT
GCCCACGGAGTCGTGGGGTGTGCTGGGAGCTCCACTCTGCTTCTCTGACTTCTGCCTGGAGACTTAGGGCACCAGGGGTTTCTCGCATAG
GACCTTTCCACCACAGCCAGCACCTGGCATCGCACCATTCTGACTCGGTTTCTCCAAACTGAAGCAGCCTCTCCCCAGGTCCAGCTCTGG
AGGGGAGGGGGATCCGACTGCTTTGGACCTAAATGGCCTCATGTGGCTGGAAGATCCTGCGGGTGGGGCTTGGGGCTCACACACCTGTAG
CACTTACTGGTAGGACCAAGCATCTTGGGGGGGTGGCCGCTGAGTGGCAGGGGACAGGAGTCCACTTTGTTTCGTGGGGAGGTCTAATCT
AGATATCGACTTGTTTTTGCACATGTTTCCTCTAGTTCTTTGTTCATAGCCCAGTAGACCTTGTTACTTCTGAGGTAAGTTAAGTAAGTT
GATTCGGTATCCCCCCATCTTGCTTCCCTAATCTATGGTCGGGAGACAGCATCAGGGTTAAGAAGACTTTTTTTTTTTTTTTTTAAACTA
GGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTGTGTTGTCTCTTGAGTTTGTCGCTCATGTGTGCAACAGGGTATGGACTA
TCTGTCTGGTGGCCCCGTTTCTGGTGGTCTGTTGGCAGGCTGGCCAGTCCAGGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTGC
CTGTGTCCATGCGCTCAGGGCCATGCTGAGGCCTGGGCCGCTGCCACGTTGGAGAAGCCCGTGTGAGAAGTGAATGCTGGGACTCAGCCT
TCAGACAGAGAGGACTGTAGGGAGGGCGGCAGGGGCCTGGAGATCCTCCTGCAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGGG
GCTGCTTCCTCCTGGAAATTGACGAGGGGTGTCTTGGGCAGAGCTGGCTCTGAGCGCCTCCATCCAAGGCCAGGTTCTCCGTTAGCTCCT
GTGGCCCCACCCTGGGCCCTGGGCTGGAATCAGGAATATTTTCCAAAGAGTGATAGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCAA
TGGGTTTTTCCCTGTACAGTAGATTTTCCAAATGTAATAAACTTTAATATAAAGTAGTCCTGTGAATGCCACTGCCTTCGCTTCTTGCCT
CTGTGCTGTGTGTGACGTGACCGGACTTTTCTGCAAACACCAACATGTTGGGAAACTTGGCTCGAATCTCTGTGCCTTCGTCTTTCCCAT
GGGGAGGGATTCTGGTTCCAGGGTCCCTCTGTGTATTTGCTTTTTTGTTTTGGCTGAAATTCTCCTGGAGGTCGGTAGGTTCAGCCAAGG
TTTTATAAGGCTGATGTCAATTTCTGTGTTGCCAAGCTCCAAGCCCCATCTTCTAAATGGCAAAGGAAGGTGGATGGCCCCAGCACAGCT
TGACCTGAGGCTGTGGTCACAGCGGAGGTGTGGAGCCGAGGCCTACCCCGCAGACACCTTGGACATCCTCCTCCCACCCGGCTGCAGAGG
CCAGAGGCCCCCAGCCCAGGGCTCCTGCACTTACTTGCTTATTTGACAACGTTTCAGCGACTCCGTTGGCCACTCCGAGAGGTGGGCCAG
TCTGTGGATCAGAGATGCACCACCAAGCCAAGGGAACCTGTGTCCGGTATTCGATACTGCGACTTTCTGCCTGGAGTGTATGACTGCACA
TGACTCGGGGGTGGGGAAAGGGGTCGGCTGACCATGCTCATCTGCTGGTCCGTGGGACGGTGCCCAAGCCAGAGGCTGGGTTCATTTGTG

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000403076_chr2_20405185_-_1847nt
ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA
TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT
GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG
AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG
CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG
GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG
TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGCAAATTGTGGC
TACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCAC
CTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTAC
AGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGC
CCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCA
GGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGTCCACTTTGTTTCGTGGGGAGGTCTAATCTAGATATCGACTTGTTTTTG
CACATGTTTCCTCTAGTTCTTTGTTCATAGCCCAGTAGACCTTGTTACTTCTGAGGTAAGTTAAGTAAGTTGATTCGGTATCCCCCCATC
TTGCTTCCCTAATCTATGGTCGGGAGACAGCATCAGGGTTAAGAAGACTTTTTTTTTTTTTTTTTAAACTAGGAGAACCAAATCTGGAAG
CCAAAATGTAGGCTTAGTTTGTGTGTTGTCTCTTGAGTTTGTCGCTCATGTGTGCAACAGGGTATGGACTATCTGTCTGGTGGCCCCGTT
TCTGGTGGTCTGTTGGCAGGCTGGCCAGTCCAGGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTGCCTGTGTCCATGCGCTCAGG
GCCATGCTGAGGCCTGGGCCGCTGCCACGTTGGAGAAGCCCGTGTGAGAAGTGAATGCTGGGACTCAGCCTTCAGACAGAGAGGACTGTA
GGGAGGGCGGCAGGGGCCTGGAGATCCTCCTGCAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGGGGCTGCTTCCTCCTGGAAAT
TGACGAGGGGTGTCTTGGGCAGAGCTGGCTCTGAGCGCCTCCATCCAAGGCCAGGTTCTCCGTTAGCTCCTGTGGCCCCACCCTGGGCCC
TGGGCTGGAATCAGGAATATTTTCCAAAGAGTGATAGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCAATGGGTTTTTCCCTGTACAG


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FusionGenePPI for LAPTM4A_SDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LAPTM4ATUBB3, ELAVL1, NEDD4, TFRC, IGF2BP3, HNRNPU, UNK, WWP2, C16orf58, KIAA1467, MTNR1ASDC1LACRT, FGF2, CCL5, CXCL8, HGF, CASK, SDCBP, CTSG, APP, AHCY, ZNF593, BAG3, CD63, PTEN, EP300, FARP1, DHRS2, GMEB2, PRDM10, CYHR1, EPHA2, CSNK1G3, OCLN, HMGCS1, CCNY, EFR3A, PTPRG, ARVCF, AMPD2, RAP2A, RFTN1, PARP2, EEPD1, GNAZ, VANGL1, RRAS, GNB4, GMEB1, FBXO46, FTO, CSNK1G2, AHNAK, PRRC1, CTH, HRAS, NCAM1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAPTM4A_SDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAPTM4A_SDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSDC1C0345967Malignant mesothelioma1CTD_human