|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 19446 |
FusionGeneSummary for LAPTM4A_SDC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LAPTM4A_SDC1 | Fusion gene ID: 19446 | Hgene | Tgene | Gene symbol | LAPTM4A | SDC1 | Gene ID | 9741 | 6382 |
| Gene name | lysosomal protein transmembrane 4 alpha | syndecan 1 | |
| Synonyms | HUMORF13|LAPTM4|MBNT|Mtrp | CD138|SDC|SYND1|syndecan | |
| Cytomap | 2p24.1 | 2p24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporter | syndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q15012 | P18827 | |
| Ensembl transtripts involved in fusion gene | ENST00000175091, | ENST00000254351, ENST00000381150, ENST00000403076, ENST00000482879, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 4 X 3 X 2=24 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LAPTM4A [Title/Abstract] AND SDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A6IW-01A | LAPTM4A | chr2 | 20251171 | - | SDC1 | chr2 | 20405185 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000175091 | ENST00000254351 | LAPTM4A | chr2 | 20251171 | - | SDC1 | chr2 | 20405185 | - |
| In-frame | ENST00000175091 | ENST00000381150 | LAPTM4A | chr2 | 20251171 | - | SDC1 | chr2 | 20405185 | - |
| In-frame | ENST00000175091 | ENST00000403076 | LAPTM4A | chr2 | 20251171 | - | SDC1 | chr2 | 20405185 | - |
| 5CDS-5UTR | ENST00000175091 | ENST00000482879 | LAPTM4A | chr2 | 20251171 | - | SDC1 | chr2 | 20405185 | - |
Top |
FusionProtFeatures for LAPTM4A_SDC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LAPTM4A | SDC1 |
| May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}. | Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SDC1 | chr2:20251171 | chr2:20405185 | ENST00000254351 | - | 0 | 5 | 23_254 | 22 | 311 | Topological domain | Extracellular |
| Tgene | >SDC1 | chr2:20251171 | chr2:20405185 | ENST00000254351 | - | 0 | 5 | 276_310 | 22 | 311 | Topological domain | Cytoplasmic |
| Tgene | >SDC1 | chr2:20251171 | chr2:20405185 | ENST00000381150 | - | 1 | 6 | 23_254 | 22 | 311 | Topological domain | Extracellular |
| Tgene | >SDC1 | chr2:20251171 | chr2:20405185 | ENST00000381150 | - | 1 | 6 | 276_310 | 22 | 311 | Topological domain | Cytoplasmic |
| Tgene | >SDC1 | chr2:20251171 | chr2:20405185 | ENST00000254351 | - | 0 | 5 | 255_275 | 22 | 311 | Transmembrane | Helical |
| Tgene | >SDC1 | chr2:20251171 | chr2:20405185 | ENST00000381150 | - | 1 | 6 | 255_275 | 22 | 311 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LAPTM4A | chr2:20251171 | chr2:20405185 | ENST00000175091 | - | 1 | 7 | 226_229 | 37 | 234 | Compositional bias | Note=Poly-Pro |
| Hgene | >LAPTM4A | chr2:20251171 | chr2:20405185 | ENST00000175091 | - | 1 | 7 | 108_128 | 37 | 234 | Transmembrane | Helical |
| Hgene | >LAPTM4A | chr2:20251171 | chr2:20405185 | ENST00000175091 | - | 1 | 7 | 160_180 | 37 | 234 | Transmembrane | Helical |
| Hgene | >LAPTM4A | chr2:20251171 | chr2:20405185 | ENST00000175091 | - | 1 | 7 | 29_49 | 37 | 234 | Transmembrane | Helical |
| Hgene | >LAPTM4A | chr2:20251171 | chr2:20405185 | ENST00000175091 | - | 1 | 7 | 82_102 | 37 | 234 | Transmembrane | Helical |
Top |
FusionGeneSequence for LAPTM4A_SDC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000254351_chr2_20405185_-_326aa MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIP TSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETS TPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGG >In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000381150_chr2_20405185_-_326aa MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIP TSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETS TPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGG >In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000403076_chr2_20405185_-_185aa MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIP TSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPVHFVSW |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000254351_chr2_20405185_-_978nt ATGGTGTCCATGAGTTTCAAGCGGAACCGCAGTGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATC ATCCTGGGGACCTGGTACATGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCC GGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCC ACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTA GTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCAT CTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCA ACCCCTGCAGGACCCAGCCAAGCTGACCTTCACACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGA GCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTCTGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTG GAGCCTGACCGCCGGAACCAGTCCCCAGTGGATCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGG GTCATTGCCGGAGGCCTCGTGGGGCTCATCTTTGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGC >In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000381150_chr2_20405185_-_978nt ATGGTGTCCATGAGTTTCAAGCGGAACCGCAGTGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATC ATCCTGGGGACCTGGTACATGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCC GGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCC ACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTA GTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCAT CTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCA ACCCCTGCAGGACCCAGCCAAGCTGACCTTCACACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGA GCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTCTGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTG GAGCCTGACCGCCGGAACCAGTCCCCAGTGGATCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGG GTCATTGCCGGAGGCCTCGTGGGGCTCATCTTTGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGC >In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000403076_chr2_20405185_-_555nt ATGGTGTCCATGAGTTTCAAGCGGAACCGCAGTGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATC ATCCTGGGGACCTGGTACATGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCC GGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCC ACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTA GTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCAT CTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGTCCACTTTGTTTCGTGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000254351_chr2_20405185_-_3455nt ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGCAAATTGTGGC TACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCAC CTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTAC AGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGC CCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCA GGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCA CACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGAGCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTC TGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTGGAGCCTGACCGCCGGAACCAGTCCCCAGTGGA TCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGGGTCATTGCCGGAGGCCTCGTGGGGCTCATCTT TGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGG CGGGGCCTACCAGAAGCCCACCAAACAGGAGGAATTCTATGCCTGACGCGGGAGCCATGCGCCCCCTCCGCCCTGCCACTCACTAGGCCC CCACTTGCCTCTTCCTTGAAGAACTGCAGGCCCTGGCCTCCCCTGCCACCAGGCCACCTCCCCAGCATTCCAGCCCCTCTGGTCGCTCCT GCCCACGGAGTCGTGGGGTGTGCTGGGAGCTCCACTCTGCTTCTCTGACTTCTGCCTGGAGACTTAGGGCACCAGGGGTTTCTCGCATAG GACCTTTCCACCACAGCCAGCACCTGGCATCGCACCATTCTGACTCGGTTTCTCCAAACTGAAGCAGCCTCTCCCCAGGTCCAGCTCTGG AGGGGAGGGGGATCCGACTGCTTTGGACCTAAATGGCCTCATGTGGCTGGAAGATCCTGCGGGTGGGGCTTGGGGCTCACACACCTGTAG CACTTACTGGTAGGACCAAGCATCTTGGGGGGGTGGCCGCTGAGTGGCAGGGGACAGGAGTCCACTTTGTTTCGTGGGGAGGTCTAATCT AGATATCGACTTGTTTTTGCACATGTTTCCTCTAGTTCTTTGTTCATAGCCCAGTAGACCTTGTTACTTCTGAGGTAAGTTAAGTAAGTT GATTCGGTATCCCCCCATCTTGCTTCCCTAATCTATGGTCGGGAGACAGCATCAGGGTTAAGAAGACTTTTTTTTTTTTTTTTTAAACTA GGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTGTGTTGTCTCTTGAGTTTGTCGCTCATGTGTGCAACAGGGTATGGACTA TCTGTCTGGTGGCCCCGTTTCTGGTGGTCTGTTGGCAGGCTGGCCAGTCCAGGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTGC CTGTGTCCATGCGCTCAGGGCCATGCTGAGGCCTGGGCCGCTGCCACGTTGGAGAAGCCCGTGTGAGAAGTGAATGCTGGGACTCAGCCT TCAGACAGAGAGGACTGTAGGGAGGGCGGCAGGGGCCTGGAGATCCTCCTGCAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGGG GCTGCTTCCTCCTGGAAATTGACGAGGGGTGTCTTGGGCAGAGCTGGCTCTGAGCGCCTCCATCCAAGGCCAGGTTCTCCGTTAGCTCCT GTGGCCCCACCCTGGGCCCTGGGCTGGAATCAGGAATATTTTCCAAAGAGTGATAGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCAA TGGGTTTTTCCCTGTACAGTAGATTTTCCAAATGTAATAAACTTTAATATAAAGTAGTCCTGTGAATGCCACTGCCTTCGCTTCTTGCCT CTGTGCTGTGTGTGACGTGACCGGACTTTTCTGCAAACACCAACATGTTGGGAAACTTGGCTCGAATCTCTGTGCCTTCGTCTTTCCCAT GGGGAGGGATTCTGGTTCCAGGGTCCCTCTGTGTATTTGCTTTTTTGTTTTGGCTGAAATTCTCCTGGAGGTCGGTAGGTTCAGCCAAGG TTTTATAAGGCTGATGTCAATTTCTGTGTTGCCAAGCTCCAAGCCCCATCTTCTAAATGGCAAAGGAAGGTGGATGGCCCCAGCACAGCT TGACCTGAGGCTGTGGTCACAGCGGAGGTGTGGAGCCGAGGCCTACCCCGCAGACACCTTGGACATCCTCCTCCCACCCGGCTGCAGAGG CCAGAGGCCCCCAGCCCAGGGCTCCTGCACTTACTTGCTTATTTGACAACGTTTCAGCGACTCCGTTGGCCACTCCGAGAGGTGGGCCAG TCTGTGGATCAGAGATGCACCACCAAGCCAAGGGAACCTGTGTCCGGTATTCGATACTGCGACTTTCTGCCTGGAGTGTATGACTGCACA TGACTCGGGGGTGGGGAAAGGGGTCGGCTGACCATGCTCATCTGCTGGTCCGTGGGACGGTGCCCAAGCCAGAGGCTGGGTTCATTTGTG >In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000381150_chr2_20405185_-_3453nt ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGCAAATTGTGGC TACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCAC CTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTAC AGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGC CCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCA GGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCA CACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGAGCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTC TGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTGGAGCCTGACCGCCGGAACCAGTCCCCAGTGGA TCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGGGTCATTGCCGGAGGCCTCGTGGGGCTCATCTT TGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGG CGGGGCCTACCAGAAGCCCACCAAACAGGAGGAATTCTATGCCTGACGCGGGAGCCATGCGCCCCCTCCGCCCTGCCACTCACTAGGCCC CCACTTGCCTCTTCCTTGAAGAACTGCAGGCCCTGGCCTCCCCTGCCACCAGGCCACCTCCCCAGCATTCCAGCCCCTCTGGTCGCTCCT GCCCACGGAGTCGTGGGGTGTGCTGGGAGCTCCACTCTGCTTCTCTGACTTCTGCCTGGAGACTTAGGGCACCAGGGGTTTCTCGCATAG GACCTTTCCACCACAGCCAGCACCTGGCATCGCACCATTCTGACTCGGTTTCTCCAAACTGAAGCAGCCTCTCCCCAGGTCCAGCTCTGG AGGGGAGGGGGATCCGACTGCTTTGGACCTAAATGGCCTCATGTGGCTGGAAGATCCTGCGGGTGGGGCTTGGGGCTCACACACCTGTAG CACTTACTGGTAGGACCAAGCATCTTGGGGGGGTGGCCGCTGAGTGGCAGGGGACAGGAGTCCACTTTGTTTCGTGGGGAGGTCTAATCT AGATATCGACTTGTTTTTGCACATGTTTCCTCTAGTTCTTTGTTCATAGCCCAGTAGACCTTGTTACTTCTGAGGTAAGTTAAGTAAGTT GATTCGGTATCCCCCCATCTTGCTTCCCTAATCTATGGTCGGGAGACAGCATCAGGGTTAAGAAGACTTTTTTTTTTTTTTTTTAAACTA GGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTGTGTTGTCTCTTGAGTTTGTCGCTCATGTGTGCAACAGGGTATGGACTA TCTGTCTGGTGGCCCCGTTTCTGGTGGTCTGTTGGCAGGCTGGCCAGTCCAGGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTGC CTGTGTCCATGCGCTCAGGGCCATGCTGAGGCCTGGGCCGCTGCCACGTTGGAGAAGCCCGTGTGAGAAGTGAATGCTGGGACTCAGCCT TCAGACAGAGAGGACTGTAGGGAGGGCGGCAGGGGCCTGGAGATCCTCCTGCAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGGG GCTGCTTCCTCCTGGAAATTGACGAGGGGTGTCTTGGGCAGAGCTGGCTCTGAGCGCCTCCATCCAAGGCCAGGTTCTCCGTTAGCTCCT GTGGCCCCACCCTGGGCCCTGGGCTGGAATCAGGAATATTTTCCAAAGAGTGATAGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCAA TGGGTTTTTCCCTGTACAGTAGATTTTCCAAATGTAATAAACTTTAATATAAAGTAGTCCTGTGAATGCCACTGCCTTCGCTTCTTGCCT CTGTGCTGTGTGTGACGTGACCGGACTTTTCTGCAAACACCAACATGTTGGGAAACTTGGCTCGAATCTCTGTGCCTTCGTCTTTCCCAT GGGGAGGGATTCTGGTTCCAGGGTCCCTCTGTGTATTTGCTTTTTTGTTTTGGCTGAAATTCTCCTGGAGGTCGGTAGGTTCAGCCAAGG TTTTATAAGGCTGATGTCAATTTCTGTGTTGCCAAGCTCCAAGCCCCATCTTCTAAATGGCAAAGGAAGGTGGATGGCCCCAGCACAGCT TGACCTGAGGCTGTGGTCACAGCGGAGGTGTGGAGCCGAGGCCTACCCCGCAGACACCTTGGACATCCTCCTCCCACCCGGCTGCAGAGG CCAGAGGCCCCCAGCCCAGGGCTCCTGCACTTACTTGCTTATTTGACAACGTTTCAGCGACTCCGTTGGCCACTCCGAGAGGTGGGCCAG TCTGTGGATCAGAGATGCACCACCAAGCCAAGGGAACCTGTGTCCGGTATTCGATACTGCGACTTTCTGCCTGGAGTGTATGACTGCACA TGACTCGGGGGTGGGGAAAGGGGTCGGCTGACCATGCTCATCTGCTGGTCCGTGGGACGGTGCCCAAGCCAGAGGCTGGGTTCATTTGTG >In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_SDC1_ENST00000403076_chr2_20405185_-_1847nt ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGCAAATTGTGGC TACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCAC CTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTAC AGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGC CCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCA GGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGTCCACTTTGTTTCGTGGGGAGGTCTAATCTAGATATCGACTTGTTTTTG CACATGTTTCCTCTAGTTCTTTGTTCATAGCCCAGTAGACCTTGTTACTTCTGAGGTAAGTTAAGTAAGTTGATTCGGTATCCCCCCATC TTGCTTCCCTAATCTATGGTCGGGAGACAGCATCAGGGTTAAGAAGACTTTTTTTTTTTTTTTTTAAACTAGGAGAACCAAATCTGGAAG CCAAAATGTAGGCTTAGTTTGTGTGTTGTCTCTTGAGTTTGTCGCTCATGTGTGCAACAGGGTATGGACTATCTGTCTGGTGGCCCCGTT TCTGGTGGTCTGTTGGCAGGCTGGCCAGTCCAGGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTGCCTGTGTCCATGCGCTCAGG GCCATGCTGAGGCCTGGGCCGCTGCCACGTTGGAGAAGCCCGTGTGAGAAGTGAATGCTGGGACTCAGCCTTCAGACAGAGAGGACTGTA GGGAGGGCGGCAGGGGCCTGGAGATCCTCCTGCAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGGGGCTGCTTCCTCCTGGAAAT TGACGAGGGGTGTCTTGGGCAGAGCTGGCTCTGAGCGCCTCCATCCAAGGCCAGGTTCTCCGTTAGCTCCTGTGGCCCCACCCTGGGCCC TGGGCTGGAATCAGGAATATTTTCCAAAGAGTGATAGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCAATGGGTTTTTCCCTGTACAG |
Top |
FusionGenePPI for LAPTM4A_SDC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LAPTM4A | TUBB3, ELAVL1, NEDD4, TFRC, IGF2BP3, HNRNPU, UNK, WWP2, C16orf58, KIAA1467, MTNR1A | SDC1 | LACRT, FGF2, CCL5, CXCL8, HGF, CASK, SDCBP, CTSG, APP, AHCY, ZNF593, BAG3, CD63, PTEN, EP300, FARP1, DHRS2, GMEB2, PRDM10, CYHR1, EPHA2, CSNK1G3, OCLN, HMGCS1, CCNY, EFR3A, PTPRG, ARVCF, AMPD2, RAP2A, RFTN1, PARP2, EEPD1, GNAZ, VANGL1, RRAS, GNB4, GMEB1, FBXO46, FTO, CSNK1G2, AHNAK, PRRC1, CTH, HRAS, NCAM1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for LAPTM4A_SDC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for LAPTM4A_SDC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SDC1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|