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Fusion gene ID: 19445

FusionGeneSummary for LAPTM4A_PUM2

Fusion gene summary

Fusion gene information	Fusion gene name: LAPTM4A_PUM2
	Fusion gene ID: 19445
		Hgene	Tgene
	Gene symbol	LAPTM4A	PUM2
	Gene ID	9741	23369
	Gene name	lysosomal protein transmembrane 4 alpha	pumilio RNA binding family member 2
	Synonyms	HUMORF13\|LAPTM4\|MBNT\|Mtrp	PUMH2\|PUML2
	Cytomap	2p24.1	2p24.1
	Type of gene	protein-coding	protein-coding
	Description	lysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporter	pumilio homolog 2pumilio-2
	Modification date	20180523	20180522
	UniProtAcc	Q15012	Q8TB72
	Ensembl transtripts involved in fusion gene	ENST00000175091,	ENST00000338086, ENST00000319801, ENST00000361078, ENST00000536417, ENST00000403432, ENST00000420234,
Fusion gene scores	* DoF score	7 X 6 X 4=168	8 X 7 X 5=280
	# samples	7	10
	** MAII score	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LAPTM4A [Title/Abstract] AND PUM2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PUM2	GO:0010608	posttranscriptional regulation of gene expression	25100735
Tgene	PUM2	GO:0043488	regulation of mRNA stability	26724866
Tgene	PUM2	GO:0051983	regulation of chromosome segregation	26724866
Tgene	PUM2	GO:1900246	positive regulation of RIG-I signaling pathway	25340845

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	STAD	TCGA-FP-8631-01A	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000175091	ENST00000338086	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
In-frame	ENST00000175091	ENST00000319801	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
In-frame	ENST00000175091	ENST00000361078	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
5CDS-5UTR	ENST00000175091	ENST00000536417	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
5CDS-5UTR	ENST00000175091	ENST00000403432	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
5CDS-5UTR	ENST00000175091	ENST00000420234	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-

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FusionProtFeatures for LAPTM4A_PUM2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LAPTM4A Q15012	PUM2 Q8TB72
May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}.	Sequence-specific RNA-binding protein that acts as apost-transcriptional repressor by binding the 3'-UTR of mRNAtargets. Binds to an RNA consensus sequence, the Pumilio ResponseElement (PRE), 5'-UGUANAUA-3', that is related to the NanosResponse Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via differentmechanisms: acts via direct recruitment of the CCR4-POP2-NOTdeadenylase leading to translational inhibition and mRNAdegradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs(PubMed:18776931, PubMed:22345517). Acts as a post-transcriptionalrepressor of E2F3 mRNAs by binding to its 3'-UTR and facilitatingmiRNA regulation (PubMed:22345517). Plays a role in cytoplasmicsensing of viral infection (PubMed:25340845). Represses a programof genes necessary to maintain genomic stability such as keymitotic, DNA repair and DNA replication factors. Its ability torepress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its highabundance and multitude of PUMILIO binding sites, is able tosequester a significant fraction of PUM1 and PUM2 in the cytoplasm(PubMed:26724866). May regulate DCUN1D3 mRNA levels(PubMed:25349211). May support proliferation and self-renewal ofstem cells. Binds specifically to miRNA MIR199A precursor, withPUM1, regulates miRNA MIR199A expression at a postranscriptionallevel (PubMed:28431233). {ECO:0000269\|PubMed:18776931,ECO:0000269\|PubMed:21397187, ECO:0000269\|PubMed:22345517,ECO:0000269\|PubMed:22955276, ECO:0000269\|PubMed:25340845,ECO:0000269\|PubMed:25349211, ECO:0000269\|PubMed:26724866,ECO:0000269\|PubMed:28431233}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

278_488

988

Compositional bias

Note=Ala-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

359_405

988

Compositional bias

Note=Gln-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

520_687

988

Compositional bias

Note=Ser-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

278_488

1065

Compositional bias

Note=Ala-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

359_405

1065

Compositional bias

Note=Gln-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

520_687

1065

Compositional bias

Note=Ser-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

278_488

1067

Compositional bias

Note=Ala-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

359_405

1067

Compositional bias

Note=Gln-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

520_687

1067

Compositional bias

Note=Ser-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

278_488

-6

1065

Compositional bias

Note=Ala-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

359_405

-6

1065

Compositional bias

Note=Gln-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

520_687

-6

1065

Compositional bias

Note=Ser-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

706_1048

988

Domain

PUM-HD

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

706_1048

1065

Domain

PUM-HD

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

706_1048

1067

Domain

PUM-HD

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

706_1048

-6

1065

Domain

PUM-HD

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

1002_1006

988

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

741_745

988

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

777_781

988

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

813_817

988

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

851_855

988

Region

Non-specific-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

887_891

988

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

923_927

988

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

959_963

988

Region

Guanine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

1002_1006

1065

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

741_745

1065

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

777_781

1065

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

813_817

1065

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

851_855

1065

Region

Non-specific-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

887_891

1065

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

923_927

1065

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

959_963

1065

Region

Guanine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

1002_1006

1067

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

741_745

1067

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

777_781

1067

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

813_817

1067

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

851_855

1067

Region

Non-specific-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

887_891

1067

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

923_927

1067

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

959_963

1067

Region

Guanine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

1002_1006

-6

1065

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

741_745

-6

1065

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

777_781

-6

1065

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

813_817

-6

1065

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

851_855

-6

1065

Region

Non-specific-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

887_891

-6

1065

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

923_927

-6

1065

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

959_963

-6

1065

Region

Guanine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

726_761

988

Repeat

Pumilio 1

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

762_797

988

Repeat

Pumilio 2

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

798_835

988

Repeat

Pumilio 3

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

836_871

988

Repeat

Pumilio 4

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

872_907

988

Repeat

Pumilio 5

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

908_943

988

Repeat

Pumilio 6

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

944_979

988

Repeat

Pumilio 7

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

983_1022

988

Repeat

Pumilio 8

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

726_761

1065

Repeat

Pumilio 1

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

762_797

1065

Repeat

Pumilio 2

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

798_835

1065

Repeat

Pumilio 3

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

836_871

1065

Repeat

Pumilio 4

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

872_907

1065

Repeat

Pumilio 5

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

908_943

1065

Repeat

Pumilio 6

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

944_979

1065

Repeat

Pumilio 7

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

983_1022

1065

Repeat

Pumilio 8

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

726_761

1067

Repeat

Pumilio 1

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

762_797

1067

Repeat

Pumilio 2

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

798_835

1067

Repeat

Pumilio 3

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

836_871

1067

Repeat

Pumilio 4

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

872_907

1067

Repeat

Pumilio 5

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

908_943

1067

Repeat

Pumilio 6

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

944_979

1067

Repeat

Pumilio 7

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

983_1022

1067

Repeat

Pumilio 8

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

726_761

-6

1065

Repeat

Pumilio 1

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

762_797

-6

1065

Repeat

Pumilio 2

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

798_835

-6

1065

Repeat

Pumilio 3

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

836_871

-6

1065

Repeat

Pumilio 4

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

872_907

-6

1065

Repeat

Pumilio 5

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

908_943

-6

1065

Repeat

Pumilio 6

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

944_979

-6

1065

Repeat

Pumilio 7

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

983_1022

-6

1065

Repeat

Pumilio 8

- In-frame and not-retained protein feature among the 13 regional features.

>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

226_229

234

Compositional bias

Note=Poly-Pro

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

108_128

234

Transmembrane

Helical

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

160_180

234

Transmembrane

Helical

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

29_49

234

Transmembrane

Helical

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

82_102

234

Transmembrane

Helical

Top

FusionGeneSequence for LAPTM4A_PUM2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_PUM2_ENST00000338086_chr2_20527139_-_37aa

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_PUM2_ENST00000319801_chr2_20527139_-_37aa

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_PUM2_ENST00000361078_chr2_20527139_-_37aa

* Fusion transcript sequences (only coding sequence (CDS) region).

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_PUM2_ENST00000338086_chr2_20527139_-_111nt
ATGGTGTCCATGAGTTTCAAGCGGAACCGCAGTGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATC

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_PUM2_ENST00000319801_chr2_20527139_-_111nt
ATGGTGTCCATGAGTTTCAAGCGGAACCGCAGTGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATC

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_PUM2_ENST00000361078_chr2_20527139_-_111nt
ATGGTGTCCATGAGTTTCAAGCGGAACCGCAGTGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATC

* Fusion transcript sequences (Full-length transcript).

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_PUM2_ENST00000338086_chr2_20527139_-_6731nt
ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA
TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT
GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG
AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG
CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG
GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG
TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGAACAGGTTTGA
TCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGCTTTTGCCTACCAAAAAGTTTTGGGAA
CCTGATGATTCAACAAAAGATGGACAAAAAGGCATATTTCTTGGGGATGATGAATGGAGAGAGACTGCATGGGGAGCTTCTCACCATTCA
ATGTCCCAGCCTATTATGGTACAGAGAAGATCTGGACAGGGTTTTCATGGAAACAGTGAAGTAAATGCAATACTGTCTCCGCGATCAGAA
AGTGGAGGCCTTGGTGTGAGCATGGTAGAATATGTATTAAGTTCTTCTCCTGCTGATAAATTGGATTCTCGATTTAGGAAGGGAAATTTT
GGCACTAGAGATGCTGAAACAGATGGACCTGAGAAAGGAGATCAAAAAGGCAAGGCTTCTCCATTTGAGGAGGACCAAAACAGAGATCTT
AAACAAGGAGATGATGATGATTCTAAAATAAATGGCAGAGGTTTGCCAAATGGAATGGATGCCGATTGCAAAGATTTTAATCGTACTCCT
GGAAGTCGTCAAGCCTCTCCAACTGAAGTAGTTGAGCGCTTGGGCCCCAATACTAATCCCTCAGAAGGACTGGGGCCTCTTCCTAATCCT
ACAGCTAATAAACCACTTGTTGAAGAATTTTCAAATCCTGAAACTCAGAATCTGGATGCCATGGAACAAGTTGGTCTGGAATCCTTACAG
TTTGACTATCCTGGTAATCAGGTACCAATGGACTCTTCAGGAGCTACTGTAGGCCTTTTTGACTACAATTCCCAGCAGCAGCTCTTTCAG
AGGACTAATGCACTAACAGTTCAACAGTTAACTGCAGCTCAACAGCAGCAATATGCATTAGCAGCAGCTCAGCAGCCACATATAGCTGGT
GTATTCTCAGCAGGCCTTGCTCCAGCTGCATTTGTGCCAAATCCATACATTATTAGTGCTGCTCCTCCAGGGACCGATCCGTATACTGCA
GCAGGATTGGCTGCAGCAGCTACATTAGCAGGTCCAGCAGTGGTTCCACCTCAGTATTACGGCGTTCCATGGGGGGTGTATCCAGCCAAC
TTATTTCAGCAGCAAGCTGCAGCTGCGGCAAATAACACAGCCAGTCAGCAAGCAGCATCACAAGCTCAGCCTGGACAGCAACAGGTTCTC
CGTGCTGGAGCAGGTCAGCGTCCTCTTACTCCCAATCAGGGTCAGCAAGGGCAGCAAGCAGAATCACTTGCGGCAGCTGCAGCAGCAAAT
CCAACATTGGCTTTTGGTCAGGGTCTTGCTACTGGCATGCCAGGCTATCAAGTACTAGCTCCAACTGCCTATTATGATCAGACTGGTGCC
TTAGTGGTTGGCCCTGGAGCAAGGACTGGCCTTGGAGCTCCAGTTCGGTTAATGGCTCCAACACCTGTTTTAATTAGTTCAGCAGCAGCA
CAAGCTGCAGCAGCAGCAGCAGCTGGAGGAACTGCAAGTAGCCTTACAGGCAGCACAAATGGTCTGTTTCGGCCAATTGGCACTCAGCCA
CCACAGCAGCAGCAACAGCAGCCAAGCACTAATCTGCAATCTAATTCATTTTATGGAAGCAGTTCTTTGACTAATAGCTCCCAGAGTAGT
TCTTTATTTTCTCATGGACCTGGTCAACCTGGAAGTACATCTCTTGGCTTTGGAAGTGGTAACTCTTTGGGTGCTGCTATAGGCTCAGCC
CTCAGTGGATTTGGTTCATCAGTTGGCAGTTCTGCAAGTAGTAGTGCCACAAGGAGAGAGTCTCTATCTACTAGCTCTGACTTGTACAAA
AGATCTAGTAGCAGCCTAGCACCCATAGGGCAACCATTTTACAATAGTCTGGGATTTTCCTCCTCTCCAAGTCCAATAGGCATGCCTCTG
CCAAGCCAAACTCCAGGACATTCACTTACGCCACCGCCATCACTTTCATCACATGGATCCTCATCCAGTTTGCATTTAGGAGGACTGACA
AATGGTAGTGGTCGATATATCTCTGCAGCACCTGGAGCAGAAGCAAAATATCGAAGTGCTTCAAGCACTTCCAGTCTATTTAGCTCCAGC
AGCCAGCTCTTTCCTCCTTCCCGGCTTCGGTATAATAGGTCTGATATTATGCCTTCTGGCCGCAGTAGATTATTGGAAGATTTCAGAAAC
AACCGCTTCCCAAACCTTCAGCTTAGAGACTTGATTGGACATATAGTTGAGTTTTCTCAAGACCAGCATGGTTCTAGATTCATACAGCAA
AAACTAGAGAGAGCTACTCCAGCTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGC
AACTATGTTATACAGAAGTTTTTTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTA
GCCTTGCAGATGTATGGCTGCCGCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGAGTGAAATGGTAAAGGAGCTGGAT
GGTCATGTGCTCAAATGTGTGAAAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTC
ATCATTGATGCTTTCAAGGGACAAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACT
GCAGAACAGACCTTACCTATCTTAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCAT
GTACTGGAACACGGTCGACCTGAAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCC
AGCAATGTAGTAGAAAAGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCT
CACAGTGCCTTATACACCATGATGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAG
ATAATCATGCACAAGATTCGACCTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTAT
TTGAAGAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAAC
CATGTGAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTG
ACTTTATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTG
GAGACCTATCAGATTGGATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGT
AAATTTTTACCTTGTAAAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCT
ACAACCCCATAGCACAACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATT
AACAATCAACTGCATAAATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAA
GTAGACAAGAATAAAGTGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTC
TCTGGCAATGTACAGAAATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGT
GCACTAAATGAAAAGTTAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAG
AATTACAGACATGTTGAGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCA
CTGAAAAGTGAATTTGATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGT
GTAGTAATAGATGTAAGTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCC
TTGGTTGTACAGGTGTACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACAT
TTACGTCCCTGCCCTCTTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTT
TATCTTTATATGGTTTCAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAAT
ATGGACCTGCTAGAATTTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATG
GAGGCCAATGCTTTTTTCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAA
GTAAGAGCAAATCTGTATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACA
TTTCCCAACAATCTTTTTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAA
AAAAACTTGCTGTGTATATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTT
GACCCACTTATGTTCAGTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGC
AGAAGAAACGCAATCTTCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAA
AGTTTGGGGATGCCAGGCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATC
CAAACACTTGTCACCGTTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTT
TTTAAAACCCACACAAAGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTA
TCAGCCCATGGTTTCAGGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTC
ATCCTTGCCCTCTGTTGGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTC
TTGGGGTCCTGATACTCATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTT
CTTGTAGAAATTTTACAGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAA
AATCACATTTCAGAATAAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGT
TTGTCTAAGTCCTGGCTCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATG

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_PUM2_ENST00000319801_chr2_20527139_-_6499nt
ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA
TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT
GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG
AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG
CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG
GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG
TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGAACAGGTTTGA
TCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGCTTTTGCCTACCAAAAAGTTTTGGGAA
CCTGATGATTCAACAAAAGATGGACAAAAAGGCATATTTCTTGGGGATGATGAATGGAGAGAGACTGCATGGGGAGCTTCTCACCATTCA
ATGTCCCAGCCTATTATGGTACAGAGAAGATCTGGACAGGGTTTTCATGGAAACAGTGAAGTAAATGCAATACTGTCTCCGCGATCAGAA
AGTGGAGGCCTTGGTGTGAGCATGGTAGAATATGTATTAAGTTCTTCTCCTGCTGATAAATTGGATTCTCGATTTAGGAAGGGAAATTTT
GGCACTAGAGATGCTGAAACAGATGGACCTGAGAAAGGAGATCAAAAAGGCAAGGCTTCTCCATTTGAGGAGGACCAAAACAGAGATCTT
AAACAAGGAGATGATGATGATTCTAAAATAAATGGCAGAGGTTTGCCAAATGGAATGGATGCCGATTGCAAAGATTTTAATCGTACTCCT
GGAAGTCGTCAAGCCTCTCCAACTGAAGTAGTTGAGCGCTTGGGCCCCAATACTAATCCCTCAGAAGGACTGGGGCCTCTTCCTAATCCT
ACAGCTAATAAACCACTTGTTGAAGAATTTTCAAATCCTGAAACTCAGAATCTGGATGCCATGGAACAAGTTGGTCTGGAATCCTTACAG
TTTGACTATCCTGGTAATCAGGTACCAATGGACTCTTCAGGAGCTACTGTAGGCCTTTTTGACTACAATTCCCAGCAGCAGCTCTTTCAG
AGGACTAATGCACTAACAGTTCAACAGTTAACTGCAGCTCAACAGCAGCAATATGCATTAGCAGCAGCTCAGCAGCCACATATAGCTGGT
GTATTCTCAGCAGGCCTTGCTCCAGCTGCATTTGTGCCAAATCCATACATTATTAGTGCTGCTCCTCCAGGGACCGATCCGTATACTGCA
GCAGGATTGGCTGCAGCAGCTACATTAGCAGGTCCAGCAGTGGTTCCACCTCAGTATTACGGCGTTCCATGGGGGGTGTATCCAGCCAAC
TTATTTCAGCAGCAAGCTGCAGCTGCGGCAAATAACACAGCCAGTCAGCAAGCAGCATCACAAGCTCAGCCTGGACAGCAACAGGTTCTC
CGTGCTGGAGCAGGTCAGCGTCCTCTTACTCCCAATCAGGGTCAGCAAGGGCAGCAAGCAGAATCACTTGCGGCAGCTGCAGCAGCAAAT
CCAACATTGGCTTTTGGTCAGGGTCTTGCTACTGGCATGCCAGGCTATCAAGTACTAGCTCCAACTGCCTATTATGATCAGACTGGTGCC
TTAGTGGTTGGCCCTGGAGCAAGGACTGGCCTTGGAGCTCCAGTTCGGTTAATGGCTCCAACACCTGTTTTAATTAGTTCAGCAGCAGCA
CAAGCTGCAGCAGCAGCAGCAGCTGGAGGAACTGCAAGTAGCCTTACAGGCAGCACAAATGGTCTGTTTCGGCCAATTGGCACTCAGCCA
CCACAGCAGCAGCAACAGCAGCCAAGCACTAATCTGCAATCTAATTCATTTTATGGAAGCAGTTCTTTGACTAATAGCTCCCAGAGTAGT
TCTTTATTTTCTCATGGACCTGGTCAACCTGGAAGTACATCTCTTGGCTTTGGAAGTGGTAACTCTTTGGGTGCTGCTATAGGCTCAGCC
CTCAGTGGATTTGGTTCATCAGGAGGACTGACAAATGGTAGTGGTCGATATATCTCTGCAGCACCTGGAGCAGAAGCAAAATATCGAAGT
GCTTCAAGCACTTCCAGTCTATTTAGCTCCAGCAGCCAGCTCTTTCCTCCTTCCCGGCTTCGGTATAATAGGTCTGATATTATGCCTTCT
GGCCGCAGTAGATTATTGGAAGATTTCAGAAACAACCGCTTCCCAAACCTTCAGCTTAGAGACTTGATTGGACATATAGTTGAGTTTTCT
CAAGACCAGCATGGTTCTAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAGCTGAGCGACAGATGGTATTTAATGAAATTCTGCAA
GCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTTTTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTG
GCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCCGCGTTATTCAGAAAGCATTAGAATCTATTTCTTCT
GACCAGCAGGTAATTAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAATGTGTGAAAGATCAGAATGGAAACCATGTTGTACAA
AAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCAAGGGACAAGTATTTGTGCTTTCAACTCATCCTTAT
GGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTACCTATCTTAGAAGAACTCCACCAACATACAGAGCAG
TTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTCGACCTGAAGACAAGAGCAAAATTGTTTCCGAAATC
AGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAAAGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCT
TTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACACCATGATGAAGGACCAGTATGCCAATTACGTGGTT
CAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGATTCGACCTCACATTACTACTTTGCGCAAATACACA
TACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATG
CTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTA
TGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGG
GGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTGGATTGCTGGCAAAGCACAGAATGCCTGTATATGAT
GTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATTTTTACCTTGTAAAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACA
GTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAACCCCATAGCACAACAGGTTTATAGAGATGTATATAGAATTATAGTCC
TTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAATCAACTGCATAAATATTATTAATATTTTAAAAAGAGTTAAGTTGTA
TTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGACAAGAATAAAGTGGTTTGAGATGAAAAGAACCTAACATTATTTACA
GTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGGCAATGTACAGAAATATTGTATATACTTACATATGTAATTGTTGTAA
GAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACTAAATGAAAAGTTAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAA
TGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTACAGACATGTTGAGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGA
GGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAAAAGTGAATTTGATAGCTCAGCATTTAAGCATGATTACATATTCAGA
TAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGTAATAGATGTAAGTTTACACTTTGAAAGGAAATCTTGTTTCAATGTT
TATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGTTGTACAGGTGTACATTTGTAAACCTTCATGCTGTAAATGGAATTTG
TTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACGTCCCTGCCCTCTTTGACCTGGCAATATAGTGTTGTATAATGTAAAT
TTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCTTTATATGGTTTCAGAAGTATGAACCAGCTTTCTTTTTATTATTGTG
AGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGACCTGCTAGAATTTGGATCACTTTCAATTGAAGTCAGGGTATTGTGC
ATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGCCAATGCTTTTTTCATCTTATTAAATGTGATGTGACTTTTTTCTTTG
TACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAGAGCAAATCTGTATGATAACATTTTTTCCTCTGGACATAAGACATAA
CAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCCCAACAATCTTTTTAAGGCAAAATTGTGACCATATGTGTATAATTAA
AATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAACTTGCTGTGTATATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGT
ATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCCACTTATGTTCAGTGCTGAAAACTAAAATGAACATGCTATTCTGTCA
GCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAGAAACGCAATCTTCTGAGCACAATATGGAATCTAAAGGTTTTATCAC
TTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTTGGGGATGCCAGGCATACTTTTTCATGTTTGGTGTTGAGTTATTTTA
CTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAACACTTGTCACCGTTCCTTCTCATAGTCACTCTGGGTCATCAGCATGT
CCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAAAACCCACACAAAGCCGCTGTCTCACTTTTTCCTACTTTACCAACCT
CAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGCCCATGGTTTCAGGATCAAAGCTGTCATGTTGGAGATTGGTAATGGC
TTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCTTGCCCTCTGTTGGCACAGGCATTATCTCTGCAATTTTAGAAAATGA
CAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGGGTCCTGATACTCATTCCCATTTGTCCCAGTGCTGACAACCCAATCT
TCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGTAGAAATTTTACAGTCTGCCATTTTGGGTGCCCACCCCAATTTTTAC
CTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCACATTTCAGAATAAAACAATTGGGCAAAACTACCTAGGCTTTACTCT
TGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTCTAAGTCCTGGCTCTTATTGGTTCATATGAAATAATGTTAACTTCAC
TTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGAATAACATTGTATGAAATAAACCTGGTCTTGTGTTTTTCTCTAGATA

>In-frame_LAPTM4A_ENST00000175091_chr2_20251171_-_PUM2_ENST00000361078_chr2_20527139_-_6736nt
ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA
TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT
GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG
AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG
CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG
GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG
TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGAACAGGTTTGA
TCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGCTTTTGCCTACCAAAAAGTTTTGGGAA
CCTGATGATTCAACAAAAGATGGACAAAAAGGCATATTTCTTGGGGATGATGAATGGAGAGAGACTGCATGGGGAGCTTCTCACCATTCA
ATGTCCCAGCCTATTATGGTACAGAGAAGATCTGGACAGGGTTTTCATGGAAACAGTGAAGTAAATGCAATACTGTCTCCGCGATCAGAA
AGTGGAGGCCTTGGTGTGAGCATGGTAGAATATGTATTAAGTTCTTCTCCTGCTGATAAATTGGATTCTCGATTTAGGAAGGGAAATTTT
GGCACTAGAGATGCTGAAACAGATGGACCTGAGAAAGGAGATCAAAAAGGCAAGGCTTCTCCATTTGAGGAGGACCAAAACAGAGATCTT
AAACAAGGAGATGATGATGATTCTAAAATAAATGGCAGAGGTTTGCCAAATGGAATGGATGCCGATTGCAAAGATTTTAATCGTACTCCT
GGAAGTCGTCAAGCCTCTCCAACTGAAGTAGTTGAGCGCTTGGGCCCCAATACTAATCCCTCAGAAGGACTGGGGCCTCTTCCTAATCCT
ACAGCTAATAAACCACTTGTTGAAGAATTTTCAAATCCTGAAACTCAGAATCTGGATGCCATGGAACAAGTTGGTCTGGAATCCTTACAG
TTTGACTATCCTGGTAATCAGGTACCAATGGACTCTTCAGGAGCTACTGTAGGCCTTTTTGACTACAATTCCCAGCAGCAGCTCTTTCAG
AGGACTAATGCACTAACAGTTCAACAGTTAACTGCAGCTCAACAGCAGCAATATGCATTAGCAGCAGCTCAGCAGCCACATATAGCTGGT
GTATTCTCAGCAGGCCTTGCTCCAGCTGCATTTGTGCCAAATCCATACATTATTAGTGCTGCTCCTCCAGGGACCGATCCGTATACTGCA
GCAGGATTGGCTGCAGCAGCTACATTAGCAGGTCCAGCAGTGGTTCCACCTCAGTATTACGGCGTTCCATGGGGGGTGTATCCAGCCAAC
TTATTTCAGCAGCAAGCTGCAGCTGCGGCAAATAACACAGCCAGTCAGCAAGCAGCATCACAAGCTCAGCCTGGACAGCAACAGGTTCTC
CGTGCTGGAGCAGGTCAGCGTCCTCTTACTCCCAATCAGGGTCAGCAAGGGCAGCAAGCAGAATCACTTGCGGCAGCTGCAGCAGCAAAT
CCAACATTGGCTTTTGGTCAGGGTCTTGCTACTGGCATGCCAGGCTATCAAGTACTAGCTCCAACTGCCTATTATGATCAGACTGGTGCC
TTAGTGGTTGGCCCTGGAGCAAGGACTGGCCTTGGAGCTCCAGTTCGGTTAATGGCTCCAACACCTGTTTTAATTAGTTCAGCAGCAGCA
CAAGCTGCAGCAGCAGCAGCAGCTGGAGGAACTGCAAGTAGCCTTACAGGCAGCACAAATGGTCTGTTTCGGCCAATTGGCACTCAGCCA
CCACAGCAGCAGCAACAGCAGCCAAGCACTAATCTGCAATCTAATTCATTTTATGGAAGCAGTTCTTTGACTAATAGCTCCCAGAGTAGT
TCTTTATTTTCTCATGGACCTGGTCAACCTGGAAGTACATCTCTTGGCTTTGGAAGTGGTAACTCTTTGGGTGCTGCTATAGGCTCAGCC
CTCAGTGGATTTGGTTCATCAGTTGGCAGTTCTGCAAGTAGTAGTGCCACAAGGAGAGAGTCTCTATCTACTAGCTCTGACTTGTACAAA
AGATCTAGTAGCAGCCTAGCACCCATAGGGCAACCATTTTACAATAGTCTGGGATTTTCCTCCTCTCCAAGTCCAATAGGCATGCCTCTG
CCAAGCCAAACTCCAGGACATTCACTTACGCCACCGCCATCACTTTCATCACATGGATCCTCATCCAGTTTGCATTTAGGAGGACTGACA
AATGGTAGTGGTCGATATATCTCTGCAGCACCTGGAGCAGAAGCAAAATATCGAAGTGCTTCAAGCACTTCCAGTCTATTTAGCTCCAGC
AGCCAGCTCTTTCCTCCTTCCCGGCTTCGGTATAATAGGTCTGATATTATGCCTTCTGGCCGCAGTAGATTATTGGAAGATTTCAGAAAC
AACCGCTTCCCAAACCTTCAGCTTAGAGACTTGATTGGACATATAGTTGAGTTTTCTCAAGACCAGCATGGTTCTAGATTCATACAGCAA
AAACTAGAGAGAGCTACTCCAGCTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGC
AACTATGTTATACAGAAGTTTTTTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTA
GCCTTGCAGATGTATGGCTGCCGCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGGTAATTAGTGAAATGGTAAAGGAG
CTGGATGGTCATGTGCTCAAATGTGTGAAAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTA
CAGTTCATCATTGATGCTTTCAAGGGACAAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCAT
TGCACTGCAGAACAGACCTTACCTATCTTAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATT
CAGCATGTACTGGAACACGGTCGACCTGAAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAA
TTTGCCAGCAATGTAGTAGAAAAGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGAT
GGTCCTCACAGTGCCTTATACACCATGATGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAG
AGAAAGATAATCATGCACAAGATTCGACCTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAG
TATTATTTGAAGAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAA
TTTAACCATGTGAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTAT
TTATTGACTTTATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCC
TGAGTGGAGACCTATCAGATTGGATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATA
TTTTGTAAATTTTTACCTTGTAAAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGT
AGGTCTACAACCCCATAGCACAACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAA
CAGATTAACAATCAACTGCATAAATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAAC
GAGTAAGTAGACAAGAATAAAGTGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAA
AATGTCTCTGGCAATGTACAGAAATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAA
TTAAGTGCACTAAATGAAAAGTTAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGC
TTATAGAATTACAGACATGTTGAGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAG
GGGCCACTGAAAAGTGAATTTGATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATT
GTGTGTGTAGTAATAGATGTAAGTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATG
CTTTCCTTGGTTGTACAGGTGTACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGT
GTACATTTACGTCCCTGCCCTCTTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAA
ATTTTTTATCTTTATATGGTTTCAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACT
GTTAATATGGACCTGCTAGAATTTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTT
ACCATGGAGGCCAATGCTTTTTTCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTAC
TCCCAAGTAAGAGCAAATCTGTATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTA
TGTACATTTCCCAACAATCTTTTTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATT
TTGGAAAAAAACTTGCTGTGTATATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATT
TATGTTGACCCACTTATGTTCAGTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAG
ATCTGCAGAAGAAACGCAATCTTCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATG
GCATAAAGTTTGGGGATGCCAGGCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCAT
TAAATCCAAACACTTGTCACCGTTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTT
CATTTTTTTAAAACCCACACAAAGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTC
TCAGTATCAGCCCATGGTTTCAGGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCT
TCCTTCATCCTTGCCCTCTGTTGGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACC
CTCTTCTTGGGGTCCTGATACTCATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTA
CCTGTTCTTGTAGAAATTTTACAGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAA
TCTGAAAATCACATTTCAGAATAAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGG
ACCAGTTTGTCTAAGTCCTGGCTCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGA

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FusionGenePPI for LAPTM4A_PUM2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
LAPTM4A	TUBB3, ELAVL1, NEDD4, TFRC, IGF2BP3, HNRNPU, UNK, WWP2, C16orf58, KIAA1467, MTNR1A	PUM2	PUM2, NANOS1, AURKA, MED4, ELAVL1, DAZ1, DAZL, NANOS3, BMI1, RBFOX2, ILF2, NTRK1, SAMD1, RBM45, CLASRP, ELAVL2, CELF5, STRBP, CDX1, LITAF, TRIM25, G3BP1

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	PUM2	chr2:20251171	chr2:20527139	ENST00000403432	-	0	21	1_260	-6	1065	SNAPIN

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	PUM2	chr2:20251171	chr2:20527139	ENST00000319801	-	-1	19	1_260	17	988	SNAPIN
Tgene	PUM2	chr2:20251171	chr2:20527139	ENST00000338086	-	-1	20	1_260	17	1065	SNAPIN
Tgene	PUM2	chr2:20251171	chr2:20527139	ENST00000361078	-	-1	20	1_260	17	1067	SNAPIN

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for LAPTM4A_PUM2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LAPTM4A_PUM2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 19445

FusionGeneSummary for LAPTM4A_PUM2

FusionProtFeatures for LAPTM4A_PUM2

FusionGeneSequence for LAPTM4A_PUM2

FusionGenePPI for LAPTM4A_PUM2

RelatedDrugs for LAPTM4A_PUM2

RelatedDiseases for LAPTM4A_PUM2