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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19443

FusionGeneSummary for LAPTM4A_NACC1

check button Fusion gene summary
Fusion gene informationFusion gene name: LAPTM4A_NACC1
Fusion gene ID: 19443
HgeneTgene
Gene symbol

LAPTM4A

NACC1

Gene ID

9741

112939

Gene namelysosomal protein transmembrane 4 alphanucleus accumbens associated 1
SynonymsHUMORF13|LAPTM4|MBNT|MtrpBEND8|BTBD14B|BTBD30|NAC-1|NAC1|NECFM
Cytomap

2p24.1

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionlysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporternucleus accumbens-associated protein 1BEN domain containing 8BTB/POZ domain-containing protein 14Bnucleus accumbens associated 1, BEN and BTB (POZ) domain containingtranscriptional repressor NAC1
Modification date2018052320180519
UniProtAcc

Q15012

Q96RE7

Ensembl transtripts involved in fusion geneENST00000175091, ENST00000292431, 
Fusion gene scores* DoF score7 X 6 X 4=1682 X 2 X 2=8
# samples 72
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: LAPTM4A [Title/Abstract] AND NACC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNACC1

GO:0051260

protein homooligomerization

17130457


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG011582LAPTM4Achr2

20251291

-NACC1chr19

13248184

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000175091ENST00000292431LAPTM4Achr2

20251291

-NACC1chr19

13248184

-

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FusionProtFeatures for LAPTM4A_NACC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAPTM4A

Q15012

NACC1

Q96RE7

May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}. Functions as a transcriptional repressor. Seems tofunction as a transcriptional corepressor in neuronal cellsthrough recruitment of HDAC3 and HDAC4. Contributes to tumorprogression, and tumor cell proliferation and survival. This maybe mediated at least in part through repressing transcriptionalactivity of GADD45GIP1. Required for recruiting the proteasomefrom the nucleus to the cytoplasm and dendritic spines.{ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAPTM4A_NACC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAPTM4A_NACC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAPTM4A_NACC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAPTM4A_NACC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource