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Fusion gene ID: 19440 |
FusionGeneSummary for LAPTM4A_BAZ2B |
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Fusion gene information | Fusion gene name: LAPTM4A_BAZ2B | Fusion gene ID: 19440 | Hgene | Tgene | Gene symbol | LAPTM4A | BAZ2B | Gene ID | 9741 | 29994 |
Gene name | lysosomal protein transmembrane 4 alpha | bromodomain adjacent to zinc finger domain 2B | |
Synonyms | HUMORF13|LAPTM4|MBNT|Mtrp | WALp4 | |
Cytomap | 2p24.1 | 2q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | lysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporter | bromodomain adjacent to zinc finger domain protein 2B | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q15012 | Q9UIF8 | |
Ensembl transtripts involved in fusion gene | ENST00000175091, | ENST00000355831, ENST00000343439, ENST00000392782, ENST00000392783, ENST00000483316, | |
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 6 X 6 X 4=144 |
# samples | 7 | 6 | |
** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LAPTM4A [Title/Abstract] AND BAZ2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW377490 | LAPTM4A | chr2 | 20237347 | + | BAZ2B | chr2 | 160230526 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000175091 | ENST00000355831 | LAPTM4A | chr2 | 20237347 | + | BAZ2B | chr2 | 160230526 | - |
intron-intron | ENST00000175091 | ENST00000343439 | LAPTM4A | chr2 | 20237347 | + | BAZ2B | chr2 | 160230526 | - |
intron-intron | ENST00000175091 | ENST00000392782 | LAPTM4A | chr2 | 20237347 | + | BAZ2B | chr2 | 160230526 | - |
intron-intron | ENST00000175091 | ENST00000392783 | LAPTM4A | chr2 | 20237347 | + | BAZ2B | chr2 | 160230526 | - |
intron-intron | ENST00000175091 | ENST00000483316 | LAPTM4A | chr2 | 20237347 | + | BAZ2B | chr2 | 160230526 | - |
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FusionProtFeatures for LAPTM4A_BAZ2B |
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Hgene | Tgene |
LAPTM4A | BAZ2B |
May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}. | May play a role in transcriptional regulationinteracting with ISWI. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LAPTM4A_BAZ2B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LAPTM4A_BAZ2B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LAPTM4A_BAZ2B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LAPTM4A_BAZ2B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |