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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19440

FusionGeneSummary for LAPTM4A_BAZ2B

check button Fusion gene summary
Fusion gene informationFusion gene name: LAPTM4A_BAZ2B
Fusion gene ID: 19440
HgeneTgene
Gene symbol

LAPTM4A

BAZ2B

Gene ID

9741

29994

Gene namelysosomal protein transmembrane 4 alphabromodomain adjacent to zinc finger domain 2B
SynonymsHUMORF13|LAPTM4|MBNT|MtrpWALp4
Cytomap

2p24.1

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionlysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporterbromodomain adjacent to zinc finger domain protein 2B
Modification date2018052320180519
UniProtAcc

Q15012

Q9UIF8

Ensembl transtripts involved in fusion geneENST00000175091, ENST00000355831, 
ENST00000343439, ENST00000392782, 
ENST00000392783, ENST00000483316, 
Fusion gene scores* DoF score7 X 6 X 4=1686 X 6 X 4=144
# samples 76
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAPTM4A [Title/Abstract] AND BAZ2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW377490LAPTM4Achr2

20237347

+BAZ2Bchr2

160230526

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000175091ENST00000355831LAPTM4Achr2

20237347

+BAZ2Bchr2

160230526

-
intron-intronENST00000175091ENST00000343439LAPTM4Achr2

20237347

+BAZ2Bchr2

160230526

-
intron-intronENST00000175091ENST00000392782LAPTM4Achr2

20237347

+BAZ2Bchr2

160230526

-
intron-intronENST00000175091ENST00000392783LAPTM4Achr2

20237347

+BAZ2Bchr2

160230526

-
intron-intronENST00000175091ENST00000483316LAPTM4Achr2

20237347

+BAZ2Bchr2

160230526

-

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FusionProtFeatures for LAPTM4A_BAZ2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAPTM4A

Q15012

BAZ2B

Q9UIF8

May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}. May play a role in transcriptional regulationinteracting with ISWI.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAPTM4A_BAZ2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAPTM4A_BAZ2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAPTM4A_BAZ2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAPTM4A_BAZ2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource