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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19438

FusionGeneSummary for LAP3_REPS2

check button Fusion gene summary
Fusion gene informationFusion gene name: LAP3_REPS2
Fusion gene ID: 19438
HgeneTgene
Gene symbol

LAP3

REPS2

Gene ID

51056

9185

Gene nameleucine aminopeptidase 3RALBP1 associated Eps domain containing 2
SynonymsHEL-S-106|LAP|LAPEP|PEPSPOB1
Cytomap

4p15.32

Xp22.2

Type of geneprotein-codingprotein-coding
Descriptioncytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidaseralBP1-associated Eps domain-containing protein 2RALBP1-interacting protein 2partner of Ral-binding protein 1partner of RalBP1
Modification date2018051920180522
UniProtAcc

P28838

Q8NFH8

Ensembl transtripts involved in fusion geneENST00000226299, ENST00000606142, 
ENST00000503467, 
ENST00000357277, 
ENST00000303843, ENST00000380064, 
ENST00000469714, 
Fusion gene scores* DoF score5 X 5 X 3=753 X 3 X 3=27
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LAP3 [Title/Abstract] AND REPS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV416019LAP3chr4

17607377

-REPS2chrX

17062375

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000226299ENST00000357277LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000226299ENST00000303843LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000226299ENST00000380064LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000226299ENST00000469714LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000606142ENST00000357277LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000606142ENST00000303843LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000606142ENST00000380064LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000606142ENST00000469714LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000503467ENST00000357277LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000503467ENST00000303843LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000503467ENST00000380064LAP3chr4

17607377

-REPS2chrX

17062375

+
intron-intronENST00000503467ENST00000469714LAP3chr4

17607377

-REPS2chrX

17062375

+

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FusionProtFeatures for LAP3_REPS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAP3

P28838

REPS2

Q8NFH8

Presumably involved in the processing and regularturnover of intracellular proteins. Catalyzes the removal ofunsubstituted N-terminal amino acids from various peptides. Involved in growth factor signaling through itsinfluence on the Ral signaling pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAP3_REPS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAP3_REPS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAP3_REPS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAP3_REPS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneREPS2C1458155Mammary Neoplasms1CTD_human