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Fusion gene ID: 19438 |
FusionGeneSummary for LAP3_REPS2 |
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Fusion gene information | Fusion gene name: LAP3_REPS2 | Fusion gene ID: 19438 | Hgene | Tgene | Gene symbol | LAP3 | REPS2 | Gene ID | 51056 | 9185 |
Gene name | leucine aminopeptidase 3 | RALBP1 associated Eps domain containing 2 | |
Synonyms | HEL-S-106|LAP|LAPEP|PEPS | POB1 | |
Cytomap | 4p15.32 | Xp22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | cytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase | ralBP1-associated Eps domain-containing protein 2RALBP1-interacting protein 2partner of Ral-binding protein 1partner of RalBP1 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | P28838 | Q8NFH8 | |
Ensembl transtripts involved in fusion gene | ENST00000226299, ENST00000606142, ENST00000503467, | ENST00000357277, ENST00000303843, ENST00000380064, ENST00000469714, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 3 X 3=27 |
# samples | 5 | 3 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LAP3 [Title/Abstract] AND REPS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CV416019 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000226299 | ENST00000357277 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000226299 | ENST00000303843 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000226299 | ENST00000380064 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000226299 | ENST00000469714 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000606142 | ENST00000357277 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000606142 | ENST00000303843 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000606142 | ENST00000380064 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000606142 | ENST00000469714 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000503467 | ENST00000357277 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000503467 | ENST00000303843 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000503467 | ENST00000380064 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
intron-intron | ENST00000503467 | ENST00000469714 | LAP3 | chr4 | 17607377 | - | REPS2 | chrX | 17062375 | + |
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FusionProtFeatures for LAP3_REPS2 |
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Hgene | Tgene |
LAP3 | REPS2 |
Presumably involved in the processing and regularturnover of intracellular proteins. Catalyzes the removal ofunsubstituted N-terminal amino acids from various peptides. | Involved in growth factor signaling through itsinfluence on the Ral signaling pathway. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LAP3_REPS2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LAP3_REPS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LAP3_REPS2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LAP3_REPS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | REPS2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |