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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19436

FusionGeneSummary for LAP3_GALNS

check button Fusion gene summary
Fusion gene informationFusion gene name: LAP3_GALNS
Fusion gene ID: 19436
HgeneTgene
Gene symbol

LAP3

GALNS

Gene ID

51056

2588

Gene nameleucine aminopeptidase 3galactosamine (N-acetyl)-6-sulfatase
SynonymsHEL-S-106|LAP|LAPEP|PEPSGALNAC6S|GAS|GalN6S|MPS4A
Cytomap

4p15.32

16q24.3

Type of geneprotein-codingprotein-coding
Descriptioncytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidaseN-acetylgalactosamine-6-sulfataseN-acetylgalactosamine-6-sulfate sulfatasechondroitinasechondroitinsulfatasegalNAc6S sulfatasegalactosamine (N-acetyl)-6-sulfate sulfatasegalactose-6-sulfate sulfatase
Modification date2018051920180522
UniProtAcc

P28838

P34059

Ensembl transtripts involved in fusion geneENST00000226299, ENST00000606142, 
ENST00000503467, 
ENST00000268695, 
ENST00000542788, ENST00000565364, 
ENST00000568311, ENST00000569433, 
Fusion gene scores* DoF score5 X 5 X 3=751 X 1 X 1=1
# samples 51
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: LAP3 [Title/Abstract] AND GALNS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-75-7027-01ALAP3chr4

17590600

+GALNSchr16

88893246

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000226299ENST00000268695LAP3chr4

17590600

+GALNSchr16

88893246

-
Frame-shiftENST00000226299ENST00000542788LAP3chr4

17590600

+GALNSchr16

88893246

-
5CDS-intronENST00000226299ENST00000565364LAP3chr4

17590600

+GALNSchr16

88893246

-
5CDS-intronENST00000226299ENST00000568311LAP3chr4

17590600

+GALNSchr16

88893246

-
5CDS-intronENST00000226299ENST00000569433LAP3chr4

17590600

+GALNSchr16

88893246

-
Frame-shiftENST00000606142ENST00000268695LAP3chr4

17590600

+GALNSchr16

88893246

-
Frame-shiftENST00000606142ENST00000542788LAP3chr4

17590600

+GALNSchr16

88893246

-
5CDS-intronENST00000606142ENST00000565364LAP3chr4

17590600

+GALNSchr16

88893246

-
5CDS-intronENST00000606142ENST00000568311LAP3chr4

17590600

+GALNSchr16

88893246

-
5CDS-intronENST00000606142ENST00000569433LAP3chr4

17590600

+GALNSchr16

88893246

-
3UTR-3CDSENST00000503467ENST00000268695LAP3chr4

17590600

+GALNSchr16

88893246

-
3UTR-3CDSENST00000503467ENST00000542788LAP3chr4

17590600

+GALNSchr16

88893246

-
3UTR-intronENST00000503467ENST00000565364LAP3chr4

17590600

+GALNSchr16

88893246

-
3UTR-intronENST00000503467ENST00000568311LAP3chr4

17590600

+GALNSchr16

88893246

-
3UTR-intronENST00000503467ENST00000569433LAP3chr4

17590600

+GALNSchr16

88893246

-

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FusionProtFeatures for LAP3_GALNS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAP3

P28838

GALNS

P34059

Presumably involved in the processing and regularturnover of intracellular proteins. Catalyzes the removal ofunsubstituted N-terminal amino acids from various peptides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAP3_GALNS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAP3_GALNS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LAP3DDA1, UBA5, TAB1, ISG15, APP, LIG4, AARSD1, AGFG1, ALAD, ARPC2, NIF3L1, OGT, SH3GL1, SH3GLB1, TPRKB, RAPGEF2, RNF2, FUBP1, MIF, PRDX1, PRDX2, TKT, VARS, NTRK1, TP53, NDUFS5, RAB7A, RBM39, ZCCHC17, U2AF2, TESGALNSNEU1, TAZ, IDS, PLAUR, DNASE2B, PTPRK, DPEP2, ISLR, NAAA, ARSA, ATXN2L, PRG3, LYZL1, P2RX5, LYPD4, LYZL2, WNT16, OLFM2, INSL5, SLAMF1, ALPPL2, TPSB2, ERLIN2, DEFA1, SIAE, TDGF1, PSG8, PRG2, SPACA4, MTNR1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAP3_GALNS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAP3_GALNS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGALNSC0086651Mucopolysaccharidosis, MPS-IV-A8ORPHANET;UNIPROT
TgeneGALNSC0021368Inflammation1CTD_human