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Fusion gene ID: 19436 |
FusionGeneSummary for LAP3_GALNS |
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Fusion gene information | Fusion gene name: LAP3_GALNS | Fusion gene ID: 19436 | Hgene | Tgene | Gene symbol | LAP3 | GALNS | Gene ID | 51056 | 2588 |
Gene name | leucine aminopeptidase 3 | galactosamine (N-acetyl)-6-sulfatase | |
Synonyms | HEL-S-106|LAP|LAPEP|PEPS | GALNAC6S|GAS|GalN6S|MPS4A | |
Cytomap | 4p15.32 | 16q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase | N-acetylgalactosamine-6-sulfataseN-acetylgalactosamine-6-sulfate sulfatasechondroitinasechondroitinsulfatasegalNAc6S sulfatasegalactosamine (N-acetyl)-6-sulfate sulfatasegalactose-6-sulfate sulfatase | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | P28838 | P34059 | |
Ensembl transtripts involved in fusion gene | ENST00000226299, ENST00000606142, ENST00000503467, | ENST00000268695, ENST00000542788, ENST00000565364, ENST00000568311, ENST00000569433, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: LAP3 [Title/Abstract] AND GALNS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-75-7027-01A | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000226299 | ENST00000268695 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
Frame-shift | ENST00000226299 | ENST00000542788 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
5CDS-intron | ENST00000226299 | ENST00000565364 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
5CDS-intron | ENST00000226299 | ENST00000568311 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
5CDS-intron | ENST00000226299 | ENST00000569433 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
Frame-shift | ENST00000606142 | ENST00000268695 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
Frame-shift | ENST00000606142 | ENST00000542788 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
5CDS-intron | ENST00000606142 | ENST00000565364 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
5CDS-intron | ENST00000606142 | ENST00000568311 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
5CDS-intron | ENST00000606142 | ENST00000569433 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
3UTR-3CDS | ENST00000503467 | ENST00000268695 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
3UTR-3CDS | ENST00000503467 | ENST00000542788 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
3UTR-intron | ENST00000503467 | ENST00000565364 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
3UTR-intron | ENST00000503467 | ENST00000568311 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
3UTR-intron | ENST00000503467 | ENST00000569433 | LAP3 | chr4 | 17590600 | + | GALNS | chr16 | 88893246 | - |
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FusionProtFeatures for LAP3_GALNS |
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Hgene | Tgene |
LAP3 | GALNS |
Presumably involved in the processing and regularturnover of intracellular proteins. Catalyzes the removal ofunsubstituted N-terminal amino acids from various peptides. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LAP3_GALNS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LAP3_GALNS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LAP3 | DDA1, UBA5, TAB1, ISG15, APP, LIG4, AARSD1, AGFG1, ALAD, ARPC2, NIF3L1, OGT, SH3GL1, SH3GLB1, TPRKB, RAPGEF2, RNF2, FUBP1, MIF, PRDX1, PRDX2, TKT, VARS, NTRK1, TP53, NDUFS5, RAB7A, RBM39, ZCCHC17, U2AF2, TES | GALNS | NEU1, TAZ, IDS, PLAUR, DNASE2B, PTPRK, DPEP2, ISLR, NAAA, ARSA, ATXN2L, PRG3, LYZL1, P2RX5, LYPD4, LYZL2, WNT16, OLFM2, INSL5, SLAMF1, ALPPL2, TPSB2, ERLIN2, DEFA1, SIAE, TDGF1, PSG8, PRG2, SPACA4, MTNR1A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LAP3_GALNS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LAP3_GALNS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GALNS | C0086651 | Mucopolysaccharidosis, MPS-IV-A | 8 | ORPHANET;UNIPROT |
Tgene | GALNS | C0021368 | Inflammation | 1 | CTD_human |