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Fusion gene ID: 19435 |
FusionGeneSummary for LAP3_DDX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LAP3_DDX1 | Fusion gene ID: 19435 | Hgene | Tgene | Gene symbol | LAP3 | DDX1 | Gene ID | 51056 | 1653 |
| Gene name | leucine aminopeptidase 3 | DEAD-box helicase 1 | |
| Synonyms | HEL-S-106|LAP|LAPEP|PEPS | DBP-RB|UKVH5d | |
| Cytomap | 4p15.32 | 2p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase | ATP-dependent RNA helicase DDX1DEAD (Asp-Glu-Ala-Asp) box helicase 1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1DEAD box polypeptide 1DEAD box protein 1DEAD box protein retinoblastomaDEAD box-1DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1DEAD/H-box h | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | P28838 | Q92499 | |
| Ensembl transtripts involved in fusion gene | ENST00000226299, ENST00000606142, ENST00000503467, | ENST00000381341, ENST00000233084, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 4 X 4 X 3=48 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LAP3 [Title/Abstract] AND DDX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DDX1 | GO:0006302 | double-strand break repair | 18710941 |
| Tgene | DDX1 | GO:0032508 | DNA duplex unwinding | 18710941 |
| Tgene | DDX1 | GO:0090305 | nucleic acid phosphodiester bond hydrolysis | 18710941 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-G2-A2EF-01A | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000226299 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| In-frame | ENST00000226299 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| In-frame | ENST00000606142 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| In-frame | ENST00000606142 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| intron-3CDS | ENST00000503467 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| intron-3CDS | ENST00000503467 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
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FusionProtFeatures for LAP3_DDX1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LAP3 | DDX1 |
| Presumably involved in the processing and regularturnover of intracellular proteins. Catalyzes the removal ofunsubstituted N-terminal amino acids from various peptides. | Acts as an ATP-dependent RNA helicase, able to unwindboth RNA-RNA and RNA-DNA duplexes. Possesses 5' single-strandedRNA overhang nuclease activity. Possesses ATPase activity onvarious RNA, but not DNA polynucleotides. May play a role in RNAclearance at DNA double-strand breaks (DSBs), thereby facilitatingthe template-guided repair of transcriptionally active regions ofthe genome. Together with RELA, acts as a coactivator to enhanceNF-kappa-B-mediated transcriptional activation. Acts as a positivetranscriptional regulator of cyclin CCND2 expression. Binds to thecyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds topoly(A) RNA. May be involved in 3'-end cleavage andpolyadenylation of pre-mRNAs. Component of the tRNA-splicingligase complex required to facilitate the enzymatic turnover ofcatalytic subunit RTCB: together with archease (ZBTB8OS), acts byfacilitating the guanylylation of RTCB, a key intermediate step intRNA ligation (PubMed:24870230). {ECO:0000269|PubMed:12183465,ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541,ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827,ECO:0000269|PubMed:24870230}. (Microbial infection) Required for HIV-1 Rev function aswell as for HIV-1 and coronavirus IBV replication. Binds to theRRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}. (Microbial infection) Required for Coronavirus IBVreplication. {ECO:0000269|PubMed:20573827}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | + | 10 | 26 | 493_681 | 234 | 741 | Domain | Helicase C-terminal |
| Tgene | >DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | + | 11 | 27 | 493_681 | 234 | 741 | Domain | Helicase C-terminal |
| Tgene | >DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | + | 10 | 26 | 370_373 | 234 | 741 | Motif | Note=DEAD box |
| Tgene | >DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | + | 11 | 27 | 370_373 | 234 | 741 | Motif | Note=DEAD box |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | + | 10 | 26 | 2_428 | 234 | 741 | Domain | Helicase ATP-binding |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | + | 10 | 26 | 70_247 | 234 | 741 | Domain | B30.2/SPRY |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | + | 11 | 27 | 2_428 | 234 | 741 | Domain | Helicase ATP-binding |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | + | 11 | 27 | 70_247 | 234 | 741 | Domain | B30.2/SPRY |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | + | 10 | 26 | 46_53 | 234 | 741 | Nucleotide binding | ATP |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | + | 11 | 27 | 46_53 | 234 | 741 | Nucleotide binding | ATP |
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FusionGeneSequence for LAP3_DDX1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LAP3_ENST00000226299_chr4_17583437_+_DDX1_ENST00000381341_chr2_15746274_+_598aa MFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLH QNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLI IGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSF DVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKE HKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLP DEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDE >In-frame_LAP3_ENST00000226299_chr4_17583437_+_DDX1_ENST00000233084_chr2_15746274_+_598aa MFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLH QNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLI IGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSF DVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKE HKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLP DEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDE >In-frame_LAP3_ENST00000606142_chr4_17583437_+_DDX1_ENST00000381341_chr2_15746274_+_567aa MTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDG YIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLV STGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHV VVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPD KKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKE KVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQE >In-frame_LAP3_ENST00000606142_chr4_17583437_+_DDX1_ENST00000233084_chr2_15746274_+_567aa MTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDG YIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLV STGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHV VVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPD KKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKE KVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LAP3_ENST00000226299_chr4_17583437_+_DDX1_ENST00000381341_chr2_15746274_+_1794nt ATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCA GACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGAT AAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCAT CAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGAT GGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAA CCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATA ATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTG GTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTT ATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTC GATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCAT GTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGAT AACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAA CATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCT GATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAA GGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCC GATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAA GAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTAC AACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAA TTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAA >In-frame_LAP3_ENST00000226299_chr4_17583437_+_DDX1_ENST00000233084_chr2_15746274_+_1794nt ATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCA GACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGAT AAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCAT CAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGAT GGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAA CCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATA ATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTG GTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTT ATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTC GATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCAT GTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGAT AACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAA CATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCT GATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAA GGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCC GATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAA GAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTAC AACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAA TTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAA >In-frame_LAP3_ENST00000606142_chr4_17583437_+_DDX1_ENST00000381341_chr2_15746274_+_1701nt ATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAA TTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAG AATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGT TACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCT TCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATT GGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTG TCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATA AATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGAT GTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTT GTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAAC ACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACAT AAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGAT AAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGA GATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGAT GAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAA AAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAAC GAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTT GATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAG >In-frame_LAP3_ENST00000606142_chr4_17583437_+_DDX1_ENST00000233084_chr2_15746274_+_1701nt ATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAA TTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAG AATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGT TACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCT TCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATT GGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTG TCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATA AATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGAT GTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTT GTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAAC ACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACAT AAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGAT AAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGA GATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGAT GAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAA AAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAAC GAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTT GATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LAP3_ENST00000226299_chr4_17583437_+_DDX1_ENST00000381341_chr2_15746274_+_2273nt GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA >In-frame_LAP3_ENST00000226299_chr4_17583437_+_DDX1_ENST00000233084_chr2_15746274_+_2263nt GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA >In-frame_LAP3_ENST00000606142_chr4_17583437_+_DDX1_ENST00000381341_chr2_15746274_+_1970nt GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT >In-frame_LAP3_ENST00000606142_chr4_17583437_+_DDX1_ENST00000233084_chr2_15746274_+_1960nt GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT |
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FusionGenePPI for LAP3_DDX1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LAP3 | DDA1, UBA5, TAB1, ISG15, APP, LIG4, AARSD1, AGFG1, ALAD, ARPC2, NIF3L1, OGT, SH3GL1, SH3GLB1, TPRKB, RAPGEF2, RNF2, FUBP1, MIF, PRDX1, PRDX2, TKT, VARS, NTRK1, TP53, NDUFS5, RAB7A, RBM39, ZCCHC17, U2AF2, TES | DDX1 | CSTF2, HNRNPK, ATM, MRE11A, RAD50, NBN, SRRM2, MYC, HDAC5, PSMA3, NDRG1, HDGF, ARRB2, HNRNPA1, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, APP, RTCB, HNRNPM, PPP1CA, EEF1A1, C14orf166, FAM98B, RNF168, RANBP9, GEMIN5, STRN, TMED9, HMCN1, PLOD3, C2orf49, SCARB2, XPO1, FGFR1OP2, SAP30BP, EIF2S1, MCCC1, RPA2, UBE2I, ALDH18A1, TPR, VASP, HEXIM1, KATNAL2, STRIP1, POP1, HAS1, HNRNPD, PLOD1, LSM14A, RBM4, RC3H1, RHOA, NUP133, HSPA1A, FN1, VCAM1, ITGA4, CTNNB1, HDAC6, NME7, YWHAQ, SH3RF2, ABCF1, NELFB, YBX3, DHX9, DYNC1H1, DYNC1I2, EDC4, EIF2B2, EIF2B3, FKBP3, FLII, LRRFIP1, EIF3K, HNRNPA2B1, HNRNPU, IGF2BP3, ILF2, KRT18, NMT1, PDCD6, POLR1C, QARS, RFC2, RFC4, RPL26L1, RPL27, YBX1, RPA3, RPA1, WWOX, ZBTB1, STAU1, HUWE1, FUS, CUL7, OBSL1, LUZP4, ESR1, RPS6KB2, MAEL, KIAA0368, PPP1R8, SHMT2, EIF4EBP1, FAM98A, PICALM, RAVER1, THUMPD1, TSTA3, NTRK1, SCARNA22, HNRNPH2, NPM1, RPL10, MCM2, SNW1, UXS1, ANKS6, RFX3, HDAC1, XYLT2, DLD, SDHA, TRIM25, G3BP1, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LAP3_DDX1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LAP3_DDX1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DDX1 | C0014173 | Endometrial Hyperplasia | 1 | CTD_human |
| Tgene | DDX1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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