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Fusion gene ID: 19423 |
FusionGeneSummary for LAMTOR1_UVRAG |
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Fusion gene information | Fusion gene name: LAMTOR1_UVRAG | Fusion gene ID: 19423 | Hgene | Tgene | Gene symbol | LAMTOR1 | UVRAG | Gene ID | 55004 | 7405 |
Gene name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | UV radiation resistance associated | |
Synonyms | C11orf59|PDRO|Ragulator1|p18|p27RF-Rho | DHTX|VPS38|p63 | |
Cytomap | 11q13.4 | 11q13.5 | |
Type of gene | protein-coding | protein-coding | |
Description | ragulator complex protein LAMTOR1RhoA activator C11orf59late endosomal/lysosomal adaptor and MAPK and MTOR activator 1lipid raft adaptor protein p18p27Kip1-releasing factor from RhoAp27kip1 releasing factor from RhoAprotein associated with DRMs and | UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6IAA8 | Q9P2Y5 | |
Ensembl transtripts involved in fusion gene | ENST00000545249, ENST00000535107, ENST00000278671, ENST00000538404, ENST00000539797, | ENST00000356136, ENST00000528420, ENST00000533454, ENST00000531818, ENST00000532130, ENST00000539288, ENST00000525872, ENST00000538870, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 24 X 13 X 11=3432 |
# samples | 1 | 25 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(25/3432*10)=-3.77904955283746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LAMTOR1 [Title/Abstract] AND UVRAG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | UVRAG | GO:0071900 | regulation of protein serine/threonine kinase activity | 22542840 |
Tgene | UVRAG | GO:0097680 | double-strand break repair via classical nonhomologous end joining | 22542840 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-UF-A7JV-01A | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000545249 | ENST00000356136 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-5UTR | ENST00000545249 | ENST00000528420 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000545249 | ENST00000533454 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000545249 | ENST00000531818 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000545249 | ENST00000532130 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000545249 | ENST00000539288 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000545249 | ENST00000525872 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000545249 | ENST00000538870 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-3CDS | ENST00000535107 | ENST00000356136 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-5UTR | ENST00000535107 | ENST00000528420 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000535107 | ENST00000533454 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000535107 | ENST00000531818 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000535107 | ENST00000532130 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000535107 | ENST00000539288 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000535107 | ENST00000525872 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000535107 | ENST00000538870 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
In-frame | ENST00000278671 | ENST00000356136 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-5UTR | ENST00000278671 | ENST00000528420 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000278671 | ENST00000533454 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000278671 | ENST00000531818 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000278671 | ENST00000532130 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000278671 | ENST00000539288 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000278671 | ENST00000525872 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5CDS-intron | ENST00000278671 | ENST00000538870 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-3CDS | ENST00000538404 | ENST00000356136 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-5UTR | ENST00000538404 | ENST00000528420 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000538404 | ENST00000533454 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000538404 | ENST00000531818 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000538404 | ENST00000532130 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000538404 | ENST00000539288 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000538404 | ENST00000525872 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
intron-intron | ENST00000538404 | ENST00000538870 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5UTR-3CDS | ENST00000539797 | ENST00000356136 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5UTR-5UTR | ENST00000539797 | ENST00000528420 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5UTR-intron | ENST00000539797 | ENST00000533454 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5UTR-intron | ENST00000539797 | ENST00000531818 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5UTR-intron | ENST00000539797 | ENST00000532130 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5UTR-intron | ENST00000539797 | ENST00000539288 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5UTR-intron | ENST00000539797 | ENST00000525872 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
5UTR-intron | ENST00000539797 | ENST00000538870 | LAMTOR1 | chr11 | 71809335 | - | UVRAG | chr11 | 75562928 | + |
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FusionProtFeatures for LAMTOR1_UVRAG |
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Hgene | Tgene |
LAMTOR1 | UVRAG |
As part of the Ragulator complex it is involved in aminoacid sensing and activation of mTORC1, a signaling complexpromoting cell growth in response to growth factors, energylevels, and amino acids. Activated by amino acids through amechanism involving the lysosomal V-ATPase, the Ragulatorfunctions as a guanine nucleotide exchange factor activating thesmall GTPases Rag. Activated Ragulator and Rag GTPases function asa scaffold recruiting mTORC1 to lysosomes where it is in turnactivated. LAMTOR1 is directly responsible for anchoring theRagulator complex to membranes. Also required for lateendosomes/lysosomes biogenesis it may regulate both the recyclingof receptors through endosomes and the MAPK signaling pathwaythrough recruitment of some of its components to late endosomes.May be involved in cholesterol homeostasis regulating LDL uptakeand cholesterol release from late endosomes/lysosomes. May alsoplay a role in RHOA activation. {ECO:0000269|PubMed:19654316,ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018,ECO:0000269|PubMed:22980980}. | Versatile protein that is involved in regulation ofdifferent cellular pathways implicated in membrane trafficking.Involved in regulation of the COPI-dependent retrograde transportfrom Golgi and the endoplasmic reticulum by associating with theNRZ complex; the function is dependent on its binding tophosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).During autophagy acts as regulatory subunit of the alternativePI3K complex II (PI3KC3-C2) that mediates formation ofphosphatidylinositol 3-phosphate and is believed to be involved inmaturation of autophagosomes and endocytosis. Activates lipidkinase activity of PIK3C3. Involved in the regulation ofdegradative endocytic trafficking and cytokinesis, and inregulation of ATG9A transport from the Golgi to the autophagosome;the functions seems to implicate its association with PI3KC3-C2(PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved inmaturation of autophagosomes and degradative endocytic traffickingindependently of BECN1 but depending on its association with aclass C Vps complex (possibly the HOPS complex); the associationis also proposed to promote autophagosome recruitment andactivation of Rab7 and endosome-endosome fusion events(PubMed:18552835). Enhances class C Vps complex (possibly HOPScomplex) association with a SNARE complex and promotes fusogenicSNARE complex formation during late endocytic membrane fusion(PubMed:24550300). In case of negative-strand RNA virus infectionis required for efficient virus entry, promotes endocytictransport of virions and is implicated in a VAMP8-specificfusogenic SNARE complex assembly (PubMed:24550300).{ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:24056303, ECO:0000305}. Involved in maintaining chromosomal stability. PromotesDNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required forcentrosome stability and proper chromosome segregation(PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >UVRAG | chr11:71809335 | chr11:75562928 | ENST00000356136 | + | 0 | 15 | 224_305 | 39 | 700 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >UVRAG | chr11:71809335 | chr11:75562928 | ENST00000356136 | + | 0 | 15 | 44_128 | 39 | 700 | Domain | Note=C2 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LAMTOR1_UVRAG |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_LAMTOR1_ENST00000545249_chr11_71809335_-_UVRAG_ENST00000356136_chr11_75562928_+_792aa MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYST RLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKN SLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTI LLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHKQ QIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDG SIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLR QTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMG ETERKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCT >In-frame_LAMTOR1_ENST00000278671_chr11_71809335_-_UVRAG_ENST00000356136_chr11_75562928_+_792aa MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYST RLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKN SLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTI LLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHKQ QIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDG SIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLR QTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMG ETERKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCT |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_LAMTOR1_ENST00000545249_chr11_71809335_-_UVRAG_ENST00000356136_chr11_75562928_+_2376nt ATGGGGTGCTGCTACAGCAGCGAGAACGAGGACTCGGACCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGCCCCCCTACC AAAGCTCTCAATGGAGCCGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATCCTTGCCAAG ACAGCCAGCAACATCATTGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAGTACAGCACC CGCTTGGCTGTGCTGAGCAGCAGCCTGACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAAGTGCTGGCC AGTGAGCCCATCCCGTTCTCTGATTTGCAGCAGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGC CATCAGCTCCTTGATACCTACTTTACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAAT TCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGG GGTGGAAAGGAGAACATCTACCAGCTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGA AACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATT CTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAG ACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAA TGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAA CAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAG GAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATT TACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGA AGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCAT AAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAG AAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGG CAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCT AAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGC TCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGA GAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTA GTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGC ACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACT GTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGAC AGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCC >In-frame_LAMTOR1_ENST00000278671_chr11_71809335_-_UVRAG_ENST00000356136_chr11_75562928_+_2376nt ATGGGGTGCTGCTACAGCAGCGAGAACGAGGACTCGGACCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGCCCCCCTACC AAAGCTCTCAATGGAGCCGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATCCTTGCCAAG ACAGCCAGCAACATCATTGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAGTACAGCACC CGCTTGGCTGTGCTGAGCAGCAGCCTGACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAAGTGCTGGCC AGTGAGCCCATCCCGTTCTCTGATTTGCAGCAGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGC CATCAGCTCCTTGATACCTACTTTACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAAT TCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGG GGTGGAAAGGAGAACATCTACCAGCTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGA AACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATT CTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAG ACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAA TGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAA CAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAG GAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATT TACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGA AGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCAT AAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAG AAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGG CAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCT AAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGC TCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGA GAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTA GTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGC ACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACT GTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGAC AGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_LAMTOR1_ENST00000545249_chr11_71809335_-_UVRAG_ENST00000356136_chr11_75562928_+_4180nt AGCGCCCGGCCCGACCCCGGCCATGGGGTGCTGCTACAGCAGCGAGAACGAGGACTCGGACCAGGACCGAGAGGAGCGGAAGCTGCTGCT GGACCCTAGCAGCCCCCCTACCAAAGCTCTCAATGGAGCCGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCT GCTCTCTTCCATCCTTGCCAAGACAGCCAGCAACATCATTGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGA CCGTGCCAGGCAGTACAGCACCCGCTTGGCTGTGCTGAGCAGCAGCCTGACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAG CCAGCCCCACCAAGTGCTGGCCAGTGAGCCCATCCCGTTCTCTGATTTGCAGCAGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCG GAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTTACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTA TAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTC TTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAGCTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTT GGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTA TTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAG AGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAA TGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTTTGGGACGGGA GGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAACTCCAGAAGGA ATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTTGCAGGCAGTT ACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGA CTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCC CCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCC ACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGG ACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACAC CTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAA AGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGT GACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAA CAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGG GCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTC AGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGC ATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTA TGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGA AGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAA AAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGC CTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCC TTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATG GTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGTTTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGA AGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCCTCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCC CCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGACATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCT TCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTAATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGG GACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATCTCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCA GGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAAAATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAG GTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGTGTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCT AGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCATGAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGAT TTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACATTGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCAT GTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCCGACCTGATTTTTTTTTACCAGCTTGGAAATTCCTCTTGAACCTACGTCTCC ATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCCATGTCTATCTAAGCGGAGGCTGTTGACTTCATTCAGTTTGCATATTGTATA TAGCAACACAAACACTTGACAGGTATATACTCCAGTCGCCACATTTGTCCTGCATAACAGCTTCACTCACAGGCCTCACCGTCACTTTAT TTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATAGCTACATTGTTGTTTTCCATGTAGAGAACTCACAGGATGACTACATCACAA ATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGATCTGCAGAAGCCCATCTTCCTCCACATGAAGAAGTGGGGCTCCTTCACCTA GAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCATTTTGGAGTCAGTGTGGGTGGAGACAGCATCGTGGATATGCACGTGCTGCGG >In-frame_LAMTOR1_ENST00000278671_chr11_71809335_-_UVRAG_ENST00000356136_chr11_75562928_+_4321nt GGGGTATTGACTGAGGCGGCCAAGCGGCTCCGGGACAGGGGGTACGGGGGGTGGGGGCGGGTGGTTGCCTGCGGGAGGCCGCCGCGGGTC ATGTGACCGGAAGGGCTCCTCACGGACGCCGTCCCTCCTCGGCGCGGCCTGAGCGCCCGGCCCGACCCCGGCCATGGGGTGCTGCTACAG CAGCGAGAACGAGGACTCGGACCAGGACCGAGAGGAGCGGAAGCTGCTGCTGGACCCTAGCAGCCCCCCTACCAAAGCTCTCAATGGAGC CGAGCCCAACTACCACAGCCTGCCTTCCGCTCGCACTGATGAGCAGGCCCTGCTCTCTTCCATCCTTGCCAAGACAGCCAGCAACATCAT TGATGTGTCTGCTGCAGACTCACAGGGCATGGAGCAGCATGAGTACATGGACCGTGCCAGGCAGTACAGCACCCGCTTGGCTGTGCTGAG CAGCAGCCTGACCCATTGGAAGAAGCTGCCACCGCTGCCGTCTCTTACCAGCCAGCCCCACCAAGTGCTGGCCAGTGAGCCCATCCCGTT CTCTGATTTGCAGCAGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATAC CTACTTTACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTG GCGAAGTCTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACAT CTACCAGCTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAAT TTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCA GAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCA GAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAAT TTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGA CAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAG AGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAA TGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCT TGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAAC AATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTA TGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCT GAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCAT ATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACT TCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGAT AACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGG AGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGA GCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGA AATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGA GTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCG CAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCT TTGTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATT GTTATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAG AGCTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAA TAATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAG GTTTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTC CCTCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAG GACATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCT TAATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCA TCTCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACA AAAATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGG GTGTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTC ATGAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGAC ATTGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCC GACCTGATTTTTTTTTACCAGCTTGGAAATTCCTCTTGAACCTACGTCTCCATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCC ATGTCTATCTAAGCGGAGGCTGTTGACTTCATTCAGTTTGCATATTGTATATAGCAACACAAACACTTGACAGGTATATACTCCAGTCGC CACATTTGTCCTGCATAACAGCTTCACTCACAGGCCTCACCGTCACTTTATTTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATA GCTACATTGTTGTTTTCCATGTAGAGAACTCACAGGATGACTACATCACAAATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGA TCTGCAGAAGCCCATCTTCCTCCACATGAAGAAGTGGGGCTCCTTCACCTAGAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCAT TTTGGAGTCAGTGTGGGTGGAGACAGCATCGTGGATATGCACGTGCTGCGGGGCCCTCCAGGGAAGTAACATTTACCAAAAAAAAAGAAA |
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FusionGenePPI for LAMTOR1_UVRAG |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LAMTOR1 | ABCF3, CCDC90B, EEF1A1, RRAGA, MME, ELAVL1, ATP6V1B1, LAMTOR2, LAMTOR3, GNAS, SLC25A46, RRAGC, RRAGD, BAG3, LAMTOR5, LAMTOR4, RRAGB, C17orf59, LIMK1, XRCC5, ATP6AP2, TMEM132A, ZNRF2, DUSP22, TBC1D7, SLC38A9 | UVRAG | BECN1, PIK3C3, VPS33A, VPS18, PIK3R4, PTPRA, KIAA0226, TGFBRAP1, VPS16, VPS11, VPS33B, VPS39, YWHAE, RALB, USP18, XPO1, MYO1C, DDB1, DDB2, CUL4A, RBX1, KIAA0226L |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | LAMTOR1 | chr11:71809335 | chr11:75562928 | ENST00000278671 | - | 4 | 5 | 121_161 | 131 | 162 | LAMTOR2 and LAMTOR3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LAMTOR1_UVRAG |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LAMTOR1_UVRAG |
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Partner | Gene | Disease ID | Disease name | # pubmeds | Source |