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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19419

FusionGeneSummary for LAMP2_FNIP2

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMP2_FNIP2
Fusion gene ID: 19419
HgeneTgene
Gene symbol

LAMP2

FNIP2

Gene ID

3920

57600

Gene namelysosomal associated membrane protein 2folliculin interacting protein 2
SynonymsCD107b|LAMP-2|LAMPB|LGP-96|LGP110FNIPL|MAPO1
Cytomap

Xq24

4q32.1

Type of geneprotein-codingprotein-coding
Descriptionlysosome-associated membrane glycoprotein 2CD107 antigen-like family member Bfolliculin-interacting protein 2FNIP1-like proteinO6-methylguanine-induced apoptosis 1 protein
Modification date2018051920180519
UniProtAcc

P13473

Q9P278

Ensembl transtripts involved in fusion geneENST00000434600, ENST00000538785, 
ENST00000200639, ENST00000371335, 
ENST00000540603, 		ENST00000264433, 
ENST00000379346, ENST00000505445, 
Fusion gene scores* DoF score4 X 3 X 3=364 X 4 X 2=32
# samples 44
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LAMP2 [Title/Abstract] AND FNIP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFNIP2

GO:0000122

negative regulation of transcription by RNA polymerase II

21209915

TgeneFNIP2

GO:0001932

regulation of protein phosphorylation

18663353

TgeneFNIP2

GO:0006468

protein phosphorylation

18663353

TgeneFNIP2

GO:0031334

positive regulation of protein complex assembly

25126726

TgeneFNIP2

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19914239


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF989399LAMP2chrX

119565109

-FNIP2chr4

159772831

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000434600ENST00000264433LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000434600ENST00000379346LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000434600ENST00000505445LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000538785ENST00000264433LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000538785ENST00000379346LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000538785ENST00000505445LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000200639ENST00000264433LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000200639ENST00000379346LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000200639ENST00000505445LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000371335ENST00000264433LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000371335ENST00000379346LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000371335ENST00000505445LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000540603ENST00000264433LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000540603ENST00000379346LAMP2chrX

119565109

-FNIP2chr4

159772831

+
intron-intronENST00000540603ENST00000505445LAMP2chrX

119565109

-FNIP2chr4

159772831

+

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FusionProtFeatures for LAMP2_FNIP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMP2

P13473

FNIP2

Q9P278

Plays an important role in chaperone-mediated autophagy,a process that mediates lysosomal degradation of proteins inresponse to various stresses and as part of the normal turnover ofproteins with a long biological half-live (PubMed:8662539,PubMed:11082038, PubMed:18644871, PubMed:24880125,PubMed:27628032). Functions by binding target proteins, such asGAPDH and MLLT11, and targeting them for lysosomal degradation(PubMed:8662539, PubMed:11082038, PubMed:18644871,PubMed:24880125). Plays a role in lysosomal protein degradation inresponse to starvation (By similarity). Required for the fusion ofautophagosomes with lysosomes during autophagy (PubMed:27628032).Cells that lack LAMP2 express normal levels of VAMP8, but fail toaccumulate STX17 on autophagosomes, which is the most likelyexplanation for the lack of fusion between autophagosomes andlysosomes (PubMed:27628032). Required for normal degradation ofthe contents of autophagosomes (PubMed:27628032). Required forefficient MHCII-mediated presentation of exogenous antigens viaits function in lysosomal protein degradation; antigenic peptidesgenerated by proteases in the endosomal/lysosomal compartment arecaptured by nascent MHCII subunits (PubMed:20518820). Is notrequired for efficient MHCII-mediated presentation of endogenousantigens (PubMed:20518820). {ECO:0000250|UniProtKB:P17046,ECO:0000269|PubMed:11082038, ECO:0000269|PubMed:18644871,ECO:0000269|PubMed:20518820, ECO:0000269|PubMed:24880125,ECO:0000269|PubMed:27628032, ECO:0000269|PubMed:8662539}. Isoform LAMP-2C: Modulates chaperone-mediated autophagy.Decreases presentation of endogenous antigens by MHCII. Does notplay a role in the presentation of exogenous and membrane-derivedantigens by MHCII. {ECO:0000269|PubMed:26856698}. Acts as a co-chaperone of HSP90AA1. Inhibits the ATPaseactivity of HSP90AA1 leading to reduction in its chaperoneactivity. Facilitates the binding of client protein FLCN toHSP90AA1 (PubMed:27353360). May play a role in the signaltransduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energyand/or nutrient sensing through the AMPK and mTOR signalingpathways (PubMed:18403135). May regulate phosphorylation ofRPS6KB1 (PubMed:18663353). {ECO:0000250|UniProtKB:Q80TD3,ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353,ECO:0000269|PubMed:27353360}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAMP2_FNIP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAMP2_FNIP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAMP2_FNIP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAMP2_FNIP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMP2C0038220Status Epilepticus1CTD_human
HgeneLAMP2C0878677Glycogen Storage Disease Type IIb1CTD_human;ORPHANET;UNIPROT