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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19397

FusionGeneSummary for LAMB3_STOX2

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMB3_STOX2
Fusion gene ID: 19397
HgeneTgene
Gene symbol

LAMB3

STOX2

Gene ID

3914

56977

Gene namelaminin subunit beta 3storkhead box 2
SynonymsAI1A|BM600-125KDA|LAM5|LAMNB1-
Cytomap

1q32.2

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit beta-3epiligrin subunit batakalinin B1 chainkalinin subunit betakalinin-140kDalaminin B1k chainlaminin S B3 chainlaminin beta 3laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD))laminin-5 subunit betanicein subunit bstorkhead-box protein 2
Modification date2018052220180519
UniProtAcc

Q13751

Q9P2F5

Ensembl transtripts involved in fusion geneENST00000356082, ENST00000391911, 
ENST00000367030, 
ENST00000511250, 
ENST00000308497, ENST00000438269, 
Fusion gene scores* DoF score6 X 5 X 2=604 X 3 X 3=36
# samples 64
** MAII scorelog2(6/60*10)=0log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LAMB3 [Title/Abstract] AND STOX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW379287LAMB3chr1

209789954

-STOX2chr4

184912322

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356082ENST00000511250LAMB3chr1

209789954

-STOX2chr4

184912322

-
intron-intronENST00000356082ENST00000308497LAMB3chr1

209789954

-STOX2chr4

184912322

-
intron-intronENST00000356082ENST00000438269LAMB3chr1

209789954

-STOX2chr4

184912322

-
intron-intronENST00000391911ENST00000511250LAMB3chr1

209789954

-STOX2chr4

184912322

-
intron-intronENST00000391911ENST00000308497LAMB3chr1

209789954

-STOX2chr4

184912322

-
intron-intronENST00000391911ENST00000438269LAMB3chr1

209789954

-STOX2chr4

184912322

-
intron-intronENST00000367030ENST00000511250LAMB3chr1

209789954

-STOX2chr4

184912322

-
intron-intronENST00000367030ENST00000308497LAMB3chr1

209789954

-STOX2chr4

184912322

-
intron-intronENST00000367030ENST00000438269LAMB3chr1

209789954

-STOX2chr4

184912322

-

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FusionProtFeatures for LAMB3_STOX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMB3

Q13751

STOX2

Q9P2F5

Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAMB3_STOX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAMB3_STOX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAMB3_STOX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LAMB3_STOX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMB3C0268374Adult junctional epidermolysis bullosa (disorder)2CTD_human;ORPHANET;UNIPROT
HgeneLAMB3C0079683Herlitz Disease1ORPHANET;UNIPROT