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Fusion gene ID: 19397 |
FusionGeneSummary for LAMB3_STOX2 |
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Fusion gene information | Fusion gene name: LAMB3_STOX2 | Fusion gene ID: 19397 | Hgene | Tgene | Gene symbol | LAMB3 | STOX2 | Gene ID | 3914 | 56977 |
Gene name | laminin subunit beta 3 | storkhead box 2 | |
Synonyms | AI1A|BM600-125KDA|LAM5|LAMNB1 | - | |
Cytomap | 1q32.2 | 4q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | laminin subunit beta-3epiligrin subunit batakalinin B1 chainkalinin subunit betakalinin-140kDalaminin B1k chainlaminin S B3 chainlaminin beta 3laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD))laminin-5 subunit betanicein subunit b | storkhead-box protein 2 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q13751 | Q9P2F5 | |
Ensembl transtripts involved in fusion gene | ENST00000356082, ENST00000391911, ENST00000367030, | ENST00000511250, ENST00000308497, ENST00000438269, | |
Fusion gene scores | * DoF score | 6 X 5 X 2=60 | 4 X 3 X 3=36 |
# samples | 6 | 4 | |
** MAII score | log2(6/60*10)=0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LAMB3 [Title/Abstract] AND STOX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW379287 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000356082 | ENST00000511250 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
intron-intron | ENST00000356082 | ENST00000308497 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
intron-intron | ENST00000356082 | ENST00000438269 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
intron-intron | ENST00000391911 | ENST00000511250 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
intron-intron | ENST00000391911 | ENST00000308497 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
intron-intron | ENST00000391911 | ENST00000438269 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
intron-intron | ENST00000367030 | ENST00000511250 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
intron-intron | ENST00000367030 | ENST00000308497 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
intron-intron | ENST00000367030 | ENST00000438269 | LAMB3 | chr1 | 209789954 | - | STOX2 | chr4 | 184912322 | - |
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FusionProtFeatures for LAMB3_STOX2 |
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Hgene | Tgene |
LAMB3 | STOX2 |
Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LAMB3_STOX2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LAMB3_STOX2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LAMB3_STOX2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LAMB3_STOX2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LAMB3 | C0268374 | Adult junctional epidermolysis bullosa (disorder) | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | LAMB3 | C0079683 | Herlitz Disease | 1 | ORPHANET;UNIPROT |