![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 19390 |
FusionGeneSummary for LAMB2_HNRNPD |
![]() |
Fusion gene information | Fusion gene name: LAMB2_HNRNPD | Fusion gene ID: 19390 | Hgene | Tgene | Gene symbol | LAMB2 | HNRNPD | Gene ID | 84823 | 3184 |
Gene name | lamin B2 | heterogeneous nuclear ribonucleoprotein D | |
Synonyms | EPM9|LAMB2|LMN2 | AUF1|AUF1A|HNRPD|P37|hnRNPD0 | |
Cytomap | 19p13.3 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | lamin-B2lamin B3 | heterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P55268 | Q14103 | |
Ensembl transtripts involved in fusion gene | ENST00000418109, ENST00000305544, ENST00000464891, | ENST00000313899, ENST00000353341, ENST00000543098, ENST00000352301, ENST00000508119, ENST00000541060, | |
Fusion gene scores | * DoF score | 3 X 4 X 1=12 | 10 X 10 X 3=300 |
# samples | 4 | 12 | |
** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/300*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LAMB2 [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA010774 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000418109 | ENST00000313899 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000418109 | ENST00000353341 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000418109 | ENST00000543098 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000418109 | ENST00000352301 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000418109 | ENST00000508119 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000418109 | ENST00000541060 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000305544 | ENST00000313899 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000305544 | ENST00000353341 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000305544 | ENST00000543098 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000305544 | ENST00000352301 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000305544 | ENST00000508119 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000305544 | ENST00000541060 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000464891 | ENST00000313899 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000464891 | ENST00000353341 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000464891 | ENST00000543098 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000464891 | ENST00000352301 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000464891 | ENST00000508119 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
intron-intron | ENST00000464891 | ENST00000541060 | LAMB2 | chr3 | 49162488 | - | HNRNPD | chr4 | 83275343 | - |
Top |
FusionProtFeatures for LAMB2_HNRNPD |
![]() |
Hgene | Tgene |
LAMB2 | HNRNPD |
Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for LAMB2_HNRNPD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for LAMB2_HNRNPD |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for LAMB2_HNRNPD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | HNRNPD | Q14103 | DB11638 | Artenimol | Heterogeneous nuclear ribonucleoprotein D0 | small molecule | approved|investigational |
Top |
RelatedDiseases for LAMB2_HNRNPD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LAMB2 | C1836876 | Pierson syndrome | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | LAMB2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | LAMB2 | C0268747 | Diffuse mesangial sclerosis (disorder) | 1 | CTD_human;HPO |
Hgene | LAMB2 | C3280113 | NEPHROTIC SYNDROME, TYPE 5, WITH OR WITHOUT OCULAR ABNORMALITIES | 1 | ORPHANET;UNIPROT |