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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19390

FusionGeneSummary for LAMB2_HNRNPD

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMB2_HNRNPD
Fusion gene ID: 19390
HgeneTgene
Gene symbol

LAMB2

HNRNPD

Gene ID

84823

3184

Gene namelamin B2heterogeneous nuclear ribonucleoprotein D
SynonymsEPM9|LAMB2|LMN2AUF1|AUF1A|HNRPD|P37|hnRNPD0
Cytomap

19p13.3

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionlamin-B2lamin B3heterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0
Modification date2018051920180523
UniProtAcc

P55268

Q14103

Ensembl transtripts involved in fusion geneENST00000418109, ENST00000305544, 
ENST00000464891, 
ENST00000313899, 
ENST00000353341, ENST00000543098, 
ENST00000352301, ENST00000508119, 
ENST00000541060, 
Fusion gene scores* DoF score3 X 4 X 1=1210 X 10 X 3=300
# samples 412
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/300*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMB2 [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA010774LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000418109ENST00000313899LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000418109ENST00000353341LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000418109ENST00000543098LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000418109ENST00000352301LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000418109ENST00000508119LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000418109ENST00000541060LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000305544ENST00000313899LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000305544ENST00000353341LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000305544ENST00000543098LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000305544ENST00000352301LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000305544ENST00000508119LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000305544ENST00000541060LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000464891ENST00000313899LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000464891ENST00000353341LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000464891ENST00000543098LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000464891ENST00000352301LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000464891ENST00000508119LAMB2chr3

49162488

-HNRNPDchr4

83275343

-
intron-intronENST00000464891ENST00000541060LAMB2chr3

49162488

-HNRNPDchr4

83275343

-

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FusionProtFeatures for LAMB2_HNRNPD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMB2

P55268

HNRNPD

Q14103

Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LAMB2_HNRNPD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LAMB2_HNRNPD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LAMB2_HNRNPD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHNRNPDQ14103DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein D0small moleculeapproved|investigational

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RelatedDiseases for LAMB2_HNRNPD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMB2C1836876Pierson syndrome2CTD_human;ORPHANET;UNIPROT
HgeneLAMB2C0033578Prostatic Neoplasms1CTD_human
HgeneLAMB2C0268747Diffuse mesangial sclerosis (disorder)1CTD_human;HPO
HgeneLAMB2C3280113NEPHROTIC SYNDROME, TYPE 5, WITH OR WITHOUT OCULAR ABNORMALITIES1ORPHANET;UNIPROT