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Fusion gene ID: 19317 |
FusionGeneSummary for L2HGDH_MBP |
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Fusion gene information | Fusion gene name: L2HGDH_MBP | Fusion gene ID: 19317 | Hgene | Tgene | Gene symbol | L2HGDH | MBP | Gene ID | 79944 | 5553 |
Gene name | L-2-hydroxyglutarate dehydrogenase | proteoglycan 2, pro eosinophil major basic protein | |
Synonyms | C14orf160|L2HGA | BMPG|MBP|MBP1|proMBP | |
Cytomap | 14q21.3 | 11q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | L-2-hydroxyglutarate dehydrogenase, mitochondrial2-hydroxyglutarate dehydrogenaseL-alpha-hydroxyglutarate dehydrogenasealpha-hydroxyglutarate oxidoreductasealpha-ketoglutarate reductaseduranin | bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9H9P8 | P02686 | |
Ensembl transtripts involved in fusion gene | ENST00000261699, ENST00000267436, ENST00000421284, ENST00000555423, ENST00000555610, ENST00000556393, | ENST00000382582, ENST00000355994, ENST00000397875, ENST00000397866, ENST00000397865, ENST00000527041, ENST00000359645, ENST00000528160, ENST00000397869, ENST00000354542, ENST00000526111, ENST00000580402, ENST00000579129, ENST00000578193, ENST00000397863, ENST00000397860, ENST00000487778, | |
Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 26 X 20 X 3=1560 |
# samples | 6 | 27 | |
** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/1560*10)=-2.53051471669878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: L2HGDH [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | L2HGDH | GO:0044267 | cellular protein metabolic process | 16005139 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA137061 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000261699 | ENST00000382582 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000355994 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000397875 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000397866 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000397865 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000527041 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000261699 | ENST00000359645 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000261699 | ENST00000528160 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000261699 | ENST00000397869 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000354542 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000526111 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000580402 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000579129 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000578193 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000397863 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000397860 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000261699 | ENST00000487778 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000382582 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000355994 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000397875 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000397866 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000397865 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000527041 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000267436 | ENST00000359645 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000267436 | ENST00000528160 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000267436 | ENST00000397869 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000354542 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000526111 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000580402 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000579129 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000578193 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000397863 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000397860 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000267436 | ENST00000487778 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000382582 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000355994 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000397875 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000397866 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000397865 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000527041 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000421284 | ENST00000359645 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000421284 | ENST00000528160 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000421284 | ENST00000397869 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000354542 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000526111 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000580402 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000579129 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000578193 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000397863 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000397860 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000421284 | ENST00000487778 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000382582 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000355994 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000397875 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000397866 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000397865 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000527041 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000555423 | ENST00000359645 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000555423 | ENST00000528160 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000555423 | ENST00000397869 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000354542 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000526111 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000580402 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000579129 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000578193 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000397863 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000397860 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555423 | ENST00000487778 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000382582 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000355994 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000397875 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000397866 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000397865 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000527041 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000555610 | ENST00000359645 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000555610 | ENST00000528160 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000555610 | ENST00000397869 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000354542 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000526111 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000580402 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000579129 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000578193 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000397863 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000397860 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000555610 | ENST00000487778 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000382582 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000355994 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000397875 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000397866 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000397865 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000527041 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000556393 | ENST00000359645 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000556393 | ENST00000528160 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-intron | ENST00000556393 | ENST00000397869 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000354542 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000526111 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000580402 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000579129 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000578193 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000397863 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000397860 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
intron-5UTR | ENST00000556393 | ENST00000487778 | L2HGDH | chr14 | 50712199 | - | MBP | chr18 | 74729012 | - |
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FusionProtFeatures for L2HGDH_MBP |
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Hgene | Tgene |
L2HGDH | MBP |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for L2HGDH_MBP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for L2HGDH_MBP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for L2HGDH_MBP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for L2HGDH_MBP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | L2HGDH | C1855995 | L-2-HYDROXYGLUTARIC ACIDURIA | 3 | ORPHANET;UNIPROT |
Hgene | L2HGDH | C2746066 | Combined D-2- and L-2-hydroxyglutaric aciduria | 3 | CTD_human |
Hgene | L2HGDH | C0014544 | Epilepsy | 1 | CTD_human |
Hgene | L2HGDH | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Hgene | L2HGDH | C3714756 | Intellectual Disability | 1 | CTD_human |
Tgene | MBP | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | MBP | C0014072 | Experimental Autoimmune Encephalomyelitis | 3 | CTD_human |
Tgene | MBP | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | MBP | C0011303 | Demyelinating Diseases | 1 | CTD_human |
Tgene | MBP | C0027873 | Neuromyelitis Optica | 1 | CTD_human |