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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19312

FusionGeneSummary for KYNU_KYNU

check button Fusion gene summary
Fusion gene informationFusion gene name: KYNU_KYNU
Fusion gene ID: 19312
HgeneTgene
Gene symbol

KYNU

KYNU

Gene ID

8942

8942

Gene namekynureninasekynureninase
SynonymsKYNUU|VCRL2KYNUU|VCRL2
Cytomap

2q22.2

2q22.2

Type of geneprotein-codingprotein-coding
DescriptionkynureninaseL-kynurenine hydrolasekynureninaseL-kynurenine hydrolase
Modification date2018052320180523
UniProtAcc

Q16719

Q16719

Ensembl transtripts involved in fusion geneENST00000264170, ENST00000375773, 
ENST00000409512, ENST00000410015, 
ENST00000264170, ENST00000375773, 
ENST00000409512, ENST00000410015, 
Fusion gene scores* DoF score1 X 2 X 1=28 X 7 X 6=336
# samples 210
** MAII scorelog2(2/2*10)=3.32192809488736log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KYNU [Title/Abstract] AND KYNU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKYNU

GO:0019805

quinolinate biosynthetic process

9291104

HgeneKYNU

GO:0034341

response to interferon-gamma

9291104

HgeneKYNU

GO:0043420

anthranilate metabolic process

11985583

TgeneKYNU

GO:0019805

quinolinate biosynthetic process

9291104

TgeneKYNU

GO:0034341

response to interferon-gamma

9291104

TgeneKYNU

GO:0043420

anthranilate metabolic process

11985583


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF907726KYNUchr2

143743591

+KYNUchr2

143712379

+
ChiTaRS3.1CB851853KYNUchr2

143746830

-KYNUchr2

143746729

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264170ENST00000264170KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000264170ENST00000375773KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000264170ENST00000409512KYNUchr2

143743591

+KYNUchr2

143712379

+
5CDS-intronENST00000264170ENST00000410015KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000375773ENST00000264170KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000375773ENST00000375773KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000375773ENST00000409512KYNUchr2

143743591

+KYNUchr2

143712379

+
5CDS-intronENST00000375773ENST00000410015KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000409512ENST00000264170KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000409512ENST00000375773KYNUchr2

143743591

+KYNUchr2

143712379

+
Frame-shiftENST00000409512ENST00000409512KYNUchr2

143743591

+KYNUchr2

143712379

+
5CDS-intronENST00000409512ENST00000410015KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-3CDSENST00000410015ENST00000264170KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-3CDSENST00000410015ENST00000375773KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-3CDSENST00000410015ENST00000409512KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-intronENST00000410015ENST00000410015KYNUchr2

143743591

+KYNUchr2

143712379

+
intron-intronENST00000264170ENST00000264170KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000264170ENST00000375773KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000264170ENST00000409512KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000264170ENST00000410015KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000375773ENST00000264170KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000375773ENST00000375773KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000375773ENST00000409512KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000375773ENST00000410015KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000409512ENST00000264170KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000409512ENST00000375773KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000409512ENST00000409512KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000409512ENST00000410015KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000410015ENST00000264170KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000410015ENST00000375773KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000410015ENST00000409512KYNUchr2

143746830

-KYNUchr2

143746729

+
intron-intronENST00000410015ENST00000410015KYNUchr2

143746830

-KYNUchr2

143746729

+

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FusionProtFeatures for KYNU_KYNU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KYNU

Q16719

KYNU

Q16719

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preferencefor the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyaseactivity. {ECO:0000269|PubMed:11985583,ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876,ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}. Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preferencefor the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyaseactivity. {ECO:0000269|PubMed:11985583,ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876,ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KYNU_KYNU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KYNU_KYNU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KYNUTPM3, SMARCD2, COIL, SEC23IP, NUP210, PALM2, SMS, PPM1G, SMEK2, SSU72, ASNS, SIRT1, SGTA, LYN, CNDP2, ADSS, BCCIP, CHORDC1, CSE1L, GDA, GNS, GSR, LDHAL6B, MVD, NAGK, C11orf58, LDHA, NDRG1, PEPD, RPS6KA1, NXF1, ADK, ASS1, CFL1, DSTN, ETFA, FUBP1, GLRX, FH, KHSRP, MEMO1, PPIA, PSAT1, SPR, RETKYNUTPM3, SMARCD2, COIL, SEC23IP, NUP210, PALM2, SMS, PPM1G, SMEK2, SSU72, ASNS, SIRT1, SGTA, LYN, CNDP2, ADSS, BCCIP, CHORDC1, CSE1L, GDA, GNS, GSR, LDHAL6B, MVD, NAGK, C11orf58, LDHA, NDRG1, PEPD, RPS6KA1, NXF1, ADK, ASS1, CFL1, DSTN, ETFA, FUBP1, GLRX, FH, KHSRP, MEMO1, PPIA, PSAT1, SPR, RET


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KYNU_KYNU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneKYNUQ16719DB00114Pyridoxal PhosphateKynureninase {ECO:0000255|HAMAP-Rule:MF_03017}small moleculeapproved|investigational|nutraceutical
TgeneKYNUQ16719DB00114Pyridoxal PhosphateKynureninase {ECO:0000255|HAMAP-Rule:MF_03017}small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for KYNU_KYNU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKYNUC0021368Inflammation1CTD_human
HgeneKYNUC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneKYNUC0041696Unipolar Depression1PSYGENET
HgeneKYNUC0268474Hydroxykynureninuria1CTD_human;ORPHANET;UNIPROT
HgeneKYNUC0344315Depressed mood1PSYGENET
HgeneKYNUC0524851Neurodegenerative Disorders1CTD_human
HgeneKYNUC1269683Major Depressive Disorder1PSYGENET
TgeneKYNUC0021368Inflammation1CTD_human
TgeneKYNUC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneKYNUC0041696Unipolar Depression1PSYGENET
TgeneKYNUC0268474Hydroxykynureninuria1CTD_human;ORPHANET;UNIPROT
TgeneKYNUC0344315Depressed mood1PSYGENET
TgeneKYNUC0524851Neurodegenerative Disorders1CTD_human
TgeneKYNUC1269683Major Depressive Disorder1PSYGENET