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Fusion gene ID: 19258 |
FusionGeneSummary for KRT19_SPINT1 |
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Fusion gene information | Fusion gene name: KRT19_SPINT1 | Fusion gene ID: 19258 | Hgene | Tgene | Gene symbol | KRT19 | SPINT1 | Gene ID | 3880 | 6692 |
Gene name | keratin 19 | serine peptidase inhibitor, Kunitz type 1 | |
Synonyms | CK19|K19|K1CS | HAI|HAI1|MANSC2 | |
Cytomap | 17q21.2 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | keratin, type I cytoskeletal 1940-kDa keratin intermediate filamentCK-19cytokeratin 19keratin 19, type Ikeratin, type I, 40-kd | kunitz-type protease inhibitor 1HAI-1hepatocyte growth factor activator inhibitor type 1serine protease inhibitor, Kunitz type 1 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P08727 | O43278 | |
Ensembl transtripts involved in fusion gene | ENST00000361566, | ENST00000562057, ENST00000344051, ENST00000431806, | |
Fusion gene scores | * DoF score | 13 X 5 X 9=585 | 3 X 3 X 1=9 |
# samples | 14 | 5 | |
** MAII score | log2(14/585*10)=-2.0630097975258 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/9*10)=2.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KRT19 [Title/Abstract] AND SPINT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KRT19 | GO:0045214 | sarcomere organization | 16000376 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI659242 | KRT19 | chr17 | 39680057 | + | SPINT1 | chr15 | 41145922 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000361566 | ENST00000562057 | KRT19 | chr17 | 39680057 | + | SPINT1 | chr15 | 41145922 | - |
intron-3CDS | ENST00000361566 | ENST00000344051 | KRT19 | chr17 | 39680057 | + | SPINT1 | chr15 | 41145922 | - |
intron-3CDS | ENST00000361566 | ENST00000431806 | KRT19 | chr17 | 39680057 | + | SPINT1 | chr15 | 41145922 | - |
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FusionProtFeatures for KRT19_SPINT1 |
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Hgene | Tgene |
KRT19 | SPINT1 |
Inhibitor of HGF activator. Also acts as an inhibitor ofmatriptase (ST14). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KRT19_SPINT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KRT19_SPINT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KRT19 | HGS, DGCR6L, SFI1, ABI2, KRT6B, PCM1, KRT15, C10orf10, EXOC8, ZNF638, USHBP1, FANCG, FAM107A, PNN, USP32, PLEKHA5, APC, POU5F1, UCHL5, GRB2, CRK, MAGOH, EIF4A3, FN1, VCAM1, ITGA4, PAN2, BAG3, KDM1A, KIFC3, KRT2, KRT19, UBE2I, EIF4E2, POLR1C, IKZF3, TFPT, TBC1D7, AMOTL2, C1orf109, EIF4ENIF1, CCDC146, CARD9, FAM124B, HAUS1, PPP1R18, CEP57L1, EED, ESR1, MCM5, CYLD, SMARCB1, UBE2A | SPINT1 | ST14, UBQLN4, FAM46A, ZNF250, NLGN3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KRT19_SPINT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KRT19_SPINT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KRT19 | C0004096 | Asthma | 1 | CTD_human |
Hgene | KRT19 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
Hgene | KRT19 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | KRT19 | C0008311 | Cholangitis | 1 | CTD_human |
Hgene | KRT19 | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
Hgene | KRT19 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | KRT19 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | KRT19 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | KRT19 | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |