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Fusion gene ID: 19253 |
FusionGeneSummary for KRT19_EXOSC10 |
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Fusion gene information | Fusion gene name: KRT19_EXOSC10 | Fusion gene ID: 19253 | Hgene | Tgene | Gene symbol | KRT19 | EXOSC10 | Gene ID | 3880 | 5394 |
Gene name | keratin 19 | exosome component 10 | |
Synonyms | CK19|K19|K1CS | PM-Scl|PM/Scl-100|PMSCL|PMSCL2|RRP6|Rrp6p|p2|p3|p4 | |
Cytomap | 17q21.2 | 1p36.22 | |
Type of gene | protein-coding | protein-coding | |
Description | keratin, type I cytoskeletal 1940-kDa keratin intermediate filamentCK-19cytokeratin 19keratin 19, type Ikeratin, type I, 40-kd | exosome component 10P100 polymyositis-scleroderma overlap syndrome-associated autoantigenautoantigen PM-SCLpolymyositis/scleroderma autoantigen 100 kDapolymyositis/scleroderma autoantigen 2 | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P08727 | Q01780 | |
Ensembl transtripts involved in fusion gene | ENST00000361566, | ENST00000304457, ENST00000376936, ENST00000544779, ENST00000485606, | |
Fusion gene scores | * DoF score | 13 X 5 X 9=585 | 7 X 7 X 4=196 |
# samples | 14 | 9 | |
** MAII score | log2(14/585*10)=-2.0630097975258 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/196*10)=-1.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KRT19 [Title/Abstract] AND EXOSC10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KRT19 | GO:0045214 | sarcomere organization | 16000376 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG151239 | KRT19 | chr17 | 39680395 | - | EXOSC10 | chr1 | 11128096 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000361566 | ENST00000304457 | KRT19 | chr17 | 39680395 | - | EXOSC10 | chr1 | 11128096 | - |
In-frame | ENST00000361566 | ENST00000376936 | KRT19 | chr17 | 39680395 | - | EXOSC10 | chr1 | 11128096 | - |
5CDS-3UTR | ENST00000361566 | ENST00000544779 | KRT19 | chr17 | 39680395 | - | EXOSC10 | chr1 | 11128096 | - |
5CDS-intron | ENST00000361566 | ENST00000485606 | KRT19 | chr17 | 39680395 | - | EXOSC10 | chr1 | 11128096 | - |
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FusionProtFeatures for KRT19_EXOSC10 |
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Hgene | Tgene |
KRT19 | EXOSC10 |
Putative catalytic component of the RNA exosome complexwhich has 3'->5' exoribonuclease activity and participates in amultitude of cellular RNA processing and degradation events. Inthe nucleus, the RNA exosome complex is involved in propermaturation of stable RNA species such as rRNA, snRNA and snoRNA,in the elimination of RNA processing by-products and non-coding'pervasive' transcripts, such as antisense RNA species andpromoter-upstream transcripts (PROMPTs), and of mRNAs withprocessing defects, thereby limiting or excluding their export tothe cytoplasm. The RNA exosome may be involved in Ig class switchrecombination (CSR) and/or Ig variable region somatichypermutation (SHM) by targeting AICDA deamination activity totranscribed dsDNA substrates. In the cytoplasm, the RNA exosomecomplex is involved in general mRNA turnover and specificallydegrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNAsurveillance pathways, preventing translation of aberrant mRNAs.It seems to be involved in degradation of histone mRNA. EXOSC10has 3'-5' exonuclease activity (By similarity). EXOSC10 isrequired for nucleolar localization of C1D and probably mediatesthe association of MTREX, C1D and MPP6 wth the RNA exosomeinvolved in the maturation of 5.8S rRNA. {ECO:0000250,ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498,ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563,ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938,ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KRT19 | chr17:39680395 | chr1:11128096 | ENST00000361566 | - | 5 | 6 | 116_133 | 316 | 401 | Region | Note=Linker 1 |
Hgene | KRT19 | chr17:39680395 | chr1:11128096 | ENST00000361566 | - | 5 | 6 | 134_225 | 316 | 401 | Region | Note=Coil 1B |
Hgene | KRT19 | chr17:39680395 | chr1:11128096 | ENST00000361566 | - | 5 | 6 | 1_79 | 316 | 401 | Region | Note=Head |
Hgene | KRT19 | chr17:39680395 | chr1:11128096 | ENST00000361566 | - | 5 | 6 | 226_248 | 316 | 401 | Region | Note=Linker 12 |
Hgene | KRT19 | chr17:39680395 | chr1:11128096 | ENST00000361566 | - | 5 | 6 | 80_115 | 316 | 401 | Region | Note=Coil 1A |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >KRT19 | chr17:39680395 | chr1:11128096 | ENST00000361566 | - | 5 | 6 | 80_391 | 316 | 401 | Domain | IF rod |
Hgene | >KRT19 | chr17:39680395 | chr1:11128096 | ENST00000361566 | - | 5 | 6 | 249_387 | 316 | 401 | Region | Note=Coil 2 |
Hgene | >KRT19 | chr17:39680395 | chr1:11128096 | ENST00000361566 | - | 5 | 6 | 388_400 | 316 | 401 | Region | Note=Rod-like helical tail |
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FusionGeneSequence for KRT19_EXOSC10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_KRT19_ENST00000361566_chr17_39680395_-_EXOSC10_ENST00000304457_chr1_11128096_-_0aa >In-frame_KRT19_ENST00000361566_chr17_39680395_-_EXOSC10_ENST00000376936_chr1_11128096_-_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_KRT19_ENST00000361566_chr17_39680395_-_EXOSC10_ENST00000304457_chr1_11128096_-_0nt >In-frame_KRT19_ENST00000361566_chr17_39680395_-_EXOSC10_ENST00000376936_chr1_11128096_-_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_KRT19_ENST00000361566_chr17_39680395_-_EXOSC10_ENST00000304457_chr1_11128096_-_1009nt GCTCCTCCCGCGAATCGCAGCTTCTGAGACCAGGGTTGCTCCGTCCGTGCTCCGCCTCGCCATGACTTCCTACAGCTATCGCCAGTCGTC GGCCACGTCGTCCTTCGGAGGCCTGGGCGGCGGCTCCGTGCGTTTTGGGCCGGGGGTCGCCTTTCGCGCGCCCAGCATTCACGGGGGCTC CGGCGGCCGCGGCGTATCCGTGTCCTCCGCCCGCTTTGTGTCCTCGTCCTCCTCGGGGGCCTACGGCGGCGGCTACGGCGGCGTCCTGAC CGCGTCCGACGGGCTGCTGGCGGGCAACGAGAAGCTAACCATGCAGAACCTCAACGACCGCCTGGCCTCCTACCTGGACAAGGTGCGCGC CCTGGAGGCGGCCAACGGCGAGCTAGAGGTGAAGATCCGCGACTGGTACCAGAAGCAGGGGCCTGGGCCCTCCCGCGACTACAGCCACTA CTACACGACCATCCAGGACCTGCGGGACAAGATTCTTGGTGCCACCATTGAGAACTCCAGGATTGTCCTGCAGATCGACAATGCCCGTCT GGCTGCAGATGACTTCCGAACCAAGTTTGAGACGGAACAGGCTCTGCGCATGAGCGTGGAGGCCGACATCAACGGCCTGCGCAGGGTGCT GGATGAGCTGACCCTGGCCAGGACCGACCTGGAGATGCAGATCGAAGGCCTGAAGGAAGAGCTGGCCTACCTGAAGAAGAACCATGAGGA GGAAATCAGTACGCTGAGGGGCCAAGTGGGAGGCCAGGTCAGTGTGGAGGTGGATTCCGCTCCGGGCACCGATCTCGCCAAGATCCTGAG TGACATGCGAAGCCAATATGAGGTCATGGCCGAGCAGAACCGGAAGGATGCTGAAGCCTGGTTCACCAGCCGGACTGAAGAATTGAACCG GGAGGTCGCTGGCCACACGGAGCAGCTCCAGATGAGCAGGTCCGAGGTTACTGACCTGCGGCGCACCCTTCAGGGTCTTGAGATTGAGCT >In-frame_KRT19_ENST00000361566_chr17_39680395_-_EXOSC10_ENST00000376936_chr1_11128096_-_1009nt GCTCCTCCCGCGAATCGCAGCTTCTGAGACCAGGGTTGCTCCGTCCGTGCTCCGCCTCGCCATGACTTCCTACAGCTATCGCCAGTCGTC GGCCACGTCGTCCTTCGGAGGCCTGGGCGGCGGCTCCGTGCGTTTTGGGCCGGGGGTCGCCTTTCGCGCGCCCAGCATTCACGGGGGCTC CGGCGGCCGCGGCGTATCCGTGTCCTCCGCCCGCTTTGTGTCCTCGTCCTCCTCGGGGGCCTACGGCGGCGGCTACGGCGGCGTCCTGAC CGCGTCCGACGGGCTGCTGGCGGGCAACGAGAAGCTAACCATGCAGAACCTCAACGACCGCCTGGCCTCCTACCTGGACAAGGTGCGCGC CCTGGAGGCGGCCAACGGCGAGCTAGAGGTGAAGATCCGCGACTGGTACCAGAAGCAGGGGCCTGGGCCCTCCCGCGACTACAGCCACTA CTACACGACCATCCAGGACCTGCGGGACAAGATTCTTGGTGCCACCATTGAGAACTCCAGGATTGTCCTGCAGATCGACAATGCCCGTCT GGCTGCAGATGACTTCCGAACCAAGTTTGAGACGGAACAGGCTCTGCGCATGAGCGTGGAGGCCGACATCAACGGCCTGCGCAGGGTGCT GGATGAGCTGACCCTGGCCAGGACCGACCTGGAGATGCAGATCGAAGGCCTGAAGGAAGAGCTGGCCTACCTGAAGAAGAACCATGAGGA GGAAATCAGTACGCTGAGGGGCCAAGTGGGAGGCCAGGTCAGTGTGGAGGTGGATTCCGCTCCGGGCACCGATCTCGCCAAGATCCTGAG TGACATGCGAAGCCAATATGAGGTCATGGCCGAGCAGAACCGGAAGGATGCTGAAGCCTGGTTCACCAGCCGGACTGAAGAATTGAACCG GGAGGTCGCTGGCCACACGGAGCAGCTCCAGATGAGCAGGTCCGAGGTTACTGACCTGCGGCGCACCCTTCAGGGTCTTGAGATTGAGCT |
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FusionGenePPI for KRT19_EXOSC10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KRT19_EXOSC10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KRT19_EXOSC10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KRT19 | C0004096 | Asthma | 1 | CTD_human |
Hgene | KRT19 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
Hgene | KRT19 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | KRT19 | C0008311 | Cholangitis | 1 | CTD_human |
Hgene | KRT19 | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
Hgene | KRT19 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | KRT19 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | KRT19 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | KRT19 | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |