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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19251

FusionGeneSummary for KRT19_CTNND1

check button Fusion gene summary
Fusion gene informationFusion gene name: KRT19_CTNND1
Fusion gene ID: 19251
HgeneTgene
Gene symbol

KRT19

CTNND1

Gene ID

3880

1500

Gene namekeratin 19catenin delta 1
SynonymsCK19|K19|K1CSBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)
Cytomap

17q21.2

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionkeratin, type I cytoskeletal 1940-kDa keratin intermediate filamentCK-19cytokeratin 19keratin 19, type Ikeratin, type I, 40-kdcatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 catenin
Modification date2018052220180523
UniProtAcc

P08727

O60716

Ensembl transtripts involved in fusion geneENST00000361566, ENST00000524630, 
ENST00000529919, ENST00000399039, 
ENST00000360682, ENST00000361796, 
ENST00000361391, ENST00000530094, 
ENST00000428599, ENST00000361332, 
ENST00000527467, ENST00000415361, 
ENST00000532245, ENST00000532463, 
ENST00000528232, ENST00000529986, 
ENST00000531014, ENST00000358694, 
ENST00000526772, ENST00000532787, 
ENST00000533667, ENST00000529873, 
ENST00000525902, ENST00000529526, 
ENST00000532649, ENST00000426142, 
ENST00000532844, ENST00000528621, 
ENST00000399050, ENST00000526357, 
ENST00000530748, ENST00000534579, 
ENST00000526938, 
Fusion gene scores* DoF score13 X 5 X 9=5858 X 7 X 5=280
# samples 149
** MAII scorelog2(14/585*10)=-2.0630097975258
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KRT19 [Title/Abstract] AND CTNND1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKRT19

GO:0045214

sarcomere organization

16000376


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CQ-6225-01AKRT19chr17

39679869

-CTNND1chr11

57574387

+
TCGARVLUSCTCGA-56-8082-01AKRT19chr17

39679869

-CTNND1chr11

57574387

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000361566ENST00000524630KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000529919KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000399039KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000360682KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000361796KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000361391KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000530094KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000428599KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000361332KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000527467KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000415361KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000532245KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000532463KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000528232KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000529986KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000531014KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000358694KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000526772KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000532787KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000533667KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000529873KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000525902KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000529526KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000532649KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000426142KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000532844KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000528621KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000399050KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000526357KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000530748KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000534579KRT19chr17

39679869

-CTNND1chr11

57574387

+
Frame-shiftENST00000361566ENST00000526938KRT19chr17

39679869

-CTNND1chr11

57574387

+

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FusionProtFeatures for KRT19_CTNND1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KRT19

P08727

CTNND1

O60716


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KRT19_CTNND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KRT19_CTNND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KRT19HGS, DGCR6L, SFI1, ABI2, KRT6B, PCM1, KRT15, C10orf10, EXOC8, ZNF638, USHBP1, FANCG, FAM107A, PNN, USP32, PLEKHA5, APC, POU5F1, UCHL5, GRB2, CRK, MAGOH, EIF4A3, FN1, VCAM1, ITGA4, PAN2, BAG3, KDM1A, KIFC3, KRT2, KRT19, UBE2I, EIF4E2, POLR1C, IKZF3, TFPT, TBC1D7, AMOTL2, C1orf109, EIF4ENIF1, CCDC146, CARD9, FAM124B, HAUS1, PPP1R18, CEP57L1, EED, ESR1, MCM5, CYLD, SMARCB1, UBE2ACTNND1CDH1, CTNNB1, EGFR, CTNNA1, CDH2, ACTG1, CTTN, FYN, LCK, SRC, YES1, PTPRJ, ZBTB33, CDH3, CDH5, MUC1, PSEN1, PTPN6, PTPRM, COL17A1, ERBB2IP, WDR48, SQSTM1, SNCA, RIPK3, ARRB2, CUL3, CSNK1E, APP, VCP, MYC, ATF2, SOX2, ATP4A, AP2M1, AURKA, KCTD6, NXF1, CCDC8, BMI1, SUMO2, NTRK1, IFI16, CEP135, TMEM17, TMEM216, XPO1, PPP4R1, FOXB1, MCM2, CDC5L, OTUB1, PPAP2B, BTRC, GSK3B, CTDSPL, MTMR7, CDH8, CTNNA3, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KRT19_CTNND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KRT19_CTNND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKRT19C0004096Asthma1CTD_human
HgeneKRT19C0004364Autoimmune Diseases1CTD_human
HgeneKRT19C0007621Neoplastic Cell Transformation1CTD_human
HgeneKRT19C0008311Cholangitis1CTD_human
HgeneKRT19C0019189Hepatitis, Chronic1CTD_human
HgeneKRT19C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneKRT19C0027626Neoplasm Invasiveness1CTD_human
HgeneKRT19C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneKRT19C1876165Copper-Overload Cirrhosis1CTD_human