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Fusion gene ID: 19241 |
FusionGeneSummary for KRT14_TYK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KRT14_TYK2 | Fusion gene ID: 19241 | Hgene | Tgene | Gene symbol | KRT14 | TYK2 | Gene ID | 3861 | 7297 |
| Gene name | keratin 14 | tyrosine kinase 2 | |
| Synonyms | CK14|EBS3|EBS4|K14|NFJ | IMD35|JTK1 | |
| Cytomap | 17q21.2 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | keratin, type I cytoskeletal 14cytokeratin 14keratin 14, type I | non-receptor tyrosine-protein kinase TYK2 | |
| Modification date | 20180520 | 20180522 | |
| UniProtAcc | P02533 | P29597 | |
| Ensembl transtripts involved in fusion gene | ENST00000167586, | ENST00000264818, ENST00000524462, ENST00000525621, ENST00000529370, ENST00000529422, | |
| Fusion gene scores | * DoF score | 5 X 1 X 3=15 | 42 X 7 X 17=4998 |
| # samples | 6 | 43 | |
| ** MAII score | log2(6/15*10)=2 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(43/4998*10)=-3.53894233649724 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KRT14 [Title/Abstract] AND TYK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KRT14 | GO:0007568 | aging | 21916889 |
| Hgene | KRT14 | GO:0042633 | hair cycle | 21916889 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-IQ-A61E-01A | KRT14 | chr17 | 39738531 | - | TYK2 | chr19 | 10491352 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000167586 | ENST00000264818 | KRT14 | chr17 | 39738531 | - | TYK2 | chr19 | 10491352 | - |
| 5CDS-intron | ENST00000167586 | ENST00000524462 | KRT14 | chr17 | 39738531 | - | TYK2 | chr19 | 10491352 | - |
| 5CDS-intron | ENST00000167586 | ENST00000525621 | KRT14 | chr17 | 39738531 | - | TYK2 | chr19 | 10491352 | - |
| 5CDS-intron | ENST00000167586 | ENST00000529370 | KRT14 | chr17 | 39738531 | - | TYK2 | chr19 | 10491352 | - |
| 5CDS-intron | ENST00000167586 | ENST00000529422 | KRT14 | chr17 | 39738531 | - | TYK2 | chr19 | 10491352 | - |
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FusionProtFeatures for KRT14_TYK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KRT14 | TYK2 |
| The nonhelical tail domain is involved in promotingKRT5-KRT14 filaments to self-organize into large bundles andenhances the mechanical properties involved in resilience ofkeratin intermediate filaments in vitro.{ECO:0000269|PubMed:11724817}. | Probably involved in intracellular signal transductionby being involved in the initiation of type I IFN signaling.Phosphorylates the interferon-alpha/beta receptor alpha chain.{ECO:0000269|PubMed:7526154}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KRT14_TYK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KRT14_TYK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KRT14 | PKP1, APC, POU5F1, PTEN, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, CAND1, NEDD8, MDM2, INPPL1, CBL, UBASH3B, GRB2, PIK3R2, SHC1, CRK, EPS15, AP2M1, KRT5, KRT3, HNRNPC, EVPL, HNRNPU, MAGOH, EIF4A3, ALB, IQCB1, HSPA5, CUL7, OBSL1, CCDC8, RPS6KB2, HNRNPA1, PTPRN2, CYLD, UBE2A | TYK2 | GNB2L1, STAT1, PRMT5, XRCC5, VAV1, IFNAR1, CRKL, JAK1, TYK2, ELP2, IL13RA1, LYN, CBL, PTPN6, PLAUR, IL6ST, FYN, PTPN1, STAM2, GHR, IRS2, DNM2, TK1, SOCS1, KLF10, LNX1, PTAFR, EIF2AK2, HSP90AA1, JAK3, COPS5, FHL3, HNRNPK, TRAF4, KRT40, KHDRBS2, SIVA1, SHMT2, MOV10, NXF1, BAG2, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, DDX5, HNRNPH1, HSPB1, CEP170B, RAN, RUVBL1, RUVBL2, SLC2A1, TCP1, ALYREF, TRIM28, TUBA4A, WDR20, EFNB2, PIH1D1, TGFBR2, LRRC46, LPAR6, RNF13, ZNF333, MIER2, SIAH2, UBE2L6, LRP8, IFT43, PMEL, TNFRSF19, GMNN, IL4R, TMCO3, GPR156, CDH8, CD79A, TNFRSF13B, HAVCR2, PROSER2, LGALS3BP, C16orf71, MAS1, NLGN3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KRT14_TYK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | KRT14 | P02533 | DB01593 | Zinc | Keratin, type I cytoskeletal 14 | small molecule | approved|investigational |
| Tgene | TYK2 | P29597 | DB08895 | Tofacitinib | Non-receptor tyrosine-protein kinase TYK2 | small molecule | approved|investigational |
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RelatedDiseases for KRT14_TYK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KRT14 | C0079295 | Epidermolysis Bullosa Herpetiformis Dowling-Meara | 18 | ORPHANET;UNIPROT |
| Hgene | KRT14 | C0080333 | Weber-Cockayne Syndrome | 10 | ORPHANET;UNIPROT |
| Hgene | KRT14 | C0079299 | Epidermolysis Bullosa Simplex Kobner | 8 | ORPHANET;UNIPROT |
| Hgene | KRT14 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | KRT14 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | KRT14 | C0040411 | Tongue Neoplasms | 1 | CTD_human |
| Hgene | KRT14 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | KRT14 | C0343111 | Naegeli syndrome | 1 | CTD_human;ORPHANET |
| Hgene | KRT14 | C0549567 | Pigmentation Disorders | 1 | CTD_human |
| Hgene | KRT14 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | KRT14 | C3715082 | EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE 1 | 1 | ORPHANET;UNIPROT |
| Tgene | TYK2 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | TYK2 | C0010346 | Crohn Disease | 1 | CTD_human |
| Tgene | TYK2 | C0023892 | Biliary cirrhosis | 1 | CTD_human |
| Tgene | TYK2 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
| Tgene | TYK2 | C0033860 | Psoriasis | 1 | CTD_human |
| Tgene | TYK2 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | TYK2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | TYK2 | C0344315 | Depressed mood | 1 | PSYGENET |
| Tgene | TYK2 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | TYK2 | C1456784 | Paranoia | 1 | CTD_human |
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