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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 19218

FusionGeneSummary for KRIT1_CDK6

check button Fusion gene summary
Fusion gene informationFusion gene name: KRIT1_CDK6
Fusion gene ID: 19218
HgeneTgene
Gene symbol

KRIT1

CDK6

Gene ID

889

1021

Gene nameKRIT1, ankyrin repeat containingcyclin dependent kinase 6
SynonymsCAM|CCM1MCPH12|PLSTIRE
Cytomap

7q21.2

7q21.2

Type of geneprotein-codingprotein-coding
Descriptionkrev interaction trapped protein 1ankyrin repeat-containing protein Krit1cerebral cavernous malformations 1 proteinkrev interaction trapped 1cyclin-dependent kinase 6cell division protein kinase 6serine/threonine-protein kinase PLSTIRE
Modification date2018052720180527
UniProtAcc

O00522

Q00534

Ensembl transtripts involved in fusion geneENST00000394507, ENST00000340022, 
ENST00000412043, ENST00000394505, 
ENST00000394503, ENST00000466166, 
ENST00000265734, ENST00000424848, 
ENST00000491250, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 7 X 4=196
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/196*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KRIT1 [Title/Abstract] AND CDK6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDK6

GO:0001954

positive regulation of cell-matrix adhesion

10205165

TgeneCDK6

GO:0003323

type B pancreatic cell development

20668294

TgeneCDK6

GO:0006468

protein phosphorylation

8114739

TgeneCDK6

GO:0010468

regulation of gene expression

15254224

TgeneCDK6

GO:0045638

negative regulation of myeloid cell differentiation

17431401

TgeneCDK6

GO:0045656

negative regulation of monocyte differentiation

26542173

TgeneCDK6

GO:0045668

negative regulation of osteoblast differentiation

15254224

TgeneCDK6

GO:0045786

negative regulation of cell cycle

14985467

TgeneCDK6

GO:2000773

negative regulation of cellular senescence

17420273


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A4OW-01AKRIT1chr7

91871348

-CDK6chr7

92247521

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394507ENST00000265734KRIT1chr7

91871348

-CDK6chr7

92247521

-
In-frameENST00000394507ENST00000424848KRIT1chr7

91871348

-CDK6chr7

92247521

-
5CDS-intronENST00000394507ENST00000491250KRIT1chr7

91871348

-CDK6chr7

92247521

-
Frame-shiftENST00000340022ENST00000265734KRIT1chr7

91871348

-CDK6chr7

92247521

-
Frame-shiftENST00000340022ENST00000424848KRIT1chr7

91871348

-CDK6chr7

92247521

-
5CDS-intronENST00000340022ENST00000491250KRIT1chr7

91871348

-CDK6chr7

92247521

-
Frame-shiftENST00000412043ENST00000265734KRIT1chr7

91871348

-CDK6chr7

92247521

-
Frame-shiftENST00000412043ENST00000424848KRIT1chr7

91871348

-CDK6chr7

92247521

-
5CDS-intronENST00000412043ENST00000491250KRIT1chr7

91871348

-CDK6chr7

92247521

-
Frame-shiftENST00000394505ENST00000265734KRIT1chr7

91871348

-CDK6chr7

92247521

-
Frame-shiftENST00000394505ENST00000424848KRIT1chr7

91871348

-CDK6chr7

92247521

-
5CDS-intronENST00000394505ENST00000491250KRIT1chr7

91871348

-CDK6chr7

92247521

-
In-frameENST00000394503ENST00000265734KRIT1chr7

91871348

-CDK6chr7

92247521

-
In-frameENST00000394503ENST00000424848KRIT1chr7

91871348

-CDK6chr7

92247521

-
5CDS-intronENST00000394503ENST00000491250KRIT1chr7

91871348

-CDK6chr7

92247521

-
intron-3CDSENST00000466166ENST00000265734KRIT1chr7

91871348

-CDK6chr7

92247521

-
intron-3CDSENST00000466166ENST00000424848KRIT1chr7

91871348

-CDK6chr7

92247521

-
intron-intronENST00000466166ENST00000491250KRIT1chr7

91871348

-CDK6chr7

92247521

-

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FusionProtFeatures for KRIT1_CDK6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KRIT1

O00522

CDK6

Q00534

Serine/threonine-protein kinase involved in the controlof the cell cycle and differentiation; promotes G1/S transition.Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclinsduring interphase at G1 to form a pRB/RB1 kinase and controls theentrance into the cell cycle. Involved in initiation andmaintenance of cell cycle exit during cell differentiation;prevents cell proliferation and regulates negatively celldifferentiation, but is required for the proliferation of specificcell types (e.g. erythroid and hematopoietic cells). Essential forcell proliferation within the dentate gyrus of the hippocampus andthe subventricular zone of the lateral ventricles. Required duringthymocyte development. Promotes the production of newborn neurons,probably by modulating G1 length. Promotes, at least inastrocytes, changes in patterns of gene expression, changes in theactin cytoskeleton including loss of stress fibers, and enhancedmotility during cell differentiation. Prevents myeloiddifferentiation by interfering with RUNX1 and reducing itstranscription transactivation activity, but promotes proliferationof normal myeloid progenitors. Delays senescence. Promotes theproliferation of beta-cells in pancreatic islets of Langerhans.May play a role in the centrosome organization during the cellcycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137,ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224,ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273,ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249,ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663,ECO:0000269|PubMed:8114739}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKRIT1chr7:91871348chr7:92247521ENST00000340022-419420_73434737DomainFERM
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394503-317420_73434689DomainFERM
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394505-419420_73434737DomainFERM
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394507-520420_73434737DomainFERM
HgeneKRIT1chr7:91871348chr7:92247521ENST00000412043-419420_73434737DomainFERM
HgeneKRIT1chr7:91871348chr7:92247521ENST00000340022-4191_17034737RegionNote=N-terminal domain similar to Nudix hydrolase domain
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394503-3171_17034689RegionNote=N-terminal domain similar to Nudix hydrolase domain
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394505-4191_17034737RegionNote=N-terminal domain similar to Nudix hydrolase domain
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394507-5201_17034737RegionNote=N-terminal domain similar to Nudix hydrolase domain
HgeneKRIT1chr7:91871348chr7:92247521ENST00000412043-4191_17034737RegionNote=N-terminal domain similar to Nudix hydrolase domain
HgeneKRIT1chr7:91871348chr7:92247521ENST00000340022-419287_31634737RepeatANK 1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000340022-419320_35034737RepeatANK 2
HgeneKRIT1chr7:91871348chr7:92247521ENST00000340022-419354_38334737RepeatANK 3
HgeneKRIT1chr7:91871348chr7:92247521ENST00000340022-419388_41934737RepeatANK 4
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394503-317287_31634689RepeatANK 1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394503-317320_35034689RepeatANK 2
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394503-317354_38334689RepeatANK 3
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394503-317388_41934689RepeatANK 4
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394505-419287_31634737RepeatANK 1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394505-419320_35034737RepeatANK 2
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394505-419354_38334737RepeatANK 3
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394505-419388_41934737RepeatANK 4
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394507-520287_31634737RepeatANK 1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394507-520320_35034737RepeatANK 2
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394507-520354_38334737RepeatANK 3
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394507-520388_41934737RepeatANK 4
HgeneKRIT1chr7:91871348chr7:92247521ENST00000412043-419287_31634737RepeatANK 1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000412043-419320_35034737RepeatANK 2
HgeneKRIT1chr7:91871348chr7:92247521ENST00000412043-419354_38334737RepeatANK 3
HgeneKRIT1chr7:91871348chr7:92247521ENST00000412043-419388_41934737RepeatANK 4
TgeneCDK6chr7:91871348chr7:92247521ENST00000265734-5813_300232327DomainProtein kinase
TgeneCDK6chr7:91871348chr7:92247521ENST00000424848-5813_300232327DomainProtein kinase
TgeneCDK6chr7:91871348chr7:92247521ENST00000265734-5819_27232327Nucleotide bindingATP
TgeneCDK6chr7:91871348chr7:92247521ENST00000424848-5819_27232327Nucleotide bindingATP


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FusionGeneSequence for KRIT1_CDK6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KRIT1_ENST00000394507_chr7_91871348_-_CDK6_ENST00000265734_chr7_92247521_-_128aa
MGNPENIEDAYVAVIRPKNTASLNSREYRAKSYERDWTPRRRRLAXRCCPSQAGFSFKICPTNXEVCNRYRXTRQRPTSEVFDIXPSQKN

>In-frame_KRIT1_ENST00000394507_chr7_91871348_-_CDK6_ENST00000424848_chr7_92247521_-_128aa
MGNPENIEDAYVAVIRPKNTASLNSREYRAKSYERDWTPRRRRLAXRCCPSQAGFSFKICPTNXEVCNRYRXTRQRPTSEVFDIXPSQKN

>In-frame_KRIT1_ENST00000394503_chr7_91871348_-_CDK6_ENST00000265734_chr7_92247521_-_128aa
MGNPENIEDAYVAVIRPKNTASLNSREYRAKSYERDWTPRRRRLAXRCCPSQAGFSFKICPTNXEVCNRYRXTRQRPTSEVFDIXPSQKN

>In-frame_KRIT1_ENST00000394503_chr7_91871348_-_CDK6_ENST00000424848_chr7_92247521_-_128aa
MGNPENIEDAYVAVIRPKNTASLNSREYRAKSYERDWTPRRRRLAXRCCPSQAGFSFKICPTNXEVCNRYRXTRQRPTSEVFDIXPSQKN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KRIT1_ENST00000394507_chr7_91871348_-_CDK6_ENST00000265734_chr7_92247521_-_385nt
ATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCT
AAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGC
CCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAAT
ATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAA

>In-frame_KRIT1_ENST00000394507_chr7_91871348_-_CDK6_ENST00000424848_chr7_92247521_-_385nt
ATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCT
AAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGC
CCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAAT
ATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAA

>In-frame_KRIT1_ENST00000394503_chr7_91871348_-_CDK6_ENST00000265734_chr7_92247521_-_385nt
ATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCT
AAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGC
CCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAAT
ATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAA

>In-frame_KRIT1_ENST00000394503_chr7_91871348_-_CDK6_ENST00000424848_chr7_92247521_-_385nt
ATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCT
AAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGC
CCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAAT
ATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_KRIT1_ENST00000394507_chr7_91871348_-_CDK6_ENST00000265734_chr7_92247521_-_11388nt
GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGA
AAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGC
GATTTCATAGCCACGGTGACTGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCT
CGGTGTCCTTCGGGAAACAGGAGGAGCAAGTTCGACTCCAGCGAGGGAAAACGGAGGTGGGAGACTGAACCATCTCCACATCTAGTTGCC
CCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCT
CATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAA
CCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATC
CCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAATCTGTGGTGAAAAGTAATTGCTAAATAG
AAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAAACATAGAAGA
TGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCC
CAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAG
ATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACC
CATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACCTCGGAGCTGAATACAGCCTGAG
GCCTCAGCAGCCGCCTTAAGCTGATCCTGCGGAGAACACCCTTGGTGGCTTATGGGTCCCCCTCAGCAAGCCCTACAGAGCTGTGGAGGA
TTGCTATCTGGAGGCCTTCCAGCTGCTGTCTTCTGGACAGGCTCTGCTTCTCCAAGGAAACCGCCTAGTTTACTGTTTTGAAATCAATGC
AAGAGTGATTGCAGCTTTATGTTCATTTGTTTGTTTGTTTGTCTGTTTGTTTCAAGAACCTGGAAAAATTCCAGAAGAAGAGAAGCTGCT
GACCAATTGTGCTGCCATTTGATTTTTCTAACCTTGAATGCTGCCAGTGTGGAGTGGGTAATCCAGGCACAGCTGAGTTATGATGTAATC
TCTCTGCAGCTGCCGGGCCTGATTTGGTACTTTTGAGTGTGTGTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGAGA
GATTCTGTGATCTTTTAAAGTGTTACTTTTTGTAAACGACAAGAATAATTCAATTTTAAAGACTCAAGGTGGTCAGTAAATAACAGGCAT
TTGTTCACTGAAGGTGATTCACCAAAATAGTCTTCTCAAATTAGAAAGTTAACCCCATGTCCTCAGCATTTCTTTTCTGGCCAAAAGCAG
TAAATTTGCTAGCAGTAAAAGATGAAGTTTTATACACACAGCAAAAAGGAGAAAAAATTCTAGTATATTTTAAGAGATGTGCATGCATTC
TATTTAGTCTTCAGAATGCTGAATTTACTTGTTGTAAGTCTATTTTAACCTTCTGTATGACATCATGCTTTATCATTTCTTTTGGAAAAT
AGCCTGTAAGCTTTTTATTACTTGCTATAGGTTTAGGGAGTGTACCTCAGATAGATTTTAAAAAAAAGAATAGAAAGCCTTTATTTCCTG
GTTTGAAATTCCTTTCTTCCCTTTTTTTGTTGTTGTTATTGTTGTTTGTTGTTGTTATTTTGTTTTTGTTTTTAGGAATTTGTCAGAAAC
TCTTTCCTGTTTTGGTTTGGAGAGTAGTTCTCTCTAACTAGAGACAGGAGTGGCCTTGAAATTTTCCTCATCTATTACACTGTACTTTCT
GCCACACACTGCCTTGTTGGCAAAGTATCCATCTTGTCTATCTCCCGGCACTTCTGAAATATATTGCTACCATTGTATAACTAATAACAG
ATTGCTTAAGCTGTTCCCATGCACCACCTGTTTGCTTGCTTTCAATGAACCTTTCATAAATTCGCAGTCTCAGCTTATGGTTTATGGCCT
CGATTCTGCAAACCTAACAGGGTCACATATGTTCTCTAATGCAGTCCTTCTACCTGGTGTTTACTTTTGTTACCTAAATAATGAGTAGGA
TCTTGTTTTGTTTTATCACCAGCACACAGATTGCTATAAACTGTTACTTTGTGAATTACATTTTTATAGAAGATATTTTCAGTGTCTTTA
CCTGAGGGTATGTCTTTAGCTATGTTTTAGGGCCATACATTTACTCTATCAAATGATCTTTTCTCCATCCCCCAGGCTGTGCTTATTTCT
AGTGCCTTGTGCTCACTCCTGCTCTCTACAGAGCCAGCCTGGCCTGGGCATTGTAAACAGCTTTTCCTTTTTCTCTTACTGTTTTCTCTA
CAGTCCTTTATATTTCATACCATCTCTGCCTTATAAGTGGTTTAGTGCTCAGTTGGCTCTAGTAACCAGAGGACACAGAAAGTATCTTTT
GGAAAGTTTAGCCACCTGTGCTTTCTGACTCAGAGTGCATGCAACAGTTAGATCATGCAACAGTTAGATTATGTTTAGGGTTAGGATTTT
CAAAGAATGGAGGTTGCTGCACTCAGAAAATAATTCAGATCATGTTTATGCATTATTAAGTTGTACTGAATTCTTTGCAGCTTAATGTGA
TATATGACTATCTTGAACAAGAGAAAAAACTAGGAGATGTTTCTCCTGAAGAGCTTTTGGGGTTGGGAACTATTCTTTTTTAATTGCTGT
ACTACTTAACATTGTTCTAATTCAGTAGCTTGAGGAACAGGAACATTGTTTTCTAGAGCAAGATAATAAAGGAGATGGGCCATACAAATG
TTTTCTACTTTCGTTGTGACAACATTGATTAGGTGTTGTCAGTACTATAAATGCTTGAGATATAATGAATCCACAGCATTCAAGGTCAGG
TCTACTCAAAGTCTCACATGGAAAAGTGAGTTCTGCCTTTCCTTTGATCGAGGGTCAAAATACAAAGACATTTTTGCTAGGGCCTACAAA
TTGAATTTAAAAACTCACTGCACTGATTCATCTGAGCTTTTTGGTTAGTATTCATGGCTAGAGTGAACATAGCTTTAGTTTTTGCTGTTG
TAAAAGTGTTTTCATAAGTTCACTCAAGAAAAATGCAGCTGTTCTGAACTGGAATTTTTCAGCATTCTTTAGAATTTTAAATGAGTAGAG
AGCTCAACTTTTATTCCTAGCATCTGCTTTTGACTCATTTCTAGGCAGTGCTTATGAAGAAAAATTAAAGCACAAACATTCTGGCATTCA
ATCGTTGGCAGATTATCTTCTGATGACACAGAATGAAAGGGCATCTCAGCCTCTCTGAACTTTGTAAAAATCTGTCCCCAGTTCTTCCAT
CGGTGTAGTTGTTGCATTTGAGTGAATACTCTCTTGATTTATGTATTTTATGTCCAGATTCGCCATTTCTGAAATCCAGATCCAACACAA
GCAGTCTTGCCGTTAGGGCATTTTGAAGCAGATAGTAGAGTAAGAACTTAGTGACTACAGCTTATTCTTCTGTAACATATGGTTTCAAAC
ATCTTTGCCAAAAGCTAAGCAGTGGTGAACTGAAAAGGGCATATTGCCCCAAGGTTACACTGAAGCAGCTCATAGCAAGTTAAAATATTG
TGACAGATTTGAAATCATGTTTGAATTTCATAGTAGGACCAGTACAAGAATGTCCCTGCTAGTTTCTGTTTGATGTTTGGTTCTGGCGGC
TCAGGCATTTTGGGAACTGTTGCACAGGGTGGAGTCAAAACAACCTACATATAAAAAGAGAAAAAGAGAAACTTGTCCATTTAGCTTTCA
TAAGAAATCCCATGGCAAAGGGTAATAAAAAGGACCTAATCTTAAAAATACAATTTCTAAGCACTTGTAAGAACCCAGTGGGTTGGAGCC
TCCCACTTTGTCCCTCCTTTGAAGTGGATGGGAACTCAAGGTGCAAAGAACCTGTTTTGGAAGAAAGCTTGGGGCCATTTCAGCCCCCTG
TATTCTCATGATTTTCTCTCAGGAAGCACACACTGTGAATGGCAGACTTTTCATTTAGCCCCAGGTGACTTACTAAAAATAGTTGAAAAT
TATTCACCTAAGAATAGAATCTCAGCATTGTGTTAAATAAAAATGAAAGCTTTAGAAGGCATGAGATGTTCCTATCTTAAATAAAGCATG
TTTCTTTTCTATAGAGAAATGTATAGTTTGACTCTCCAGAATGTACTATCCATCTTGATGAGAAAACTCTTAAATAGTACCAAACATTTT
GAACTTTAAATTATGTATTTAAAGTGAGTGTTTAAGAAACTGTAGCTGCTTCTTTTACAAGTGGTGCCTATTAAAGTCAGTAATGGCCAT
TATTGTTCCATTGTGGAAATTAAATTATGTAAGCTTCCTAATATCATAAACATATTAAAATTCTTCTAAAATATTGCTTTTCTTTTAAGT
GACAATTTGACTATTCTTATGATAAGCACATGAGAGTGTCTTACATTTTCCAAAAGCAGGCTTTAATTGCATAGTTGAGTCTAGGAAAAA
ATAATGTTAAAAGTGAATATGCCACCATAATTACTTAATTATGTTAGTATAGAAACTACAGAATATTTACCCTGGAAAGAAAATATTGGA
ATGTTATTATAAACTCTTAGATATTTATATAATTCAAAAGAATGCATGTTTCACATTGTGACAGATAAAGATGTATGATTTCTAAGGCTT
TAAAAATTATTCATAAAACAGTGGGCAATAGATAAAGGAAATTCTGGAGAAAATGAAGGTATTTAAAGGGTAGTTTCAAAGCTATATATA
TTTTGAAGGATATATTCTTTATGAACAAATATATTGTAAAAATTTATACTAAGGTCATCTGGTAACTGTGGGATTAATATGGTCGAAAAC
AAATGTTATGGAGAAGCTGTCCCAAGCAAACTAAATTACCTGTACTTTTTTCCCATTTCAAGGGAAGAGGCAACCACATGAAGCAATACT
TCTTACACATGCCTAAGAACGTTCATTGAAAAAATAAATTTTTAAAAGGCATGTGTTTCCTATGCCACCAATACTTTTGAAAAATTGTGA
ACCTTACCCAAAACCATTTATCATGTCCATTAAGTATATTTGGGTATATAATTAGGAAGATATTTACATGTTCCATCTCCACAGTGGAAA
AACTTATTGAGGCTACCAAAGTGTGCCAAGAAATGTAAGTCCTTAGAGTAATTAGAAATGCTGTTTTCCTCAAAAGCATGAGAAACTAGC
ATTTTCATTTCTTATTTACTCCCTTTCTATATCAATGCAATTCACAACCCAATTTTAATACATCCCTATATCTCAAGCATTTCTATCTTG
TACTTTTTCAGAAAATAAACCAAAAATAATCCTTTGGTCTCTCTATCTTCTGACCTTTGTAAGCAACAGAAATGTAAAAACAGAAGGGGT
CCAATTTTTACACGTTTTTTTCTCAAGTAGCCTTTCTGGGGATTTTTATTTTCTTAATGAAGTGCCAATCAGCTTTTCAAAATGTTTTCT
ATTTCTCAGCATTTCCAGGAAGTGATAACGTTTAGCTAAATGAGTAGAAGTGGACTTCCTTCAACATATTGTTACCTTGTCTAGCCTTAG
GAAGAAAACAAGAGCCACCTGAAAATAAATACAGGCTCTTTTCGAGCATCTGCTGAAATACTGTTACAGCAATTTGAAGTTGATGTGGTA
GGAAAGGAAGGTGACTTTTCTTGCAAAAGTCTTTCTAAACATTCACACTGTCCTAAGAGATGAGCTTTCTTGTTTTATTCCGGTATATTC
CACAAGGTGGCACTTTTAGAGAAAAACAAATCTGATGAAGACTAAAGAGGTACTTCTAAAAGAGATTTCATTCTAACTTTATTTTTCTGC
GCATATTTAACTCTTTCCTAGCACTTGTTTTTTGGGATGATTAATAGTCTCTATAATGTTCTGTAACTTCAATATTTTACTTGTTACCTA
GGTTCTGAACAATTGTCTGCAAATAAATTGTTCTTAAGGATGGATAATACACCCATTTTGATCATTTAAGTAAAGAAAGCCTAGTCATTC
ATTCAGTCAAGAAAAAATTTTTGAAGTACCCAGTTACCTTACTTTTCTAGATTAAAACAGGCTTAGTTACTAAAAAGGCAGTCCTCATCT
GTGAACAGGATAGTTTCGTTAGAAGTATAAAACTCCTTTAGTGGCCCCAGTTAAAACACACATACCCTCTCTGCTGCTTTCAAATTCCCT
AGCATGGTGGCCTTTCAACATTGATTAAATTTTAAAATCCTAATTTAAAGATCAGGTGAGCAAAATGAGTAGCACATCAGTAATTCAGTA
GACAAAACTTTTGTCTGAAAAATTGCTGTATTGAAACAGAGCCCTAAAATACCAAAAGACCAGGTAATTTTAACATTTGTGGAATCACAA
ATGTAAATTCATAAGAAGCTCTAATTAAAAAAAAAAAGTCTGAAGTATATGAGCATAACAACTTAGGAGTGTGTCTACATACTTAACTTT
TGAAGTTTTTTGGCAACTTTATATACTTTTTTTAAATTTACAAGTCTACTTAAAGACTTCTTATACCCCAAATGATTAAGTTAATTTTAG
AGGTCACCTTTCTCACAGCAGTGTCACTTGAAATTTAGTAGGGAAGGATATTGCAGTATTTTTCAGTTTCCTTAGCACAGCACCACAGAA
AGCAGCTTATTCCTTTTGAGTGGCAGACACTCGACGGTGCCTGCCCAACTTTCCTCCTGAGTGGCAAGCAGATGAGTCTCAGTAATTCAT
ACTGAACCAAAATGCCACATACACTAGGGGCAGTCAGAAACTGGCTGAGAAATCCCCCGCCTCATTCGCCCCTCTGCTCCCAGGAACTAG
AGTCCAGTTAAAGCCCCTATGCGAAAGGCCGAATTCCACCCCAGGGTTTGTTATAACAGTGGCCAGTCTGAACCCCATTTGCTCGTGCTC
AAAACTTGATTCCCACTTGAAAGCCTTCCGGGCGCGCTGCCTCGTTGCCCCGCCCCTTTGGCAGGAGAGAGGCAGTGGGCGAGGCCGGGC
TGGGGCCCCGCCTCCCACTCACCTGCCGGTGCCTGAAATTATGTGCGGCCCCGCGGGCTGCTTTCCGAGGTCAGAGTGCCCTGCTGCTGT
CTCAGAGGCATCTGTTCTGCAAATCTTAGGAAGAAAAATGTCCCTAGTAGCAAACGGGTGTCTTCTGTGCATAAATAAGTACAACACAAT
TCTCCGAAAGTTCGGGTAAAAAGAGATGCGGTAGCAGCTGCCCTGTGTGAAGCTGTCTACCCCGCATCTCTCAGGCGCTAAGCTCAGTTT
TTGTTTTTGTTTTTGTTTTTTTAAAGAAAAGATGTATAATTGCAGGAATTTTTTTTTATTTTTTTATTTTCCATCATTCTATATATGTGA
TGGTGAAAGATATGCCTGGAAAAGTTTTGTTTTGAAAAGTTTATTTTCTGCTTCGTCTTCAGTTGGCAAAAGCTCTCAATTCTTTAGCTT
CCAGTTTCTTTTCTCTCTTTTTCTTTGTTAGGTAATTAAAGGTATGTAAACAAATTATCTCATGTAGCAGGGGATTTTCATGTTGAGAGG
AATCTTCCGTGTGAGTTGTTTGGTCACACAAATAACCCTTTCTCAATTTTAGGAGTTTGGATTGTCAAATGTAGGTTTTTCTCAAAGGGG
GCATATAACTACATATTGACTGCCAAGAACTATGACTGTAGCACTAATCAGCACACATAGAGCCACACAATTATTTAATTTCTAACTCTC
TGTGGTCCCTAGAAAAATTCCGTTGATGTGCTTAGGTTAAAGTTCTGAAGATACCCGTTGTACCCTTACTTGAAAGTTTCTAATCTTAAG
TTTTATGAAATGCAATAATATGTATCAGCTAGCAATATTTCTGTGATCACCAACAACTCTCAGTTTGATCTTAAAGTCTGAATAATAAAA
CAAATCCCAGCAGTAATACATTTCTTAAACCTCACAGTGCATGATATATCTTTTCATTCTGATCCTGTGTTTGCAAAAATATACACATGT
ATATCATAGTTCCTCACTTTTTATTCATTTGTTTTCCTATTACCTGTAGTAAATATATTAGTTAGTACATGGAATTTATAGCATCAGCTA
CCCCCAGGAACAGCACCTGACAGGCGGGGGATTTTTTTTCAAGTTGTTCTACATTTGCATAAATTATTTCTATTATTATTCATGTATGTT
ATTTATTTCTGAATCACACTAGTCCTGTGAAAGTACAACTGAAGGCAGAAAGTGTTAGGATTTTGCATCTAATGTTCATTATCATGGTAT
TGATGGACCTAAGAAAATAAAAATTAGACTAAGCCCCCAAATAAGCTGCATGCATTTGTAACATGATTAGTAGATTTGAATATATAGATG
TAGTATTTTGGGTATCTAGGTGTTTTATCATTATGTAAAGGAATTAAAGTAAAGGACTTTGTAGTTGTTTTTATTAAATATGCATATAGT
AGAGTGCAAAAATATAGCAAAAATAAAAACTAAAGGTAGAAAAGCATTTTAGATATGCCTTAATTTAGAAACTGTGCCAGGTGGCCCTCG
GAATAGATGCCAGGCAGAGACCAGTGCCTGGGTGGTGCCTCCTCTTGTCTGCCCTCATGAAGAAGCTTCCCTCACGTGATGTAGTGCCCT
CGTAGGTGTCATGTGGAGTAGTGGGAACAGGCAGTACTGTTGAGAGGAGAGCAGTGTGAGAGTTTTTCTGTAGAAGCAGAACTGTCAGCT
TGTGCCTTGAGGCTTCCAGAACGTGTCAGATGGAGAAGTCCAAGTTTCCATGCTTCAGGCAACTTAGCTGTGTACAGAAGCAATCCAGTG
TGGTAATAAAAAGCAAGGATTGCCTGTATAATTTATTATAAAATAAAAGGGATTTTAACAACCAACAATTCCCAACACCTCAAAAGCTTG
TTGCATTTTTTGGTATTTGAGGTTTTTATCTGAAGGTTAAAGGGCAAGTGTTTGGTATAGAAGAGCAGTATGTGTTAAGAAAAGAAAAAT
ATTGGTTCACGTAGAGTGCAAATTAGAACTAGAAAGTTTTATACGATTATCATTTTGAGATGTGTTAAAGTAGGTTTTCACTGTAAAATG
TATTAGTGTTTCTGCATTGCCATAGGGCCTGGTTAAAACTTTCTCTTAGGTTTCAGGAAGACTGTCACATACAGTAAGCTTTTTTCCTTC
TGACTTATAATAGAAAATGTTTTGAAAGTAAAAAAAAAAAATCTAATTTGGAAATTTGACTTGTTAGTTTCTGTGTTTGAAATCATGGTT
CTAGAAATGTAGAAATTGTGTATATCAGATACTCATCTAGGCTGTGTGAACCAGCCCAAGATGACCAACATCCCCACACCTCTACATCTC
TGTCCCCTGTATCTCTTCCTTTCTACCACTAAAGTGTTCCCTGCTACCATCCTGGCTTGTCCACATGGTGCTCTCCATCTTCCTCCACAT
CATGGACCACAGGTGTGCCTGTCTAGGCCTGGCCACCACTCCCAACTTGACCTAGCCACATTCATCTAGAGATGGTTCCTGATGCTGGGC
ACAGACTGTGCTCATGGCACCCATTAGAAATGCCTCTAGCATCTTTGTATGCATCTTGATTTTTAAACCAAGTCATTGTACAGAGCATTC
AGTTTTGGCTGTGGTACCAAGAGAAAAACTAATCAAGAATATAAACCACATTCCAGGCTGCTGTTTTCTCTCCATCTACAGGCCACACTT
TTACTGTATTTCTTCATACTTGAAATTCATTCTGCTATTTTCATATCAGGGTACAGACTTATAAGGGTGCATGTTCCTTAAAGGTGCATA
ATTATTCTTATTCCGTTTGCTTATATTGCTACAGAATGCTCTGTTTTGGTGCTTTGAGTTCTGCAGACCCAAGAAGCAGTGTGGAAATTC
ACTGCCTGGGACACAGTCTTATAAGAATGTTGGCAGGTGACTTTGTATCAGATGTTGCTTCTCTTTTCTCTGTACACAGATTGAGAGTTA
CCACAGTGGCCTGTCGGGTCCACCCTGTGGGTGCAGCACAGCTCTCTGAAAGCAAGAACCTTCCTACCTATTCTAACGTTTTTGCCCTCT
AAGAAAAATGGCCTCAGGTATGGTATAGACATAGCAAGAGGGGAAGGGCTGTCTCACTCTAGCAACCATCCCTCCATTACACACAGAAAG
CCCTCTTGAAGCAAAAGAAGAAGAAAGAAAGAAAGCTTATCTCTAAGGCTACTGTCTTCAGAATGCTCTGAGCTGAATGCTCTTGCTCCT
TTCCCAAGAGGCAGATGAAAATATAGCCAGTTTATCTATACCCTTCCTATCTGAGGAGGAGAATAGAAAAGTAGGGTAAATATGTAACGT
AAAATATGTCATTCAAGGACCACCAAAACTTTAAGTACCCTATCATTAAAAATCTGGTTTTAAAAGTAGCTCAAGTAAGGGATGCTTTGT
GACCCAGGGTTTCTGAAGTCAGATAGCCATTCTTACCTGCCCCTTACTCTGACTTATTGGGAAAGGGAGAACTGCAGTGGTGTTTCTGTT
GCAGTGGCAAAGGTAACATGTCAGAAAATTCAGAGGGTTGCATACCAATAATCCTTTGGAAACTGGATGTCTTACTGGGTGCTAGAATGA
AAATGTAGGTATTTATTGTCAGATGATGAAGTTCATTGTTTTTTTCAAAATTGGTGTTGAAATATCACTGTCCAATGTGTTCACTTATGT
GAAAGCTAAATTGAATGAGGCAAAAAGAGCAAATAGTTTGTATATTTGTAATACCTTTTGTATTTCTTACAATAAAAATATTGGTAGCAA
ATAAAAATAATAAAAACAATAACTTTAAACTGCTTTCTGGAGATGAATTACTCTCCTGGCTATTTTCTTTTTTACTTTAATGTAAAATGA

>In-frame_KRIT1_ENST00000394507_chr7_91871348_-_CDK6_ENST00000424848_chr7_92247521_-_1169nt
GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGA
AAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGC
GATTTCATAGCCACGGTGACTGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCT
CGGTGTCCTTCGGGAAACAGGAGGAGCAAGTTCGACTCCAGCGAGGGAAAACGGAGGTGGGAGACTGAACCATCTCCACATCTAGTTGCC
CCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCT
CATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAA
CCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATC
CCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAATCTGTGGTGAAAAGTAATTGCTAAATAG
AAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAAACATAGAAGA
TGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCC
CAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAG
ATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACC

>In-frame_KRIT1_ENST00000394503_chr7_91871348_-_CDK6_ENST00000265734_chr7_92247521_-_11001nt
ATAGCCACGGTAACGGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCT
GAGGTGCGAGGAGAGGGAAGGACAGTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTC
ATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACG
CTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAA
CCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGCAATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAA
GAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATG
TTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTAC
TTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCA
AAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACCTCGGAGCTGAATACAGCCTGAGGCCTCAGCAGCCGCCTTAAGCTGATCC
TGCGGAGAACACCCTTGGTGGCTTATGGGTCCCCCTCAGCAAGCCCTACAGAGCTGTGGAGGATTGCTATCTGGAGGCCTTCCAGCTGCT
GTCTTCTGGACAGGCTCTGCTTCTCCAAGGAAACCGCCTAGTTTACTGTTTTGAAATCAATGCAAGAGTGATTGCAGCTTTATGTTCATT
TGTTTGTTTGTTTGTCTGTTTGTTTCAAGAACCTGGAAAAATTCCAGAAGAAGAGAAGCTGCTGACCAATTGTGCTGCCATTTGATTTTT
CTAACCTTGAATGCTGCCAGTGTGGAGTGGGTAATCCAGGCACAGCTGAGTTATGATGTAATCTCTCTGCAGCTGCCGGGCCTGATTTGG
TACTTTTGAGTGTGTGTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGAGAGATTCTGTGATCTTTTAAAGTGTTACT
TTTTGTAAACGACAAGAATAATTCAATTTTAAAGACTCAAGGTGGTCAGTAAATAACAGGCATTTGTTCACTGAAGGTGATTCACCAAAA
TAGTCTTCTCAAATTAGAAAGTTAACCCCATGTCCTCAGCATTTCTTTTCTGGCCAAAAGCAGTAAATTTGCTAGCAGTAAAAGATGAAG
TTTTATACACACAGCAAAAAGGAGAAAAAATTCTAGTATATTTTAAGAGATGTGCATGCATTCTATTTAGTCTTCAGAATGCTGAATTTA
CTTGTTGTAAGTCTATTTTAACCTTCTGTATGACATCATGCTTTATCATTTCTTTTGGAAAATAGCCTGTAAGCTTTTTATTACTTGCTA
TAGGTTTAGGGAGTGTACCTCAGATAGATTTTAAAAAAAAGAATAGAAAGCCTTTATTTCCTGGTTTGAAATTCCTTTCTTCCCTTTTTT
TGTTGTTGTTATTGTTGTTTGTTGTTGTTATTTTGTTTTTGTTTTTAGGAATTTGTCAGAAACTCTTTCCTGTTTTGGTTTGGAGAGTAG
TTCTCTCTAACTAGAGACAGGAGTGGCCTTGAAATTTTCCTCATCTATTACACTGTACTTTCTGCCACACACTGCCTTGTTGGCAAAGTA
TCCATCTTGTCTATCTCCCGGCACTTCTGAAATATATTGCTACCATTGTATAACTAATAACAGATTGCTTAAGCTGTTCCCATGCACCAC
CTGTTTGCTTGCTTTCAATGAACCTTTCATAAATTCGCAGTCTCAGCTTATGGTTTATGGCCTCGATTCTGCAAACCTAACAGGGTCACA
TATGTTCTCTAATGCAGTCCTTCTACCTGGTGTTTACTTTTGTTACCTAAATAATGAGTAGGATCTTGTTTTGTTTTATCACCAGCACAC
AGATTGCTATAAACTGTTACTTTGTGAATTACATTTTTATAGAAGATATTTTCAGTGTCTTTACCTGAGGGTATGTCTTTAGCTATGTTT
TAGGGCCATACATTTACTCTATCAAATGATCTTTTCTCCATCCCCCAGGCTGTGCTTATTTCTAGTGCCTTGTGCTCACTCCTGCTCTCT
ACAGAGCCAGCCTGGCCTGGGCATTGTAAACAGCTTTTCCTTTTTCTCTTACTGTTTTCTCTACAGTCCTTTATATTTCATACCATCTCT
GCCTTATAAGTGGTTTAGTGCTCAGTTGGCTCTAGTAACCAGAGGACACAGAAAGTATCTTTTGGAAAGTTTAGCCACCTGTGCTTTCTG
ACTCAGAGTGCATGCAACAGTTAGATCATGCAACAGTTAGATTATGTTTAGGGTTAGGATTTTCAAAGAATGGAGGTTGCTGCACTCAGA
AAATAATTCAGATCATGTTTATGCATTATTAAGTTGTACTGAATTCTTTGCAGCTTAATGTGATATATGACTATCTTGAACAAGAGAAAA
AACTAGGAGATGTTTCTCCTGAAGAGCTTTTGGGGTTGGGAACTATTCTTTTTTAATTGCTGTACTACTTAACATTGTTCTAATTCAGTA
GCTTGAGGAACAGGAACATTGTTTTCTAGAGCAAGATAATAAAGGAGATGGGCCATACAAATGTTTTCTACTTTCGTTGTGACAACATTG
ATTAGGTGTTGTCAGTACTATAAATGCTTGAGATATAATGAATCCACAGCATTCAAGGTCAGGTCTACTCAAAGTCTCACATGGAAAAGT
GAGTTCTGCCTTTCCTTTGATCGAGGGTCAAAATACAAAGACATTTTTGCTAGGGCCTACAAATTGAATTTAAAAACTCACTGCACTGAT
TCATCTGAGCTTTTTGGTTAGTATTCATGGCTAGAGTGAACATAGCTTTAGTTTTTGCTGTTGTAAAAGTGTTTTCATAAGTTCACTCAA
GAAAAATGCAGCTGTTCTGAACTGGAATTTTTCAGCATTCTTTAGAATTTTAAATGAGTAGAGAGCTCAACTTTTATTCCTAGCATCTGC
TTTTGACTCATTTCTAGGCAGTGCTTATGAAGAAAAATTAAAGCACAAACATTCTGGCATTCAATCGTTGGCAGATTATCTTCTGATGAC
ACAGAATGAAAGGGCATCTCAGCCTCTCTGAACTTTGTAAAAATCTGTCCCCAGTTCTTCCATCGGTGTAGTTGTTGCATTTGAGTGAAT
ACTCTCTTGATTTATGTATTTTATGTCCAGATTCGCCATTTCTGAAATCCAGATCCAACACAAGCAGTCTTGCCGTTAGGGCATTTTGAA
GCAGATAGTAGAGTAAGAACTTAGTGACTACAGCTTATTCTTCTGTAACATATGGTTTCAAACATCTTTGCCAAAAGCTAAGCAGTGGTG
AACTGAAAAGGGCATATTGCCCCAAGGTTACACTGAAGCAGCTCATAGCAAGTTAAAATATTGTGACAGATTTGAAATCATGTTTGAATT
TCATAGTAGGACCAGTACAAGAATGTCCCTGCTAGTTTCTGTTTGATGTTTGGTTCTGGCGGCTCAGGCATTTTGGGAACTGTTGCACAG
GGTGGAGTCAAAACAACCTACATATAAAAAGAGAAAAAGAGAAACTTGTCCATTTAGCTTTCATAAGAAATCCCATGGCAAAGGGTAATA
AAAAGGACCTAATCTTAAAAATACAATTTCTAAGCACTTGTAAGAACCCAGTGGGTTGGAGCCTCCCACTTTGTCCCTCCTTTGAAGTGG
ATGGGAACTCAAGGTGCAAAGAACCTGTTTTGGAAGAAAGCTTGGGGCCATTTCAGCCCCCTGTATTCTCATGATTTTCTCTCAGGAAGC
ACACACTGTGAATGGCAGACTTTTCATTTAGCCCCAGGTGACTTACTAAAAATAGTTGAAAATTATTCACCTAAGAATAGAATCTCAGCA
TTGTGTTAAATAAAAATGAAAGCTTTAGAAGGCATGAGATGTTCCTATCTTAAATAAAGCATGTTTCTTTTCTATAGAGAAATGTATAGT
TTGACTCTCCAGAATGTACTATCCATCTTGATGAGAAAACTCTTAAATAGTACCAAACATTTTGAACTTTAAATTATGTATTTAAAGTGA
GTGTTTAAGAAACTGTAGCTGCTTCTTTTACAAGTGGTGCCTATTAAAGTCAGTAATGGCCATTATTGTTCCATTGTGGAAATTAAATTA
TGTAAGCTTCCTAATATCATAAACATATTAAAATTCTTCTAAAATATTGCTTTTCTTTTAAGTGACAATTTGACTATTCTTATGATAAGC
ACATGAGAGTGTCTTACATTTTCCAAAAGCAGGCTTTAATTGCATAGTTGAGTCTAGGAAAAAATAATGTTAAAAGTGAATATGCCACCA
TAATTACTTAATTATGTTAGTATAGAAACTACAGAATATTTACCCTGGAAAGAAAATATTGGAATGTTATTATAAACTCTTAGATATTTA
TATAATTCAAAAGAATGCATGTTTCACATTGTGACAGATAAAGATGTATGATTTCTAAGGCTTTAAAAATTATTCATAAAACAGTGGGCA
ATAGATAAAGGAAATTCTGGAGAAAATGAAGGTATTTAAAGGGTAGTTTCAAAGCTATATATATTTTGAAGGATATATTCTTTATGAACA
AATATATTGTAAAAATTTATACTAAGGTCATCTGGTAACTGTGGGATTAATATGGTCGAAAACAAATGTTATGGAGAAGCTGTCCCAAGC
AAACTAAATTACCTGTACTTTTTTCCCATTTCAAGGGAAGAGGCAACCACATGAAGCAATACTTCTTACACATGCCTAAGAACGTTCATT
GAAAAAATAAATTTTTAAAAGGCATGTGTTTCCTATGCCACCAATACTTTTGAAAAATTGTGAACCTTACCCAAAACCATTTATCATGTC
CATTAAGTATATTTGGGTATATAATTAGGAAGATATTTACATGTTCCATCTCCACAGTGGAAAAACTTATTGAGGCTACCAAAGTGTGCC
AAGAAATGTAAGTCCTTAGAGTAATTAGAAATGCTGTTTTCCTCAAAAGCATGAGAAACTAGCATTTTCATTTCTTATTTACTCCCTTTC
TATATCAATGCAATTCACAACCCAATTTTAATACATCCCTATATCTCAAGCATTTCTATCTTGTACTTTTTCAGAAAATAAACCAAAAAT
AATCCTTTGGTCTCTCTATCTTCTGACCTTTGTAAGCAACAGAAATGTAAAAACAGAAGGGGTCCAATTTTTACACGTTTTTTTCTCAAG
TAGCCTTTCTGGGGATTTTTATTTTCTTAATGAAGTGCCAATCAGCTTTTCAAAATGTTTTCTATTTCTCAGCATTTCCAGGAAGTGATA
ACGTTTAGCTAAATGAGTAGAAGTGGACTTCCTTCAACATATTGTTACCTTGTCTAGCCTTAGGAAGAAAACAAGAGCCACCTGAAAATA
AATACAGGCTCTTTTCGAGCATCTGCTGAAATACTGTTACAGCAATTTGAAGTTGATGTGGTAGGAAAGGAAGGTGACTTTTCTTGCAAA
AGTCTTTCTAAACATTCACACTGTCCTAAGAGATGAGCTTTCTTGTTTTATTCCGGTATATTCCACAAGGTGGCACTTTTAGAGAAAAAC
AAATCTGATGAAGACTAAAGAGGTACTTCTAAAAGAGATTTCATTCTAACTTTATTTTTCTGCGCATATTTAACTCTTTCCTAGCACTTG
TTTTTTGGGATGATTAATAGTCTCTATAATGTTCTGTAACTTCAATATTTTACTTGTTACCTAGGTTCTGAACAATTGTCTGCAAATAAA
TTGTTCTTAAGGATGGATAATACACCCATTTTGATCATTTAAGTAAAGAAAGCCTAGTCATTCATTCAGTCAAGAAAAAATTTTTGAAGT
ACCCAGTTACCTTACTTTTCTAGATTAAAACAGGCTTAGTTACTAAAAAGGCAGTCCTCATCTGTGAACAGGATAGTTTCGTTAGAAGTA
TAAAACTCCTTTAGTGGCCCCAGTTAAAACACACATACCCTCTCTGCTGCTTTCAAATTCCCTAGCATGGTGGCCTTTCAACATTGATTA
AATTTTAAAATCCTAATTTAAAGATCAGGTGAGCAAAATGAGTAGCACATCAGTAATTCAGTAGACAAAACTTTTGTCTGAAAAATTGCT
GTATTGAAACAGAGCCCTAAAATACCAAAAGACCAGGTAATTTTAACATTTGTGGAATCACAAATGTAAATTCATAAGAAGCTCTAATTA
AAAAAAAAAAGTCTGAAGTATATGAGCATAACAACTTAGGAGTGTGTCTACATACTTAACTTTTGAAGTTTTTTGGCAACTTTATATACT
TTTTTTAAATTTACAAGTCTACTTAAAGACTTCTTATACCCCAAATGATTAAGTTAATTTTAGAGGTCACCTTTCTCACAGCAGTGTCAC
TTGAAATTTAGTAGGGAAGGATATTGCAGTATTTTTCAGTTTCCTTAGCACAGCACCACAGAAAGCAGCTTATTCCTTTTGAGTGGCAGA
CACTCGACGGTGCCTGCCCAACTTTCCTCCTGAGTGGCAAGCAGATGAGTCTCAGTAATTCATACTGAACCAAAATGCCACATACACTAG
GGGCAGTCAGAAACTGGCTGAGAAATCCCCCGCCTCATTCGCCCCTCTGCTCCCAGGAACTAGAGTCCAGTTAAAGCCCCTATGCGAAAG
GCCGAATTCCACCCCAGGGTTTGTTATAACAGTGGCCAGTCTGAACCCCATTTGCTCGTGCTCAAAACTTGATTCCCACTTGAAAGCCTT
CCGGGCGCGCTGCCTCGTTGCCCCGCCCCTTTGGCAGGAGAGAGGCAGTGGGCGAGGCCGGGCTGGGGCCCCGCCTCCCACTCACCTGCC
GGTGCCTGAAATTATGTGCGGCCCCGCGGGCTGCTTTCCGAGGTCAGAGTGCCCTGCTGCTGTCTCAGAGGCATCTGTTCTGCAAATCTT
AGGAAGAAAAATGTCCCTAGTAGCAAACGGGTGTCTTCTGTGCATAAATAAGTACAACACAATTCTCCGAAAGTTCGGGTAAAAAGAGAT
GCGGTAGCAGCTGCCCTGTGTGAAGCTGTCTACCCCGCATCTCTCAGGCGCTAAGCTCAGTTTTTGTTTTTGTTTTTGTTTTTTTAAAGA
AAAGATGTATAATTGCAGGAATTTTTTTTTATTTTTTTATTTTCCATCATTCTATATATGTGATGGTGAAAGATATGCCTGGAAAAGTTT
TGTTTTGAAAAGTTTATTTTCTGCTTCGTCTTCAGTTGGCAAAAGCTCTCAATTCTTTAGCTTCCAGTTTCTTTTCTCTCTTTTTCTTTG
TTAGGTAATTAAAGGTATGTAAACAAATTATCTCATGTAGCAGGGGATTTTCATGTTGAGAGGAATCTTCCGTGTGAGTTGTTTGGTCAC
ACAAATAACCCTTTCTCAATTTTAGGAGTTTGGATTGTCAAATGTAGGTTTTTCTCAAAGGGGGCATATAACTACATATTGACTGCCAAG
AACTATGACTGTAGCACTAATCAGCACACATAGAGCCACACAATTATTTAATTTCTAACTCTCTGTGGTCCCTAGAAAAATTCCGTTGAT
GTGCTTAGGTTAAAGTTCTGAAGATACCCGTTGTACCCTTACTTGAAAGTTTCTAATCTTAAGTTTTATGAAATGCAATAATATGTATCA
GCTAGCAATATTTCTGTGATCACCAACAACTCTCAGTTTGATCTTAAAGTCTGAATAATAAAACAAATCCCAGCAGTAATACATTTCTTA
AACCTCACAGTGCATGATATATCTTTTCATTCTGATCCTGTGTTTGCAAAAATATACACATGTATATCATAGTTCCTCACTTTTTATTCA
TTTGTTTTCCTATTACCTGTAGTAAATATATTAGTTAGTACATGGAATTTATAGCATCAGCTACCCCCAGGAACAGCACCTGACAGGCGG
GGGATTTTTTTTCAAGTTGTTCTACATTTGCATAAATTATTTCTATTATTATTCATGTATGTTATTTATTTCTGAATCACACTAGTCCTG
TGAAAGTACAACTGAAGGCAGAAAGTGTTAGGATTTTGCATCTAATGTTCATTATCATGGTATTGATGGACCTAAGAAAATAAAAATTAG
ACTAAGCCCCCAAATAAGCTGCATGCATTTGTAACATGATTAGTAGATTTGAATATATAGATGTAGTATTTTGGGTATCTAGGTGTTTTA
TCATTATGTAAAGGAATTAAAGTAAAGGACTTTGTAGTTGTTTTTATTAAATATGCATATAGTAGAGTGCAAAAATATAGCAAAAATAAA
AACTAAAGGTAGAAAAGCATTTTAGATATGCCTTAATTTAGAAACTGTGCCAGGTGGCCCTCGGAATAGATGCCAGGCAGAGACCAGTGC
CTGGGTGGTGCCTCCTCTTGTCTGCCCTCATGAAGAAGCTTCCCTCACGTGATGTAGTGCCCTCGTAGGTGTCATGTGGAGTAGTGGGAA
CAGGCAGTACTGTTGAGAGGAGAGCAGTGTGAGAGTTTTTCTGTAGAAGCAGAACTGTCAGCTTGTGCCTTGAGGCTTCCAGAACGTGTC
AGATGGAGAAGTCCAAGTTTCCATGCTTCAGGCAACTTAGCTGTGTACAGAAGCAATCCAGTGTGGTAATAAAAAGCAAGGATTGCCTGT
ATAATTTATTATAAAATAAAAGGGATTTTAACAACCAACAATTCCCAACACCTCAAAAGCTTGTTGCATTTTTTGGTATTTGAGGTTTTT
ATCTGAAGGTTAAAGGGCAAGTGTTTGGTATAGAAGAGCAGTATGTGTTAAGAAAAGAAAAATATTGGTTCACGTAGAGTGCAAATTAGA
ACTAGAAAGTTTTATACGATTATCATTTTGAGATGTGTTAAAGTAGGTTTTCACTGTAAAATGTATTAGTGTTTCTGCATTGCCATAGGG
CCTGGTTAAAACTTTCTCTTAGGTTTCAGGAAGACTGTCACATACAGTAAGCTTTTTTCCTTCTGACTTATAATAGAAAATGTTTTGAAA
GTAAAAAAAAAAAATCTAATTTGGAAATTTGACTTGTTAGTTTCTGTGTTTGAAATCATGGTTCTAGAAATGTAGAAATTGTGTATATCA
GATACTCATCTAGGCTGTGTGAACCAGCCCAAGATGACCAACATCCCCACACCTCTACATCTCTGTCCCCTGTATCTCTTCCTTTCTACC
ACTAAAGTGTTCCCTGCTACCATCCTGGCTTGTCCACATGGTGCTCTCCATCTTCCTCCACATCATGGACCACAGGTGTGCCTGTCTAGG
CCTGGCCACCACTCCCAACTTGACCTAGCCACATTCATCTAGAGATGGTTCCTGATGCTGGGCACAGACTGTGCTCATGGCACCCATTAG
AAATGCCTCTAGCATCTTTGTATGCATCTTGATTTTTAAACCAAGTCATTGTACAGAGCATTCAGTTTTGGCTGTGGTACCAAGAGAAAA
ACTAATCAAGAATATAAACCACATTCCAGGCTGCTGTTTTCTCTCCATCTACAGGCCACACTTTTACTGTATTTCTTCATACTTGAAATT
CATTCTGCTATTTTCATATCAGGGTACAGACTTATAAGGGTGCATGTTCCTTAAAGGTGCATAATTATTCTTATTCCGTTTGCTTATATT
GCTACAGAATGCTCTGTTTTGGTGCTTTGAGTTCTGCAGACCCAAGAAGCAGTGTGGAAATTCACTGCCTGGGACACAGTCTTATAAGAA
TGTTGGCAGGTGACTTTGTATCAGATGTTGCTTCTCTTTTCTCTGTACACAGATTGAGAGTTACCACAGTGGCCTGTCGGGTCCACCCTG
TGGGTGCAGCACAGCTCTCTGAAAGCAAGAACCTTCCTACCTATTCTAACGTTTTTGCCCTCTAAGAAAAATGGCCTCAGGTATGGTATA
GACATAGCAAGAGGGGAAGGGCTGTCTCACTCTAGCAACCATCCCTCCATTACACACAGAAAGCCCTCTTGAAGCAAAAGAAGAAGAAAG
AAAGAAAGCTTATCTCTAAGGCTACTGTCTTCAGAATGCTCTGAGCTGAATGCTCTTGCTCCTTTCCCAAGAGGCAGATGAAAATATAGC
CAGTTTATCTATACCCTTCCTATCTGAGGAGGAGAATAGAAAAGTAGGGTAAATATGTAACGTAAAATATGTCATTCAAGGACCACCAAA
ACTTTAAGTACCCTATCATTAAAAATCTGGTTTTAAAAGTAGCTCAAGTAAGGGATGCTTTGTGACCCAGGGTTTCTGAAGTCAGATAGC
CATTCTTACCTGCCCCTTACTCTGACTTATTGGGAAAGGGAGAACTGCAGTGGTGTTTCTGTTGCAGTGGCAAAGGTAACATGTCAGAAA
ATTCAGAGGGTTGCATACCAATAATCCTTTGGAAACTGGATGTCTTACTGGGTGCTAGAATGAAAATGTAGGTATTTATTGTCAGATGAT
GAAGTTCATTGTTTTTTTCAAAATTGGTGTTGAAATATCACTGTCCAATGTGTTCACTTATGTGAAAGCTAAATTGAATGAGGCAAAAAG
AGCAAATAGTTTGTATATTTGTAATACCTTTTGTATTTCTTACAATAAAAATATTGGTAGCAAATAAAAATAATAAAAACAATAACTTTA
AACTGCTTTCTGGAGATGAATTACTCTCCTGGCTATTTTCTTTTTTACTTTAATGTAAAATGAGTATAACTGTAGTGAGTAAAATTCATT

>In-frame_KRIT1_ENST00000394503_chr7_91871348_-_CDK6_ENST00000424848_chr7_92247521_-_782nt
ATAGCCACGGTAACGGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCT
GAGGTGCGAGGAGAGGGAAGGACAGTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTC
ATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACG
CTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAA
CCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGCAATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAA
GAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATG
TTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTAC
TTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCA


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FusionGenePPI for KRIT1_CDK6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KRIT1RAP1A, ITGB1BP1, DAPK1, RCHY1, RGS4, TRPV4, PLCB3, PLCB1, PIK3C3, PIK3R4, FAS, RAP1B, NXF1, CCM2, HEG1, SLC34A2, UBFD1CDK6CDKN2C, CDKN2A, CCND1, CDKN2D, PPP2CA, PPM1B, CDK2, CCND2, CCND3, CDKN1B, CDC37, FBXO7, CDKN1A, UHRF2, CDK5R1, ELAVL1, CCNE1, CCNA2, KIF26B, RB1, CDK7, ATXN1, HIST1H1A, PML, HSP90AA1, FOXM1, ZSCAN1, SYNPO2, DEDD2, SRSF12, ZNF101, SNIP1, ZNF335, PRX, EBF4, EIF4ENIF1, RBM23, BCL11A, TCEB3B, PPHLN1, TRA2A, SENP3, NIPBL, CBY1, SSBP2, SIRT1, POGZ, LPIN1, ANKRD12, TPX2, TRAK1, CASC3, CLASRP, PPARGC1A, MSL3, SORBS1, ABI2, N4BP1, VGLL4, TJP2, SRSF11, ZMYM3, ZNF174, SLBP, ZFP36, MZF1, KLF10, TFDP1, ZEB1, SOX5, SOX10, SRSF1, SRSF2, SRSF7, TRA2B, RBL1, RBL2, NUMA1, NFATC3, MYC, MEF2D, MLLT3, ISL1, HSF1, EZH2, FOXO3, ELK1, ATF6B, DDIT3, CDC6, MCM2, MCM10, UCHL1, CDKN2B, WDR33, CDKL3, CDK6, DMBT1, AMY2A, PIGR, CDK4, DAB1, PSMA3, RTFDC1, HSP90AA5P, UBE2W, CCNT2, CCNT1, RCHY1, EIF2AK1, CDKN1C, NTRK1, RUNX1, CTNNB1, AR, VHL, FGFR3, USP17L2, MCF2L2, PAK4, FKBP5, FAM26E, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKRIT1chr7:91871348chr7:92247521ENST00000340022-419172_19534737ITGB1BP1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394503-317172_19534689ITGB1BP1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394505-419172_19534737ITGB1BP1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394507-520172_19534737ITGB1BP1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000412043-419172_19534737ITGB1BP1
HgeneKRIT1chr7:91871348chr7:92247521ENST00000340022-419430_45234737RAP1B
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394503-317430_45234689RAP1B
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394505-419430_45234737RAP1B
HgeneKRIT1chr7:91871348chr7:92247521ENST00000394507-520430_45234737RAP1B
HgeneKRIT1chr7:91871348chr7:92247521ENST00000412043-419430_45234737RAP1B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KRIT1_CDK6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCDK6Q00534DB09073PalbociclibCyclin-dependent kinase 6small moleculeapproved|investigational

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RelatedDiseases for KRIT1_CDK6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKRIT1C2919945Cavernous Hemangioma of Brain1ORPHANET;UNIPROT
TgeneCDK6C0025149Medulloblastoma2CTD_human
TgeneCDK6C0003873Rheumatoid Arthritis1CTD_human
TgeneCDK6C0008625Chromosome Aberrations1CTD_human
TgeneCDK6C0017636Glioblastoma1CTD_human
TgeneCDK6C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneCDK6C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneCDK6C0263454Chloracne1CTD_human
TgeneCDK6C0345967Malignant mesothelioma1CTD_human
TgeneCDK6C0677866Brain Stem Neoplasms1CTD_human
TgeneCDK6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneCDK6C4015156MICROCEPHALY 12, PRIMARY, AUTOSOMAL RECESSIVE1UNIPROT