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Fusion gene ID: 19163 |
FusionGeneSummary for KPNA1_GMPS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KPNA1_GMPS | Fusion gene ID: 19163 | Hgene | Tgene | Gene symbol | KPNA1 | GMPS | Gene ID | 3836 | 8833 |
| Gene name | karyopherin subunit alpha 1 | guanine monophosphate synthase | |
| Synonyms | IPOA5|NPI-1|RCH2|SRP1 | GATD7 | |
| Cytomap | 3q21.1 | 3q25.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | importin subunit alpha-5RAG cohort protein 2SRP1-betaimportin alpha 5importin subunit alpha-1importin-alpha-S1karyopherin alpha 1 (importin alpha 5)nucleoprotein interactor 1recombination activating gene cohort 2 | GMP synthase [glutamine-hydrolyzing]GMP synthaseGMP synthetaseMLL/GMPS fusion proteinglutamine amidotransferaseguanine monophosphate synthetaseguanosine 5'-monophosphate synthasetesticular tissue protein Li 82 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P52294 | P49915 | |
| Ensembl transtripts involved in fusion gene | ENST00000344337, ENST00000466923, | ENST00000496455, ENST00000295920, ENST00000476145, | |
| Fusion gene scores | * DoF score | 7 X 4 X 7=196 | 3 X 2 X 2=12 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/12*10)=2.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KPNA1 [Title/Abstract] AND GMPS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-78-7147-01A | KPNA1 | chr3 | 122215284 | - | GMPS | chr3 | 155637022 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344337 | ENST00000496455 | KPNA1 | chr3 | 122215284 | - | GMPS | chr3 | 155637022 | + |
| In-frame | ENST00000344337 | ENST00000295920 | KPNA1 | chr3 | 122215284 | - | GMPS | chr3 | 155637022 | + |
| 5CDS-intron | ENST00000344337 | ENST00000476145 | KPNA1 | chr3 | 122215284 | - | GMPS | chr3 | 155637022 | + |
| intron-3CDS | ENST00000466923 | ENST00000496455 | KPNA1 | chr3 | 122215284 | - | GMPS | chr3 | 155637022 | + |
| intron-3CDS | ENST00000466923 | ENST00000295920 | KPNA1 | chr3 | 122215284 | - | GMPS | chr3 | 155637022 | + |
| intron-intron | ENST00000466923 | ENST00000476145 | KPNA1 | chr3 | 122215284 | - | GMPS | chr3 | 155637022 | + |
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FusionProtFeatures for KPNA1_GMPS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KPNA1 | GMPS |
| Functions in nuclear protein import as an adapterprotein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLSmotif. Docking of the importin/substrate complex to the nuclearpore complex (NPC) is mediated by KPNB1 through binding tonucleoporin FxFG repeats and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to importin-beta and the three components separate andimportin-alpha and -beta are re-exported from the nucleus to thecytoplasm where GTP hydrolysis releases Ran from importin. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. In vitro, mediates the nuclearimport of human cytomegalovirus UL84 by recognizing a non-classical NLS. | Involved in the de novo synthesis of guanine nucleotideswhich are not only essential for DNA and RNA synthesis, but alsoprovide GTP, which is involved in a number of cellular processesimportant for cell division. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 25_28 | 43 | 539 | Compositional bias | Note=Poly-Arg |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 1_57 | 43 | 539 | Domain | IBB |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 42_51 | 43 | 539 | Motif | Nuclear localization signal |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 149_241 | 43 | 539 | Region | NLS binding site (major) |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 245_437 | 43 | 539 | Region | Note=Binding to RAG1 |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 318_406 | 43 | 539 | Region | NLS binding site (minor) |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 118_161 | 43 | 539 | Repeat | Note=ARM 2 |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 162_206 | 43 | 539 | Repeat | Note=ARM 3 |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 207_245 | 43 | 539 | Repeat | Note=ARM 4 |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 246_290 | 43 | 539 | Repeat | Note=ARM 5 |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 291_330 | 43 | 539 | Repeat | Note=ARM 6 |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 331_372 | 43 | 539 | Repeat | Note=ARM 7 |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 373_412 | 43 | 539 | Repeat | Note=ARM 8 |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 413_457 | 43 | 539 | Repeat | Note=ARM 9 |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 460_504 | 43 | 539 | Repeat | Note=ARM 10%3B atypical |
| Hgene | >KPNA1 | chr3:122215284 | chr3:155637022 | ENST00000344337 | - | 2 | 14 | 77_117 | 43 | 539 | Repeat | Note=ARM 1%3B truncated |
| Tgene | GMPS | chr3:122215284 | chr3:155637022 | ENST00000496455 | + | 8 | 16 | 217_435 | 404 | 694 | Domain | GMPS ATP-PPase |
| Tgene | GMPS | chr3:122215284 | chr3:155637022 | ENST00000496455 | + | 8 | 16 | 27_216 | 404 | 694 | Domain | Glutamine amidotransferase type-1 |
| Tgene | GMPS | chr3:122215284 | chr3:155637022 | ENST00000496455 | + | 8 | 16 | 244_250 | 404 | 694 | Nucleotide binding | ATP |
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FusionGeneSequence for KPNA1_GMPS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KPNA1_ENST00000344337_chr3_122215284_-_GMPS_ENST00000496455_chr3_155637022_+_333aa MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAE EPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWE SLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSC >In-frame_KPNA1_ENST00000344337_chr3_122215284_-_GMPS_ENST00000295920_chr3_155637022_+_333aa MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAE EPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWE SLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KPNA1_ENST00000344337_chr3_122215284_-_GMPS_ENST00000496455_chr3_155637022_+_999nt ATGACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAA GAAGGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATT TTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAA GAACCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACC CTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTG CTGCCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAA TCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCT CCTACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAG TCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGC CAGAGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTG GTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAG >In-frame_KPNA1_ENST00000344337_chr3_122215284_-_GMPS_ENST00000295920_chr3_155637022_+_999nt ATGACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAA GAAGGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATT TTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAA GAACCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACC CTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTG CTGCCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAA TCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCT CCTACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAG TCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGC CAGAGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTG GTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KPNA1_ENST00000344337_chr3_122215284_-_GMPS_ENST00000496455_chr3_155637022_+_7510nt GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATTTTG GGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAA CCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACCCTA TTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTG CCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAATCA CTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCTCCT ACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAGTCT GGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAG AGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTGGTA TTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGG GAGTAATAAACTTCTTGTTCTATTAAAGTACCGTGTGCAGTTTAAATTGATTAGAAATCATTCCCATTATTGACATGCAGTACTGTGAAA AGAGTTACTGGAGCAGCTACATCACATCTGAGTTCTCCACAGCAAAAATCTACGGCTTAAGAGCTGAGTTGGGGATAACCAAAAGGGACT GAAGAGTTTGTACGGGTAAATAATCAAAGCACCATTGCCTACACTCAGACAGATTGATACTGCTTTTGCCTTTGCCTCACTTATTCTTTA TGTATAAATTCACTGTTGATGTCTCTGTGAATATGTATGAAGGTGGGTGAATTTGGGGGTAATTATGGGCTTCTGTCTCCTTACCAGTTT CTAAGAACTGTTAGAAACGCCCATTATTTACCAGTGTTACTTACTACTTATATATACTTTTTGGAGAATCAGTTTTCTTATAAGTAATCT TATTTCTCCAAAGGGTGAAAAAGAGATGAACATATCAGATAAAGGTATAGGTGGGCTATTCCAGCCACTTTTGAAGGACACTGAGGGTAT AAAATGTAAGCTACCATAAGATGGAAAAGCACCAGGAATTTGTTGATGTACTTTTGAATTTTATTTCACAGCCTTGGGAGGAAGAAACTA TGAGTGGTCTCAGATGTCTATGAATGGTCTTAAAATGTTTTCAAACCATGTTCCACATAGATGCCATGTTATTCAATGTCAGCTTGTTTA TTAGTAAGGAGCTTTATCCTCCTAGCCTTATATTACCAGCCCCCCACAGCCTTGCATAGAAAGTTTCTGTTATCTCCTTAGAAGAAACTG GCTCAATGACGTTTCTGGTGTAGTGCAGATAGAGGTCAAGAGGAGCATTTTCATCTCTTCTTTTGCTGGTCAGAGAAACGGTTCTGAGAT CACAGAAGCTATGATGCATACCTACAGCTTACAAAAGGGAGAGGAAAAATGTTTATATCATCTAGTAAACAGTTGTAAAATGAGCTTTTA AATCTAATCTATAGACATATTATTCATTGCTCAGACACCTGTGAACAGTCTTGATACATGCAAGATGTTTGCCAAACTTTGTAATCCTTT CTACTAGCTATAAGAGAGGATTTAAGAACTGGTGTAGGACTTGTTGCCATCACCACCAGTTTCTAACAGATCTTTTATAACATTCACATA AGTACTGTAGACAGTAGTAGACTTAAACTCTCCGTTTCTCTCAGTATTTTAGCTAAGAATGTTACCATATTTTTCTCTTAACAATTCCAT CTCAGGTTGCTGCTGCTTGTCTAGTTTAAAAGGTCAGATCTATTAATCAGGAATGAAATTTTATTTGGGATTCAGTGTTAGACAAACAAC AAAATGATGCGTGGCAGAAGTCATCTTTTTATTCTGGCTGGTCCAGGGAACAAGAAAACTGCTGCTGGACCAGCAAGGGAAGAGTTTCTG TCTGTCTTAACAGAAATCTGTCCCCAAGACAAAGGGGTACTTGACTCCTACAAAACTTAAAGGGTACATTCTCTATCTGATGAGGAGGTA CTCATTATGGCCTTCTGGAAAGAGGCTATGTTAGTGATCTGGTCTTTACAGATTTAGAGTCATGTTATTTGAAAGCTAGAATAGACAACC TATAAAATGCTTACCAACATGTGTCAGTACACGTTTATGTTTATATGAAAAAAAATTTCTAGCCACAGTGTCTTATGATTTTGTATTGAA GCAAACAGTAGGAATTTTGGAAAAATAGAGAGTAAGAATGTGTGTTCTATGGAACACTGCTCCACTGAGAAGGTCCATGTAAAAAGGATT AGGTGGTCATATAAGTTTGGGGAACATAAGCTCACTTGTCCTTTCCTGGAGATTCATGGTATATAATATTCAAAGCTCTGAGAAATTCTG AAGTTAAAAACAATTGTTAAATTCTGCTTAAATTAGTGTTTTCCTGATATTTGTTTTTTGAACACCTTTTATATAATCCCTTCTAATATA TACTTAGTATATACTTAATATAATATTGGGAAAATTGTTACTCCAAAGCACATCTTGACATGACATAGTTTCTTAAAAATCCAAATTTTC TGGAACTCAGAAATTTCCTAATATTTAGCACACTGTCTTCTTTTGCACAGCACTTTTTGCTTTGTGCCATATAGCATTACTCTGTACCTT CACAGTATTTCATCTGAGCCACTGAGGAAAGTTAAAGGTTGCACTTCCATTTTACAGTTAAGAAAACAAGCTCACCTTAGGCATGGTTAC TTAATTAATTTCAGAATTAAATTTCAGGTTTCCTTAGTCCAGATTGTCCTGATGTGTATTCTGACACCTAAAATTATATAAACATTTATG GGATGCTTATTTTACTAAGACTAGAATGGTGGCTACCTGGCTAATAACATTCATCATTGGTTATTCTGGGCATATCATGACTTTATTCCC GTTGCTTACCATCTACCTGGGACACATCTCTCTTTGATTAAATATATTCTTTTTCTTTGTACTTTTTAGGTAGACAGAGAATGTAGATCA TTGAAAGCATTATTTATTCCTAAGATTGGCAGGCACAGAATCATTTTTAAGAACCAAATACCCAGTCCTGCCTTAAAGGCCACATCTATG ATCATCAGCTCTGTTAGAAATAACAGCCTGGCATAATTCCTAAATACAAGTCTGTAGATATATCCAGGAGATAGGGTTACACTGTTTTCT AACCTTTTTTAAATCCCTTAATCTTGAGGTAAACTGCATGCATTTAGTCAAACAAGCATCATAAAATTTGTTTCCTCACTGTTTGGGCTT AACCTCCTGATAGCCTGTTTTACTGAATAACTTGACCCTAACCTGTAGAGAATAAGAGCATTCAAATTAGGAAGGCAGGACTATCCATCT TTAGTGCTTTTCCTGCCGTTAAACAACAATGTGAACTTGGTCAAGTCATTTCTGTTCTTTATCTGTGACATGAGGTAACTGTATTAAATT TTCAGCATCAAATCCAGCTATAAATTTGTATTTTGTAAACAAGAGAAAGTAAAGCAGGAGACAGAATGGAGAAGCTGGATAGTGTTTTTT TTTTTTTTTTTTAAGGTTCTTTTATCATCAGATATGACACAAAGGGAAACATCAAAATGCACCGTAAAGTTAAATCCTAGTTACCTTTTT TTGAAGCTGTTGGCAAGGTTTGACCACTTGGGGCATCTTCTGCTGTGAGATGACACTTGAAAAACACCCATCAAAGTTTTCCTGGTAGGA ATCTCTCTTTACTGCGTGTTTTTTTGAAAAGCTGACAGAGAATATGCTTTGGCTTTGACACTAATGAAGTCACCCATCATCAATTACATA CAGCTAATTGTTGGGAGCTAGAGCTAGAATCCAAGCTTTCTGATTCTCTGCATGGAAGAGGAAATGCTCTAGGGCCCTTCAGGGCAAATC TTAAAAGGAAGTTCTTGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGATCAGGA GATCGAGACCATCTTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAACAAATTAGCTGGGCGCGGTGGCGGGTGCCTGTAGTC CCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCCTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATAGTGCCACTGCACTCCGGC CTGGTGAAAGAGCGAGACTCAGTCTCAAAAAAAAAAAAAAAAGGAAGTTCTTAGTGTGTAATTGACCATCAGGGATAAATGGGCTTCAAA AGTGTTAATTGTCTCCTTACTTACAGTGAGTTTCTAGAGATAGCCCTGTCTTTCAGAAATTCTCTGACATCTGCTTGCGCAATGTTATAA CCACTTTCCCACACTACTCCCCTCCAGAAATCTCATTGATATGTGGCGAGGACACGCCTTAGCTATCACCCCAATGGATGCTTCTTTCAT TGACCCAAATCCAGAATGTAATGGGGAACTGAATACAAGTTGGATGTCTCCACCCTTGGAAAGCACATCTTTTGTTCTTACTGAAGTAGT TTAACACCACCAGATGATCAAGGGATCAGGGTATCTTTCTGGTATCTTTTTAATCACTGAAGGACTTTGACAGCAGTAATGGTGGCATTG TTGACTCTTAAATTTCTGAACGTTTCACTTAATGGCAAGTGAAGAGATATAGAATCCCCCAAAGAGTGTCAAGATGCTAACTTCCAACCC TATTTTTATGTACTGAAGAGGCCTCAGTGTCTCACTGAACTCTAACCTTTTTGTCAGTGTTCCTCAACACTGGATGCGTATTATTACATA ACCTGAGGAGTTAAAAAATACAATAACCAGATGTCCAATTAAATAAAATTAGAATCTGGAGGAGGTAGAACTCAAGCATTTACAGTTTTG TTTTGTTTTTTTTTTAAGACAGAGTCTCGCTCTGTCCCCAAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCTTCGTGGGTTCA CGCCATTCTCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCGGCTAATTTTTTTGTACTTTTTAGTAGAG ACAGGGTTTCACTGTGTTATACAGGATGGTCTCGATCTCCCGACCTCATGATCCGCCCGCCTCGGCCTCTCAGAGTGCTGGGATTACAGG CGTGAGCCACCACGCCCGGCAAGCATTTACAGTTTTAAATCTCCCAGTCAGAATAAATTCTTATTGAGGGCCATACCTAGCCTGTCTTCA TCAAACTCATAGGTGAATCTTTGTCAAACCTATAGGAGAGAGATGCAGGCCATAGAGATGGTCTTGCTGAAGGTCTTATAGCTAAATTAG TTCAGATCCAGGAACCAGATTCTGGAACTGATTGCACCTATATTATGTTGTGTGTCAGACACTCCCAGGACCTGTTTGGTAATAATTAGG ACAGCTGACATACTTGTTGCTAATTTTGAGATCTGGGCAACAACTGTGTAGGCTGTTCTTTCAACCTCTTTCTTCTTACTTCTTTACTTT TCCTTCAGAGAGGAGAAAGCCACCCCTGTGCTATAGCCACCGCTCCAATTCTGACTCTAGCTAGGTCATGAAACAGACTGAGCTATTATT GCATCAACACATAAATCCTGTCATTTGGGTATTATTCTTTAGAGAACTAGAGATTACCTAGCTGCAACCTAAGTTTCCTGAATTAGAATC ATTTGAGCAGCACCATCTTAATTGGCTCATTAACATATTTGTGACCAGGCACAGTGGCGCATGCCTGTAATCCCAGCACTTTGGGAGGCC GAGGCGGGCGGATCTCTTGAGGTCAGGAGTTTGAGACCAGCGTGGCCAACATGGTGAAACCCCATTTCTACTAAAAATGTAAAAATTAGC TGGGCTTGGTGGCGCGCGCCTGTAATCCCAGCTACTCGGAAGGCTGAGGTGTGAGAATCACTTAAACCCGGGAGATGGAGGTTGCAGTGA GCAGAGATTGCGCCACTGCACTCCAGCCTAGGTGACAAGAATGAGACTCCGTCTTAAAACAAAAACAACATATTTGTTCACTTTTGAACC CTGTGGTGTCTTTTAACTTTGTTAAGGGCCCTTGGTTAGCAAAATTATGAAAGTTTAGGAAATTTGGCTATTGAGTATATTAAGTACAAC TACAAAATCCTCTGAGTTCTCCAGGAAGCCTAAACCTTGAGCAGTATCTTATTCAAGTGGAGTATATATCTTCAAGAATACAGATTTTTA AGGTAAGTAGTTTTTCGTCTTTGCATCTCCTAAGACCATTGTTAACAACCTTGATATTAAACGAAGAAGTGAATGTAAACCTCCTTTTGA ACATATTTTTTATAAAGAAATATTTTGTTAATTGGAGTAAGTAGTATTGTTATGAAATCACTGTGTAATTGTTAATTGTAAACTGCAATG TCTATTTTGTGTTGTAACAATGTTGCCATAAAATAGCTTTGCTAAATGTGAAATGACTTTAATCCCTTTTGTCTTCAATATACTTCATAA AGGAGGAAATGATGATTTACACAATTTGTCATGAAGCTTCCGTGTTTATGAGAAATTCCAAGAAGTAAGAGCCAAGAGGACAGATATTAT CAGAATATGGGACATAAGAAATTGCATATAGTGTCAAGGGTTTCTATATAACAACTTAATTTATTTCCCTTGCATATATAGTAGGGGTTA ACATTTTGCTCAATGTTAACGGGGGACATAATGGACATAAAACATTGGATAGCTTTTTATTTAAATGAGCTAAAGGTGTGCGTATACACA >In-frame_KPNA1_ENST00000344337_chr3_122215284_-_GMPS_ENST00000295920_chr3_155637022_+_1194nt GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATTTTG GGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAA CCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACCCTA TTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTG CCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAATCA CTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCTCCT ACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAGTCT GGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAG AGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTGGTA TTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGG |
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FusionGenePPI for KPNA1_GMPS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KPNA1 | LYAR, NUP62, NUP54, RANBP2, UBR5, RAG1, CSE1L, KPNB1, RUNX1T1, STAT1, USP1, SLX4, MEPCE, TPX2, PRPF19, PRPF31, PLRG1, AICDA, CTNNBL1, CUL4B, HSPA4, CDKN1B, SKP2, CUL3, CUL1, COPS5, CAND1, NOSIP, DCAF8, TAF9, ANP32A, TP53BP1, LMO4, HDAC6, HDAC1, HDAC2, BCAR3, ANP32B, IL1RAP, ORC4, FOSL1, CRADD, GOPC, CLK3, HECW2, GABPA, DCAF6, KCTD12, LIMCH1, NPM1, TRMT61A, XRN2, NUP50, CLK4, FANCD2, FBL, IPO5, KPNA2, NOP56, NOP58, RPS19, MORF4L1, MORF4L2, RAN, SUB1, NTRK1, NUP153, PHAX, CDKN2AIP, CHD8, LMNB1, TRIM27, SMARCA4, SMARCD2, VPS72, USP7, RUVBL1, RNMT, MTA2, NCOR1, TSSC4, TADA3, RUVBL2, ADNP, SF3B1, MBD3, GATAD2A, SUPT20H, GATAD2B, MTA3, ANP32E, KIAA2013, C12orf45, ARID2, FOXB1, FOXE1, CRY2, MCM2, SNW1, IKBKG, RBBP4, PHB2, MDM2, PTPN2, STYX, SREK1IP1, PKM, NR3C1, SENP2, CD2BP2, G3BP1, LMNA, GTF2IRD1, BRD1 | GMPS | USP7, BABAM1, TCEAL1, DDA1, PRKAG2, SIRT7, CUL3, AHCY, APRT, FN1, VCAM1, ITGA4, AGPAT2, FBXO6, COASY, EFHD2, ENO2, PNP, PPME1, RCN1, MTAP, PSMD5, RAB1A, TSTA3, TNRC6B, CTPS1, GLO1, DDX5, HSPB1, RPIA, IMPDH1, IMPDH2, NTRK1, PAX6, KIF7, AGO2, CRY1, MCM2, CDC5L, TRIM21, TP53, PPM1G, GTF2E2, FOXA1, UHRF2, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KPNA1_GMPS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | GMPS | P49915 | DB00142 | Glutamic Acid | GMP synthase [glutamine-hydrolyzing] | small molecule | approved|nutraceutical |
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RelatedDiseases for KPNA1_GMPS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KPNA1 | C0036341 | Schizophrenia | 1 | CTD_human |
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