|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 19156 |
FusionGeneSummary for KNSTRN_BUB1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KNSTRN_BUB1B | Fusion gene ID: 19156 | Hgene | Tgene | Gene symbol | KNSTRN | BUB1B | Gene ID | 90417 | 701 |
| Gene name | kinetochore localized astrin (SPAG5) binding protein | BUB1 mitotic checkpoint serine/threonine kinase B | |
| Synonyms | C15orf23|HSD11|SKAP|TRAF4AF1 | BUB1beta|BUBR1|Bub1A|MAD3L|MVA1|SSK1|hBUBR1 | |
| Cytomap | 15q15.1 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | small kinetochore-associated proteinTRAF4 associated factor 1kinastrinkinetochore-localized astrin-binding proteinputative TRAF4-associated factor 1small kinetochore associated proteinsmall kinetochore-associated protein, kinetochore-localized astri | mitotic checkpoint serine/threonine-protein kinase BUB1 betaBUB1B, mitotic checkpoint serine/threonine kinaseMAD3/BUB1-related protein kinasebudding uninhibited by benzimidazoles 1 homolog betamitotic checkpoint kinase MAD3L | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9Y448 | O60566 | |
| Ensembl transtripts involved in fusion gene | ENST00000416151, ENST00000249776, ENST00000448395, ENST00000608100, | ENST00000287598, ENST00000412359, ENST00000560120, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 4=80 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KNSTRN [Title/Abstract] AND BUB1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-25-1323-01A | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000416151 | ENST00000287598 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| In-frame | ENST00000416151 | ENST00000412359 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| 5CDS-intron | ENST00000416151 | ENST00000560120 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| In-frame | ENST00000249776 | ENST00000287598 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| In-frame | ENST00000249776 | ENST00000412359 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| 5CDS-intron | ENST00000249776 | ENST00000560120 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| 3UTR-3CDS | ENST00000448395 | ENST00000287598 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| 3UTR-3CDS | ENST00000448395 | ENST00000412359 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| 3UTR-intron | ENST00000448395 | ENST00000560120 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| In-frame | ENST00000608100 | ENST00000287598 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| In-frame | ENST00000608100 | ENST00000412359 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
| 5CDS-intron | ENST00000608100 | ENST00000560120 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
Top |
FusionProtFeatures for KNSTRN_BUB1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KNSTRN | BUB1B |
| Essential component of the mitotic spindle required forfaithful chromosome segregation and progression into anaphase(PubMed:19667759). Promotes the metaphase-to-anaphase transitionand is required for chromosome alignment, normal timing of sisterchromatid segregation, and maintenance of spindle polearchitecture (PubMed:19667759, PubMed:22110139). The astrin(SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required forkinetochore oscillations and dynamics of microtubule plus-endsduring live cell mitosis, possibly by forming a link betweenspindle microtubule plus-ends and mitotic chromosomes to achievefaithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, theseresults need additional evidences (PubMed:24718257).{ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792,ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123,ECO:0000305|PubMed:24718257}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000249776 | + | 8 | 9 | 166_216 | 274 | 317 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000416151 | + | 8 | 9 | 166_216 | 274 | 287 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000448395 | + | 7 | 8 | 166_216 | 253 | 407 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | + | 13 | 23 | 766_1050 | 578 | 1051 | Domain | Note=Protein kinase |
| Tgene | >BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | + | 13 | 23 | 766_1050 | 592 | 1065 | Domain | Note=Protein kinase |
| Tgene | >BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | + | 13 | 23 | 772_780 | 578 | 1051 | Nucleotide binding | ATP |
| Tgene | >BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | + | 13 | 23 | 772_780 | 592 | 1065 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000249776 | + | 8 | 9 | 248_316 | 274 | 317 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000416151 | + | 8 | 9 | 248_316 | 274 | 287 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000448395 | + | 7 | 8 | 248_316 | 253 | 407 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | + | 13 | 23 | 209_215 | 578 | 1051 | Compositional bias | Note=Poly-Glu |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | + | 13 | 23 | 209_215 | 592 | 1065 | Compositional bias | Note=Poly-Glu |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | + | 13 | 23 | 62_226 | 578 | 1051 | Domain | BUB1 N-terminal |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | + | 13 | 23 | 62_226 | 592 | 1065 | Domain | BUB1 N-terminal |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | + | 13 | 23 | 111_118 | 578 | 1051 | Motif | Nuclear localization signal |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | + | 13 | 23 | 224_232 | 578 | 1051 | Motif | Note=D-box |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | + | 13 | 23 | 111_118 | 592 | 1065 | Motif | Nuclear localization signal |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | + | 13 | 23 | 224_232 | 592 | 1065 | Motif | Note=D-box |
Top |
FusionGeneSequence for KNSTRN_BUB1B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KNSTRN_ENST00000416151_chr15_40684224_+_BUB1B_ENST00000287598_chr15_40498385_+_747aa MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVTSLQ PPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQM EELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTL SIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQTRRQLLKSLPELSASAELCIEDRPMPKLE IEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFTINLKLKERLNEDFDHFCSCTQTQDGCIVWHQTINCFTL QDLLQHSETITHEITVLIITNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPTDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQ ILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFD >In-frame_KNSTRN_ENST00000416151_chr15_40684224_+_BUB1B_ENST00000412359_chr15_40498385_+_747aa MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVTSLQ PPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQM EELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTL SIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQTRRQLLKSLPELSASAELCIEDRPMPKLE IEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFTINLKLKERLNEDFDHFCSCTQTQDGCIVWHQTINCFTL QDLLQHSETITHEITVLIITNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPTDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQ ILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFD >In-frame_KNSTRN_ENST00000249776_chr15_40684224_+_BUB1B_ENST00000287598_chr15_40498385_+_747aa MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVTSLQ PPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQM EELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTL SIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQTRRQLLKSLPELSASAELCIEDRPMPKLE IEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFTINLKLKERLNEDFDHFCSCTQTQDGCIVWHQTINCFTL QDLLQHSETITHEITVLIITNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPTDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQ ILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFD >In-frame_KNSTRN_ENST00000249776_chr15_40684224_+_BUB1B_ENST00000412359_chr15_40498385_+_747aa MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVTSLQ PPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQM EELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTL SIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQTRRQLLKSLPELSASAELCIEDRPMPKLE IEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFTINLKLKERLNEDFDHFCSCTQTQDGCIVWHQTINCFTL QDLLQHSETITHEITVLIITNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPTDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQ ILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFD >In-frame_KNSTRN_ENST00000608100_chr15_40684224_+_BUB1B_ENST00000287598_chr15_40498385_+_669aa MTSVVKTVTSLQPPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSK QKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEE LKLFNETAKKQMEELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQ QTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQTRRQLLKSLPELSASAE LCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFTINLKLKERLNEDFDHFCSCTQTQDGC IVWHQTINCFTLQDLLQHSETITHEITVLIITNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPTDCNKNNQALKIVDFSYSVDLRVQL DVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVL >In-frame_KNSTRN_ENST00000608100_chr15_40684224_+_BUB1B_ENST00000412359_chr15_40498385_+_669aa MTSVVKTVTSLQPPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSK QKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEE LKLFNETAKKQMEELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQ QTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQTRRQLLKSLPELSASAE LCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFTINLKLKERLNEDFDHFCSCTQTQDGC IVWHQTINCFTLQDLLQHSETITHEITVLIITNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPTDCNKNNQALKIVDFSYSVDLRVQL DVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KNSTRN_ENST00000416151_chr15_40684224_+_BUB1B_ENST00000287598_chr15_40498385_+_2241nt ATGGCGGCTCCCGAAGCCCCGCCCCTGGACAGAGTTTTCCGTACAACATGGCTGTCTACAGAGTGCGATTCCCACCCACTTCCGCCTAGC TACCGGAAGTTTCTATTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGGGAATCTTTTAAACGAGAGCGAGAAG GACTGCGGGCAGGACCGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGTGGTTAAGACAGTGTATAGCCTGCAG CCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCTCTTACCTGTTAGGTCCAAAGAAGTC GATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAGACGAGAGAATGGGCAAATGAAAGCT ACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGAGGAAGAGCTCAAGGACAAGAACCAG CTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGACCTGACCCAGAAGGTAGAGCTGCTG GAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAGTGAGACCCTGGCATCACGACAAGAA TCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTTTAACGAAACAGCCAAAAAGCAGATG GAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTTCAGAAATGTAACAATTTGTCCTAAC CCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAATGTCCTTGAAGGATCTCCCTTCTGAT CCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTGTGGCACTATCTACAGTCAGACTCTC AGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTCTGGTTCTTCTGCCTCGGTTGCAAGC ACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAACCCTACTCAGTCACCATGGTGTTCA CAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGAAGACAGACCAATGCCTAAGTTGGAA ATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGAAGATTACAAGTTATTCTGGGTGGCG CCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTATATCAACCTCAAGTTAAAGGAACGT TTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCACCAATATATAAACTGCTTCACCCTT CAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCTTTTGACAATAGTGGAGATGCTACAC AAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGATCCCTATGATTGTAACAAGAACAAT CAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTACCCTCAGCGGCTTTCGGACTGTACAG ATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTATAGCAGATTTAGCACATTTACTATTG TTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGAGCTAAAAGATGGTGAATTGTGGAAT AAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGCAGCAGAAATGAATGGGGTTTTTGAC >In-frame_KNSTRN_ENST00000416151_chr15_40684224_+_BUB1B_ENST00000412359_chr15_40498385_+_2241nt ATGGCGGCTCCCGAAGCCCCGCCCCTGGACAGAGTTTTCCGTACAACATGGCTGTCTACAGAGTGCGATTCCCACCCACTTCCGCCTAGC TACCGGAAGTTTCTATTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGGGAATCTTTTAAACGAGAGCGAGAAG GACTGCGGGCAGGACCGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGTGGTTAAGACAGTGTATAGCCTGCAG CCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCTCTTACCTGTTAGGTCCAAAGAAGTC GATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAGACGAGAGAATGGGCAAATGAAAGCT ACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGAGGAAGAGCTCAAGGACAAGAACCAG CTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGACCTGACCCAGAAGGTAGAGCTGCTG GAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAGTGAGACCCTGGCATCACGACAAGAA TCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTTTAACGAAACAGCCAAAAAGCAGATG GAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTTCAGAAATGTAACAATTTGTCCTAAC CCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAATGTCCTTGAAGGATCTCCCTTCTGAT CCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTGTGGCACTATCTACAGTCAGACTCTC AGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTCTGGTTCTTCTGCCTCGGTTGCAAGC ACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAACCCTACTCAGTCACCATGGTGTTCA CAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGAAGACAGACCAATGCCTAAGTTGGAA ATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGAAGATTACAAGTTATTCTGGGTGGCG CCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTATATCAACCTCAAGTTAAAGGAACGT TTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCACCAATATATAAACTGCTTCACCCTT CAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCTTTTGACAATAGTGGAGATGCTACAC AAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGATCCCTATGATTGTAACAAGAACAAT CAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTACCCTCAGCGGCTTTCGGACTGTACAG ATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTATAGCAGATTTAGCACATTTACTATTG TTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGAGCTAAAAGATGGTGAATTGTGGAAT AAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGCAGCAGAAATGAATGGGGTTTTTGAC >In-frame_KNSTRN_ENST00000249776_chr15_40684224_+_BUB1B_ENST00000287598_chr15_40498385_+_2241nt ATGGCGGCTCCCGAAGCCCCGCCCCTGGACAGAGTTTTCCGTACAACATGGCTGTCTACAGAGTGCGATTCCCACCCACTTCCGCCTAGC TACCGGAAGTTTCTATTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGGGAATCTTTTAAACGAGAGCGAGAAG GACTGCGGGCAGGACCGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGTGGTTAAGACAGTGTATAGCCTGCAG CCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCTCTTACCTGTTAGGTCCAAAGAAGTC GATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAGACGAGAGAATGGGCAAATGAAAGCT ACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGAGGAAGAGCTCAAGGACAAGAACCAG CTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGACCTGACCCAGAAGGTAGAGCTGCTG GAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAGTGAGACCCTGGCATCACGACAAGAA TCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTTTAACGAAACAGCCAAAAAGCAGATG GAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTTCAGAAATGTAACAATTTGTCCTAAC CCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAATGTCCTTGAAGGATCTCCCTTCTGAT CCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTGTGGCACTATCTACAGTCAGACTCTC AGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTCTGGTTCTTCTGCCTCGGTTGCAAGC ACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAACCCTACTCAGTCACCATGGTGTTCA CAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGAAGACAGACCAATGCCTAAGTTGGAA ATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGAAGATTACAAGTTATTCTGGGTGGCG CCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTATATCAACCTCAAGTTAAAGGAACGT TTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCACCAATATATAAACTGCTTCACCCTT CAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCTTTTGACAATAGTGGAGATGCTACAC AAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGATCCCTATGATTGTAACAAGAACAAT CAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTACCCTCAGCGGCTTTCGGACTGTACAG ATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTATAGCAGATTTAGCACATTTACTATTG TTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGAGCTAAAAGATGGTGAATTGTGGAAT AAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGCAGCAGAAATGAATGGGGTTTTTGAC >In-frame_KNSTRN_ENST00000249776_chr15_40684224_+_BUB1B_ENST00000412359_chr15_40498385_+_2241nt ATGGCGGCTCCCGAAGCCCCGCCCCTGGACAGAGTTTTCCGTACAACATGGCTGTCTACAGAGTGCGATTCCCACCCACTTCCGCCTAGC TACCGGAAGTTTCTATTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGGGAATCTTTTAAACGAGAGCGAGAAG GACTGCGGGCAGGACCGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGTGGTTAAGACAGTGTATAGCCTGCAG CCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCTCTTACCTGTTAGGTCCAAAGAAGTC GATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAGACGAGAGAATGGGCAAATGAAAGCT ACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGAGGAAGAGCTCAAGGACAAGAACCAG CTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGACCTGACCCAGAAGGTAGAGCTGCTG GAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAGTGAGACCCTGGCATCACGACAAGAA TCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTTTAACGAAACAGCCAAAAAGCAGATG GAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTTCAGAAATGTAACAATTTGTCCTAAC CCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAATGTCCTTGAAGGATCTCCCTTCTGAT CCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTGTGGCACTATCTACAGTCAGACTCTC AGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTCTGGTTCTTCTGCCTCGGTTGCAAGC ACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAACCCTACTCAGTCACCATGGTGTTCA CAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGAAGACAGACCAATGCCTAAGTTGGAA ATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGAAGATTACAAGTTATTCTGGGTGGCG CCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTATATCAACCTCAAGTTAAAGGAACGT TTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCACCAATATATAAACTGCTTCACCCTT CAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCTTTTGACAATAGTGGAGATGCTACAC AAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGATCCCTATGATTGTAACAAGAACAAT CAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTACCCTCAGCGGCTTTCGGACTGTACAG ATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTATAGCAGATTTAGCACATTTACTATTG TTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGAGCTAAAAGATGGTGAATTGTGGAAT AAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGCAGCAGAAATGAATGGGGTTTTTGAC >In-frame_KNSTRN_ENST00000608100_chr15_40684224_+_BUB1B_ENST00000287598_chr15_40498385_+_2007nt ATGACCAGTGTGGTTAAGACAGTGTATAGCCTGCAGCCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACT TCTAAGAGTCTCTTACCTGTTAGGTCCAAAGAAGTCGATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATC ACCAAACTGAGACGAGAGAATGGGCAAATGAAAGCTACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAG CAAAAATCAGAGGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGA GAGCTGAAGGACCTGACCCAGAAGGTAGAGCTGCTGGAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCA GCTTTAGGCAGTGAGACCCTGGCATCACGACAAGAATCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAG CTGAAGCTTTTTAACGAAACAGCCAAAAAGCAGATGGAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATT ATCACAGGCTTCAGAAATGTAACAATTTGTCCTAACCCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTT CATGAGATAATGTCCTTGAAGGATCTCCCTTCTGATCCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAG CAGACAGCTTGTGGCACTATCTACAGTCAGACTCTCAGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCC TCTGGCTTCTCTGGTTCTTCTGCCTCGGTTGCAAGCACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAG ACTTCAGAAAACCCTACTCAGTCACCATGGTGTTCACAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAG TTGTGTATAGAAGACAGACCAATGCCTAAGTTGGAAATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATAC CTAATATGTGAAGATTACAAGTTATTCTGGGTGGCGCCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCA TGGGACTTTTATATCAACCTCAAGTTAAAGGAACGTTTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGT ATTGTTTGGCACCAATATATAAACTGCTTCACCCTTCAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATT ATTTATAACCTTTTGACAATAGTGGAGATGCTACACAAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAAC AGAATCCACGATCCCTATGATTGTAACAAGAACAATCAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTG GATGTTTTTACCCTCAGCGGCTTTCGGACTGTACAGATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGAC CTGTTTGGTATAGCAGATTTAGCACATTTACTATTGTTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAA AATATTTCTGAGCTAAAAGATGGTGAATTGTGGAATAAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTT GGGGAGCTTGCAGCAGAAATGAATGGGGTTTTTGACACTACATTCCAAAGTCACCTGAACAAAGCCTTATGGAAGGTAGGGAAGTTAACT >In-frame_KNSTRN_ENST00000608100_chr15_40684224_+_BUB1B_ENST00000412359_chr15_40498385_+_2007nt ATGACCAGTGTGGTTAAGACAGTGTATAGCCTGCAGCCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACT TCTAAGAGTCTCTTACCTGTTAGGTCCAAAGAAGTCGATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATC ACCAAACTGAGACGAGAGAATGGGCAAATGAAAGCTACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAG CAAAAATCAGAGGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGA GAGCTGAAGGACCTGACCCAGAAGGTAGAGCTGCTGGAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCA GCTTTAGGCAGTGAGACCCTGGCATCACGACAAGAATCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAG CTGAAGCTTTTTAACGAAACAGCCAAAAAGCAGATGGAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATT ATCACAGGCTTCAGAAATGTAACAATTTGTCCTAACCCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTT CATGAGATAATGTCCTTGAAGGATCTCCCTTCTGATCCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAG CAGACAGCTTGTGGCACTATCTACAGTCAGACTCTCAGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCC TCTGGCTTCTCTGGTTCTTCTGCCTCGGTTGCAAGCACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAG ACTTCAGAAAACCCTACTCAGTCACCATGGTGTTCACAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAG TTGTGTATAGAAGACAGACCAATGCCTAAGTTGGAAATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATAC CTAATATGTGAAGATTACAAGTTATTCTGGGTGGCGCCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCA TGGGACTTTTATATCAACCTCAAGTTAAAGGAACGTTTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGT ATTGTTTGGCACCAATATATAAACTGCTTCACCCTTCAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATT ATTTATAACCTTTTGACAATAGTGGAGATGCTACACAAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAAC AGAATCCACGATCCCTATGATTGTAACAAGAACAATCAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTG GATGTTTTTACCCTCAGCGGCTTTCGGACTGTACAGATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGAC CTGTTTGGTATAGCAGATTTAGCACATTTACTATTGTTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAA AATATTTCTGAGCTAAAAGATGGTGAATTGTGGAATAAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTT GGGGAGCTTGCAGCAGAAATGAATGGGGTTTTTGACACTACATTCCAAAGTCACCTGAACAAAGCCTTATGGAAGGTAGGGAAGTTAACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KNSTRN_ENST00000416151_chr15_40684224_+_BUB1B_ENST00000287598_chr15_40498385_+_2733nt ATTAGCTCCATTCAAGCCTACAAATTGCATCACCCTCCTCCTCTGCCCAGACCTGGGGGCTCCAACACCTTTCGCTAGGTCTGGCTCTGG CCTCTGAGCGAACCTTCCGTACAGTATGGCGGCTCCCGAAGCCCCGCCCCTGGACAGAGTTTTCCGTACAACATGGCTGTCTACAGAGTG CGATTCCCACCCACTTCCGCCTAGCTACCGGAAGTTTCTATTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGG GAATCTTTTAAACGAGAGCGAGAAGGACTGCGGGCAGGACCGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGT GGTTAAGACAGTGTATAGCCTGCAGCCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCT CTTACCTGTTAGGTCCAAAGAAGTCGATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAG ACGAGAGAATGGGCAAATGAAAGCTACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGA GGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGA CCTGACCCAGAAGGTAGAGCTGCTGGAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAG TGAGACCCTGGCATCACGACAAGAATCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTT TAACGAAACAGCCAAAAAGCAGATGGAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTT CAGAAATGTAACAATTTGTCCTAACCCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAAT GTCCTTGAAGGATCTCCCTTCTGATCCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTG TGGCACTATCTACAGTCAGACTCTCAGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTC TGGTTCTTCTGCCTCGGTTGCAAGCACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAA CCCTACTCAGTCACCATGGTGTTCACAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGA AGACAGACCAATGCCTAAGTTGGAAATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGA AGATTACAAGTTATTCTGGGTGGCGCCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTA TATCAACCTCAAGTTAAAGGAACGTTTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCA CCAATATATAAACTGCTTCACCCTTCAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCT TTTGACAATAGTGGAGATGCTACACAAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGA TCCCTATGATTGTAACAAGAACAATCAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTAC CCTCAGCGGCTTTCGGACTGTACAGATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTAT AGCAGATTTAGCACATTTACTATTGTTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGA GCTAAAAGATGGTGAATTGTGGAATAAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGC AGCAGAAATGAATGGGGTTTTTGACACTACATTCCAAAGTCACCTGAACAAAGCCTTATGGAAGGTAGGGAAGTTAACTAGTCCTGGGGC TTTGCTCTTTCAGTGAGCTAGGCAATCAAGTCTCACAGATTGCTGCCTCAGAGCAATGGTTGTATTGTGGAACACTGAAACTGTATGTGC TGTAATTTAATTTAGGACACATTTAGATGCACTACCATTGCTGTTCTACTTTTTGGTACAGGTATATTTTGACGTCACTGATATTTTTTA TACAGTGATATACTTACTCATGGCCTTGTCTAACTTTTGTGAAGAACTATTTTATTCTAAACAGACTCATTACAAATGGTTACCTTGTTA TTTAACCCATTTGTCTCTACTTTTCCCTGTACTTTTCCCATTTGTAATTTGTAAAATGTTCTCTTATGATCACCATGTATTTTGTAAATA >In-frame_KNSTRN_ENST00000416151_chr15_40684224_+_BUB1B_ENST00000412359_chr15_40498385_+_2635nt ATTAGCTCCATTCAAGCCTACAAATTGCATCACCCTCCTCCTCTGCCCAGACCTGGGGGCTCCAACACCTTTCGCTAGGTCTGGCTCTGG CCTCTGAGCGAACCTTCCGTACAGTATGGCGGCTCCCGAAGCCCCGCCCCTGGACAGAGTTTTCCGTACAACATGGCTGTCTACAGAGTG CGATTCCCACCCACTTCCGCCTAGCTACCGGAAGTTTCTATTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGG GAATCTTTTAAACGAGAGCGAGAAGGACTGCGGGCAGGACCGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGT GGTTAAGACAGTGTATAGCCTGCAGCCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCT CTTACCTGTTAGGTCCAAAGAAGTCGATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAG ACGAGAGAATGGGCAAATGAAAGCTACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGA GGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGA CCTGACCCAGAAGGTAGAGCTGCTGGAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAG TGAGACCCTGGCATCACGACAAGAATCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTT TAACGAAACAGCCAAAAAGCAGATGGAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTT CAGAAATGTAACAATTTGTCCTAACCCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAAT GTCCTTGAAGGATCTCCCTTCTGATCCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTG TGGCACTATCTACAGTCAGACTCTCAGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTC TGGTTCTTCTGCCTCGGTTGCAAGCACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAA CCCTACTCAGTCACCATGGTGTTCACAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGA AGACAGACCAATGCCTAAGTTGGAAATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGA AGATTACAAGTTATTCTGGGTGGCGCCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTA TATCAACCTCAAGTTAAAGGAACGTTTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCA CCAATATATAAACTGCTTCACCCTTCAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCT TTTGACAATAGTGGAGATGCTACACAAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGA TCCCTATGATTGTAACAAGAACAATCAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTAC CCTCAGCGGCTTTCGGACTGTACAGATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTAT AGCAGATTTAGCACATTTACTATTGTTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGA GCTAAAAGATGGTGAATTGTGGAATAAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGC AGCAGAAATGAATGGGGTTTTTGACACTACATTCCAAAGTCACCTGAACAAAGCCTTATGGAAGGTAGGGAAGTTAACTAGTCCTGGGGC TTTGCTCTTTCAGTGAGCTAGGCAATCAAGTCTCACAGATTGCTGCCTCAGAGCAATGGTTGTATTGTGGAACACTGAAACTGTATGTGC TGTAATTTAATTTAGGACACATTTAGATGCACTACCATTGCTGTTCTACTTTTTGGTACAGGTATATTTTGACGTCACTGATATTTTTTA TACAGTGATATACTTACTCATGGCCTTGTCTAACTTTTGTGAAGAACTATTTTATTCTAAACAGACTCATTACAAATGGTTACCTTGTTA >In-frame_KNSTRN_ENST00000249776_chr15_40684224_+_BUB1B_ENST00000287598_chr15_40498385_+_2733nt ATTAGCTCCATTCAAGCCTACAAATTGCATCACCCTCCTCCTCTGCCCAGACCTGGGGGCTCCAACACCTTTCGCTAGGTCTGGCTCTGG CCTCTGAGCGAACCTTCCGTACAGTATGGCGGCTCCCGAAGCCCCGCCCCTGGACAGAGTTTTCCGTACAACATGGCTGTCTACAGAGTG CGATTCCCACCCACTTCCGCCTAGCTACCGGAAGTTTCTATTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGG GAATCTTTTAAACGAGAGCGAGAAGGACTGCGGGCAGGACCGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGT GGTTAAGACAGTGTATAGCCTGCAGCCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCT CTTACCTGTTAGGTCCAAAGAAGTCGATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAG ACGAGAGAATGGGCAAATGAAAGCTACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGA GGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGA CCTGACCCAGAAGGTAGAGCTGCTGGAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAG TGAGACCCTGGCATCACGACAAGAATCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTT TAACGAAACAGCCAAAAAGCAGATGGAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTT CAGAAATGTAACAATTTGTCCTAACCCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAAT GTCCTTGAAGGATCTCCCTTCTGATCCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTG TGGCACTATCTACAGTCAGACTCTCAGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTC TGGTTCTTCTGCCTCGGTTGCAAGCACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAA CCCTACTCAGTCACCATGGTGTTCACAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGA AGACAGACCAATGCCTAAGTTGGAAATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGA AGATTACAAGTTATTCTGGGTGGCGCCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTA TATCAACCTCAAGTTAAAGGAACGTTTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCA CCAATATATAAACTGCTTCACCCTTCAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCT TTTGACAATAGTGGAGATGCTACACAAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGA TCCCTATGATTGTAACAAGAACAATCAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTAC CCTCAGCGGCTTTCGGACTGTACAGATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTAT AGCAGATTTAGCACATTTACTATTGTTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGA GCTAAAAGATGGTGAATTGTGGAATAAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGC AGCAGAAATGAATGGGGTTTTTGACACTACATTCCAAAGTCACCTGAACAAAGCCTTATGGAAGGTAGGGAAGTTAACTAGTCCTGGGGC TTTGCTCTTTCAGTGAGCTAGGCAATCAAGTCTCACAGATTGCTGCCTCAGAGCAATGGTTGTATTGTGGAACACTGAAACTGTATGTGC TGTAATTTAATTTAGGACACATTTAGATGCACTACCATTGCTGTTCTACTTTTTGGTACAGGTATATTTTGACGTCACTGATATTTTTTA TACAGTGATATACTTACTCATGGCCTTGTCTAACTTTTGTGAAGAACTATTTTATTCTAAACAGACTCATTACAAATGGTTACCTTGTTA TTTAACCCATTTGTCTCTACTTTTCCCTGTACTTTTCCCATTTGTAATTTGTAAAATGTTCTCTTATGATCACCATGTATTTTGTAAATA >In-frame_KNSTRN_ENST00000249776_chr15_40684224_+_BUB1B_ENST00000412359_chr15_40498385_+_2635nt ATTAGCTCCATTCAAGCCTACAAATTGCATCACCCTCCTCCTCTGCCCAGACCTGGGGGCTCCAACACCTTTCGCTAGGTCTGGCTCTGG CCTCTGAGCGAACCTTCCGTACAGTATGGCGGCTCCCGAAGCCCCGCCCCTGGACAGAGTTTTCCGTACAACATGGCTGTCTACAGAGTG CGATTCCCACCCACTTCCGCCTAGCTACCGGAAGTTTCTATTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGG GAATCTTTTAAACGAGAGCGAGAAGGACTGCGGGCAGGACCGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGT GGTTAAGACAGTGTATAGCCTGCAGCCCCCCTCTGCGCTGAGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCT CTTACCTGTTAGGTCCAAAGAAGTCGATGTTTCCAAACAGCTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAG ACGAGAGAATGGGCAAATGAAAGCTACTGACACTGCCACCAGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGA GGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAGCCGTCAACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGA CCTGACCCAGAAGGTAGAGCTGCTGGAGAAGTTTCGGGACAACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAG TGAGACCCTGGCATCACGACAAGAATCCACTACTGATCACATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTT TAACGAAACAGCCAAAAAGCAGATGGAGGAGTTACAGGATGAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTT CAGAAATGTAACAATTTGTCCTAACCCAGAAGACACTTGTGACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAAT GTCCTTGAAGGATCTCCCTTCTGATCCTGAGAGACTGTTACCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTG TGGCACTATCTACAGTCAGACTCTCAGCATCAAGAAGCTGAGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTC TGGTTCTTCTGCCTCGGTTGCAAGCACCTCCTCCATCAAATGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAA CCCTACTCAGTCACCATGGTGTTCACAGTATCGCAGACAGCTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGA AGACAGACCAATGCCTAAGTTGGAAATTGAGAAGGAAATTGAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGA AGATTACAAGTTATTCTGGGTGGCGCCAAGAAACTCTGCAGAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTA TATCAACCTCAAGTTAAAGGAACGTTTAAATGAAGATTTTGATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCA CCAATATATAAACTGCTTCACCCTTCAGGATCTTCTCCAACACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCT TTTGACAATAGTGGAGATGCTACACAAAGCAGAAATAGTCCATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGA TCCCTATGATTGTAACAAGAACAATCAAGCTTTGAAGATAGTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTAC CCTCAGCGGCTTTCGGACTGTACAGATCCTGGAAGGACAAAAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTAT AGCAGATTTAGCACATTTACTATTGTTCAAGGAACACCTACAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGA GCTAAAAGATGGTGAATTGTGGAATAAATTCTTTGTGCGGATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGC AGCAGAAATGAATGGGGTTTTTGACACTACATTCCAAAGTCACCTGAACAAAGCCTTATGGAAGGTAGGGAAGTTAACTAGTCCTGGGGC TTTGCTCTTTCAGTGAGCTAGGCAATCAAGTCTCACAGATTGCTGCCTCAGAGCAATGGTTGTATTGTGGAACACTGAAACTGTATGTGC TGTAATTTAATTTAGGACACATTTAGATGCACTACCATTGCTGTTCTACTTTTTGGTACAGGTATATTTTGACGTCACTGATATTTTTTA TACAGTGATATACTTACTCATGGCCTTGTCTAACTTTTGTGAAGAACTATTTTATTCTAAACAGACTCATTACAAATGGTTACCTTGTTA >In-frame_KNSTRN_ENST00000608100_chr15_40684224_+_BUB1B_ENST00000287598_chr15_40498385_+_2513nt TTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGGGAATCTTTTAAACGAGAGCGAGAAGGACTGCGGGCAGGAC CGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGTGGTTAAGACAGTGTATAGCCTGCAGCCCCCCTCTGCGCTG AGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCTCTTACCTGTTAGGTCCAAAGAAGTCGATGTTTCCAAACAG CTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAGACGAGAGAATGGGCAAATGAAAGCTACTGACACTGCCACC AGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGAGGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAGCCGTC AACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGACCTGACCCAGAAGGTAGAGCTGCTGGAGAAGTTTCGGGAC AACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAGTGAGACCCTGGCATCACGACAAGAATCCACTACTGATCAC ATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTTTAACGAAACAGCCAAAAAGCAGATGGAGGAGTTACAGGAT GAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTTCAGAAATGTAACAATTTGTCCTAACCCAGAAGACACTTGT GACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAATGTCCTTGAAGGATCTCCCTTCTGATCCTGAGAGACTGTTA CCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTGTGGCACTATCTACAGTCAGACTCTCAGCATCAAGAAGCTG AGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTCTGGTTCTTCTGCCTCGGTTGCAAGCACCTCCTCCATCAAA TGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAACCCTACTCAGTCACCATGGTGTTCACAGTATCGCAGACAG CTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGAAGACAGACCAATGCCTAAGTTGGAAATTGAGAAGGAAATT GAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGAAGATTACAAGTTATTCTGGGTGGCGCCAAGAAACTCTGCA GAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTATATCAACCTCAAGTTAAAGGAACGTTTAAATGAAGATTTT GATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCACCAATATATAAACTGCTTCACCCTTCAGGATCTTCTCCAA CACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCTTTTGACAATAGTGGAGATGCTACACAAAGCAGAAATAGTC CATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGATCCCTATGATTGTAACAAGAACAATCAAGCTTTGAAGATA GTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTACCCTCAGCGGCTTTCGGACTGTACAGATCCTGGAAGGACAA AAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTATAGCAGATTTAGCACATTTACTATTGTTCAAGGAACACCTA CAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGAGCTAAAAGATGGTGAATTGTGGAATAAATTCTTTGTGCGG ATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGCAGCAGAAATGAATGGGGTTTTTGACACTACATTCCAAAGT CACCTGAACAAAGCCTTATGGAAGGTAGGGAAGTTAACTAGTCCTGGGGCTTTGCTCTTTCAGTGAGCTAGGCAATCAAGTCTCACAGAT TGCTGCCTCAGAGCAATGGTTGTATTGTGGAACACTGAAACTGTATGTGCTGTAATTTAATTTAGGACACATTTAGATGCACTACCATTG CTGTTCTACTTTTTGGTACAGGTATATTTTGACGTCACTGATATTTTTTATACAGTGATATACTTACTCATGGCCTTGTCTAACTTTTGT GAAGAACTATTTTATTCTAAACAGACTCATTACAAATGGTTACCTTGTTATTTAACCCATTTGTCTCTACTTTTCCCTGTACTTTTCCCA >In-frame_KNSTRN_ENST00000608100_chr15_40684224_+_BUB1B_ENST00000412359_chr15_40498385_+_2415nt TTTGAAACCCAGGCGGCCGACTTAGCCGGTGGCACGACAGTTGCTGCAGGGAATCTTTTAAACGAGAGCGAGAAGGACTGCGGGCAGGAC CGGCGGGCTCCTGGGGTTCAGCCGTGCCGCCTCGTTACGATGACCAGTGTGGTTAAGACAGTGTATAGCCTGCAGCCCCCCTCTGCGCTG AGCGGCGGCCAGCCGGCAGACACACAAACTCGGGCCACTTCTAAGAGTCTCTTACCTGTTAGGTCCAAAGAAGTCGATGTTTCCAAACAG CTTCATTCAGGAGGTCCAGAGAATGATGTTACAAAAATCACCAAACTGAGACGAGAGAATGGGCAAATGAAAGCTACTGACACTGCCACC AGAAGGAATGTCAGAAAAGGCTACAAACCACTGAGTAAGCAAAAATCAGAGGAAGAGCTCAAGGACAAGAACCAGCTGTTAGAAGCCGTC AACAAGCAGTTGCACCAGAAGTTGACTGAAACTCAGGGAGAGCTGAAGGACCTGACCCAGAAGGTAGAGCTGCTGGAGAAGTTTCGGGAC AACTGTTTGGCAATTTTGGAGAGCAAGGGCCTTGATCCAGCTTTAGGCAGTGAGACCCTGGCATCACGACAAGAATCCACTACTGATCAC ATGGACTCTATGTTGCTGTTAGAAACTTTGCAAGAGGAGCTGAAGCTTTTTAACGAAACAGCCAAAAAGCAGATGGAGGAGTTACAGGAT GAATTTACAGGAATTGAACCCTTGAGCGAGGATGCCATTATCACAGGCTTCAGAAATGTAACAATTTGTCCTAACCCAGAAGACACTTGT GACTTTGCCAGAGCAGCTCGTTTTGTATCCACTCCTTTTCATGAGATAATGTCCTTGAAGGATCTCCCTTCTGATCCTGAGAGACTGTTA CCGGAAGAAGATCTAGATGTAAAGACCTCTGAGGACCAGCAGACAGCTTGTGGCACTATCTACAGTCAGACTCTCAGCATCAAGAAGCTG AGCCCAATTATTGAAGACAGTCGTGAAGCCACACACTCCTCTGGCTTCTCTGGTTCTTCTGCCTCGGTTGCAAGCACCTCCTCCATCAAA TGTCTTCAAATTCCTGAGAAACTAGAACTTACTAATGAGACTTCAGAAAACCCTACTCAGTCACCATGGTGTTCACAGTATCGCAGACAG CTACTGAAGTCCCTACCAGAGTTAAGTGCCTCTGCAGAGTTGTGTATAGAAGACAGACCAATGCCTAAGTTGGAAATTGAGAAGGAAATT GAATTAGGTAATGAGGATTACTGCATTAAACGAGAATACCTAATATGTGAAGATTACAAGTTATTCTGGGTGGCGCCAAGAAACTCTGCA GAATTAACAGTAATAAAGGTATCTTCTCAACCTGTCCCATGGGACTTTTATATCAACCTCAAGTTAAAGGAACGTTTAAATGAAGATTTT GATCATTTTTGCAGCTGTTATCAATATCAAGATGGCTGTATTGTTTGGCACCAATATATAAACTGCTTCACCCTTCAGGATCTTCTCCAA CACAGTGAATATATTACCCATGAAATAACAGTGTTGATTATTTATAACCTTTTGACAATAGTGGAGATGCTACACAAAGCAGAAATAGTC CATGGTGACTTGAGTCCAAGGTGTCTGATTCTCAGAAACAGAATCCACGATCCCTATGATTGTAACAAGAACAATCAAGCTTTGAAGATA GTGGACTTTTCCTACAGTGTTGACCTTAGGGTGCAGCTGGATGTTTTTACCCTCAGCGGCTTTCGGACTGTACAGATCCTGGAAGGACAA AAGATCCTGGCTAACTGTTCTTCTCCCTACCAGGTAGACCTGTTTGGTATAGCAGATTTAGCACATTTACTATTGTTCAAGGAACACCTA CAGGTCTTCTGGGATGGGTCCTTCTGGAAACTTAGCCAAAATATTTCTGAGCTAAAAGATGGTGAATTGTGGAATAAATTCTTTGTGCGG ATTCTGAATGCCAATGATGAGGCCACAGTGTCTGTTCTTGGGGAGCTTGCAGCAGAAATGAATGGGGTTTTTGACACTACATTCCAAAGT CACCTGAACAAAGCCTTATGGAAGGTAGGGAAGTTAACTAGTCCTGGGGCTTTGCTCTTTCAGTGAGCTAGGCAATCAAGTCTCACAGAT TGCTGCCTCAGAGCAATGGTTGTATTGTGGAACACTGAAACTGTATGTGCTGTAATTTAATTTAGGACACATTTAGATGCACTACCATTG CTGTTCTACTTTTTGGTACAGGTATATTTTGACGTCACTGATATTTTTTATACAGTGATATACTTACTCATGGCCTTGTCTAACTTTTGT |
Top |
FusionGenePPI for KNSTRN_BUB1B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KNSTRN | MPP6, MAPK6, CHMP1B, CLU, ENO1, SHMT2, MOV10, NXF1, NUPR1, ZDHHC17, USB1, CCDC101, CEP170, IFT57, C17orf59, CCDC67, PRPF19, HSPA8, HSPA1A, HSPA6, HSPB1, PCM1, SPICE1, CEP44, DCTN1, HSPA5, KIF22, DYNLL1, MAPRE1, SMEK1, SSSCA1, TACC1, CCDC89, SYCE3, IFT74, COPS7B | BUB1B | HDAC1, BRCA2, SNCG, CDC20, BUB3, MAD2L1, CENPE, AP2B1, APC, CDC27, CDC16, ANAPC7, UBE2C, PARP1, KAT2B, ANAPC4, BUB1, MIS12, ZWINT, BUB1B, NSL1, DNMBP, MXI1, MDM2, MAD2L1BP, PLK1, TUBB, CASC5, TP73, AJUBA, AURKB, PLK3, PTTG1, SGOL1, DAXX, FZR1, TRIM33, COMMD4, GANAB, PRKCSH, PNMA2, UGP2, TRIP13, SUMO1, ANAPC1, ANAPC2, BAG2, DSN1, ZFC3H1, CCT2, EEF2, HSPB1, HSPH1, NDC80, NUF2, PMF1, PSMA3, PSMA4, PSMA6, PSMB5, PSMD6, RPL39, SKIV2L2, RAE1, UBR5, CCNA2, FBXW7, BTRC, MED4, XPO1, CD14, CDC23, SMEK1, CERK, ANAPC10, NEK2, SNW1, CDC5L, PPP2R5A, TYW3, HDAC2, HDAC3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000249776 | + | 8 | 9 | 159_316 | 274 | 317 | SPAG5 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000416151 | + | 8 | 9 | 159_316 | 274 | 287 | SPAG5 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000448395 | + | 7 | 8 | 159_316 | 253 | 407 | SPAG5 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for KNSTRN_BUB1B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for KNSTRN_BUB1B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KNSTRN | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | BUB1B | C0018273 | Growth Disorders | 1 | CTD_human |
| Tgene | BUB1B | C0025958 | Microcephaly | 1 | CTD_human |
| Tgene | BUB1B | C0206656 | Rhabdomyosarcoma, Embryonal | 1 | CTD_human |
| Tgene | BUB1B | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | BUB1B | C1850343 | MOSAIC VARIEGATED ANEUPLOIDY SYNDROME | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | BUB1B | C1864389 | PREMATURE CHROMATID SEPARATION TRAIT | 1 | CTD_human;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|