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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19153

FusionGeneSummary for KNG1_ALB

check button Fusion gene summary
Fusion gene informationFusion gene name: KNG1_ALB
Fusion gene ID: 19153
HgeneTgene
Gene symbol

KNG1

ALB

Gene ID

3827

213

Gene namekininogen 1albumin
SynonymsBDK|BK|HMWK|KNGHSA|PRO0883|PRO0903|PRO1341
Cytomap

3q27.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionkininogen-1alpha-2-thiol proteinase inhibitorbradykininfitzgerald factorhigh molecular weight kininogenwilliams-Fitzgerald-Flaujeac factorserum albumin
Modification date2018052320180522
UniProtAcc

P01042

P02768

Ensembl transtripts involved in fusion geneENST00000287611, ENST00000265023, 
ENST00000447445, 		ENST00000295897, 
ENST00000415165, ENST00000503124, 
ENST00000509063, ENST00000401494, 
ENST00000505649, 
Fusion gene scores* DoF score1 X 1 X 1=127 X 26 X 2=1404
# samples 133
** MAII scorelog2(1/1*10)=3.32192809488736log2(33/1404*10)=-2.08900500605874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KNG1 [Title/Abstract] AND ALB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKNG1

GO:0007162

negative regulation of cell adhesion

11970955

HgeneKNG1

GO:0007204

positive regulation of cytosolic calcium ion concentration

16014619

HgeneKNG1

GO:0030195

negative regulation of blood coagulation

11970955

HgeneKNG1

GO:0045861

negative regulation of proteolysis

3488317

TgeneALB

GO:0009267

cellular response to starvation

16245148

TgeneALB

GO:0019836

hemolysis by symbiont of host erythrocytes

16394536

TgeneALB

GO:0043066

negative regulation of apoptotic process

16153637

TgeneALB

GO:0051659

maintenance of mitochondrion location

16153637


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA640348KNG1chr3

186435462

+ALBchr4

74270004

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000287611ENST00000295897KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-5UTRENST00000287611ENST00000415165KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000287611ENST00000503124KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000287611ENST00000509063KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000287611ENST00000401494KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000287611ENST00000505649KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-5UTRENST00000265023ENST00000295897KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-5UTRENST00000265023ENST00000415165KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000265023ENST00000503124KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000265023ENST00000509063KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000265023ENST00000401494KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000265023ENST00000505649KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-5UTRENST00000447445ENST00000295897KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-5UTRENST00000447445ENST00000415165KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000447445ENST00000503124KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000447445ENST00000509063KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000447445ENST00000401494KNG1chr3

186435462

+ALBchr4

74270004

+
5CDS-intronENST00000447445ENST00000505649KNG1chr3

186435462

+ALBchr4

74270004

+

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FusionProtFeatures for KNG1_ALB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KNG1

P01042

ALB

P02768

(1) Kininogens are inhibitors of thiol proteases; (2)HMW-kininogen plays an important role in blood coagulation byhelping to position optimally prekallikrein and factor XI next tofactor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptidebradykinin that is released from HMW-kininogen shows a variety ofphysiological effects: (4A) influence in smooth musclecontraction, (4B) induction of hypotension, (4C) natriuresis anddiuresis, (4D) decrease in blood glucose level, (4E) it is amediator of inflammation and causes (4E1) increase in vascularpermeability, (4E2) stimulation of nociceptors (4E3) release ofother mediators of inflammation (e.g. prostaglandins), (4F) it hasa cardioprotective effect (directly via bradykinin action,indirectly via endothelium-derived relaxing factor action); (5)LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in bloodclotting.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KNG1_ALB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KNG1_ALB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KNG1_ALB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneKNG1P01042DB01593ZincKininogen-1small moleculeapproved|investigational
TgeneALBP02768DB00493CefotaximeSerum albuminsmall moleculeapproved
TgeneALBP02768DB01045RifampicinSerum albuminsmall moleculeapproved
TgeneALBP02768DB03255PhenolSerum albuminsmall moleculeapproved|experimental
TgeneALBP02768DB00276AmsacrineSerum albuminsmall moleculeapproved|investigational
TgeneALBP02768DB00545PyridostigmineSerum albuminsmall moleculeapproved|investigational
TgeneALBP02768DB06713NorelgestrominSerum albuminsmall moleculeapproved|investigational
TgeneALBP02768DB11638ArtenimolSerum albuminsmall moleculeapproved|investigational
TgeneALBP02768DB00199ErythromycinSerum albuminsmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for KNG1_ALB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKNG1C0020429Hyperalgesia17CTD_human
HgeneKNG1C0020649Hypotension9CTD_human
HgeneKNG1C0030193Pain6CTD_human
HgeneKNG1C0011609Drug Eruptions2CTD_human
HgeneKNG1C0027055Myocardial Reperfusion Injury2CTD_human
HgeneKNG1C2609414Acute kidney injury2CTD_human
HgeneKNG1C0002792anaphylaxis1CTD_human
HgeneKNG1C0003811Cardiac Arrhythmia1CTD_human
HgeneKNG1C0010200Coughing1CTD_human
HgeneKNG1C0013604Edema1CTD_human
HgeneKNG1C0015379Extravasation of Diagnostic and Therapeutic Materials1CTD_human
HgeneKNG1C0019243Angioedemas, Hereditary1CTD_human
HgeneKNG1C0020452Hyperemia1CTD_human
HgeneKNG1C0020453Hyperesthesia1CTD_human
HgeneKNG1C0020517Hypersensitivity1CTD_human
HgeneKNG1C0020538Hypertensive disease1CTD_human
HgeneKNG1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneKNG1C0024667Animal Mammary Neoplasms1CTD_human
HgeneKNG1C0039231Tachycardia1CTD_human
HgeneKNG1C0428977Bradycardia1CTD_human
HgeneKNG1C2931758Acquired angioedema1CTD_human
TgeneALBC0033687Proteinuria9CTD_human
TgeneALBC0017658Glomerulonephritis8CTD_human
TgeneALBC0022658Kidney Diseases8CTD_human
TgeneALBC0017665Membranous glomerulonephritis6CTD_human
TgeneALBC0027697Nephritis6CTD_human
TgeneALBC0027707Nephritis, Interstitial4CTD_human
TgeneALBC0038454Cerebrovascular accident4CTD_human
TgeneALBC0342185Hyperthyroxinemia, Familial Dysalbuminemic4CTD_human;UNIPROT
TgeneALBC0023893Liver Cirrhosis, Experimental3CTD_human
TgeneALBC0025290Aseptic Meningitis3CTD_human
TgeneALBC2609414Acute kidney injury3CTD_human
TgeneALBC0014544Epilepsy2CTD_human
TgeneALBC0020649Hypotension2CTD_human;HPO
TgeneALBC0023890Liver Cirrhosis2CTD_human
TgeneALBC0027726Nephrotic Syndrome2CTD_human
TgeneALBC0036830Serum Sickness2CTD_human
TgeneALBC0162557Liver Failure, Acute2CTD_human
TgeneALBC4277682Chemical and Drug Induced Liver Injury2CTD_human
TgeneALBC0002994Angioedema1CTD_human
TgeneALBC0003460Anuria1CTD_human
TgeneALBC0004509Azoospermia1CTD_human
TgeneALBC0006111Brain Diseases1CTD_human
TgeneALBC0007222Cardiovascular Diseases1CTD_human
TgeneALBC0007786Brain Ischemia1CTD_human
TgeneALBC0011581Depressive disorder1CTD_human
TgeneALBC0011875Diabetic Angiopathies1CTD_human
TgeneALBC0011881Diabetic Nephropathy1CTD_human
TgeneALBC0013502Echinococcosis1CTD_human
TgeneALBC0016059Fibrosis1CTD_human
TgeneALBC0017662Glomerulonephritis, Membranoproliferative1CTD_human
TgeneALBC0018799Heart Diseases1CTD_human
TgeneALBC0018801Heart failure1CTD_human
TgeneALBC0019061Hemolytic-Uremic Syndrome1CTD_human
TgeneALBC0019158Hepatitis1CTD_human
TgeneALBC0019693HIV Infections1CTD_human
TgeneALBC0019699HIV Seropositivity1CTD_human
TgeneALBC0020517Hypersensitivity1CTD_human
TgeneALBC0020522Delayed Hypersensitivity1CTD_human
TgeneALBC0020538Hypertensive disease1CTD_human
TgeneALBC0022548Keloid1CTD_human
TgeneALBC0022661Kidney Failure, Chronic1CTD_human
TgeneALBC0026848Myopathy1CTD_human
TgeneALBC0027055Myocardial Reperfusion Injury1CTD_human
TgeneALBC0027720Nephrosis1CTD_human
TgeneALBC0028797Occupational Diseases1CTD_human
TgeneALBC0030193Pain1CTD_human
TgeneALBC0030286Pancreatic Diseases1CTD_human
TgeneALBC0030305Pancreatitis1CTD_human
TgeneALBC0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneALBC0035242Respiratory Tract Diseases1CTD_human
TgeneALBC0035457Rhinitis, Allergic, Perennial1CTD_human
TgeneALBC0038325Stevens-Johnson Syndrome1CTD_human
TgeneALBC0038356Stomach Neoplasms1CTD_human
TgeneALBC0040034Thrombocytopenia1CTD_human
TgeneALBC0041755Adverse reaction to drug1CTD_human
TgeneALBC0042109Urticaria1CTD_human
TgeneALBC0042164Uveitis1CTD_human
TgeneALBC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneALBC0239981Hypoalbuminemia1CTD_human;HPO
TgeneALBC0993582Arthritis, Experimental1CTD_human