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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 19131

FusionGeneSummary for KMT2C_SND1

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2C_SND1
Fusion gene ID: 19131
HgeneTgene
Gene symbol

KMT2C

SND1

Gene ID

58508

27044

Gene namelysine methyltransferase 2Cstaphylococcal nuclease and tudor domain containing 1
SynonymsHALR|KLEFS2|MLL3TDRD11|Tudor-SN|p100
Cytomap

7q36.1

7q32.1

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage lestaphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11
Modification date2018052320180523
UniProtAcc

Q8NEZ4

Q7KZF4

Ensembl transtripts involved in fusion geneENST00000262189, ENST00000355193, 
ENST00000485655, ENST00000485241, 
ENST00000354725, ENST00000467238, 
Fusion gene scores* DoF score18 X 16 X 10=288020 X 15 X 10=3000
# samples 2221
** MAII scorelog2(22/2880*10)=-3.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/3000*10)=-3.83650126771712
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2C [Title/Abstract] AND SND1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A8NI-01AKMT2Cchr7

152132711

-SND1chr7

127447538

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262189ENST00000354725KMT2Cchr7

152132711

-SND1chr7

127447538

+
5CDS-intronENST00000262189ENST00000467238KMT2Cchr7

152132711

-SND1chr7

127447538

+
In-frameENST00000355193ENST00000354725KMT2Cchr7

152132711

-SND1chr7

127447538

+
5CDS-intronENST00000355193ENST00000467238KMT2Cchr7

152132711

-SND1chr7

127447538

+
intron-3CDSENST00000485655ENST00000354725KMT2Cchr7

152132711

-SND1chr7

127447538

+
intron-intronENST00000485655ENST00000467238KMT2Cchr7

152132711

-SND1chr7

127447538

+
intron-3CDSENST00000485241ENST00000354725KMT2Cchr7

152132711

-SND1chr7

127447538

+
intron-intronENST00000485241ENST00000467238KMT2Cchr7

152132711

-SND1chr7

127447538

+

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FusionProtFeatures for KMT2C_SND1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

SND1

Q7KZF4

Histone methyltransferase. Methylates 'Lys-4' of histoneH3. H3 'Lys-4' methylation represents a specific tag forepigenetic transcriptional activation. Central component of theMLL2/3 complex, a coactivator complex of nuclear receptors,involved in transcriptional coactivation. KMT2C/MLL3 may be acatalytic subunit of this complex. May be involved inleukemogenesis and developmental disorder.{ECO:0000269|PubMed:17500065}. Functions as a bridging factor between STAT6 and thebasal transcription factor. Plays a role in PIM1 regulation of MYBactivity. Functions as a transcriptional coactivator for theEpstein-Barr virus nuclear antigen 2 (EBNA2).{ECO:0000269|PubMed:7651391}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-15934_46534912DNA bindingNote=A.T hook
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-16034_46534969DNA bindingNote=A.T hook
TgeneSND1chr7:152132711chr7:127447538ENST00000354725+924525_660384911DomainTNase-like 4
TgeneSND1chr7:152132711chr7:127447538ENST00000354725+924729_787384911DomainTudor
TgeneSND1chr7:152132711chr7:127447538ENST00000354725+924388_392384911MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1591338_1366534912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1591754_1787534912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1593054_3081534912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1593173_3272534912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1593391_3433534912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-159644_672534912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-15992_112534912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1601338_1366534969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1601754_1787534969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1603054_3081534969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1603173_3272534969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1603391_3433534969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-160644_672534969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-16092_112534969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1591719_1796534912Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1591834_2281534912Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1592412_2630534912Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1592690_2786534912Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1593012_3509534912Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1593277_3381534912Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1601719_1796534969Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1601834_2281534969Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1602412_2630534969Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1602690_2786534969Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1603012_3509534969Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1603277_3381534969Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-159436_489534912DomainDHHC
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1594545_4605534912DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1594606_4691534912DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1594771_4887534912DomainSET
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1594895_4911534912DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-160436_489534969DomainDHHC
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1604545_4605534969DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1604606_4691534969DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1604771_4887534969DomainSET
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1604895_4911534969DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1594848_4849534912RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1604848_4849534969RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1591007_1057534912Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1591084_1139534912Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-159227_262534912Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-159283_331534912Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-159341_391534912Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-159344_389534912Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-159388_438534912Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1594399_4439534912Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-1594460_4507534912Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-159464_520534912Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000262189-159957_1010534912Zinc fingerPHD-type 5
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1601007_1057534969Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1601084_1139534969Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-160227_262534969Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-160283_331534969Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-160341_391534969Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-160344_389534969Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-160388_438534969Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1604399_4439534969Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-1604460_4507534969Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-160464_520534969Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:127447538ENST00000355193-160957_1010534969Zinc fingerPHD-type 5
TgeneSND1chr7:152132711chr7:127447538ENST00000354725+92418_166384911DomainTNase-like 1
TgeneSND1chr7:152132711chr7:127447538ENST00000354725+924193_328384911DomainTNase-like 2
TgeneSND1chr7:152132711chr7:127447538ENST00000354725+924341_496384911DomainTNase-like 3
TgeneSND1chr7:152132711chr7:127447538ENST00000354725+924321_325384911MotifNuclear localization signal


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FusionGeneSequence for KMT2C_SND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KMT2C_ENST00000262189_chr7_152132711_-_SND1_ENST00000354725_chr7_127447538_+_580aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKIRTRNCVPCMTFLTCLRPGNFFEKSLLGRRSMXRWT
TLDQPAQPQRQCLPFQSVPVPLSPLEEXTLLRLLSAKVXPQXSDTGRMMTRDHHTTMNCLLQRPELLRMAKDCIARRKCLSTVLQIYLGI
PKKQSSSCLFFSGQVVLKLWWNTSSVVLVSNSICQRKLALSPSCLQALNAPEEPETSQAWCRKESPSARKLHFSPRNWCCSERWRWRWRA
WTRPATLSAGCTSTVPTCPSCWWSTRSPRSTSPPNAAPTTSPCCLPRRPQSRRKRRSGPTMRSSPWRRXCQCWRRRSDLLATSPCLXLRS
LMTCTSTCRMWRPAPSWRSXWRTCAMTLPVTPLXRAPMPPAGESSALPNLXMENGTVPEXRKSSLLPKYMSSTLTTATERSCHPPAWVPY
HLPSALGCCQLKPRSMPSPSSRCPKMMMPARTPWTAXFGISRTLSACSTWNTXVPAAPMSPCSLQIPRAMWGWAWXRKGWSWWRCARRNS

>In-frame_KMT2C_ENST00000355193_chr7_152132711_-_SND1_ENST00000354725_chr7_127447538_+_580aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKIRTRNCVPCMTFLTCLRPGNFFEKSLLGRRSMXRWT
TLDQPAQPQRQCLPFQSVPVPLSPLEEXTLLRLLSAKVXPQXSDTGRMMTRDHHTTMNCLLQRPELLRMAKDCIARRKCLSTVLQIYLGI
PKKQSSSCLFFSGQVVLKLWWNTSSVVLVSNSICQRKLALSPSCLQALNAPEEPETSQAWCRKESPSARKLHFSPRNWCCSERWRWRWRA
WTRPATLSAGCTSTVPTCPSCWWSTRSPRSTSPPNAAPTTSPCCLPRRPQSRRKRRSGPTMRSSPWRRXCQCWRRRSDLLATSPCLXLRS
LMTCTSTCRMWRPAPSWRSXWRTCAMTLPVTPLXRAPMPPAGESSALPNLXMENGTVPEXRKSSLLPKYMSSTLTTATERSCHPPAWVPY
HLPSALGCCQLKPRSMPSPSSRCPKMMMPARTPWTAXFGISRTLSACSTWNTXVPAAPMSPCSLQIPRAMWGWAWXRKGWSWWRCARRNS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KMT2C_ENST00000262189_chr7_152132711_-_SND1_ENST00000354725_chr7_127447538_+_1742nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAGATAAGAACAAGAAACTGC
GTCCCCTGTATGACATTCCTTACATGTTTGAGGCCCGGGAATTTCTTCGAAAAAAGCTTATTGGGAAGAAGGTCAATGTGACGGTGGACT
ACATTAGACCAGCCAGCCCAGCCACAGAGACAGTGCCTGCCTTTTCAGAGCGTACCTGTGCCACTGTCACCATTGGAGGAATAAACATTG
CTGAGGCTCTTGTCAGCAAAGGTCTAGCCACAGTGATCAGATACCGGCAGGATGATGACCAGAGATCATCACACTACGATGAACTGCTTG
CTGCAGAGGCCAGAGCTATTAAGAATGGCAAAGGATTGCATAGCAAGAAGGAAGTGCCTATCCACCGTGTTGCAGATATATCTGGGGATA
CCCAAAAAGCAAAGCAGTTCCTGCCTTTTCTTCAGCGGGCAGGTCGTTCTGAAGCTGTGGTGGAATACGTCTTCAGTGGTTCTCGTCTCA
AACTCTATTTGCCAAAGGAAACTTGCCTTATCACCTTCTTGCTTGCAGGCATTGAATGCCCCAGAGGAGCCCGAAACCTCCCAGGCTTGG
TGCAGGAAGGAGAGCCCTTCAGCGAGGAAGCTACACTTTTCACCAAGGAACTGGTGCTGCAGCGAGAGGTGGAGGTGGAGGTGGAGAGCA
TGGACAAGGCCGGCAACTTTATCGGCTGGCTGCACATCGACGGTGCCAACCTGTCCGTCCTGCTGGTGGAGCACGCGCTCTCCAAGGTCC
ACTTCACCGCCGAACGCAGCTCCTACTACAAGTCCCTGCTGTCTGCCGAGGAGGCCGCAAAGCAGAAGAAAGAGAAGGTCTGGGCCCACT
ATGAGGAGCAGCCCGTGGAGGAGGTGATGCCAGTGCTGGAGGAGAAGGAGCGATCTGCTAGCTACAAGCCCGTGTTTGTGACTGAGATCA
CTGATGACCTGCACTTCTACGTGCAGGATGTGGAGACCGGCACCCAGTTGGAGAAGCTGATGGAGAACATGCGCAATGACATTGCCAGTC
ACCCCCCTGTAGAGGGCTCCTATGCCCCCCGCAGGGGAGAGTTCTGCATTGCCAAATTTGTAGATGGAGAATGGTACCGTGCCCGAGTAG
AGAAAGTCGAGTCTCCTGCCAAAATACATGTCTTCTACATTGACTACGGCAACAGAGAGGTCCTGCCATCCACCCGCCTGGGTACCCTAT
CACCTGCCTTCAGCACTCGGGTGCTGCCAGCTCAAGCCACGGAGTATGCCTTCGCCTTCATCCAGGTGCCCCAAGATGATGATGCCCGCA
CGGACGCCGTGGACAGCGTAGTTCGGGATATCCAGAACACTCAGTGCCTGCTCAACGTGGAACACCTGAGTGCCGGCTGCCCCCATGTCA
CCCTGCAGTTTGCAGATTCCAAGGGCGATGTGGGGCTGGGCTTGGTGAAGGAAGGGCTGGTCATGGTGGAGGTGCGCAAGGAGAAACAGT
TCCAGAAAGTGATCACAGAATACCTGAATGCCCAAGAGTCAGCCAAGAGCGCCAGGCTGAACCTGTGGCGCTATGGAGACTTTCGAGCTG

>In-frame_KMT2C_ENST00000355193_chr7_152132711_-_SND1_ENST00000354725_chr7_127447538_+_1742nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAGATAAGAACAAGAAACTGC
GTCCCCTGTATGACATTCCTTACATGTTTGAGGCCCGGGAATTTCTTCGAAAAAAGCTTATTGGGAAGAAGGTCAATGTGACGGTGGACT
ACATTAGACCAGCCAGCCCAGCCACAGAGACAGTGCCTGCCTTTTCAGAGCGTACCTGTGCCACTGTCACCATTGGAGGAATAAACATTG
CTGAGGCTCTTGTCAGCAAAGGTCTAGCCACAGTGATCAGATACCGGCAGGATGATGACCAGAGATCATCACACTACGATGAACTGCTTG
CTGCAGAGGCCAGAGCTATTAAGAATGGCAAAGGATTGCATAGCAAGAAGGAAGTGCCTATCCACCGTGTTGCAGATATATCTGGGGATA
CCCAAAAAGCAAAGCAGTTCCTGCCTTTTCTTCAGCGGGCAGGTCGTTCTGAAGCTGTGGTGGAATACGTCTTCAGTGGTTCTCGTCTCA
AACTCTATTTGCCAAAGGAAACTTGCCTTATCACCTTCTTGCTTGCAGGCATTGAATGCCCCAGAGGAGCCCGAAACCTCCCAGGCTTGG
TGCAGGAAGGAGAGCCCTTCAGCGAGGAAGCTACACTTTTCACCAAGGAACTGGTGCTGCAGCGAGAGGTGGAGGTGGAGGTGGAGAGCA
TGGACAAGGCCGGCAACTTTATCGGCTGGCTGCACATCGACGGTGCCAACCTGTCCGTCCTGCTGGTGGAGCACGCGCTCTCCAAGGTCC
ACTTCACCGCCGAACGCAGCTCCTACTACAAGTCCCTGCTGTCTGCCGAGGAGGCCGCAAAGCAGAAGAAAGAGAAGGTCTGGGCCCACT
ATGAGGAGCAGCCCGTGGAGGAGGTGATGCCAGTGCTGGAGGAGAAGGAGCGATCTGCTAGCTACAAGCCCGTGTTTGTGACTGAGATCA
CTGATGACCTGCACTTCTACGTGCAGGATGTGGAGACCGGCACCCAGTTGGAGAAGCTGATGGAGAACATGCGCAATGACATTGCCAGTC
ACCCCCCTGTAGAGGGCTCCTATGCCCCCCGCAGGGGAGAGTTCTGCATTGCCAAATTTGTAGATGGAGAATGGTACCGTGCCCGAGTAG
AGAAAGTCGAGTCTCCTGCCAAAATACATGTCTTCTACATTGACTACGGCAACAGAGAGGTCCTGCCATCCACCCGCCTGGGTACCCTAT
CACCTGCCTTCAGCACTCGGGTGCTGCCAGCTCAAGCCACGGAGTATGCCTTCGCCTTCATCCAGGTGCCCCAAGATGATGATGCCCGCA
CGGACGCCGTGGACAGCGTAGTTCGGGATATCCAGAACACTCAGTGCCTGCTCAACGTGGAACACCTGAGTGCCGGCTGCCCCCATGTCA
CCCTGCAGTTTGCAGATTCCAAGGGCGATGTGGGGCTGGGCTTGGTGAAGGAAGGGCTGGTCATGGTGGAGGTGCGCAAGGAGAAACAGT
TCCAGAAAGTGATCACAGAATACCTGAATGCCCAAGAGTCAGCCAAGAGCGCCAGGCTGAACCTGTGGCGCTATGGAGACTTTCGAGCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_KMT2C_ENST00000262189_chr7_152132711_-_SND1_ENST00000354725_chr7_127447538_+_2510nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAGATAAGAACAAGAAACTGCGTCCCCTGTATGACATTCCTTACATGTTTGAGGCCCGGGAATTTCTTCGAA
AAAAGCTTATTGGGAAGAAGGTCAATGTGACGGTGGACTACATTAGACCAGCCAGCCCAGCCACAGAGACAGTGCCTGCCTTTTCAGAGC
GTACCTGTGCCACTGTCACCATTGGAGGAATAAACATTGCTGAGGCTCTTGTCAGCAAAGGTCTAGCCACAGTGATCAGATACCGGCAGG
ATGATGACCAGAGATCATCACACTACGATGAACTGCTTGCTGCAGAGGCCAGAGCTATTAAGAATGGCAAAGGATTGCATAGCAAGAAGG
AAGTGCCTATCCACCGTGTTGCAGATATATCTGGGGATACCCAAAAAGCAAAGCAGTTCCTGCCTTTTCTTCAGCGGGCAGGTCGTTCTG
AAGCTGTGGTGGAATACGTCTTCAGTGGTTCTCGTCTCAAACTCTATTTGCCAAAGGAAACTTGCCTTATCACCTTCTTGCTTGCAGGCA
TTGAATGCCCCAGAGGAGCCCGAAACCTCCCAGGCTTGGTGCAGGAAGGAGAGCCCTTCAGCGAGGAAGCTACACTTTTCACCAAGGAAC
TGGTGCTGCAGCGAGAGGTGGAGGTGGAGGTGGAGAGCATGGACAAGGCCGGCAACTTTATCGGCTGGCTGCACATCGACGGTGCCAACC
TGTCCGTCCTGCTGGTGGAGCACGCGCTCTCCAAGGTCCACTTCACCGCCGAACGCAGCTCCTACTACAAGTCCCTGCTGTCTGCCGAGG
AGGCCGCAAAGCAGAAGAAAGAGAAGGTCTGGGCCCACTATGAGGAGCAGCCCGTGGAGGAGGTGATGCCAGTGCTGGAGGAGAAGGAGC
GATCTGCTAGCTACAAGCCCGTGTTTGTGACTGAGATCACTGATGACCTGCACTTCTACGTGCAGGATGTGGAGACCGGCACCCAGTTGG
AGAAGCTGATGGAGAACATGCGCAATGACATTGCCAGTCACCCCCCTGTAGAGGGCTCCTATGCCCCCCGCAGGGGAGAGTTCTGCATTG
CCAAATTTGTAGATGGAGAATGGTACCGTGCCCGAGTAGAGAAAGTCGAGTCTCCTGCCAAAATACATGTCTTCTACATTGACTACGGCA
ACAGAGAGGTCCTGCCATCCACCCGCCTGGGTACCCTATCACCTGCCTTCAGCACTCGGGTGCTGCCAGCTCAAGCCACGGAGTATGCCT
TCGCCTTCATCCAGGTGCCCCAAGATGATGATGCCCGCACGGACGCCGTGGACAGCGTAGTTCGGGATATCCAGAACACTCAGTGCCTGC
TCAACGTGGAACACCTGAGTGCCGGCTGCCCCCATGTCACCCTGCAGTTTGCAGATTCCAAGGGCGATGTGGGGCTGGGCTTGGTGAAGG
AAGGGCTGGTCATGGTGGAGGTGCGCAAGGAGAAACAGTTCCAGAAAGTGATCACAGAATACCTGAATGCCCAAGAGTCAGCCAAGAGCG
CCAGGCTGAACCTGTGGCGCTATGGAGACTTTCGAGCTGATGATGCAGACGAATTTGGCTACAGCCGCTAAGGAGGGGATCGGGTTTGGC
CCCCAGCCCCGCTCACGCCAGTCCCTCTTCCTCTGCCGGGAGGGTGTTTTCAACTCCAAACCCCAGAGAGGGGTTGTAGATTGGGTCCAG
CTTTGCTTCAGTGTGTGGAAATGTCTCGTGGGGTGGCATCGGGGCTGCGGGGTGGGGACCCCAAGGCTTTCTGGGGCAGACCCTTGTCCT
CTGGGATGATGGGCACTGCTATCCACAGTCTCTGCCAGTTGGTTTTATTTGGAGGTTTGTGGGCTTTTTTTAAAAAAAAAAAGTCCTCAA
ATCAGGAAGAAACATCAAAGACTATGTCCTAGTGGAGGGAGTAATCCTAACACCCAGGCTGGCCGCCAGCTGGCACCTGCCTCTATCCCA
GACTGCCCTCGTCCCAGCTCTCTGTCCAACTGTTGATTATGTGATTTTTCTGATACGTCCATTCTCAAATGCCAGTGTGTTCACATCTTC

>In-frame_KMT2C_ENST00000355193_chr7_152132711_-_SND1_ENST00000354725_chr7_127447538_+_2510nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAGATAAGAACAAGAAACTGCGTCCCCTGTATGACATTCCTTACATGTTTGAGGCCCGGGAATTTCTTCGAA
AAAAGCTTATTGGGAAGAAGGTCAATGTGACGGTGGACTACATTAGACCAGCCAGCCCAGCCACAGAGACAGTGCCTGCCTTTTCAGAGC
GTACCTGTGCCACTGTCACCATTGGAGGAATAAACATTGCTGAGGCTCTTGTCAGCAAAGGTCTAGCCACAGTGATCAGATACCGGCAGG
ATGATGACCAGAGATCATCACACTACGATGAACTGCTTGCTGCAGAGGCCAGAGCTATTAAGAATGGCAAAGGATTGCATAGCAAGAAGG
AAGTGCCTATCCACCGTGTTGCAGATATATCTGGGGATACCCAAAAAGCAAAGCAGTTCCTGCCTTTTCTTCAGCGGGCAGGTCGTTCTG
AAGCTGTGGTGGAATACGTCTTCAGTGGTTCTCGTCTCAAACTCTATTTGCCAAAGGAAACTTGCCTTATCACCTTCTTGCTTGCAGGCA
TTGAATGCCCCAGAGGAGCCCGAAACCTCCCAGGCTTGGTGCAGGAAGGAGAGCCCTTCAGCGAGGAAGCTACACTTTTCACCAAGGAAC
TGGTGCTGCAGCGAGAGGTGGAGGTGGAGGTGGAGAGCATGGACAAGGCCGGCAACTTTATCGGCTGGCTGCACATCGACGGTGCCAACC
TGTCCGTCCTGCTGGTGGAGCACGCGCTCTCCAAGGTCCACTTCACCGCCGAACGCAGCTCCTACTACAAGTCCCTGCTGTCTGCCGAGG
AGGCCGCAAAGCAGAAGAAAGAGAAGGTCTGGGCCCACTATGAGGAGCAGCCCGTGGAGGAGGTGATGCCAGTGCTGGAGGAGAAGGAGC
GATCTGCTAGCTACAAGCCCGTGTTTGTGACTGAGATCACTGATGACCTGCACTTCTACGTGCAGGATGTGGAGACCGGCACCCAGTTGG
AGAAGCTGATGGAGAACATGCGCAATGACATTGCCAGTCACCCCCCTGTAGAGGGCTCCTATGCCCCCCGCAGGGGAGAGTTCTGCATTG
CCAAATTTGTAGATGGAGAATGGTACCGTGCCCGAGTAGAGAAAGTCGAGTCTCCTGCCAAAATACATGTCTTCTACATTGACTACGGCA
ACAGAGAGGTCCTGCCATCCACCCGCCTGGGTACCCTATCACCTGCCTTCAGCACTCGGGTGCTGCCAGCTCAAGCCACGGAGTATGCCT
TCGCCTTCATCCAGGTGCCCCAAGATGATGATGCCCGCACGGACGCCGTGGACAGCGTAGTTCGGGATATCCAGAACACTCAGTGCCTGC
TCAACGTGGAACACCTGAGTGCCGGCTGCCCCCATGTCACCCTGCAGTTTGCAGATTCCAAGGGCGATGTGGGGCTGGGCTTGGTGAAGG
AAGGGCTGGTCATGGTGGAGGTGCGCAAGGAGAAACAGTTCCAGAAAGTGATCACAGAATACCTGAATGCCCAAGAGTCAGCCAAGAGCG
CCAGGCTGAACCTGTGGCGCTATGGAGACTTTCGAGCTGATGATGCAGACGAATTTGGCTACAGCCGCTAAGGAGGGGATCGGGTTTGGC
CCCCAGCCCCGCTCACGCCAGTCCCTCTTCCTCTGCCGGGAGGGTGTTTTCAACTCCAAACCCCAGAGAGGGGTTGTAGATTGGGTCCAG
CTTTGCTTCAGTGTGTGGAAATGTCTCGTGGGGTGGCATCGGGGCTGCGGGGTGGGGACCCCAAGGCTTTCTGGGGCAGACCCTTGTCCT
CTGGGATGATGGGCACTGCTATCCACAGTCTCTGCCAGTTGGTTTTATTTGGAGGTTTGTGGGCTTTTTTTAAAAAAAAAAAGTCCTCAA
ATCAGGAAGAAACATCAAAGACTATGTCCTAGTGGAGGGAGTAATCCTAACACCCAGGCTGGCCGCCAGCTGGCACCTGCCTCTATCCCA
GACTGCCCTCGTCCCAGCTCTCTGTCCAACTGTTGATTATGTGATTTTTCTGATACGTCCATTCTCAAATGCCAGTGTGTTCACATCTTC


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FusionGenePPI for KMT2C_SND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KMT2CAK1, NCOA6, ASH2L, RBBP5, HIST2H3C, ASCL2, KDM6A, SMARCB1, MAPK14, JUN, PAXIP1, H3F3A, PAGR1, WDR82, CDC73, TSC22D1, KDM4B, ELAVL1, WDR5, HIST1H3A, APPL2, ERP44, HIST3H3, DPY30, MTNR1B, FOXA1, TRIM25SND1IKBKE, SNW1, RBPJ, GTF2E2, GTF2E1, MYB, PIM1, STAT6, POLR2A, USP22, PDPK1, PRKAA1, UBA5, LZTR1, DHX9, CREBBP, RBM39, SIRT7, CUL3, CDK2, CAND1, APP, RPS3, HNRNPM, TOMM22, RPL19, MYBBP1A, SMNDC1, RPS20, NENF, RPL4, VDAC2, ILF2, SRSF3, HNRNPU, RPN1, HNRNPR, SSR3, FN1, VCAM1, CSNK2A1, ITGA4, G3BP1, PRPF8, RNU1-1, RNU2-1, RNU4-1, RNU6-1, RNU5A-1, MAK, TARDBP, EIF3CL, RPS11, RPS2, RPS6, RPS9, DDX3X, RPL23A, RPL35, RPS16, RPS26, RPS27, RPS3A, SHFM1, LIN28A, HUWE1, RAPGEF2, MDM2, CUL7, OBSL1, CCDC8, UBE2I, ESR1, MMP28, TDRD3, TXNDC5, NTRK1, NPM1, RPL10, CNOT1, MCM2, U2AF2, CDH1, PTP4A1, MTDH, PA2G4, TRAP1, ANXA5, SNRPB2, EIF5B, GPI, IDH2, PDIA3, UBE2N, MRPL12, CRNN, ZNF207, CPNE3, CS, PYGL, SF3A3, DNAJC8, PLS3, CPSF6, NANS, SF3A1, ECHS1, SRP68, MYL12B, AIMP1, CYLD, DLD, DLST, PDHA1, SOD1, TRIM25, BRCA1, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KMT2C_SND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KMT2C_SND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKMT2CC0001418Adenocarcinoma1CTD_human
HgeneKMT2CC0005695Bladder Neoplasm1CTD_human
HgeneKMT2CC0007138Carcinoma, Transitional Cell1CTD_human
HgeneKMT2CC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKMT2CC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneKMT2CC0023897Liver Diseases, Parasitic1CTD_human
HgeneKMT2CC0036920Sezary Syndrome1CTD_human
HgeneKMT2CC0038356Stomach Neoplasms1CTD_human
HgeneKMT2CC0206698Cholangiocarcinoma1CTD_human
HgeneKMT2CC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneKMT2CC2239176Liver carcinoma1CTD_human
TgeneSND1C0004352Autistic Disorder1CTD_human
TgeneSND1C0024121Lung Neoplasms1CTD_human