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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 19124

FusionGeneSummary for KMT2C_GTF2IRD1

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2C_GTF2IRD1
Fusion gene ID: 19124
HgeneTgene
Gene symbol

KMT2C

GTF2IRD1

Gene ID

58508

9569

Gene namelysine methyltransferase 2CGTF2I repeat domain containing 1
SynonymsHALR|KLEFS2|MLL3BEN|CREAM1|GTF3|MUSTRD1|RBAP2|WBS|WBSCR11|WBSCR12|hMusTRD1alpha1
Cytomap

7q36.1

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage legeneral transcription factor II-I repeat domain-containing protein 1USE B1-binding proteinWilliams-Beuren syndrome chromosome region 11binding factor for early enhancergeneral transcription factor 3general transcription factor IIImuscle TFII-I repea
Modification date2018052320180522
UniProtAcc

Q8NEZ4

Q9UHL9

Ensembl transtripts involved in fusion geneENST00000262189, ENST00000355193, 
ENST00000485655, ENST00000485241, 
ENST00000265755, ENST00000455841, 
ENST00000424337, ENST00000476977, 
ENST00000489094, 
Fusion gene scores* DoF score18 X 16 X 10=28804 X 4 X 5=80
# samples 225
** MAII scorelog2(22/2880*10)=-3.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2C [Title/Abstract] AND GTF2IRD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-CV-7440-01AKMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262189ENST00000265755KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
In-frameENST00000262189ENST00000455841KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
In-frameENST00000262189ENST00000424337KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
In-frameENST00000262189ENST00000476977KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
5CDS-intronENST00000262189ENST00000489094KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
In-frameENST00000355193ENST00000265755KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
In-frameENST00000355193ENST00000455841KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
In-frameENST00000355193ENST00000424337KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
In-frameENST00000355193ENST00000476977KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
5CDS-intronENST00000355193ENST00000489094KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-3CDSENST00000485655ENST00000265755KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-3CDSENST00000485655ENST00000455841KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-3CDSENST00000485655ENST00000424337KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-3CDSENST00000485655ENST00000476977KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-intronENST00000485655ENST00000489094KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-3CDSENST00000485241ENST00000265755KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-3CDSENST00000485241ENST00000455841KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-3CDSENST00000485241ENST00000424337KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-3CDSENST00000485241ENST00000476977KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+
intron-intronENST00000485241ENST00000489094KMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

+

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FusionProtFeatures for KMT2C_GTF2IRD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

GTF2IRD1

Q9UHL9

Histone methyltransferase. Methylates 'Lys-4' of histoneH3. H3 'Lys-4' methylation represents a specific tag forepigenetic transcriptional activation. Central component of theMLL2/3 complex, a coactivator complex of nuclear receptors,involved in transcriptional coactivation. KMT2C/MLL3 may be acatalytic subunit of this complex. May be involved inleukemogenesis and developmental disorder.{ECO:0000269|PubMed:17500065}. May be a transcription regulator involved in cell-cycleprogression and skeletal muscle differentiation. May repress GTF2Itranscriptional functions, by preventing its nuclear residency, orby inhibiting its transcriptional activation. May contribute toslow-twitch fiber type specificity during myogenesis and inregenerating muscles. Binds troponin I slow-muscle fiber enhancer(USE B1). Binds specifically and with high affinity to the EFGsequences derived from the early enhancer of HOXC8 (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:11438732}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559644_67213204912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-255992_11213204912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560644_67213204969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-256092_11213204969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-255934_4613204912DNA bindingNote=A.T hook
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-256034_4613204969DNA bindingNote=A.T hook
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559436_48913204912DomainDHHC
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560436_48913204969DomainDHHC
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591007_105713204912Zinc fingerPHD-type 6
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591084_113913204912Zinc fingerPHD-type 7
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559227_26213204912Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559283_33113204912Zinc fingerPHD-type 1
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559341_39113204912Zinc fingerPHD-type 2
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559344_38913204912Zinc fingerRING-type
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559388_43813204912Zinc fingerPHD-type 3
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559464_52013204912Zinc fingerPHD-type 4
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559957_101013204912Zinc fingerPHD-type 5
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601007_105713204969Zinc fingerPHD-type 6
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601084_113913204969Zinc fingerPHD-type 7
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560227_26213204969Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560283_33113204969Zinc fingerPHD-type 1
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560341_39113204969Zinc fingerPHD-type 2
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560344_38913204969Zinc fingerRING-type
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560388_43813204969Zinc fingerPHD-type 3
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560464_52013204969Zinc fingerPHD-type 4
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560957_101013204969Zinc fingerPHD-type 5
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000265755+2127906_930788960Compositional biasNote=Ser-rich
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000424337+2127906_930773945Compositional biasNote=Ser-rich
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000455841+2127906_930805977Compositional biasNote=Ser-rich
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000265755+2127898_905788960MotifNuclear localization signal
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000424337+2127898_905773945MotifNuclear localization signal
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000455841+2127898_905805977MotifNuclear localization signal
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000265755+2127793_887788960RepeatNote=GTF2I-like 5
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000424337+2127793_887773945RepeatNote=GTF2I-like 5

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591338_136613204912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591754_178713204912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593054_308113204912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593173_327213204912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593391_343313204912Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601338_136613204969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601754_178713204969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603054_308113204969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603173_327213204969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603391_343313204969Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591719_179613204912Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591834_228113204912Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25592412_263013204912Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25592690_278613204912Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593012_350913204912Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593277_338113204912Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601719_179613204969Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601834_228113204969Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25602412_263013204969Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25602690_278613204969Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603012_350913204969Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603277_338113204969Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594545_460513204912DomainFYR N-terminal
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594606_469113204912DomainFYR C-terminal
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594771_488713204912DomainSET
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594895_491113204912DomainPost-SET
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604545_460513204969DomainFYR N-terminal
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604606_469113204969DomainFYR C-terminal
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604771_488713204969DomainSET
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604895_491113204969DomainPost-SET
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594848_484913204912RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604848_484913204969RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594399_443913204912Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594460_450713204912Zinc fingerPHD-type 8
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604399_443913204969Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604460_450713204969Zinc fingerPHD-type 8
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000265755+2127119_213788960RepeatNote=GTF2I-like 1
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000265755+2127342_436788960RepeatNote=GTF2I-like 2
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000265755+2127556_650788960RepeatNote=GTF2I-like 3
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000265755+2127696_790788960RepeatNote=GTF2I-like 4
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000424337+2127119_213773945RepeatNote=GTF2I-like 1
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000424337+2127342_436773945RepeatNote=GTF2I-like 2
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000424337+2127556_650773945RepeatNote=GTF2I-like 3
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000424337+2127696_790773945RepeatNote=GTF2I-like 4
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000455841+2127119_213805977RepeatNote=GTF2I-like 1
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000455841+2127342_436805977RepeatNote=GTF2I-like 2
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000455841+2127556_650805977RepeatNote=GTF2I-like 3
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000455841+2127696_790805977RepeatNote=GTF2I-like 4
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST00000455841+2127793_887805977RepeatNote=GTF2I-like 5


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FusionGeneSequence for KMT2C_GTF2IRD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000265755_chr7_74004180_+_1492aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSA
EEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLL
VNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWH
HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKM
SSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGN
IMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVS
IKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPK
TYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKYGEAL
GLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEG

>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000455841_chr7_74004180_+_1492aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSA
EEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLL
VNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWH
HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKM
SSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGN
IMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVS
IKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPK
TYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKYGEAL
GLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEG

>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000424337_chr7_74004180_+_1492aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSA
EEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLL
VNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWH
HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKM
SSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGN
IMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVS
IKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPK
TYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKYGEAL
GLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEG

>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000476977_chr7_74004180_+_1508aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSA
EEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLL
VNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWH
HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKM
SSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGN
IMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVS
IKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPK
TYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKYGEAL
GLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEG

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000265755_chr7_74004180_+_1492aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSA
EEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLL
VNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWH
HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKM
SSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGN
IMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVS
IKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPK
TYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKYGEAL
GLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEG

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000455841_chr7_74004180_+_1492aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSA
EEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLL
VNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWH
HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKM
SSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGN
IMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVS
IKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPK
TYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKYGEAL
GLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEG

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000424337_chr7_74004180_+_1492aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSA
EEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLL
VNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWH
HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKM
SSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGN
IMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVS
IKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPK
TYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKYGEAL
GLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEG

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000476977_chr7_74004180_+_1508aa
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSA
EEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLL
VNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWH
HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKM
SSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGN
IMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVS
IKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPK
TYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKYGEAL
GLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000265755_chr7_74004180_+_4476nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAA
ACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACAGAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCA
GAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACTCTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTG
GTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGTTACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTA
AAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCTTCTAACAAGAAGGACATTGATGACAACAGCAATGGAACC
TATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAAGAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGT
GTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAACTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAA
GCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAGTGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTA
GTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTTTGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAG
AAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTTCAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACAC
ATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGCGACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACT
ACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCATTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTG
TGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGATACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCA
GTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATATGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCAC
CACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGTCCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAA
GACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGACAAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAA
GAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTACAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACA
GATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTCTCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAG
TCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAACAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGT
CTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAACAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATG
TCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATGGAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATC
ACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTATCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAA
TCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATTTCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTA
CAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATGGACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAA
GATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAGTCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGAT
GTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTGCATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAAC
ATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAACCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCT
CGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCCTGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAA
CCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGGTCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGA
CTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGAGCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCA
TCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTTTCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGT
GTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGTTCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGT
ATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGCACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGA
AGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTAGACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAG
TGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTAAGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCT
TGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAAGATCTTATTCTGCAATGTAGACAATGTGATAGATGGATG
CATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCAGACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATG
CCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCACAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAG
ACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTACAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCA
AAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTTCAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGAT
GGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAATCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAA
ACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCATACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGA
AGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCCTCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGAT
GATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAGGTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTG
GGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCAGACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCC
TTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAGGCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTC
CAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGCAGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGA
AATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCGGATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAA

>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000455841_chr7_74004180_+_4476nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAA
ACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACAGAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCA
GAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACTCTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTG
GTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGTTACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTA
AAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCTTCTAACAAGAAGGACATTGATGACAACAGCAATGGAACC
TATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAAGAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGT
GTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAACTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAA
GCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAGTGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTA
GTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTTTGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAG
AAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTTCAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACAC
ATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGCGACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACT
ACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCATTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTG
TGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGATACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCA
GTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATATGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCAC
CACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGTCCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAA
GACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGACAAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAA
GAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTACAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACA
GATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTCTCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAG
TCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAACAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGT
CTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAACAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATG
TCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATGGAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATC
ACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTATCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAA
TCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATTTCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTA
CAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATGGACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAA
GATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAGTCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGAT
GTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTGCATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAAC
ATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAACCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCT
CGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCCTGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAA
CCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGGTCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGA
CTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGAGCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCA
TCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTTTCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGT
GTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGTTCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGT
ATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGCACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGA
AGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTAGACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAG
TGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTAAGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCT
TGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAAGATCTTATTCTGCAATGTAGACAATGTGATAGATGGATG
CATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCAGACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATG
CCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCACAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAG
ACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTACAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCA
AAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTTCAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGAT
GGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAATCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAA
ACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCATACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGA
AGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCCTCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGAT
GATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAGGTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTG
GGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCAGACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCC
TTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAGGCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTC
CAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGCAGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGA
AATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCGGATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAA

>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000424337_chr7_74004180_+_4476nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAA
ACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACAGAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCA
GAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACTCTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTG
GTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGTTACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTA
AAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCTTCTAACAAGAAGGACATTGATGACAACAGCAATGGAACC
TATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAAGAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGT
GTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAACTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAA
GCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAGTGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTA
GTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTTTGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAG
AAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTTCAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACAC
ATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGCGACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACT
ACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCATTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTG
TGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGATACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCA
GTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATATGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCAC
CACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGTCCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAA
GACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGACAAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAA
GAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTACAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACA
GATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTCTCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAG
TCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAACAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGT
CTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAACAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATG
TCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATGGAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATC
ACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTATCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAA
TCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATTTCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTA
CAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATGGACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAA
GATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAGTCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGAT
GTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTGCATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAAC
ATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAACCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCT
CGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCCTGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAA
CCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGGTCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGA
CTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGAGCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCA
TCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTTTCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGT
GTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGTTCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGT
ATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGCACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGA
AGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTAGACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAG
TGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTAAGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCT
TGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAAGATCTTATTCTGCAATGTAGACAATGTGATAGATGGATG
CATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCAGACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATG
CCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCACAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAG
ACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTACAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCA
AAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTTCAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGAT
GGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAATCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAA
ACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCATACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGA
AGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCCTCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGAT
GATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAGGTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTG
GGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCAGACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCC
TTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAGGCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTC
CAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGCAGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGA
AATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCGGATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAA

>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000476977_chr7_74004180_+_4524nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAA
ACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACAGAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCA
GAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACTCTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTG
GTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGTTACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTA
AAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCTTCTAACAAGAAGGACATTGATGACAACAGCAATGGAACC
TATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAAGAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGT
GTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAACTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAA
GCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAGTGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTA
GTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTTTGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAG
AAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTTCAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACAC
ATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGCGACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACT
ACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCATTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTG
TGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGATACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCA
GTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATATGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCAC
CACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGTCCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAA
GACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGACAAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAA
GAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTACAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACA
GATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTCTCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAG
TCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAACAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGT
CTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAACAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATG
TCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATGGAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATC
ACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTATCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAA
TCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATTTCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTA
CAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATGGACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAA
GATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAGTCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGAT
GTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTGCATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAAC
ATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAACCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCT
CGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCCTGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAA
CCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGGTCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGA
CTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGAGCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCA
TCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTTTCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGT
GTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGTTCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGT
ATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGCACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGA
AGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTAGACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAG
TGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTAAGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCT
TGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAAGATCTTATTCTGCAATGTAGACAATGTGATAGATGGATG
CATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCAGACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATG
CCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCACAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAG
ACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTACAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCA
AAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTTCAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGAT
GGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAATCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAA
ACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCATACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGA
AGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCCTCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGAT
GATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAGGTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTG
GGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCAGACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCC
TTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAGGCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTC
CAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGCAGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGA
AATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCGGATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGGTA
AAGTTGCACCGATTTGGACTCCGGCACTCATCTCTGTGGCCCTCACCCCTCTGTCTGGCAGGGCCGTCTACTCTGGGATGTGGGCCCAGG

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000265755_chr7_74004180_+_4476nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAA
ACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACAGAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCA
GAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACTCTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTG
GTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGTTACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTA
AAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCTTCTAACAAGAAGGACATTGATGACAACAGCAATGGAACC
TATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAAGAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGT
GTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAACTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAA
GCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAGTGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTA
GTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTTTGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAG
AAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTTCAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACAC
ATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGCGACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACT
ACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCATTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTG
TGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGATACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCA
GTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATATGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCAC
CACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGTCCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAA
GACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGACAAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAA
GAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTACAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACA
GATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTCTCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAG
TCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAACAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGT
CTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAACAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATG
TCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATGGAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATC
ACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTATCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAA
TCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATTTCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTA
CAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATGGACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAA
GATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAGTCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGAT
GTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTGCATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAAC
ATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAACCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCT
CGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCCTGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAA
CCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGGTCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGA
CTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGAGCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCA
TCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTTTCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGT
GTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGTTCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGT
ATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGCACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGA
AGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTAGACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAG
TGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTAAGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCT
TGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAAGATCTTATTCTGCAATGTAGACAATGTGATAGATGGATG
CATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCAGACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATG
CCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCACAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAG
ACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTACAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCA
AAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTTCAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGAT
GGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAATCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAA
ACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCATACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGA
AGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCCTCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGAT
GATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAGGTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTG
GGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCAGACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCC
TTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAGGCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTC
CAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGCAGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGA
AATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCGGATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAA

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000455841_chr7_74004180_+_4476nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAA
ACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACAGAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCA
GAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACTCTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTG
GTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGTTACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTA
AAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCTTCTAACAAGAAGGACATTGATGACAACAGCAATGGAACC
TATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAAGAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGT
GTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAACTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAA
GCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAGTGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTA
GTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTTTGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAG
AAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTTCAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACAC
ATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGCGACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACT
ACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCATTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTG
TGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGATACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCA
GTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATATGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCAC
CACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGTCCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAA
GACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGACAAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAA
GAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTACAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACA
GATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTCTCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAG
TCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAACAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGT
CTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAACAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATG
TCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATGGAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATC
ACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTATCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAA
TCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATTTCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTA
CAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATGGACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAA
GATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAGTCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGAT
GTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTGCATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAAC
ATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAACCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCT
CGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCCTGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAA
CCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGGTCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGA
CTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGAGCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCA
TCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTTTCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGT
GTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGTTCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGT
ATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGCACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGA
AGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTAGACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAG
TGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTAAGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCT
TGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAAGATCTTATTCTGCAATGTAGACAATGTGATAGATGGATG
CATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCAGACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATG
CCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCACAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAG
ACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTACAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCA
AAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTTCAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGAT
GGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAATCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAA
ACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCATACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGA
AGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCCTCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGAT
GATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAGGTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTG
GGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCAGACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCC
TTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAGGCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTC
CAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGCAGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGA
AATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCGGATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAA

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000424337_chr7_74004180_+_4476nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAA
ACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACAGAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCA
GAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACTCTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTG
GTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGTTACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTA
AAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCTTCTAACAAGAAGGACATTGATGACAACAGCAATGGAACC
TATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAAGAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGT
GTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAACTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAA
GCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAGTGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTA
GTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTTTGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAG
AAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTTCAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACAC
ATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGCGACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACT
ACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCATTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTG
TGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGATACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCA
GTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATATGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCAC
CACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGTCCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAA
GACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGACAAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAA
GAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTACAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACA
GATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTCTCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAG
TCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAACAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGT
CTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAACAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATG
TCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATGGAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATC
ACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTATCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAA
TCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATTTCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTA
CAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATGGACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAA
GATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAGTCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGAT
GTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTGCATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAAC
ATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAACCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCT
CGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCCTGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAA
CCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGGTCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGA
CTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGAGCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCA
TCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTTTCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGT
GTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGTTCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGT
ATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGCACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGA
AGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTAGACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAG
TGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTAAGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCT
TGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAAGATCTTATTCTGCAATGTAGACAATGTGATAGATGGATG
CATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCAGACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATG
CCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCACAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAG
ACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTACAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCA
AAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTTCAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGAT
GGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAATCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAA
ACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCATACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGA
AGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCCTCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGAT
GATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAGGTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTG
GGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCAGACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCC
TTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAGGCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTC
CAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGCAGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGA
AATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCGGATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAA

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000476977_chr7_74004180_+_4524nt
ATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCACCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCA
GCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCTTTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAA
ACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACAGAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCA
GAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACTCTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTG
GTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGTTACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTA
AAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCTTCTAACAAGAAGGACATTGATGACAACAGCAATGGAACC
TATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAAGAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGT
GTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAACTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAA
GCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAGTGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTA
GTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTTTGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAG
AAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTTCAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACAC
ATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGCGACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACT
ACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCATTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTG
TGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGATACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCA
GTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATATGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCAC
CACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGTCCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAA
GACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGACAAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAA
GAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTACAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACA
GATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTCTCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAG
TCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAACAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGT
CTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAACAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATG
TCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATGGAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATC
ACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTATCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAA
TCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATTTCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTA
CAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATGGACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAA
GATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAGTCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGAT
GTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTGCATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAAC
ATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAACCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCT
CGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCCTGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAA
CCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGGTCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGA
CTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGAGCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCA
TCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTTTCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGT
GTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGTTCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGT
ATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGCACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGA
AGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTAGACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAG
TGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTAAGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCT
TGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAAGATCTTATTCTGCAATGTAGACAATGTGATAGATGGATG
CATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCAGACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATG
CCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCACAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAG
ACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTACAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCA
AAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTTCAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGAT
GGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAATCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAA
ACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCATACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGA
AGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCCTCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGAT
GATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAGGTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTG
GGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCAGACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCC
TTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAGGCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTC
CAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGCAGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGA
AATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCGGATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGGTA
AAGTTGCACCGATTTGGACTCCGGCACTCATCTCTGTGGCCCTCACCCCTCTGTCTGGCAGGGCCGTCTACTCTGGGATGTGGGCCCAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000265755_chr7_74004180_+_4852nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAG
GTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTGGGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCA
GACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCCTTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAG
GCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTCCAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGC
AGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGAAATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCG
GATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAATGGCCAATGTACATGGTGGACTATGCCGGCCTGAACGTGCAGCTCCCGGGA
CCTCTTAATTACTAGACCTCAGTACTGAATCAGGACCTCACTCAGAAAGACTAAAGGAAATGTAATTTATGTACAAAATGTATATTCGGA

>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000455841_chr7_74004180_+_4866nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAG
GTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTGGGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCA
GACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCCTTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAG
GCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTCCAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGC
AGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGAAATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCG
GATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAATGGCCAATGTACATGGTGGACTATGCCGGCCTGAACGTGCAGCTCCCGGGA
CCTCTTAATTACTAGACCTCAGTACTGAATCAGGACCTCACTCAGAAAGACTAAAGGAAATGTAATTTATGTACAAAATGTATATTCGGA
TATGTATCGATGCCTTTTAGTTTTTCCAATGATTTTTACACTATATTCCTGCCACCAAGGCCTTTTTAAATAAGTAAAAAAAGAAAAAAA

>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000424337_chr7_74004180_+_4863nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAG
GTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTGGGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCA
GACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCCTTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAG
GCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTCCAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGC
AGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGAAATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCG
GATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAATGGCCAATGTACATGGTGGACTATGCCGGCCTGAACGTGCAGCTCCCGGGA
CCTCTTAATTACTAGACCTCAGTACTGAATCAGGACCTCACTCAGAAAGACTAAAGGAAATGTAATTTATGTACAAAATGTATATTCGGA
TATGTATCGATGCCTTTTAGTTTTTCCAATGATTTTTACACTATATTCCTGCCACCAAGGCCTTTTTAAATAAGTAAAAAAAGAAAAAAA

>In-frame_KMT2C_ENST00000262189_chr7_151902191_-_GTF2IRD1_ENST00000476977_chr7_74004180_+_6037nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAG
GTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTGGGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCA
GACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCCTTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAG
GCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTCCAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGC
AGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGAAATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCG
GATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGGTAAAGTTGCACCGATTTGGACTCCGGCACTCATCTCTGTGGCCCTCACCCCTC
TGTCTGGCAGGGCCGTCTACTCTGGGATGTGGGCCCAGGGGACGGGGAGGCACTGGGCTTTGAGTGGGGACCTTCCGGCCTCGGGGGTTA
TAGATGCATCCACCTGTCTCACCCAAGAGGTAGCCCATCCTTCTCGTGGGGTACTCACAGGCACTCAGGCAGGAATTCACATCCTCGCTG
GGCAGATGGGCCGGCTGAGGTCCACCTGCCCACACCCTTCAGCCGCACCAGAGCTGGAGACATGAAAAGACATGGCTGGCGGGTGCAGTG
GCTCACGCCTGTAATCCCAGCACTTTGGCAGGTCAAGTCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGGCTGACCAACACGGGG
AAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGCAAAGTGGGGCATAGTGGCTCATGCCTGTAATCCCAGCTACTTGGAAGGCTGA
GATAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAATGAGCCGAGGTCGCGCCATTGCACTGCAGCCTGGGCAACAAGAGTGAAAC
ACTGTCTCAGAAAAAAAAATTAGCCAGGCATGGTGGCACGTGCCTGTGGTCGCAGCTACTTGGGAGGCTGGGGCAGGAGGATCATTTGAG
CCCAAGGGGATTGAGGCTGCAGTGAGCCAAGATCGTCCCATTGCACTCCAGCCTGGGCAAGAGAACGAGACTCCATCTCAAAAATAAATA
AATAGGCTGGGTGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGCAGGCGGATCACTTGAGGCTCAGGAGTTCAAGAC
CAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAATAGAAAAATTAGCCGGGCATGGTGGCGGGCGCCTATAATCCCAGCTACTC
GGGAGGCTGAGGCAGGAGACTCGCTTGAACCCGCGGGGCCAAGGTTGCAGTGAGCCGAGATTGCATCACTGCACTCCAGCCTGGGCAGAA
GAGTGAAACTCCATCTCAAAAAAATAAAAAATATAAATAAATAGCCTCTGAGAAAGCTCTTCCAAAAGCAGAACTAAGCATTTTGGGTTT
GTTCCGCATCACCTGGAGTCCTAATCCAGTCCCTTTGTCCCTCTCTCTAGCAATGGCCAATGTACATGGTGGACTATGCCGGCCTGAACG
TGCAGCTCCCGGGACCTCTTAATTACTAGACCTCAGTACTGAATCAGGACCTCACTCAGAAAGACTAAAGGAAATGTAATTTATGTACAA
AATGTATATTCGGATATGTATCGATGCCTTTTAGTTTTTCCAATGATTTTTACACTATATTCCTGCCACCAAGGCCTTTTTAAATAAGTA

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000265755_chr7_74004180_+_4852nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAG
GTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTGGGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCA
GACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCCTTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAG
GCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTCCAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGC
AGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGAAATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCG
GATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAATGGCCAATGTACATGGTGGACTATGCCGGCCTGAACGTGCAGCTCCCGGGA
CCTCTTAATTACTAGACCTCAGTACTGAATCAGGACCTCACTCAGAAAGACTAAAGGAAATGTAATTTATGTACAAAATGTATATTCGGA

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000455841_chr7_74004180_+_4866nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAG
GTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTGGGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCA
GACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCCTTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAG
GCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTCCAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGC
AGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGAAATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCG
GATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAATGGCCAATGTACATGGTGGACTATGCCGGCCTGAACGTGCAGCTCCCGGGA
CCTCTTAATTACTAGACCTCAGTACTGAATCAGGACCTCACTCAGAAAGACTAAAGGAAATGTAATTTATGTACAAAATGTATATTCGGA
TATGTATCGATGCCTTTTAGTTTTTCCAATGATTTTTACACTATATTCCTGCCACCAAGGCCTTTTTAAATAAGTAAAAAAAGAAAAAAA

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000424337_chr7_74004180_+_4863nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAG
GTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTGGGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCA
GACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCCTTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAG
GCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTCCAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGC
AGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGAAATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCG
GATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGCAATGGCCAATGTACATGGTGGACTATGCCGGCCTGAACGTGCAGCTCCCGGGA
CCTCTTAATTACTAGACCTCAGTACTGAATCAGGACCTCACTCAGAAAGACTAAAGGAAATGTAATTTATGTACAAAATGTATATTCGGA
TATGTATCGATGCCTTTTAGTTTTTCCAATGATTTTTACACTATATTCCTGCCACCAAGGCCTTTTTAAATAAGTAAAAAAAGAAAAAAA

>In-frame_KMT2C_ENST00000355193_chr7_151902191_-_GTF2IRD1_ENST00000476977_chr7_74004180_+_6037nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGATGAAGATGACGCCAACAGACTCGGGGAGAAGGTGATCCTGCGGGAGCAG
GTGAAGGAACTCTTCAACGAGAAATACGGTGAGGCCCTGGGCCTGAACCGGCCGGTGCTGGTCCCTTATAAACTAATCCGGGACAGCCCA
GACGCCGTGGAGGTCACGGGTCTGCCTGATGACATCCCCTTCCGGAACCCCAACACGTACGACATCCACCGGCTGGAGAAGATCCTGAAG
GCCCGAGAGCATGTCCGCATGGTCATCATTAACCAGCTCCAACCCTTTGCAGAAATCTGCAATGATGCCAAGGTGCCAGCCAAAGACAGC
AGCATTCCCAAGCGCAAGAGAAAGCGGGTCTCGGAAGGAAATTCCGTCTCCTCTTCCTCCTCGTCTTCCTCTTCCTCGTCCTCTAACCCG
GATTCAGTGGCATCGGCCAACCAGATCTCACTCGTGGTAAAGTTGCACCGATTTGGACTCCGGCACTCATCTCTGTGGCCCTCACCCCTC
TGTCTGGCAGGGCCGTCTACTCTGGGATGTGGGCCCAGGGGACGGGGAGGCACTGGGCTTTGAGTGGGGACCTTCCGGCCTCGGGGGTTA
TAGATGCATCCACCTGTCTCACCCAAGAGGTAGCCCATCCTTCTCGTGGGGTACTCACAGGCACTCAGGCAGGAATTCACATCCTCGCTG
GGCAGATGGGCCGGCTGAGGTCCACCTGCCCACACCCTTCAGCCGCACCAGAGCTGGAGACATGAAAAGACATGGCTGGCGGGTGCAGTG
GCTCACGCCTGTAATCCCAGCACTTTGGCAGGTCAAGTCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGGCTGACCAACACGGGG
AAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGCAAAGTGGGGCATAGTGGCTCATGCCTGTAATCCCAGCTACTTGGAAGGCTGA
GATAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAATGAGCCGAGGTCGCGCCATTGCACTGCAGCCTGGGCAACAAGAGTGAAAC
ACTGTCTCAGAAAAAAAAATTAGCCAGGCATGGTGGCACGTGCCTGTGGTCGCAGCTACTTGGGAGGCTGGGGCAGGAGGATCATTTGAG
CCCAAGGGGATTGAGGCTGCAGTGAGCCAAGATCGTCCCATTGCACTCCAGCCTGGGCAAGAGAACGAGACTCCATCTCAAAAATAAATA
AATAGGCTGGGTGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGCAGGCGGATCACTTGAGGCTCAGGAGTTCAAGAC
CAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAATAGAAAAATTAGCCGGGCATGGTGGCGGGCGCCTATAATCCCAGCTACTC
GGGAGGCTGAGGCAGGAGACTCGCTTGAACCCGCGGGGCCAAGGTTGCAGTGAGCCGAGATTGCATCACTGCACTCCAGCCTGGGCAGAA
GAGTGAAACTCCATCTCAAAAAAATAAAAAATATAAATAAATAGCCTCTGAGAAAGCTCTTCCAAAAGCAGAACTAAGCATTTTGGGTTT
GTTCCGCATCACCTGGAGTCCTAATCCAGTCCCTTTGTCCCTCTCTCTAGCAATGGCCAATGTACATGGTGGACTATGCCGGCCTGAACG
TGCAGCTCCCGGGACCTCTTAATTACTAGACCTCAGTACTGAATCAGGACCTCACTCAGAAAGACTAAAGGAAATGTAATTTATGTACAA
AATGTATATTCGGATATGTATCGATGCCTTTTAGTTTTTCCAATGATTTTTACACTATATTCCTGCCACCAAGGCCTTTTTAAATAAGTA


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FusionGenePPI for KMT2C_GTF2IRD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KMT2CAK1, NCOA6, ASH2L, RBBP5, HIST2H3C, ASCL2, KDM6A, SMARCB1, MAPK14, JUN, PAXIP1, H3F3A, PAGR1, WDR82, CDC73, TSC22D1, KDM4B, ELAVL1, WDR5, HIST1H3A, APPL2, ERP44, HIST3H3, DPY30, MTNR1B, FOXA1, TRIM25GTF2IRD1HDAC3, PIAS2, SMAD2, USF1, UBC, EXOSC4, BRCA1, MAGEA10, GTF2IRD2B, FBXW11, HNRNPD, SORT1, XRCC1, SYNCRIP, TOR1AIP1, SGTB, BAG6, WASF3, ZNF23, LRRIQ1, PPP2R2D, NOLC1, KIFAP3, AKNAD1, TRIM25, CBX5, CBX1, CBX3, SP1, ALMS1, ATF7IP, ATP2C1, HTRA4, INTS12, KPNA1, KPNA3, KPNA4, MBD3L1, PKP2, SPTLC1, TMEM55A, USP20, VIMP, DCAF6, KPNA2, PIAS1, ZC4H2, ZMYM5, PKP1, ZMYM2, ZMYM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KMT2C_GTF2IRD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KMT2C_GTF2IRD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKMT2CC0001418Adenocarcinoma1CTD_human
HgeneKMT2CC0005695Bladder Neoplasm1CTD_human
HgeneKMT2CC0007138Carcinoma, Transitional Cell1CTD_human
HgeneKMT2CC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKMT2CC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneKMT2CC0023897Liver Diseases, Parasitic1CTD_human
HgeneKMT2CC0036920Sezary Syndrome1CTD_human
HgeneKMT2CC0038356Stomach Neoplasms1CTD_human
HgeneKMT2CC0206698Cholangiocarcinoma1CTD_human
HgeneKMT2CC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneKMT2CC2239176Liver carcinoma1CTD_human
TgeneGTF2IRD1C0175702Williams Syndrome1CTD_human;ORPHANET
TgeneGTF2IRD1C0376634Craniofacial Abnormalities1CTD_human