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Fusion gene ID: 19109 |
FusionGeneSummary for KMT2A_TET1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KMT2A_TET1 | Fusion gene ID: 19109 | Hgene | Tgene | Gene symbol | KMT2A | TET1 | Gene ID | 4297 | 80312 |
| Gene name | lysine methyltransferase 2A | tet methylcytosine dioxygenase 1 | |
| Synonyms | ALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTS | CXXC6|LCX|bA119F7.1 | |
| Cytomap | 11q23.3 | 10q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like | methylcytosine dioxygenase TET1CXXC finger 6CXXC zinc finger 6CXXC-type zinc finger protein 6TET1 splice variant VP_DE4TET1 splice variant VP_DE456leukemia-associated protein with a CXXC domainten-eleven translocation 1 gene proteinten-eleven tran | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q03164 | Q8NFU7 | |
| Ensembl transtripts involved in fusion gene | ENST00000534358, ENST00000389506, ENST00000354520, ENST00000420751, | ENST00000373644, | |
| Fusion gene scores | * DoF score | 31 X 72 X 6=13392 | 2 X 4 X 3=24 |
| # samples | 129 | 5 | |
| ** MAII score | log2(129/13392*10)=-3.37592846223973 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KMT2A [Title/Abstract] AND TET1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KMT2A | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20861184 |
| Hgene | KMT2A | GO:0051568 | histone H3-K4 methylation | 19556245 |
| Hgene | KMT2A | GO:0065003 | protein-containing complex assembly | 15199122 |
| Hgene | KMT2A | GO:0080182 | histone H3-K4 trimethylation | 20861184 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | FM165189 | KMT2A | chr11 | 118355463 | + | TET1 | chr10 | 70440909 | + | ||
| ChiTaRS3.1 | FM165196 | KMT2A | chr11 | 118355030 | + | TET1 | chr10 | 70441154 | + | ||
| ChiTaRS3.1 | FM165191 | KMT2A | chr11 | 118352101 | + | TET1 | chr10 | 70449334 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000534358 | ENST00000373644 | KMT2A | chr11 | 118355463 | + | TET1 | chr10 | 70440909 | + |
| intron-intron | ENST00000389506 | ENST00000373644 | KMT2A | chr11 | 118355463 | + | TET1 | chr10 | 70440909 | + |
| intron-intron | ENST00000354520 | ENST00000373644 | KMT2A | chr11 | 118355463 | + | TET1 | chr10 | 70440909 | + |
| intron-intron | ENST00000420751 | ENST00000373644 | KMT2A | chr11 | 118355463 | + | TET1 | chr10 | 70440909 | + |
| In-frame | ENST00000534358 | ENST00000373644 | KMT2A | chr11 | 118355030 | + | TET1 | chr10 | 70441154 | + |
| In-frame | ENST00000389506 | ENST00000373644 | KMT2A | chr11 | 118355030 | + | TET1 | chr10 | 70441154 | + |
| In-frame | ENST00000354520 | ENST00000373644 | KMT2A | chr11 | 118355030 | + | TET1 | chr10 | 70441154 | + |
| 3UTR-3CDS | ENST00000420751 | ENST00000373644 | KMT2A | chr11 | 118355030 | + | TET1 | chr10 | 70441154 | + |
| intron-intron | ENST00000534358 | ENST00000373644 | KMT2A | chr11 | 118352101 | + | TET1 | chr10 | 70449334 | + |
| intron-intron | ENST00000389506 | ENST00000373644 | KMT2A | chr11 | 118352101 | + | TET1 | chr10 | 70449334 | + |
| intron-intron | ENST00000354520 | ENST00000373644 | KMT2A | chr11 | 118352101 | + | TET1 | chr10 | 70449334 | + |
| intron-intron | ENST00000420751 | ENST00000373644 | KMT2A | chr11 | 118352101 | + | TET1 | chr10 | 70449334 | + |
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FusionProtFeatures for KMT2A_TET1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KMT2A | TET1 |
| Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNAdemethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine(5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probablyconstitutes the first step in cytosine demethylation. Methylationat the C5 position of cytosine bases is an epigenetic modificationof the mammalian genome which plays an important role intranscriptional regulation. In addition to its role in DNAdemethylation, plays a more general role in chromatin regulation.Preferentially binds to CpG-rich sequences at promoters of bothtranscriptionally active and Polycomb-repressed genes. Involved inthe recruitment of the O-GlcNAc transferase OGT to CpG-richtranscription start sites of active genes, thereby promotinghistone H2B GlcNAcylation by OGT. Also involved in transcriptionrepression of a subset of genes through recruitment oftranscriptional repressors to promoters. Involved in the balancebetween pluripotency and lineage commitment of cells it plays arole in embryonic stem cells maintenance and inner cell mass cellspecification. Plays an important role in the tumorigenicity ofglioblastoma cells. TET1-mediated production of 5hmC acts as arecruitment signal for the CHTOP-methylosome complex to selectivesites on the chromosome, where it methylates H4R3 and activatesthe transcription of genes involved in glioblastomagenesis(PubMed:25284789). {ECO:0000269|PubMed:12124344,ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393,ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364,ECO:0000269|PubMed:25284789}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 137_143 | 1406 | 3932 | Compositional bias | Note=Poly-Gly |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 17_102 | 1406 | 3932 | Compositional bias | Note=Ala/Gly/Ser-rich |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 561_564 | 1406 | 3932 | Compositional bias | Note=Poly-Pro |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 568_571 | 1406 | 3932 | Compositional bias | Note=Poly-Pro |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 137_143 | 1406 | 3970 | Compositional bias | Note=Poly-Gly |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 17_102 | 1406 | 3970 | Compositional bias | Note=Ala/Gly/Ser-rich |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 561_564 | 1406 | 3970 | Compositional bias | Note=Poly-Pro |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 568_571 | 1406 | 3970 | Compositional bias | Note=Poly-Pro |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 137_143 | 1406 | 3973 | Compositional bias | Note=Poly-Gly |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 17_102 | 1406 | 3973 | Compositional bias | Note=Ala/Gly/Ser-rich |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 561_564 | 1406 | 3973 | Compositional bias | Note=Poly-Pro |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 568_571 | 1406 | 3973 | Compositional bias | Note=Poly-Pro |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 169_180 | 1406 | 3932 | DNA binding | Note=A.T hook 1 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 217_227 | 1406 | 3932 | DNA binding | Note=A.T hook 2 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 301_309 | 1406 | 3932 | DNA binding | Note=A.T hook 3 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 169_180 | 1406 | 3970 | DNA binding | Note=A.T hook 1 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 217_227 | 1406 | 3970 | DNA binding | Note=A.T hook 2 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 301_309 | 1406 | 3970 | DNA binding | Note=A.T hook 3 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 169_180 | 1406 | 3973 | DNA binding | Note=A.T hook 1 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 217_227 | 1406 | 3973 | DNA binding | Note=A.T hook 2 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 301_309 | 1406 | 3973 | DNA binding | Note=A.T hook 3 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 1147_1195 | 1406 | 3932 | Zinc finger | CXXC-type |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 1147_1195 | 1406 | 3970 | Zinc finger | CXXC-type |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 1147_1195 | 1406 | 3973 | Zinc finger | CXXC-type |
| Tgene | >TET1 | chr11:118355030 | chr10:70441154 | ENST00000373644 | + | 7 | 12 | 2043_2045 | 1608 | 2137 | Region | 2-oxoglutarate binding |
| Tgene | >TET1 | chr11:118355030 | chr10:70441154 | ENST00000373644 | + | 7 | 12 | 2049_2051 | 1608 | 2137 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 1703_1748 | 1406 | 3932 | Domain | Bromo%3B divergent |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 2018_2074 | 1406 | 3932 | Domain | FYR N-terminal |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 3666_3747 | 1406 | 3932 | Domain | FYR C-terminal |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 3829_3945 | 1406 | 3932 | Domain | SET |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 3953_3969 | 1406 | 3932 | Domain | Post-SET |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 1703_1748 | 1406 | 3970 | Domain | Bromo%3B divergent |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 2018_2074 | 1406 | 3970 | Domain | FYR N-terminal |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 3666_3747 | 1406 | 3970 | Domain | FYR C-terminal |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 3829_3945 | 1406 | 3970 | Domain | SET |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 3953_3969 | 1406 | 3970 | Domain | Post-SET |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 1703_1748 | 1406 | 3973 | Domain | Bromo%3B divergent |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 2018_2074 | 1406 | 3973 | Domain | FYR N-terminal |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 3666_3747 | 1406 | 3973 | Domain | FYR C-terminal |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 3829_3945 | 1406 | 3973 | Domain | SET |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 3953_3969 | 1406 | 3973 | Domain | Post-SET |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 3906_3907 | 1406 | 3932 | Region | S-adenosyl-L-methionine binding |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 3906_3907 | 1406 | 3970 | Region | S-adenosyl-L-methionine binding |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 3906_3907 | 1406 | 3973 | Region | S-adenosyl-L-methionine binding |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 1431_1482 | 1406 | 3932 | Zinc finger | PHD-type 1 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 1479_1533 | 1406 | 3932 | Zinc finger | PHD-type 2 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 1566_1627 | 1406 | 3932 | Zinc finger | PHD-type 3 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 1870_1910 | 1406 | 3932 | Zinc finger | C2HC pre-PHD-type |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 1931_1978 | 1406 | 3932 | Zinc finger | PHD-type 4 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 1431_1482 | 1406 | 3970 | Zinc finger | PHD-type 1 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 1479_1533 | 1406 | 3970 | Zinc finger | PHD-type 2 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 1566_1627 | 1406 | 3970 | Zinc finger | PHD-type 3 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 1870_1910 | 1406 | 3970 | Zinc finger | C2HC pre-PHD-type |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 1931_1978 | 1406 | 3970 | Zinc finger | PHD-type 4 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 1431_1482 | 1406 | 3973 | Zinc finger | PHD-type 1 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 1479_1533 | 1406 | 3973 | Zinc finger | PHD-type 2 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 1566_1627 | 1406 | 3973 | Zinc finger | PHD-type 3 |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 1870_1910 | 1406 | 3973 | Zinc finger | C2HC pre-PHD-type |
| Hgene | >KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 1931_1978 | 1406 | 3973 | Zinc finger | PHD-type 4 |
| Tgene | TET1 | chr11:118355030 | chr10:70441154 | ENST00000373644 | + | 7 | 12 | 528_674 | 1608 | 2137 | Region | Note=Sufficient for binding to genomic CpG islands |
| Tgene | TET1 | chr11:118355030 | chr10:70441154 | ENST00000373644 | + | 7 | 12 | 584_625 | 1608 | 2137 | Zinc finger | CXXC-type |
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FusionGeneSequence for KMT2A_TET1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KMT2A_ENST00000534358_chr11_118355030_+_TET1_ENST00000373644_chr10_70441154_+_1935aa MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYE NVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSG AIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFIL KSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPT LSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGP >In-frame_KMT2A_ENST00000389506_chr11_118355030_+_TET1_ENST00000373644_chr10_70441154_+_1935aa MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYE NVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSG AIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFIL KSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPT LSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGP >In-frame_KMT2A_ENST00000354520_chr11_118355030_+_TET1_ENST00000373644_chr10_70441154_+_1935aa MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYE NVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSG AIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFIL KSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPT LSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KMT2A_ENST00000534358_chr11_118355030_+_TET1_ENST00000373644_chr10_70441154_+_5805nt ATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGGGGCGCCGGGGCCTAGGGGGCGCC CCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGGCGCCCCCCTCCCCCCCGGCTGTG GCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAGCAGCCTCCTCGTCGTCCGCCTCG TCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCGACGCGGCGCTGCAGGTCTCGGCC GCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCGGAGAGGATGAGCAATTCTTAGGT TTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTCGAAAACCTCGTGGGAGACCTAGA AGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAGAGACCAAATCTGGAGATAAGATC AAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAATCAAAATAACACATGGAAAGGAC ATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTACGTTTCAGCAAGCCACAAAGATT AAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAGGAAGGAAGGGGGTACAAATTGTA CGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTGAACTGGAAAAGCCCCAGAAAGTC CGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTCGAAGGATTAAGCCAGTTAGGATT ATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGGCTCAAAAGAAAATTGAAAAAGAA GCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTGTTGTCAGTGCTATCTCCTCGCGG ATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGATTAGAGTCTACACCGAATAGTAGA TTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGTCTTCAGACTCCTCTCGATCTAGT AGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGCGGAGCGATACCCCTGAAGTTCAT CCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAGTGTCGGAGAGAAGTTTTGGATCT AGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTCCACCTCTGCTGACTCCACCGCCA CCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAGCATCACCATTTTTGCCTGCTTCC ACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAAAGCATTCTAGGTCAGAGCCACAA TACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGACCCCCTCCACTAACTCCCGAGGAC GTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCCATTCTGGAACAAGGTTTGATATG CACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTGAGTCTGTAACCTTGCCTAGTAAT CGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTCCTATTCGATCTGAACCAAGATCT CCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCCCGTCTTCTGTCTCTTCCTCGTTA AGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCCTGACTCAGTCTGGGGAATCTGCA GAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTACTCCTCTCTTCCCTTGGTTTACC CCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAGATGCTGACAAGAGCGTGGAGAAG GACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAAGGAAAAAGGGATCAGAAATTCAG AGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCACTTCATCTTCTGCCAAAAAAGCA ACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATACAACAGCTGTCAAAACCAAAATA CTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCCTGGAGAAGGAGAAAACCCTCTGC CTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGGCAGACAAGCTTCCAATGACTGAC AAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTCTTAAACAAACCGACCAGCCCAAA GCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCAGAAGAGCAGCTGTTGCCCTTGGC CGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAAAGATTTTGTCTTCCATGGGGAAT GATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTAAACCTGTCACTAGAAACAAGGCA CCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGGTGCCTGAGGACTGTGGTGTTTGT ACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAAAATGTCAGAATCTACAATGGATG CCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCAGTGAAAAGAAAGACAGCAAAGAG AGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTGCCCCAAAGAAAAGCAGTAGTGAG CCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAATCCAAACAGGCCACCACTCCAGCT TCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAGGACCGCCAAGAAAAGAAGTTCCC AAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCAAACAGAAAAAAGTGGCTCCCCGC CCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGAATGCAGGCACTTTGAACATCCTC AGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAGTGGACTTTAAGGAAAAAAACCTT GAAGATAACTTACAGAGTTTGGCTACACGATTAGCTCCAATTTATAAGCAGTATGCTCCAGTAGCTTACCAAAATCAGGTGGAATATGAA AATGTTGCCCGAGAATGTCGGCTTGGCAGCAAGGAAGGTCGTCCCTTCTCTGGGGTCACTGCTTGCCTGGACTTCTGTGCTCATCCCCAC AGGGACATTCACAACATGAATAATGGAAGCACTGTGGTTTGTACCTTAACTCGAGAAGATAACCGCTCTTTGGGTGTTATTCCTCAAGAT GAGCAGCTCCATGTGCTACCTCTTTATAAGCTTTCAGACACAGATGAGTTTGGCTCCAAGGAAGGAATGGAAGCCAAGATCAAATCTGGG GCCATCGAGGTCCTGGCACCCCGCCGCAAAAAAAGAACGTGTTTCACTCAGCCTGTTCCCCGTTCTGGAAAGAAGAGGGCTGCGATGATG ACAGAGGTTCTTGCACATAAGATAAGGGCAGTGGAAAAGAAACCTATTCCCCGAATCAAGCGGAAGAATAACTCAACAACAACAAACAAC AGTAAGCCTTCGTCACTGCCAACCTTAGGGAGTAACACTGAGACCGTGCAACCTGAAGTAAAAAGTGAAACCGAACCCCATTTTATCTTA AAAAGTTCAGACAACACTAAAACTTATTCGCTGATGCCATCCGCTCCTCACCCAGTGAAAGAGGCATCTCCAGGCTTCTCCTGGTCCCCG AAGACTGCTTCAGCCACACCAGCTCCACTGAAGAATGACGCAACAGCCTCATGCGGGTTTTCAGAAAGAAGCAGCACTCCCCACTGTACG ATGCCTTCGGGAAGACTCAGTGGTGCCAATGCAGCTGCTGCTGATGGCCCTGGCATTTCACAGCTTGGCGAAGTGGCTCCTCTCCCCACC CTGTCTGCTCCTGTGATGGAGCCCCTCATTAATTCTGAGCCTTCCACTGGTGTGACTGAGCCGCTAACGCCTCATCAGCCAAACCACCAG CCCTCCTTCCTCACCTCTCCTCAAGACCTTGCCTCTTCTCCAATGGAAGAAGATGAGCAGCATTCTGAAGCAGATGAGCCTCCATCAGAC GAACCCCTATCTGATGACCCCCTGTCACCTGCTGAGGAGAAATTGCCCCACATTGATGAGTATTGGTCAGACAGTGAGCACATCTTTTTG GATGCAAATATTGGTGGGGTGGCCATCGCACCTGCTCACGGCTCGGTTTTGATTGAGTGTGCCCGGCGAGAGCTGCACGCTACCACTCCT GTTGAGCACCCCAACCGTAATCATCCAACCCGCCTCTCCCTTGTCTTTTACCAGCACAAAAACCTAAATAAGCCCCAACATGGTTTTGAA CTAAACAAGATTAAGTTTGAGGCTAAAGAAGCTAAGAATAAGAAAATGAAGGCCTCAGAGCAAAAAGACCAGGCAGCTAATGAAGGTCCA GAACAGTCCTCTGAAGTAAATGAATTGAACCAAATTCCTTCTCATAAAGCATTAACATTAACCCATGACAATGTTGTCACCGTGTCCCCT >In-frame_KMT2A_ENST00000389506_chr11_118355030_+_TET1_ENST00000373644_chr10_70441154_+_5805nt ATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGGGGCGCCGGGGCCTAGGGGGCGCC CCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGGCGCCCCCCTCCCCCCCGGCTGTG GCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAGCAGCCTCCTCGTCGTCCGCCTCG TCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCGACGCGGCGCTGCAGGTCTCGGCC GCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCGGAGAGGATGAGCAATTCTTAGGT TTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTCGAAAACCTCGTGGGAGACCTAGA AGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAGAGACCAAATCTGGAGATAAGATC AAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAATCAAAATAACACATGGAAAGGAC ATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTACGTTTCAGCAAGCCACAAAGATT AAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAGGAAGGAAGGGGGTACAAATTGTA CGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTGAACTGGAAAAGCCCCAGAAAGTC CGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTCGAAGGATTAAGCCAGTTAGGATT ATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGGCTCAAAAGAAAATTGAAAAAGAA GCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTGTTGTCAGTGCTATCTCCTCGCGG ATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGATTAGAGTCTACACCGAATAGTAGA TTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGTCTTCAGACTCCTCTCGATCTAGT AGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGCGGAGCGATACCCCTGAAGTTCAT CCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAGTGTCGGAGAGAAGTTTTGGATCT AGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTCCACCTCTGCTGACTCCACCGCCA CCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAGCATCACCATTTTTGCCTGCTTCC ACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAAAGCATTCTAGGTCAGAGCCACAA TACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGACCCCCTCCACTAACTCCCGAGGAC GTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCCATTCTGGAACAAGGTTTGATATG CACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTGAGTCTGTAACCTTGCCTAGTAAT CGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTCCTATTCGATCTGAACCAAGATCT CCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCCCGTCTTCTGTCTCTTCCTCGTTA AGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCCTGACTCAGTCTGGGGAATCTGCA GAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTACTCCTCTCTTCCCTTGGTTTACC CCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAGATGCTGACAAGAGCGTGGAGAAG GACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAAGGAAAAAGGGATCAGAAATTCAG AGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCACTTCATCTTCTGCCAAAAAAGCA ACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATACAACAGCTGTCAAAACCAAAATA CTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCCTGGAGAAGGAGAAAACCCTCTGC CTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGGCAGACAAGCTTCCAATGACTGAC AAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTCTTAAACAAACCGACCAGCCCAAA GCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCAGAAGAGCAGCTGTTGCCCTTGGC CGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAAAGATTTTGTCTTCCATGGGGAAT GATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTAAACCTGTCACTAGAAACAAGGCA CCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGGTGCCTGAGGACTGTGGTGTTTGT ACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAAAATGTCAGAATCTACAATGGATG CCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCAGTGAAAAGAAAGACAGCAAAGAG AGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTGCCCCAAAGAAAAGCAGTAGTGAG CCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAATCCAAACAGGCCACCACTCCAGCT TCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAGGACCGCCAAGAAAAGAAGTTCCC AAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCAAACAGAAAAAAGTGGCTCCCCGC CCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGAATGCAGGCACTTTGAACATCCTC AGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAGTGGACTTTAAGGAAAAAAACCTT GAAGATAACTTACAGAGTTTGGCTACACGATTAGCTCCAATTTATAAGCAGTATGCTCCAGTAGCTTACCAAAATCAGGTGGAATATGAA AATGTTGCCCGAGAATGTCGGCTTGGCAGCAAGGAAGGTCGTCCCTTCTCTGGGGTCACTGCTTGCCTGGACTTCTGTGCTCATCCCCAC AGGGACATTCACAACATGAATAATGGAAGCACTGTGGTTTGTACCTTAACTCGAGAAGATAACCGCTCTTTGGGTGTTATTCCTCAAGAT GAGCAGCTCCATGTGCTACCTCTTTATAAGCTTTCAGACACAGATGAGTTTGGCTCCAAGGAAGGAATGGAAGCCAAGATCAAATCTGGG GCCATCGAGGTCCTGGCACCCCGCCGCAAAAAAAGAACGTGTTTCACTCAGCCTGTTCCCCGTTCTGGAAAGAAGAGGGCTGCGATGATG ACAGAGGTTCTTGCACATAAGATAAGGGCAGTGGAAAAGAAACCTATTCCCCGAATCAAGCGGAAGAATAACTCAACAACAACAAACAAC AGTAAGCCTTCGTCACTGCCAACCTTAGGGAGTAACACTGAGACCGTGCAACCTGAAGTAAAAAGTGAAACCGAACCCCATTTTATCTTA AAAAGTTCAGACAACACTAAAACTTATTCGCTGATGCCATCCGCTCCTCACCCAGTGAAAGAGGCATCTCCAGGCTTCTCCTGGTCCCCG AAGACTGCTTCAGCCACACCAGCTCCACTGAAGAATGACGCAACAGCCTCATGCGGGTTTTCAGAAAGAAGCAGCACTCCCCACTGTACG ATGCCTTCGGGAAGACTCAGTGGTGCCAATGCAGCTGCTGCTGATGGCCCTGGCATTTCACAGCTTGGCGAAGTGGCTCCTCTCCCCACC CTGTCTGCTCCTGTGATGGAGCCCCTCATTAATTCTGAGCCTTCCACTGGTGTGACTGAGCCGCTAACGCCTCATCAGCCAAACCACCAG CCCTCCTTCCTCACCTCTCCTCAAGACCTTGCCTCTTCTCCAATGGAAGAAGATGAGCAGCATTCTGAAGCAGATGAGCCTCCATCAGAC GAACCCCTATCTGATGACCCCCTGTCACCTGCTGAGGAGAAATTGCCCCACATTGATGAGTATTGGTCAGACAGTGAGCACATCTTTTTG GATGCAAATATTGGTGGGGTGGCCATCGCACCTGCTCACGGCTCGGTTTTGATTGAGTGTGCCCGGCGAGAGCTGCACGCTACCACTCCT GTTGAGCACCCCAACCGTAATCATCCAACCCGCCTCTCCCTTGTCTTTTACCAGCACAAAAACCTAAATAAGCCCCAACATGGTTTTGAA CTAAACAAGATTAAGTTTGAGGCTAAAGAAGCTAAGAATAAGAAAATGAAGGCCTCAGAGCAAAAAGACCAGGCAGCTAATGAAGGTCCA GAACAGTCCTCTGAAGTAAATGAATTGAACCAAATTCCTTCTCATAAAGCATTAACATTAACCCATGACAATGTTGTCACCGTGTCCCCT >In-frame_KMT2A_ENST00000354520_chr11_118355030_+_TET1_ENST00000373644_chr10_70441154_+_5805nt ATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGGGGCGCCGGGGCCTAGGGGGCGCC CCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGGCGCCCCCCTCCCCCCCGGCTGTG GCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAGCAGCCTCCTCGTCGTCCGCCTCG TCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCGACGCGGCGCTGCAGGTCTCGGCC GCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCGGAGAGGATGAGCAATTCTTAGGT TTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTCGAAAACCTCGTGGGAGACCTAGA AGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAGAGACCAAATCTGGAGATAAGATC AAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAATCAAAATAACACATGGAAAGGAC ATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTACGTTTCAGCAAGCCACAAAGATT AAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAGGAAGGAAGGGGGTACAAATTGTA CGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTGAACTGGAAAAGCCCCAGAAAGTC CGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTCGAAGGATTAAGCCAGTTAGGATT ATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGGCTCAAAAGAAAATTGAAAAAGAA GCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTGTTGTCAGTGCTATCTCCTCGCGG ATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGATTAGAGTCTACACCGAATAGTAGA TTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGTCTTCAGACTCCTCTCGATCTAGT AGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGCGGAGCGATACCCCTGAAGTTCAT CCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAGTGTCGGAGAGAAGTTTTGGATCT AGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTCCACCTCTGCTGACTCCACCGCCA CCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAGCATCACCATTTTTGCCTGCTTCC ACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAAAGCATTCTAGGTCAGAGCCACAA TACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGACCCCCTCCACTAACTCCCGAGGAC GTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCCATTCTGGAACAAGGTTTGATATG CACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTGAGTCTGTAACCTTGCCTAGTAAT CGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTCCTATTCGATCTGAACCAAGATCT CCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCCCGTCTTCTGTCTCTTCCTCGTTA AGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCCTGACTCAGTCTGGGGAATCTGCA GAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTACTCCTCTCTTCCCTTGGTTTACC CCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAGATGCTGACAAGAGCGTGGAGAAG GACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAAGGAAAAAGGGATCAGAAATTCAG AGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCACTTCATCTTCTGCCAAAAAAGCA ACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATACAACAGCTGTCAAAACCAAAATA CTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCCTGGAGAAGGAGAAAACCCTCTGC CTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGGCAGACAAGCTTCCAATGACTGAC AAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTCTTAAACAAACCGACCAGCCCAAA GCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCAGAAGAGCAGCTGTTGCCCTTGGC CGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAAAGATTTTGTCTTCCATGGGGAAT GATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTAAACCTGTCACTAGAAACAAGGCA CCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGGTGCCTGAGGACTGTGGTGTTTGT ACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAAAATGTCAGAATCTACAATGGATG CCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCAGTGAAAAGAAAGACAGCAAAGAG AGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTGCCCCAAAGAAAAGCAGTAGTGAG CCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAATCCAAACAGGCCACCACTCCAGCT TCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAGGACCGCCAAGAAAAGAAGTTCCC AAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCAAACAGAAAAAAGTGGCTCCCCGC CCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGAATGCAGGCACTTTGAACATCCTC AGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAGTGGACTTTAAGGAAAAAAACCTT GAAGATAACTTACAGAGTTTGGCTACACGATTAGCTCCAATTTATAAGCAGTATGCTCCAGTAGCTTACCAAAATCAGGTGGAATATGAA AATGTTGCCCGAGAATGTCGGCTTGGCAGCAAGGAAGGTCGTCCCTTCTCTGGGGTCACTGCTTGCCTGGACTTCTGTGCTCATCCCCAC AGGGACATTCACAACATGAATAATGGAAGCACTGTGGTTTGTACCTTAACTCGAGAAGATAACCGCTCTTTGGGTGTTATTCCTCAAGAT GAGCAGCTCCATGTGCTACCTCTTTATAAGCTTTCAGACACAGATGAGTTTGGCTCCAAGGAAGGAATGGAAGCCAAGATCAAATCTGGG GCCATCGAGGTCCTGGCACCCCGCCGCAAAAAAAGAACGTGTTTCACTCAGCCTGTTCCCCGTTCTGGAAAGAAGAGGGCTGCGATGATG ACAGAGGTTCTTGCACATAAGATAAGGGCAGTGGAAAAGAAACCTATTCCCCGAATCAAGCGGAAGAATAACTCAACAACAACAAACAAC AGTAAGCCTTCGTCACTGCCAACCTTAGGGAGTAACACTGAGACCGTGCAACCTGAAGTAAAAAGTGAAACCGAACCCCATTTTATCTTA AAAAGTTCAGACAACACTAAAACTTATTCGCTGATGCCATCCGCTCCTCACCCAGTGAAAGAGGCATCTCCAGGCTTCTCCTGGTCCCCG AAGACTGCTTCAGCCACACCAGCTCCACTGAAGAATGACGCAACAGCCTCATGCGGGTTTTCAGAAAGAAGCAGCACTCCCCACTGTACG ATGCCTTCGGGAAGACTCAGTGGTGCCAATGCAGCTGCTGCTGATGGCCCTGGCATTTCACAGCTTGGCGAAGTGGCTCCTCTCCCCACC CTGTCTGCTCCTGTGATGGAGCCCCTCATTAATTCTGAGCCTTCCACTGGTGTGACTGAGCCGCTAACGCCTCATCAGCCAAACCACCAG CCCTCCTTCCTCACCTCTCCTCAAGACCTTGCCTCTTCTCCAATGGAAGAAGATGAGCAGCATTCTGAAGCAGATGAGCCTCCATCAGAC GAACCCCTATCTGATGACCCCCTGTCACCTGCTGAGGAGAAATTGCCCCACATTGATGAGTATTGGTCAGACAGTGAGCACATCTTTTTG GATGCAAATATTGGTGGGGTGGCCATCGCACCTGCTCACGGCTCGGTTTTGATTGAGTGTGCCCGGCGAGAGCTGCACGCTACCACTCCT GTTGAGCACCCCAACCGTAATCATCCAACCCGCCTCTCCCTTGTCTTTTACCAGCACAAAAACCTAAATAAGCCCCAACATGGTTTTGAA CTAAACAAGATTAAGTTTGAGGCTAAAGAAGCTAAGAATAAGAAAATGAAGGCCTCAGAGCAAAAAGACCAGGCAGCTAATGAAGGTCCA GAACAGTCCTCTGAAGTAAATGAATTGAACCAAATTCCTTCTCATAAAGCATTAACATTAACCCATGACAATGTTGTCACCGTGTCCCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KMT2A_ENST00000534358_chr11_118355030_+_TET1_ENST00000373644_chr10_70441154_+_8496nt CTGCTTCACTTCACGGGGCGAACATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGG GGCGCCGGGGCCTAGGGGGCGCCCCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGG CGCCCCCCTCCCCCCCGGCTGTGGCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAG CAGCCTCCTCGTCGTCCGCCTCGTCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCG ACGCGGCGCTGCAGGTCTCGGCCGCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCG GAGAGGATGAGCAATTCTTAGGTTTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTC GAAAACCTCGTGGGAGACCTAGAAGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAG AGACCAAATCTGGAGATAAGATCAAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAA TCAAAATAACACATGGAAAGGACATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTA CGTTTCAGCAAGCCACAAAGATTAAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAG GAAGGAAGGGGGTACAAATTGTACGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTG AACTGGAAAAGCCCCAGAAAGTCCGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTC GAAGGATTAAGCCAGTTAGGATTATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGG CTCAAAAGAAAATTGAAAAAGAAGCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTG TTGTCAGTGCTATCTCCTCGCGGATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGAT TAGAGTCTACACCGAATAGTAGATTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGT CTTCAGACTCCTCTCGATCTAGTAGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGC GGAGCGATACCCCTGAAGTTCATCCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAG TGTCGGAGAGAAGTTTTGGATCTAGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTC CACCTCTGCTGACTCCACCGCCACCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAG CATCACCATTTTTGCCTGCTTCCACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAA AGCATTCTAGGTCAGAGCCACAATACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGAC CCCCTCCACTAACTCCCGAGGACGTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCC ATTCTGGAACAAGGTTTGATATGCACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTG AGTCTGTAACCTTGCCTAGTAATCGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTC CTATTCGATCTGAACCAAGATCTCCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCC CGTCTTCTGTCTCTTCCTCGTTAAGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCC TGACTCAGTCTGGGGAATCTGCAGAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTA CTCCTCTCTTCCCTTGGTTTACCCCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAG ATGCTGACAAGAGCGTGGAGAAGGACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAA GGAAAAAGGGATCAGAAATTCAGAGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCA CTTCATCTTCTGCCAAAAAAGCAACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATA CAACAGCTGTCAAAACCAAAATACTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCC TGGAGAAGGAGAAAACCCTCTGCCTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGG CAGACAAGCTTCCAATGACTGACAAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTC TTAAACAAACCGACCAGCCCAAAGCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCA GAAGAGCAGCTGTTGCCCTTGGCCGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAA AGATTTTGTCTTCCATGGGGAATGATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTA AACCTGTCACTAGAAACAAGGCACCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGG TGCCTGAGGACTGTGGTGTTTGTACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAA AATGTCAGAATCTACAATGGATGCCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCA GTGAAAAGAAAGACAGCAAAGAGAGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTG CCCCAAAGAAAAGCAGTAGTGAGCCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAAT CCAAACAGGCCACCACTCCAGCTTCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAG GACCGCCAAGAAAAGAAGTTCCCAAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCA AACAGAAAAAAGTGGCTCCCCGCCCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGA ATGCAGGCACTTTGAACATCCTCAGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAG TGGACTTTAAGGAAAAAAACCTTGAAGATAACTTACAGAGTTTGGCTACACGATTAGCTCCAATTTATAAGCAGTATGCTCCAGTAGCTT ACCAAAATCAGGTGGAATATGAAAATGTTGCCCGAGAATGTCGGCTTGGCAGCAAGGAAGGTCGTCCCTTCTCTGGGGTCACTGCTTGCC TGGACTTCTGTGCTCATCCCCACAGGGACATTCACAACATGAATAATGGAAGCACTGTGGTTTGTACCTTAACTCGAGAAGATAACCGCT CTTTGGGTGTTATTCCTCAAGATGAGCAGCTCCATGTGCTACCTCTTTATAAGCTTTCAGACACAGATGAGTTTGGCTCCAAGGAAGGAA TGGAAGCCAAGATCAAATCTGGGGCCATCGAGGTCCTGGCACCCCGCCGCAAAAAAAGAACGTGTTTCACTCAGCCTGTTCCCCGTTCTG GAAAGAAGAGGGCTGCGATGATGACAGAGGTTCTTGCACATAAGATAAGGGCAGTGGAAAAGAAACCTATTCCCCGAATCAAGCGGAAGA ATAACTCAACAACAACAAACAACAGTAAGCCTTCGTCACTGCCAACCTTAGGGAGTAACACTGAGACCGTGCAACCTGAAGTAAAAAGTG AAACCGAACCCCATTTTATCTTAAAAAGTTCAGACAACACTAAAACTTATTCGCTGATGCCATCCGCTCCTCACCCAGTGAAAGAGGCAT CTCCAGGCTTCTCCTGGTCCCCGAAGACTGCTTCAGCCACACCAGCTCCACTGAAGAATGACGCAACAGCCTCATGCGGGTTTTCAGAAA GAAGCAGCACTCCCCACTGTACGATGCCTTCGGGAAGACTCAGTGGTGCCAATGCAGCTGCTGCTGATGGCCCTGGCATTTCACAGCTTG GCGAAGTGGCTCCTCTCCCCACCCTGTCTGCTCCTGTGATGGAGCCCCTCATTAATTCTGAGCCTTCCACTGGTGTGACTGAGCCGCTAA CGCCTCATCAGCCAAACCACCAGCCCTCCTTCCTCACCTCTCCTCAAGACCTTGCCTCTTCTCCAATGGAAGAAGATGAGCAGCATTCTG AAGCAGATGAGCCTCCATCAGACGAACCCCTATCTGATGACCCCCTGTCACCTGCTGAGGAGAAATTGCCCCACATTGATGAGTATTGGT CAGACAGTGAGCACATCTTTTTGGATGCAAATATTGGTGGGGTGGCCATCGCACCTGCTCACGGCTCGGTTTTGATTGAGTGTGCCCGGC GAGAGCTGCACGCTACCACTCCTGTTGAGCACCCCAACCGTAATCATCCAACCCGCCTCTCCCTTGTCTTTTACCAGCACAAAAACCTAA ATAAGCCCCAACATGGTTTTGAACTAAACAAGATTAAGTTTGAGGCTAAAGAAGCTAAGAATAAGAAAATGAAGGCCTCAGAGCAAAAAG ACCAGGCAGCTAATGAAGGTCCAGAACAGTCCTCTGAAGTAAATGAATTGAACCAAATTCCTTCTCATAAAGCATTAACATTAACCCATG ACAATGTTGTCACCGTGTCCCCTTATGCTCTCACACACGTTGCGGGGCCCTATAACCATTGGGTCTGAAGGCTTTTCTCCCCCTCTTAAT GCCTTTGCTAGTGCAGTGTATTTTTTCAAGGTGCTGTTAAAAGAAAGTCATGTTGTCGTTTACTATCTTCATCTCACCCATTTCAAGTCT GAGGTAAAAAAATAATAATGATAACAAAACGGGGTGGGTATTCTTAACTGTGACTATATTTTGACAATTGGTAGAAGGTGCACATTTTAA GCAAAAATAAAAGTTTTATAGTTTTAAATACATAAAGAAATGTTTCAGTTAGGCATTAACCTTGATAGAATCACTCAGTTTGGTGCTTTA AATTAAGTCTGTTTACTATGAAACAAGAGTCATTTTTAGAGGATTTTAACAGGTTCATGTTCTATGATGTAAAATCAAGACACACAGTGT TAACTCTACACAGCTTCTGGTGCTTAACCACATCCACACAGTTAAAAATAAGCTGAATTATTATTTCATGGTGCCATTGTTCCAACATCT TCCAATCATTGCTAGAAAATTGGCATATTCCTTTGAAATAAACTTATGAAATGTTTTCTCTCTTAAAATATTTCTCCTGTGTAAAATAAA TCATTGTTGTTAGTAATGGTTGGAGGCTGTTCATAAATTGTAAATATATATTTTAAAAGCACTTTCTATTTTTAAAAGTAACTTGAAATA ATATAGTATAAGAATCCTATTGTCTATTGTTTGTGCATATTTGCATACAAGAGAAATCATTTATCCTTGCTGTGTAGAGTTCCATCTTGT TAACTGCAGTATGTATTCTAATCATGTATATGGTTTGTGTTCTTTTACTGTGTCCTCTCACATTCAAGTATTAGCAACTTGCAGTATATA AAATAGTTAGATAATGAGAAGTTGTTAATTATCTCTAAAATTGGAATTAGGAAGCATATCACCAATACTGATTAACATTCTCTTTGGAAC TAGGTAAGAGTGGTCTCTTCTTATTGAACAACCTCAATTTAGTTTCATCCCACCTTTCTCAGTATAATCCATGAGAGGTGTTTCCAAAAG GAGATGAGGGAACAGGATAGGTTTCAGAAGAGTCAAATGCTTCTAATGTCTCAAGGTGATAAAATACAAAAACTAAGTAGACAGATATTT GTACTGAAGTCTGATACAGAATTAGAAAAAAAAAATTCTTGTTGAAATATTTTGAAAACAAATTCCCTACTATCATCACATGCCTCCCCA ACCCCAAGTCAAAAACAAGAGGAATGGTACTACAAACATGGCTTTGTCCATTAAGAGCTAATTCATTTGTTTATCTTAGCATACTAGATT TGGGAAAATGATAACTCATCTTTTCTGATAATTGCCTATGTTCTAGGTAACAGGAAAACAGGCATTAAGTTTATTTTAGTCTTCCCATTT TCTTCCTATTACTTTATTGACTCATTTTATTGCAAAACAAAAAGGATTACCCAAACAACATGTTTCGAACAAGGAGAATTTTCAATGAAA TACTTGATTCTGTTAAAATGCAGAGGTGCTATAACATTCAAAGTGTCAGATTCCTTGGGAGTATGGAAAACCTAATGGTGCTTCTCCCTT GGAAATGCCATAGGAAGCCCACAACCGCTAACACTTACAATTTTGGTGCAAAAGCAAACAGTTCCAGCAGGCTCTCTAAAGAAAAACTCA TTGTAACTTATTAAAATAATATCTGGTGCAAAGTATCTGTTTTGAGCTTTTGACTAATCCAAGTAAAGGAATATGAAGGGATTGTAAAAA ACAAAATGTCCATTGATAGACCATCGTGTACAAGTAGATTTCTGCTTGTTGAATATGTAAAATAGGGTAATTCATTGACTTGTTTTAGTA TTTTGTGTGCCTTAGATTTCCGTTTTAAGACATGTATATTTTTGTGAGCCTAAGGTTTCTTATATACATATAAGTATATAAATAAGTGAT TGTTTATTGCTTCAGCTGCTTCAACAAGATATTTACTAGTATTAGACTATCAGGAATACACCCTTGCGAGATTATGTTTTAGATTTTAGG CCTTAGCTCCCACTAGAAATTATTTCTTCACCAGATTTAATGGATAAAGTTTTATGGCTCTTTATGCATCCACTCATCTACTCATTCTTC GAGTCTACACTTATTGAATGCCTGCAAAATCTAAGTATCACTTTTATTTTTCTTTGGATCACCACCTATGACATAGTAAACTTGAAGAAT AAAAACTACCCTCAGAAATATTTTTAAAAGAAGTAGCAAATTATCTTCAGTATAATCCATGGTAATGTATGCAGTAATTCAAATTGATCT CTCTCTCAATAGGTTTCTTAACAATCTAAACTTGAAACATCAATGTTAATTTTTGGAACTATTGGGATTTGTGACGCTTGTTGCAGTTTA CCAAAACAAGTATTTGAAAATATATAGTATCAACTGAAATGTTTCCATTCCGTTGTTGTAGTTAACATCATGAATGGACTTCTTAAGCTG ATTACCCCACTGTGGGAACCAAATTGGATTCCTACTTTGTTGGACTCTCTTTCCTGATTTTAACAATTTACCATCCCATTCTCTGCCCTG TGATTTTTTTTAAAAGCTTATTCAATGTTCTGCAGCATTGTGATTGTATGCTGGCTACACTGCTTTTAGAATGCTCTTTCTCATGAAGCA >In-frame_KMT2A_ENST00000389506_chr11_118355030_+_TET1_ENST00000373644_chr10_70441154_+_8473nt ATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGGGGCGCCGGGGCCTAGGGGGCGCC CCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGGCGCCCCCCTCCCCCCCGGCTGTG GCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAGCAGCCTCCTCGTCGTCCGCCTCG TCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCGACGCGGCGCTGCAGGTCTCGGCC GCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCGGAGAGGATGAGCAATTCTTAGGT TTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTCGAAAACCTCGTGGGAGACCTAGA AGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAGAGACCAAATCTGGAGATAAGATC AAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAATCAAAATAACACATGGAAAGGAC ATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTACGTTTCAGCAAGCCACAAAGATT AAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAGGAAGGAAGGGGGTACAAATTGTA CGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTGAACTGGAAAAGCCCCAGAAAGTC CGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTCGAAGGATTAAGCCAGTTAGGATT ATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGGCTCAAAAGAAAATTGAAAAAGAA GCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTGTTGTCAGTGCTATCTCCTCGCGG ATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGATTAGAGTCTACACCGAATAGTAGA TTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGTCTTCAGACTCCTCTCGATCTAGT AGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGCGGAGCGATACCCCTGAAGTTCAT CCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAGTGTCGGAGAGAAGTTTTGGATCT AGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTCCACCTCTGCTGACTCCACCGCCA CCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAGCATCACCATTTTTGCCTGCTTCC ACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAAAGCATTCTAGGTCAGAGCCACAA TACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGACCCCCTCCACTAACTCCCGAGGAC GTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCCATTCTGGAACAAGGTTTGATATG CACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTGAGTCTGTAACCTTGCCTAGTAAT CGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTCCTATTCGATCTGAACCAAGATCT CCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCCCGTCTTCTGTCTCTTCCTCGTTA AGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCCTGACTCAGTCTGGGGAATCTGCA GAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTACTCCTCTCTTCCCTTGGTTTACC CCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAGATGCTGACAAGAGCGTGGAGAAG GACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAAGGAAAAAGGGATCAGAAATTCAG AGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCACTTCATCTTCTGCCAAAAAAGCA ACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATACAACAGCTGTCAAAACCAAAATA CTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCCTGGAGAAGGAGAAAACCCTCTGC CTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGGCAGACAAGCTTCCAATGACTGAC AAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTCTTAAACAAACCGACCAGCCCAAA GCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCAGAAGAGCAGCTGTTGCCCTTGGC CGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAAAGATTTTGTCTTCCATGGGGAAT GATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTAAACCTGTCACTAGAAACAAGGCA CCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGGTGCCTGAGGACTGTGGTGTTTGT ACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAAAATGTCAGAATCTACAATGGATG CCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCAGTGAAAAGAAAGACAGCAAAGAG AGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTGCCCCAAAGAAAAGCAGTAGTGAG CCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAATCCAAACAGGCCACCACTCCAGCT TCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAGGACCGCCAAGAAAAGAAGTTCCC AAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCAAACAGAAAAAAGTGGCTCCCCGC CCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGAATGCAGGCACTTTGAACATCCTC AGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAGTGGACTTTAAGGAAAAAAACCTT GAAGATAACTTACAGAGTTTGGCTACACGATTAGCTCCAATTTATAAGCAGTATGCTCCAGTAGCTTACCAAAATCAGGTGGAATATGAA AATGTTGCCCGAGAATGTCGGCTTGGCAGCAAGGAAGGTCGTCCCTTCTCTGGGGTCACTGCTTGCCTGGACTTCTGTGCTCATCCCCAC AGGGACATTCACAACATGAATAATGGAAGCACTGTGGTTTGTACCTTAACTCGAGAAGATAACCGCTCTTTGGGTGTTATTCCTCAAGAT GAGCAGCTCCATGTGCTACCTCTTTATAAGCTTTCAGACACAGATGAGTTTGGCTCCAAGGAAGGAATGGAAGCCAAGATCAAATCTGGG GCCATCGAGGTCCTGGCACCCCGCCGCAAAAAAAGAACGTGTTTCACTCAGCCTGTTCCCCGTTCTGGAAAGAAGAGGGCTGCGATGATG ACAGAGGTTCTTGCACATAAGATAAGGGCAGTGGAAAAGAAACCTATTCCCCGAATCAAGCGGAAGAATAACTCAACAACAACAAACAAC AGTAAGCCTTCGTCACTGCCAACCTTAGGGAGTAACACTGAGACCGTGCAACCTGAAGTAAAAAGTGAAACCGAACCCCATTTTATCTTA AAAAGTTCAGACAACACTAAAACTTATTCGCTGATGCCATCCGCTCCTCACCCAGTGAAAGAGGCATCTCCAGGCTTCTCCTGGTCCCCG AAGACTGCTTCAGCCACACCAGCTCCACTGAAGAATGACGCAACAGCCTCATGCGGGTTTTCAGAAAGAAGCAGCACTCCCCACTGTACG ATGCCTTCGGGAAGACTCAGTGGTGCCAATGCAGCTGCTGCTGATGGCCCTGGCATTTCACAGCTTGGCGAAGTGGCTCCTCTCCCCACC CTGTCTGCTCCTGTGATGGAGCCCCTCATTAATTCTGAGCCTTCCACTGGTGTGACTGAGCCGCTAACGCCTCATCAGCCAAACCACCAG CCCTCCTTCCTCACCTCTCCTCAAGACCTTGCCTCTTCTCCAATGGAAGAAGATGAGCAGCATTCTGAAGCAGATGAGCCTCCATCAGAC GAACCCCTATCTGATGACCCCCTGTCACCTGCTGAGGAGAAATTGCCCCACATTGATGAGTATTGGTCAGACAGTGAGCACATCTTTTTG GATGCAAATATTGGTGGGGTGGCCATCGCACCTGCTCACGGCTCGGTTTTGATTGAGTGTGCCCGGCGAGAGCTGCACGCTACCACTCCT GTTGAGCACCCCAACCGTAATCATCCAACCCGCCTCTCCCTTGTCTTTTACCAGCACAAAAACCTAAATAAGCCCCAACATGGTTTTGAA CTAAACAAGATTAAGTTTGAGGCTAAAGAAGCTAAGAATAAGAAAATGAAGGCCTCAGAGCAAAAAGACCAGGCAGCTAATGAAGGTCCA GAACAGTCCTCTGAAGTAAATGAATTGAACCAAATTCCTTCTCATAAAGCATTAACATTAACCCATGACAATGTTGTCACCGTGTCCCCT TATGCTCTCACACACGTTGCGGGGCCCTATAACCATTGGGTCTGAAGGCTTTTCTCCCCCTCTTAATGCCTTTGCTAGTGCAGTGTATTT TTTCAAGGTGCTGTTAAAAGAAAGTCATGTTGTCGTTTACTATCTTCATCTCACCCATTTCAAGTCTGAGGTAAAAAAATAATAATGATA ACAAAACGGGGTGGGTATTCTTAACTGTGACTATATTTTGACAATTGGTAGAAGGTGCACATTTTAAGCAAAAATAAAAGTTTTATAGTT TTAAATACATAAAGAAATGTTTCAGTTAGGCATTAACCTTGATAGAATCACTCAGTTTGGTGCTTTAAATTAAGTCTGTTTACTATGAAA CAAGAGTCATTTTTAGAGGATTTTAACAGGTTCATGTTCTATGATGTAAAATCAAGACACACAGTGTTAACTCTACACAGCTTCTGGTGC TTAACCACATCCACACAGTTAAAAATAAGCTGAATTATTATTTCATGGTGCCATTGTTCCAACATCTTCCAATCATTGCTAGAAAATTGG CATATTCCTTTGAAATAAACTTATGAAATGTTTTCTCTCTTAAAATATTTCTCCTGTGTAAAATAAATCATTGTTGTTAGTAATGGTTGG AGGCTGTTCATAAATTGTAAATATATATTTTAAAAGCACTTTCTATTTTTAAAAGTAACTTGAAATAATATAGTATAAGAATCCTATTGT CTATTGTTTGTGCATATTTGCATACAAGAGAAATCATTTATCCTTGCTGTGTAGAGTTCCATCTTGTTAACTGCAGTATGTATTCTAATC ATGTATATGGTTTGTGTTCTTTTACTGTGTCCTCTCACATTCAAGTATTAGCAACTTGCAGTATATAAAATAGTTAGATAATGAGAAGTT GTTAATTATCTCTAAAATTGGAATTAGGAAGCATATCACCAATACTGATTAACATTCTCTTTGGAACTAGGTAAGAGTGGTCTCTTCTTA TTGAACAACCTCAATTTAGTTTCATCCCACCTTTCTCAGTATAATCCATGAGAGGTGTTTCCAAAAGGAGATGAGGGAACAGGATAGGTT TCAGAAGAGTCAAATGCTTCTAATGTCTCAAGGTGATAAAATACAAAAACTAAGTAGACAGATATTTGTACTGAAGTCTGATACAGAATT AGAAAAAAAAAATTCTTGTTGAAATATTTTGAAAACAAATTCCCTACTATCATCACATGCCTCCCCAACCCCAAGTCAAAAACAAGAGGA ATGGTACTACAAACATGGCTTTGTCCATTAAGAGCTAATTCATTTGTTTATCTTAGCATACTAGATTTGGGAAAATGATAACTCATCTTT TCTGATAATTGCCTATGTTCTAGGTAACAGGAAAACAGGCATTAAGTTTATTTTAGTCTTCCCATTTTCTTCCTATTACTTTATTGACTC ATTTTATTGCAAAACAAAAAGGATTACCCAAACAACATGTTTCGAACAAGGAGAATTTTCAATGAAATACTTGATTCTGTTAAAATGCAG AGGTGCTATAACATTCAAAGTGTCAGATTCCTTGGGAGTATGGAAAACCTAATGGTGCTTCTCCCTTGGAAATGCCATAGGAAGCCCACA ACCGCTAACACTTACAATTTTGGTGCAAAAGCAAACAGTTCCAGCAGGCTCTCTAAAGAAAAACTCATTGTAACTTATTAAAATAATATC TGGTGCAAAGTATCTGTTTTGAGCTTTTGACTAATCCAAGTAAAGGAATATGAAGGGATTGTAAAAAACAAAATGTCCATTGATAGACCA TCGTGTACAAGTAGATTTCTGCTTGTTGAATATGTAAAATAGGGTAATTCATTGACTTGTTTTAGTATTTTGTGTGCCTTAGATTTCCGT TTTAAGACATGTATATTTTTGTGAGCCTAAGGTTTCTTATATACATATAAGTATATAAATAAGTGATTGTTTATTGCTTCAGCTGCTTCA ACAAGATATTTACTAGTATTAGACTATCAGGAATACACCCTTGCGAGATTATGTTTTAGATTTTAGGCCTTAGCTCCCACTAGAAATTAT TTCTTCACCAGATTTAATGGATAAAGTTTTATGGCTCTTTATGCATCCACTCATCTACTCATTCTTCGAGTCTACACTTATTGAATGCCT GCAAAATCTAAGTATCACTTTTATTTTTCTTTGGATCACCACCTATGACATAGTAAACTTGAAGAATAAAAACTACCCTCAGAAATATTT TTAAAAGAAGTAGCAAATTATCTTCAGTATAATCCATGGTAATGTATGCAGTAATTCAAATTGATCTCTCTCTCAATAGGTTTCTTAACA ATCTAAACTTGAAACATCAATGTTAATTTTTGGAACTATTGGGATTTGTGACGCTTGTTGCAGTTTACCAAAACAAGTATTTGAAAATAT ATAGTATCAACTGAAATGTTTCCATTCCGTTGTTGTAGTTAACATCATGAATGGACTTCTTAAGCTGATTACCCCACTGTGGGAACCAAA TTGGATTCCTACTTTGTTGGACTCTCTTTCCTGATTTTAACAATTTACCATCCCATTCTCTGCCCTGTGATTTTTTTTAAAAGCTTATTC AATGTTCTGCAGCATTGTGATTGTATGCTGGCTACACTGCTTTTAGAATGCTCTTTCTCATGAAGCAAGGAAATAAATTTGTTTGAAATG >In-frame_KMT2A_ENST00000354520_chr11_118355030_+_TET1_ENST00000373644_chr10_70441154_+_8473nt ATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGGGGCGCCGGGGCCTAGGGGGCGCC CCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGGCGCCCCCCTCCCCCCCGGCTGTG GCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAGCAGCCTCCTCGTCGTCCGCCTCG TCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCGACGCGGCGCTGCAGGTCTCGGCC GCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCGGAGAGGATGAGCAATTCTTAGGT TTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTCGAAAACCTCGTGGGAGACCTAGA AGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAGAGACCAAATCTGGAGATAAGATC AAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAATCAAAATAACACATGGAAAGGAC ATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTACGTTTCAGCAAGCCACAAAGATT AAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAGGAAGGAAGGGGGTACAAATTGTA CGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTGAACTGGAAAAGCCCCAGAAAGTC CGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTCGAAGGATTAAGCCAGTTAGGATT ATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGGCTCAAAAGAAAATTGAAAAAGAA GCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTGTTGTCAGTGCTATCTCCTCGCGG ATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGATTAGAGTCTACACCGAATAGTAGA TTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGTCTTCAGACTCCTCTCGATCTAGT AGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGCGGAGCGATACCCCTGAAGTTCAT CCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAGTGTCGGAGAGAAGTTTTGGATCT AGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTCCACCTCTGCTGACTCCACCGCCA CCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAGCATCACCATTTTTGCCTGCTTCC ACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAAAGCATTCTAGGTCAGAGCCACAA TACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGACCCCCTCCACTAACTCCCGAGGAC GTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCCATTCTGGAACAAGGTTTGATATG CACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTGAGTCTGTAACCTTGCCTAGTAAT CGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTCCTATTCGATCTGAACCAAGATCT CCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCCCGTCTTCTGTCTCTTCCTCGTTA AGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCCTGACTCAGTCTGGGGAATCTGCA GAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTACTCCTCTCTTCCCTTGGTTTACC CCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAGATGCTGACAAGAGCGTGGAGAAG GACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAAGGAAAAAGGGATCAGAAATTCAG AGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCACTTCATCTTCTGCCAAAAAAGCA ACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATACAACAGCTGTCAAAACCAAAATA CTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCCTGGAGAAGGAGAAAACCCTCTGC CTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGGCAGACAAGCTTCCAATGACTGAC AAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTCTTAAACAAACCGACCAGCCCAAA GCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCAGAAGAGCAGCTGTTGCCCTTGGC CGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAAAGATTTTGTCTTCCATGGGGAAT GATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTAAACCTGTCACTAGAAACAAGGCA CCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGGTGCCTGAGGACTGTGGTGTTTGT ACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAAAATGTCAGAATCTACAATGGATG CCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCAGTGAAAAGAAAGACAGCAAAGAG AGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTGCCCCAAAGAAAAGCAGTAGTGAG CCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAATCCAAACAGGCCACCACTCCAGCT TCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAGGACCGCCAAGAAAAGAAGTTCCC AAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCAAACAGAAAAAAGTGGCTCCCCGC CCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGAATGCAGGCACTTTGAACATCCTC AGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAGTGGACTTTAAGGAAAAAAACCTT GAAGATAACTTACAGAGTTTGGCTACACGATTAGCTCCAATTTATAAGCAGTATGCTCCAGTAGCTTACCAAAATCAGGTGGAATATGAA AATGTTGCCCGAGAATGTCGGCTTGGCAGCAAGGAAGGTCGTCCCTTCTCTGGGGTCACTGCTTGCCTGGACTTCTGTGCTCATCCCCAC AGGGACATTCACAACATGAATAATGGAAGCACTGTGGTTTGTACCTTAACTCGAGAAGATAACCGCTCTTTGGGTGTTATTCCTCAAGAT GAGCAGCTCCATGTGCTACCTCTTTATAAGCTTTCAGACACAGATGAGTTTGGCTCCAAGGAAGGAATGGAAGCCAAGATCAAATCTGGG GCCATCGAGGTCCTGGCACCCCGCCGCAAAAAAAGAACGTGTTTCACTCAGCCTGTTCCCCGTTCTGGAAAGAAGAGGGCTGCGATGATG ACAGAGGTTCTTGCACATAAGATAAGGGCAGTGGAAAAGAAACCTATTCCCCGAATCAAGCGGAAGAATAACTCAACAACAACAAACAAC AGTAAGCCTTCGTCACTGCCAACCTTAGGGAGTAACACTGAGACCGTGCAACCTGAAGTAAAAAGTGAAACCGAACCCCATTTTATCTTA AAAAGTTCAGACAACACTAAAACTTATTCGCTGATGCCATCCGCTCCTCACCCAGTGAAAGAGGCATCTCCAGGCTTCTCCTGGTCCCCG AAGACTGCTTCAGCCACACCAGCTCCACTGAAGAATGACGCAACAGCCTCATGCGGGTTTTCAGAAAGAAGCAGCACTCCCCACTGTACG ATGCCTTCGGGAAGACTCAGTGGTGCCAATGCAGCTGCTGCTGATGGCCCTGGCATTTCACAGCTTGGCGAAGTGGCTCCTCTCCCCACC CTGTCTGCTCCTGTGATGGAGCCCCTCATTAATTCTGAGCCTTCCACTGGTGTGACTGAGCCGCTAACGCCTCATCAGCCAAACCACCAG CCCTCCTTCCTCACCTCTCCTCAAGACCTTGCCTCTTCTCCAATGGAAGAAGATGAGCAGCATTCTGAAGCAGATGAGCCTCCATCAGAC GAACCCCTATCTGATGACCCCCTGTCACCTGCTGAGGAGAAATTGCCCCACATTGATGAGTATTGGTCAGACAGTGAGCACATCTTTTTG GATGCAAATATTGGTGGGGTGGCCATCGCACCTGCTCACGGCTCGGTTTTGATTGAGTGTGCCCGGCGAGAGCTGCACGCTACCACTCCT GTTGAGCACCCCAACCGTAATCATCCAACCCGCCTCTCCCTTGTCTTTTACCAGCACAAAAACCTAAATAAGCCCCAACATGGTTTTGAA CTAAACAAGATTAAGTTTGAGGCTAAAGAAGCTAAGAATAAGAAAATGAAGGCCTCAGAGCAAAAAGACCAGGCAGCTAATGAAGGTCCA GAACAGTCCTCTGAAGTAAATGAATTGAACCAAATTCCTTCTCATAAAGCATTAACATTAACCCATGACAATGTTGTCACCGTGTCCCCT TATGCTCTCACACACGTTGCGGGGCCCTATAACCATTGGGTCTGAAGGCTTTTCTCCCCCTCTTAATGCCTTTGCTAGTGCAGTGTATTT TTTCAAGGTGCTGTTAAAAGAAAGTCATGTTGTCGTTTACTATCTTCATCTCACCCATTTCAAGTCTGAGGTAAAAAAATAATAATGATA ACAAAACGGGGTGGGTATTCTTAACTGTGACTATATTTTGACAATTGGTAGAAGGTGCACATTTTAAGCAAAAATAAAAGTTTTATAGTT TTAAATACATAAAGAAATGTTTCAGTTAGGCATTAACCTTGATAGAATCACTCAGTTTGGTGCTTTAAATTAAGTCTGTTTACTATGAAA CAAGAGTCATTTTTAGAGGATTTTAACAGGTTCATGTTCTATGATGTAAAATCAAGACACACAGTGTTAACTCTACACAGCTTCTGGTGC TTAACCACATCCACACAGTTAAAAATAAGCTGAATTATTATTTCATGGTGCCATTGTTCCAACATCTTCCAATCATTGCTAGAAAATTGG CATATTCCTTTGAAATAAACTTATGAAATGTTTTCTCTCTTAAAATATTTCTCCTGTGTAAAATAAATCATTGTTGTTAGTAATGGTTGG AGGCTGTTCATAAATTGTAAATATATATTTTAAAAGCACTTTCTATTTTTAAAAGTAACTTGAAATAATATAGTATAAGAATCCTATTGT CTATTGTTTGTGCATATTTGCATACAAGAGAAATCATTTATCCTTGCTGTGTAGAGTTCCATCTTGTTAACTGCAGTATGTATTCTAATC ATGTATATGGTTTGTGTTCTTTTACTGTGTCCTCTCACATTCAAGTATTAGCAACTTGCAGTATATAAAATAGTTAGATAATGAGAAGTT GTTAATTATCTCTAAAATTGGAATTAGGAAGCATATCACCAATACTGATTAACATTCTCTTTGGAACTAGGTAAGAGTGGTCTCTTCTTA TTGAACAACCTCAATTTAGTTTCATCCCACCTTTCTCAGTATAATCCATGAGAGGTGTTTCCAAAAGGAGATGAGGGAACAGGATAGGTT TCAGAAGAGTCAAATGCTTCTAATGTCTCAAGGTGATAAAATACAAAAACTAAGTAGACAGATATTTGTACTGAAGTCTGATACAGAATT AGAAAAAAAAAATTCTTGTTGAAATATTTTGAAAACAAATTCCCTACTATCATCACATGCCTCCCCAACCCCAAGTCAAAAACAAGAGGA ATGGTACTACAAACATGGCTTTGTCCATTAAGAGCTAATTCATTTGTTTATCTTAGCATACTAGATTTGGGAAAATGATAACTCATCTTT TCTGATAATTGCCTATGTTCTAGGTAACAGGAAAACAGGCATTAAGTTTATTTTAGTCTTCCCATTTTCTTCCTATTACTTTATTGACTC ATTTTATTGCAAAACAAAAAGGATTACCCAAACAACATGTTTCGAACAAGGAGAATTTTCAATGAAATACTTGATTCTGTTAAAATGCAG AGGTGCTATAACATTCAAAGTGTCAGATTCCTTGGGAGTATGGAAAACCTAATGGTGCTTCTCCCTTGGAAATGCCATAGGAAGCCCACA ACCGCTAACACTTACAATTTTGGTGCAAAAGCAAACAGTTCCAGCAGGCTCTCTAAAGAAAAACTCATTGTAACTTATTAAAATAATATC TGGTGCAAAGTATCTGTTTTGAGCTTTTGACTAATCCAAGTAAAGGAATATGAAGGGATTGTAAAAAACAAAATGTCCATTGATAGACCA TCGTGTACAAGTAGATTTCTGCTTGTTGAATATGTAAAATAGGGTAATTCATTGACTTGTTTTAGTATTTTGTGTGCCTTAGATTTCCGT TTTAAGACATGTATATTTTTGTGAGCCTAAGGTTTCTTATATACATATAAGTATATAAATAAGTGATTGTTTATTGCTTCAGCTGCTTCA ACAAGATATTTACTAGTATTAGACTATCAGGAATACACCCTTGCGAGATTATGTTTTAGATTTTAGGCCTTAGCTCCCACTAGAAATTAT TTCTTCACCAGATTTAATGGATAAAGTTTTATGGCTCTTTATGCATCCACTCATCTACTCATTCTTCGAGTCTACACTTATTGAATGCCT GCAAAATCTAAGTATCACTTTTATTTTTCTTTGGATCACCACCTATGACATAGTAAACTTGAAGAATAAAAACTACCCTCAGAAATATTT TTAAAAGAAGTAGCAAATTATCTTCAGTATAATCCATGGTAATGTATGCAGTAATTCAAATTGATCTCTCTCTCAATAGGTTTCTTAACA ATCTAAACTTGAAACATCAATGTTAATTTTTGGAACTATTGGGATTTGTGACGCTTGTTGCAGTTTACCAAAACAAGTATTTGAAAATAT ATAGTATCAACTGAAATGTTTCCATTCCGTTGTTGTAGTTAACATCATGAATGGACTTCTTAAGCTGATTACCCCACTGTGGGAACCAAA TTGGATTCCTACTTTGTTGGACTCTCTTTCCTGATTTTAACAATTTACCATCCCATTCTCTGCCCTGTGATTTTTTTTAAAAGCTTATTC AATGTTCTGCAGCATTGTGATTGTATGCTGGCTACACTGCTTTTAGAATGCTCTTTCTCATGAAGCAAGGAAATAAATTTGTTTGAAATG |
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FusionGenePPI for KMT2A_TET1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KMT2A | PPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, ZNF131, ASB7 | TET1 | MBD3, VPRBP, DDB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 1584_1600 | 1406 | 3932 | histone H3K4me3 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 1584_1600 | 1406 | 3970 | histone H3K4me3 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 1584_1600 | 1406 | 3973 | histone H3K4me3 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000354520 | + | 9 | 35 | 3764_3771 | 1406 | 3932 | WDR5 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000389506 | + | 9 | 36 | 3764_3771 | 1406 | 3970 | WDR5 |
| Hgene | KMT2A | chr11:118355030 | chr10:70441154 | ENST00000534358 | + | 9 | 36 | 3764_3771 | 1406 | 3973 | WDR5 |
| Tgene | TET1 | chr11:118355030 | chr10:70441154 | ENST00000373644 | + | 7 | 12 | 1580_1593 | 1608 | 2137 | DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for KMT2A_TET1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KMT2A_TET1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KMT2A | C0023418 | leukemia | 2 | CTD_human |
| Hgene | KMT2A | C0023467 | Leukemia, Myelocytic, Acute | 2 | CTD_human |
| Hgene | KMT2A | C0023470 | Myeloid Leukemia | 2 | CTD_human |
| Hgene | KMT2A | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 2 | CTD_human |
| Hgene | KMT2A | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | KMT2A | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | KMT2A | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Hgene | KMT2A | C0008625 | Chromosome Aberrations | 1 | CTD_human |
| Hgene | KMT2A | C0023448 | Lymphoid leukemia | 1 | CTD_human |
| Hgene | KMT2A | C0023465 | Acute monocytic leukemia | 1 | CTD_human |
| Hgene | KMT2A | C0023479 | Acute myelomonocytic leukemia | 1 | CTD_human |
| Hgene | KMT2A | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | KMT2A | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | KMT2A | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Hgene | KMT2A | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | TET1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Tgene | TET1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | TET1 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | TET1 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
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