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Fusion gene ID: 19079 |
FusionGeneSummary for KLK6_BAD |
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Fusion gene information | Fusion gene name: KLK6_BAD | Fusion gene ID: 19079 | Hgene | Tgene | Gene symbol | KLK6 | BAD | Gene ID | 5653 | 572 |
Gene name | kallikrein related peptidase 6 | BCL2 associated agonist of cell death | |
Synonyms | Bssp|Klk7|PRSS18|PRSS9|SP59|hK6 | BBC2|BCL2L8 | |
Cytomap | 19q13.41 | 11q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | kallikrein-6kallikrein 6neurosinprotease Mserine protease 18serine protease 9zyme | bcl2-associated agonist of cell deathBCL-X/BCL-2 binding proteinBCL2-antagonist of cell death proteinBCL2-binding component 6BCL2-binding proteinbcl-2-binding component 6bcl-2-like protein 8bcl-XL/Bcl-2-associated death promoterbcl2 antagonist of | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q92876 | Q92934 | |
Ensembl transtripts involved in fusion gene | ENST00000376851, ENST00000310157, ENST00000391808, ENST00000456750, ENST00000376853, ENST00000594641, ENST00000424910, | ENST00000394532, ENST00000309032, ENST00000544785, ENST00000394531, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 6 X 5 X 6=180 |
# samples | 2 | 9 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(9/180*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KLK6 [Title/Abstract] AND BAD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KLK6 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | 16885167 |
Tgene | BAD | GO:0006915 | apoptotic process | 19667065 |
Tgene | BAD | GO:0043065 | positive regulation of apoptotic process | 9388232 |
Tgene | BAD | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 18402937 |
Tgene | BAD | GO:0045862 | positive regulation of proteolysis | 18387192 |
Tgene | BAD | GO:0046931 | pore complex assembly | 19667065|21081150 |
Tgene | BAD | GO:0071316 | cellular response to nicotine | 18676776 |
Tgene | BAD | GO:0097202 | activation of cysteine-type endopeptidase activity | 18387192 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE717737 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000376851 | ENST00000394532 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000376851 | ENST00000309032 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000376851 | ENST00000544785 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000376851 | ENST00000394531 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000310157 | ENST00000394532 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000310157 | ENST00000309032 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000310157 | ENST00000544785 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000310157 | ENST00000394531 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000391808 | ENST00000394532 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000391808 | ENST00000309032 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000391808 | ENST00000544785 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000391808 | ENST00000394531 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000456750 | ENST00000394532 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000456750 | ENST00000309032 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000456750 | ENST00000544785 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000456750 | ENST00000394531 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000376853 | ENST00000394532 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000376853 | ENST00000309032 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000376853 | ENST00000544785 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000376853 | ENST00000394531 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000594641 | ENST00000394532 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000594641 | ENST00000309032 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000594641 | ENST00000544785 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000594641 | ENST00000394531 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000424910 | ENST00000394532 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000424910 | ENST00000309032 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000424910 | ENST00000544785 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
intron-intron | ENST00000424910 | ENST00000394531 | KLK6 | chr19 | 51470504 | - | BAD | chr11 | 64046471 | + |
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FusionProtFeatures for KLK6_BAD |
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Hgene | Tgene |
KLK6 | BAD |
Serine protease which exhibits a preference for Arg overLys in the substrate P1 position and for Ser or Pro in the P2position. Shows activity against amyloid precursor protein, myelinbasic protein, gelatin, casein and extracellular matrix proteinssuch as fibronectin, laminin, vitronectin and collagen. Degradesalpha-synuclein and prevents its polymerization, indicating thatit may be involved in the pathogenesis of Parkinson disease andother synucleinopathies. May be involved in regulation of axonoutgrowth following spinal cord injury. Tumor cells treated with aneutralizing KLK6 antibody migrate less than control cells,suggesting a role in invasion and metastasis.{ECO:0000269|PubMed:11983703, ECO:0000269|PubMed:12878203,ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:15557757,ECO:0000269|PubMed:16321973, ECO:0000269|PubMed:16987227}. | Promotes cell death. Successfully competes for thebinding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the levelof heterodimerization of these proteins with BAX. Can reverse thedeath repressor activity of Bcl-X(L), but not that of Bcl-2 (Bysimilarity). Appears to act as a link between growth factorreceptor signaling and the apoptotic pathways. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KLK6_BAD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KLK6_BAD |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLK6_BAD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLK6_BAD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | BAD | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Tgene | BAD | C0007787 | Transient Ischemic Attack | 1 | CTD_human |
Tgene | BAD | C0023418 | leukemia | 1 | CTD_human |