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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19078

FusionGeneSummary for KLK4_ZNF827

check button Fusion gene summary
Fusion gene informationFusion gene name: KLK4_ZNF827
Fusion gene ID: 19078
HgeneTgene
Gene symbol

KLK4

ZNF827

Gene ID

9622

152485

Gene namekallikrein related peptidase 4zinc finger protein 827
SynonymsAI2A1|ARM1|EMSP|EMSP1|KLK-L1|PRSS17|PSTS|kallikrein-
Cytomap

19q13.41

4q31.21-q31.22

Type of geneprotein-codingprotein-coding
Descriptionkallikrein-4androgen-regulated message 1enamel matrix serine protease 1enamel matrix serine proteinase 1kallikrein-like protein 1prostaseserine protease 17zinc finger protein 827
Modification date2018052320180523
UniProtAcc

Q9Y5K2

Q17R98

Ensembl transtripts involved in fusion geneENST00000324041, ENST00000597441, 
ENST00000431178, 		ENST00000508784, 
ENST00000513320, ENST00000379448, 
ENST00000511534, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 4 X 7=280
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLK4 [Title/Abstract] AND ZNF827 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-8256-01AKLK4chr19

51409608

-ZNF827chr4

146859787

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000324041ENST00000508784KLK4chr19

51409608

-ZNF827chr4

146859787

-
5CDS-intronENST00000324041ENST00000513320KLK4chr19

51409608

-ZNF827chr4

146859787

-
5CDS-intronENST00000324041ENST00000379448KLK4chr19

51409608

-ZNF827chr4

146859787

-
5CDS-intronENST00000324041ENST00000511534KLK4chr19

51409608

-ZNF827chr4

146859787

-
Frame-shiftENST00000597441ENST00000508784KLK4chr19

51409608

-ZNF827chr4

146859787

-
5CDS-intronENST00000597441ENST00000513320KLK4chr19

51409608

-ZNF827chr4

146859787

-
5CDS-intronENST00000597441ENST00000379448KLK4chr19

51409608

-ZNF827chr4

146859787

-
5CDS-intronENST00000597441ENST00000511534KLK4chr19

51409608

-ZNF827chr4

146859787

-
intron-3CDSENST00000431178ENST00000508784KLK4chr19

51409608

-ZNF827chr4

146859787

-
intron-intronENST00000431178ENST00000513320KLK4chr19

51409608

-ZNF827chr4

146859787

-
intron-intronENST00000431178ENST00000379448KLK4chr19

51409608

-ZNF827chr4

146859787

-
intron-intronENST00000431178ENST00000511534KLK4chr19

51409608

-ZNF827chr4

146859787

-

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FusionProtFeatures for KLK4_ZNF827


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLK4

Q9Y5K2

ZNF827

Q17R98

Has a major role in enamel formation (PubMed:15235027).Required during the maturation stage of tooth development forclearance of enamel proteins and normal structural patterning ofthe crystalline matrix (By similarity).{ECO:0000250|UniProtKB:Q9Z0M1, ECO:0000269|PubMed:15235027}. May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLK4chr19:51409608chr4:146859787ENST00000324041-5531_252449255DomainPeptidase S1
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-015311_354-22995Compositional biasNote=Pro-rich
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-015961_972-22995Compositional biasNote=Poly-Ser
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--115311_354141976Compositional biasNote=Pro-rich
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--115961_972141976Compositional biasNote=Poly-Ser
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-0151019_1041-22995Zinc fingerC2H2-type 8
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-0151047_1069-22995Zinc fingerC2H2-type 9
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-015374_396-22995Zinc fingerC2H2-type 1
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-015402_424-22995Zinc fingerC2H2-type 2
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-015433_455-22995Zinc fingerC2H2-type 3
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-015817_839-22995Zinc fingerC2H2-type 4
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-015845_867-22995Zinc fingerC2H2-type 5
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-015897_919-22995Zinc fingerC2H2-type 6
TgeneZNF827chr19:51409608chr4:146859787ENST00000379448-015929_952-22995Zinc fingerC2H2-type 7
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--1151019_1041141976Zinc fingerC2H2-type 8
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--1151047_1069141976Zinc fingerC2H2-type 9
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--115374_396141976Zinc fingerC2H2-type 1
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--115402_424141976Zinc fingerC2H2-type 2
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--115433_455141976Zinc fingerC2H2-type 3
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--115817_839141976Zinc fingerC2H2-type 4
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--115845_867141976Zinc fingerC2H2-type 5
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--115897_919141976Zinc fingerC2H2-type 6
TgeneZNF827chr19:51409608chr4:146859787ENST00000508784--115929_952141976Zinc fingerC2H2-type 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLK4_ZNF827


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KLK4_ENST00000324041_chr19_51409608_-_ZNF827_ENST00000508784_chr4_146859787_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KLK4_ENST00000324041_chr19_51409608_-_ZNF827_ENST00000508784_chr4_146859787_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_KLK4_ENST00000324041_chr19_51409608_-_ZNF827_ENST00000508784_chr4_146859787_-_8810nt
ATGGCCACAGCAGGAAATCCCTGGGGCTGGTTCCTGGGGTACCTCATCCTTGGTGTCGCAGGATCGCTCGTCTCTGGTAGCTGCAGCCAA
ATCATAAACGGCGAGGACTGCAGCCCGCACTCGCAGCCCTGGCAGGCGGCACTGGTCATGGAAAACGAATTGTTCTGCTCGGGCGTCCTG
GTGCATCCGCAGTGGGTGCTGTCAGCCGCACACTGTTTCCAGAACTCCTACACCATCGGGCTGGGCCTGCACAGTCTTGAGGCCGACCAA
GAGCCAGGGAGCCAGATGGTGGAGGCCAGCCTCTCCGTACGGCACCCAGAGTACAACAGACCCTTGCTCGCTAACGACCTCATGCTCATC
AAGTTGGACGAATCCGTGTCCGAGTCTGACACCATCCGGAGCATCAGCATTGCTTCGCAGTGCCCTACCGCGGGGAACTCTTGCCTCGTT
TCTGGCTGGGGTCTGCTGGCGAACGGCAGAATGCCTACCGTGCTGCAGTGCGTGAACGTGTCGGTGGTGTCTGAGGAGGTCTGCAGTAAG
CTCTATGACCCGCTGTACCACCCCAGCATGTTCTGCGCCGGCGGAGGGCACGACCAGAAGGACTCCTGCAACGGTGACTCTGGGGGGCCC
CTGATCTGCAACGGGTACTTGCAGGGCCTTGTGTCTTTCGGAAAAGCCCCGTGTGGCCAAGTTGGCGTGCCAGGTGTCTACACCAACCTC
TGCAAATTCACTGAGTGGATAGAGAAAACCGTCCAGGCCAGTTAACTCTGGGGACTGGGAACCCATGAAATTGACCCCCAAATACATCCT
GCGGAAGGAATTCAGGAATATCTGTTCCCAGCCCCTCCTCCCTCAGGCCCAGGAGTCCAGGCCCCCAGCCCCTCCTCCCTCAAACCAAGG
GTACAGATCCCCAGCCCCTCCTCCCTCAGACCCAGGAGTCCAGACCCCCCAGCCCCTCCTCCCTCAGACCCAGGAGTCCAGCCCCTCCTC
CCTCAGACCCAGGAGTCCAGACCCCCCAGCCCCTCCTCCCTCAGACCCAGGAGTCCAGCCCCTCCTCCCTCAGACCCAGGAGTCCAGACC
CCCCAGCCCCTCCTCCCTCAGACCCAGGGGTCCAGGCCCCCAACCCCTCCTCCCTCAGACTCAGAGGTCCAGGCCCCCAACCCCTCCTTC
CCCAGACCCAGAGGTCCAGGTCCCAGCCCCTCCTCCCTCAGACCCAGCGGTCCAATGCCACCTAGACTCTCCCTGTACACAGTGCCCCCT
TGTGGCACGTTGACCCAACCTTACCAGTTGGTTTTTCATTTTTTGTCCCTTTCCCCTAGATCCAGAAATAAAGTCTAAGAGAAGCGCAAA
AAAAAAAAAAGGAAAAAAGAAAGGAAAGAAAAGAAGAAAACCCCTCTTCTGGCTCCAGGAAACAAGCTTCAACCCATTGCACACACCGGA
GAAGGGGTTTCCCCCTGCCCGCCCGCCCGCCCCCCAACTACCTCCCCGCTCCTGCCAGTGTCTGCCTCTCTGCCCCCACGGGGGTTTATT
TGATCTCACATTAACCAAGGAGGAGAATGTGAGAAAAGGGGGAAAATGCCCAGGAGGAAGCAGGAGCAGCCCAAGCGCCTTCCCTCACAT
GTTAGTAGGCAGGAAGAGGCGGAGGGAGAGCTCAGTGAAGGAGAACACTGGTATGGAAACTCTTCAGAGACTCCGTCAGAAGCATCCTAT
GGGGAAGTCCAGGAGAACTATAAGTTGTCTCTGGAGGACCGGATCCAGGAGCAGTCCACGTCCCCGGACACCTCCTTGGGAAGCACGACT
CCCAGCAGCCACACGTTGGAGCTGGTGGCACTGGACAGTGAGGTCCTGCGAGACTCACTGCAGTGTCAAGATCACCTTTCCCCGGGAGTG
TCTTCTTTGTGTGACGATGACCCAGGCTCCAACAAGCCCCTGAGCAGCAATTTGAGGCGGCTGCTGGAGGCTGGTTCCCTCAAACTCGAT
GCTGCAGCCACGGCTAATGGCAGAGTGGAGTCCCCCGTAAACGTTGGCTCGAACCTCTCCTTTTCCCCGCCTTCCCACCACGCCCAGCAG
CTCAGTGTTCTGGCCAGGAAGTTGGCCGAGAAGCAGGAACAGAATGACCAATACACTCCAAGTAACCGTTTTATATGGAATCAAGGTAAG
TGGTTGCCAAACTCAACCACCACCTGCAGCTTGTCTCCGGATTCAGCCATCCTAAAACTGAAAGCTGCAGCCAATGCCGTTCTGCAGGAC
AAATCTCTCACCAGGACTGAGGAGACCATGCGATTTGAGTCCTTTTCCTCCCCTTTTAGCTCCCAGTCTGCCAGTTCTACCTTGGCCGCT
TTGTCCAAGAAGGTCAGTGAAAGAAGTTTGACTCCTGGTCAGGAGCACCCTCCACCGGCCAGCTCCTTCCTTTCCCTGGCTTCTATGACC
TCCTCAGCGGCCCTTCTGAAGGAGGTGGCCGCAAGGGCTGCGGGCAGTCTTCTGGCTGAGAAATCATCGCTGCTGCCTGAGGACCCTCTA
CCGCCCCCGCCTTCAGAGAAGAAACCAGAAAAAGTCACTCCGCCACCTCCACCGCCACCTCCACCACCTCCACCACCACCACCACAATCC
CTGGAATTATTATTACTCCCAGTTCCTAAGGGAAGAGTTTCTAAACCCTCCAATTCAGCCTCAGAAGAGGAAAGTGGAAAGCCTTTCCAG
TGTCCAATATGTGGTTTGGTTATTAAAAGGAAGAGTTACTGGAAGCGGCACATGGTGATTCACACAGGTTTAAAAAGTCATCAGTGTCCG
CTCTGTCCATTCCGGTGTGCTCGCAAGGACAATCTCAAATCCCACATGAAGGTTCATCAGCACCAGGATCGGGGAGAGACCTTTCAGTGC
CAGCTGTGCCCTTTTACTTCCTCACGCCACTTCAGCCTGAAACTCCACATGCGTTGCCATCAGCACTTCCTGAGGACAGAAGCCAAGGTG
AAGGAGGAGATCCCAGACCCAGATGTCAAGGGATCTCCCCACCTCAGTGACAGTGCCTGCCTGGGGCAGCAAAGGGAAGGAGGAGGGACA
GAGCTAGTGGGGACCATGATGACGTCTAACACTCCAGAGAGGACTAGCCAGGGAGGGGCTGGCGTCTCGCCTTTGCTGGTGAAGGAGGAA
CCCAAGGAAGATAACGGCCTGCCCACCTCCTTTACTTTGAATGCTGCCGACAGGCCCGCCAACCACACAAAGCTGAAAGACCCCTCCGAG
TATGTGGCCAACAGTGCGTCAGCATTGTTCAGCCAGGACATCTCTGTTAAGATGGCGTCTGATTTTCTCATGAAGCTGTCAGCTGCAAAT
CAGAAGGAGCCCATGAATCTTAATTTTAAAGTGAAAGAGGAGCCTAAGGAAGGGGAGTCCCTAAGCACGACTTTGCCTCGGTCCAGCTAT
GTGTTCAGCCCGGAATCTGAAGTGTCAGCCCCAGGCGTCTCTGAGGACGCACTAAAGCCCCAGGAAGGGAAGGGAAGTGTGCTAAGGCGG
GATGTGTCAGTCAAAGCAGCCTCTGAACTTCTCATGAAACTCTCAGCGGAAAGCTACAAGGAAACACAGATGGTGAAGATTAAAGAGGAA
CCCATGGAGGTTGACATCCAGGACTCCCATGTCTCGATATCACCCAGCCGGAATGTTGGCTACAGCACTTTAATCGGGCGAGAGAAAACC
GAACCCTTACAGAAGATGCCAGAGGGCAGAGTACCCCCAGAGAGAAACCTCTTCAGTCAGGATATCTCTGTGAAAATGGCTTCCGAGCTC
CTCTTTCAACTGTCAGAAAAAGTGAGCAAAGAGCACAATCATACAAAAGAAAACACCATCCGGACCACGACCAGCCCTTTCTTTTCAGAA
GACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAACTGCTGCCCAGTGACTCCGTGCTGCACGGAAGAATATCAGCTCCAGAA
ACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCCTGGAAATTCAATGACCAGCTTTTTCCCTGTGACGTGTGTGGGAAAGTG
TTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCACACAGAGGAAAGAAAATACAAATGCCACTTGTGCCCCTATGCTGCTAAG
TGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTGAAGCTGGTGAGTACAGACACCGAGGACATTGTCAGCGCCGTCACCTCT
GAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGTCACGTGTGTGGATTTGAGACCGAGCTCAATGTCCAGTTTGTCAGCCAC
ATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATCTGCTGCACTGCCTGCGACTTCGTCACCATGGAGGAAGCAGAGATAAAG
ACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACCCCCAGCGAATCAAATAGCCCCTCTTCATCCTCCCTCTCAGCTCTGAGT
GATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAAAACAAGGGCGGGAACAATCTGCTGGTCATCTCTGTCATGCCTGGGAGC
CAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTCGAATGTGTTTTTTGCAACTTTGTCTGCAAGACGAAGAACATGTTTGAG
CGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGTGATGTGTGCCACAAGTTCATGAAGACCCCCGAACAGCTGCTGGAGCAT
AAGAAATGCCACACTGTCCCCACCGGTGGGCTCAACTCAGGACAGTGGTGAGTTTCAGACTCCTCTAGGTGCCCATTCTGCATTTATTCC
ACCAACCGCCCCGCTGCCATGGAGTGCCACCTCAAGACCCACTACAAGATGGAGTACAAGTGCCGGATCTGCCAGACGGTGAAGGCCAAC
CAGCTGGAGCTGGAGACGCACACCCGGGAGCACCGCCTGGGCAACCACTACAAGTGCGACCAGTGCGGCTACCTGTCCAAGACCGCCAAC
AAGCTCATCGAGCACGTGCGCGTCCACACCGGGGAGCGGCCCTTCCACTGTGACCAGTGCAGCTACAGCTGCAAGCGCAAGGACAATCTC
AACCTGCACAAGAAGCTGAAGCACGCCCCACGCCAGACCTTCAGCTGCGAAGAGTGCCTGTTCAAGACCACACACCCTTTCGTCTTCAGC
CGCCACGTCAAGAAGCACCAGAGTGGGGACTGCCCCGAGGAGGACAAGAAGGGCCTGTGTCCAGCCCCCAAGGAACCGGCCGGCCCGGGG
GCCCCGCTCCTGGTGGTCGGGAGCTCCCGGAATCTCCTGTCTCCCCTGTCAGTTATGTCTGCCTCCCAGGCTCTGCAGACCGTGGCCCTG
TCGGCAGCCCACGGCAGCAGCTCAGAGCCCAACCTGGCACTCAAGGCTTTGGCCTTCAACGGCTCCCCTTTGCGCTTTGACAAGTACCGG
AACTCAGATTTTGCCCATCTCATTCCCTTGACAATGTTATACCCCAAGAACCACTTGGATCTCACATTCCACCCTCCCCGACCTCAGACT
GCGCCTCCCAGCATCCCCTCACCCAAACACTCCTTCCTGGCCTATCTCGGACTGAGAGAAAGAGCAGAGACTGTCTGAGGGCAGCCATGT
TCTGTACCAAAAACAGAGAGACAAAAGACAAAAAAAAAAAAAAAAACCACAAAACTTAAACACAACCCCAGCAGGTGTATGTTGCTGCAA
AACCTACAGACCCCGATGGGTCTGGAACATGTGTACTGTATATCTTTAGTAAGGAATAGAAAATTGGCTCTGTGTGTATACCTATTGCAT
TGACCTGAAAGCTGCTTTATCCAATCTTCAGAGAGGTGACCTACTGCATACTTCTACCTTCAGAGGCATGCCTCCCCAGCCACCCACTCC
CACTCTCAGCCCTTCTCCGTACTTTTCTCTGAAAGGAATCTTGTCTTGTTAAACCCTAAAGAGAGTGTCCTTAATAGCAATCAGCACTTG
TAAGCTTATATACTGGTGCATTTGGTTTTCTGTTGGGTGAATGCGGTGTGTGGGCGTTTGTGGATTCTGAAAGAGAAAGCCGTGTGTCGT
GTGCCATGACATTTCTATTGCACATTCTTTGTACTGGCTTCTTTAACAGCGATGAACGTTCTTTTCCCTCCTGGGTTGTTCATCCACGAC
AGTCTCTCCCTGTGCTCCTTCATCACCTTTCCCTCTCTCTTTGATGGCTACAGAGTGGTAGGGCCTGGTGCTTAGTCGATGAAGGAATGG
TAGCCATCTACAGTGCTGCTGGAGATTTCCGCCAGAGCGCTGGAGACCTTGCGCTCAGATCTTCTCTGGTGATGAAGAGGCGAGGAATCA
AGTGACTGATCTGGAAGAAATATCTCGCAGCACTGCAGCTAACATCACAGAACTTAAGTGTGTTTTGTGTGTGTGCCCACACGTAGACAA
ATGTGTACGGTGCACACACACAGTGCATCATTTTTTAAGGGCAGATTATATATATATATGAGATGTATTAATTCAGTGGTTACCATTTGT
TTGCAGGAAAAAGAAATGTATGGGTGAAAAAATTTATGGTTGATAAATCCAGCCAAGGAGATTAAAAGGGGTTTGGATAAATTCTGGGTA
TAAATGCTCAGACTAAAAAAAAGAAATGGCAGTTTTGCACAGTGCTATGGTCTTGCACTAGTTTTTGTTTCTCATCTGAAAAAAAAAAAG
TAAAATAAAAGGAAGAAAATGTACCTTTTTTATGGAATGAGTAGACTGTATGTTTGAAGATTTAGCCACAACCTCTTTGACATATAATGA
CGCAACAAAAAGGTGCTGTTTAGTCCTATGGTTCAGTTTATGCCCCTGACAAGTTTCCATTGTGTTTTGCCGATCTTCTGGCTAATCGTG
GTATCCTCCATGTTATTAGTAATTCTGTATTCCATTTTGTTAACGCCTGGTAGATGTAACCTGCTAGGAGGCTAACTTTATACTTATTTA
AAAGCTCTTATTTTGTGGTCATTAAAATGGCAATTTATGTGCAGCACTTTATTGCAGCAGGAAGCAGGTGTGGGTTGGTTGTAAAGCTCT
TTGCTAATCTTAAAAAGTAATGGGTGATTTAAAAAGAAAAAAGGAAAAAAATCTTTGGCTGAATATGTTCATTGCTTGTATTTTTAAAAC
AACAGAATTTCCAGTATGAAACAGGCTGAAAGAGCAGGAAGAAATGTTCTTTGTATAATAATGGGAAGTTTGGAATATAAAAGTTTATAT
ATTATTTATCTATTGGAGAACTGGTGTACAGGAGGAACATTTTCTTACTGTGTTGCTGTTTTCCATCATGTGTTATCCTAAGAGTTGGGG
TTTTTTAAAATCTGTTTCACCAGGGGAAAATAAAAGCATCCCTAATGTTCTTCCTCTAGTCAGTTTGCTTTGCTGAAAGCTCCCTGGAAA
TTAGTACAGTTCTACAGGAAGCCAGAAGACTGTACTGTCTGTCCACACCATGGTCTCCTCAGTCCCCTCCACGCCAGCCCCTCTTCCCCA
CACCTAGTAGGTGTGCTACACCTCCCTTTGCCAGTCATCCCGCCATGGATGGGGAGCCTACTTGGTGCCCTGGCAAACCTGTTTACACTA
AGGAGATGCCCACAGGGAGCGGGAAGCTCCCAAACCCTCAGTCATTCTCCAGCAGAGACCTTTGCTCTTGGCCAGGTTTGAAACGATGTT
CAACCTCGCCACGTCAATGTCTCAGTAAAAGACACTATAGATAGTTATGGACAATACACTCCAAGAATACTGGGCTTATGGGTGGGTTGG
TTTTTTGTTTTGTTTTGTTTTGTTTTCAAGTCATGTCTTTATCCCCATATAATGGAGAATGTGCCACTTGGCTAATAATGTGTTTTCAAA
ACTACAAGTTCAGTGATGACAGGAAAGAGGGCTAAAGTAGTCCCACAGAGGCTGGTAGAAAAGGCGAATCACACTTAAGCACCAGCAGGT
TAAAAACCTGAAAGGGTGGCCCTGACAATTCAGACTATAGGTTTTACAGCATGCCACTTGTGCAATAGGAGGTCTAGGGTTGAAACTTTC
AAGAACGAGAGGAGGTGAAGGAAGGAGACGTTTACTGCTCAAATGCCATGCATTTCACTGCTTGCCACTGAACTTGTATTTGAATGACTT
AGTAATGCTTAATATAATTGGGCAACTTTTTTAGCACTTTGGAAAGAGTCATCAATCTTTCTGGTAAATTATAAAAGTTTTCTGAGTGAG
AAAAGGTGTGTTTGGAGTTTGTTTGACTTTTTATATTATTATTGTTATTAATAAAGAAAAAAATCTACAGCATTTTTCAGACTCCACCCT
AGAAAATATGTACCCCTGAATTTGGTTTGCAGTTTGATACTCAGGGAAGGATGTATTCCATAGATATCCTTTCCGTATAAAACACTAACA
TCTTTGAGAAATTCACCTACCAACTAACTTCAATTGTTGTCACTATGCATTCTTCAATGAAAACTAGCTTATTTTTCCATATAGTAATGC
AGTTAGGGTTCTCAGCACTTTCTTTCTTCTATCCTTTTTTTAACTCTTCATATTATGTTCAGATGATCATACTGTCAAGGTTTGTGTACA
TTACTGAAAATTTGTATTGTATAAAGCTTTTTGCATTACGAGGCTGTACAGGGTCATTTTGACAGTAACTGGTATATTCCTTTGCATCTT


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FusionGenePPI for KLK4_ZNF827


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KLK4SHBG, TYRO3, HLA-DRA, KCNIP4ZNF827PPP1CA, UBE2E1, ATP6V1E1, CHERP, VPS45, UNC80, HDAC1, GATAD2A, GATAD2B, RBBP7, RBBP4, CHD3, CHD4, MTA1, MTA2, MTA3, HDAC2, MCPH1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLK4_ZNF827


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLK4_ZNF827


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource