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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19058

FusionGeneSummary for KLHL8_HIST1H2AC

check button Fusion gene summary
Fusion gene informationFusion gene name: KLHL8_HIST1H2AC
Fusion gene ID: 19058
HgeneTgene
Gene symbol

KLHL8

HIST1H2AC

Gene ID

57563

8334

Gene namekelch like family member 8histone cluster 1 H2A family member c
Synonyms-H2A/l|H2AFL|dJ221C16.4
Cytomap

4q22.1

6p22.2

Type of geneprotein-codingprotein-coding
Descriptionkelch-like protein 8kelch-like 8histone H2A type 1-CH2A histone family, member Lhistone 1, H2achistone H2A/lhistone H2AChistone cluster 1, H2ac
Modification date2018052220180523
UniProtAcc

Q9P2G9

Q93077

Ensembl transtripts involved in fusion geneENST00000273963, ENST00000498875, 
ENST00000425278, ENST00000545252, 
ENST00000512111, ENST00000506274, 
ENST00000377791, ENST00000602637, 
Fusion gene scores* DoF score2 X 2 X 1=410 X 4 X 5=200
# samples 210
** MAII scorelog2(2/4*10)=2.32192809488736log2(10/200*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLHL8 [Title/Abstract] AND HIST1H2AC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLHL8

GO:0006511

ubiquitin-dependent protein catabolic process

19158078

HgeneKLHL8

GO:0016567

protein ubiquitination

19158078


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ348909KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000273963ENST00000377791KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-3UTRENST00000273963ENST00000602637KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-intronENST00000498875ENST00000377791KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-3UTRENST00000498875ENST00000602637KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-intronENST00000425278ENST00000377791KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-3UTRENST00000425278ENST00000602637KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-intronENST00000545252ENST00000377791KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-3UTRENST00000545252ENST00000602637KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-intronENST00000512111ENST00000377791KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-3UTRENST00000512111ENST00000602637KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-intronENST00000506274ENST00000377791KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-
intron-3UTRENST00000506274ENST00000602637KLHL8chr4

88088395

+HIST1H2ACchr6

26138694

-

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FusionProtFeatures for KLHL8_HIST1H2AC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLHL8

Q9P2G9

HIST1H2AC

Q93077

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin ligase complex required for The BCR(KLHL8) ubiquitinligase complex mediates ubiquitination and degradation of RAPSN.{ECO:0000269|PubMed:19158078}. Core component of nucleosome. Nucleosomes wrap andcompact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLHL8_HIST1H2AC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLHL8_HIST1H2AC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLHL8_HIST1H2AC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLHL8_HIST1H2AC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource