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Fusion gene ID: 19058 |
FusionGeneSummary for KLHL8_HIST1H2AC |
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Fusion gene information | Fusion gene name: KLHL8_HIST1H2AC | Fusion gene ID: 19058 | Hgene | Tgene | Gene symbol | KLHL8 | HIST1H2AC | Gene ID | 57563 | 8334 |
Gene name | kelch like family member 8 | histone cluster 1 H2A family member c | |
Synonyms | - | H2A/l|H2AFL|dJ221C16.4 | |
Cytomap | 4q22.1 | 6p22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | kelch-like protein 8kelch-like 8 | histone H2A type 1-CH2A histone family, member Lhistone 1, H2achistone H2A/lhistone H2AChistone cluster 1, H2ac | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9P2G9 | Q93077 | |
Ensembl transtripts involved in fusion gene | ENST00000273963, ENST00000498875, ENST00000425278, ENST00000545252, ENST00000512111, ENST00000506274, | ENST00000377791, ENST00000602637, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 10 X 4 X 5=200 |
# samples | 2 | 10 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(10/200*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KLHL8 [Title/Abstract] AND HIST1H2AC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KLHL8 | GO:0006511 | ubiquitin-dependent protein catabolic process | 19158078 |
Hgene | KLHL8 | GO:0016567 | protein ubiquitination | 19158078 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ348909 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000273963 | ENST00000377791 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-3UTR | ENST00000273963 | ENST00000602637 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-intron | ENST00000498875 | ENST00000377791 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-3UTR | ENST00000498875 | ENST00000602637 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-intron | ENST00000425278 | ENST00000377791 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-3UTR | ENST00000425278 | ENST00000602637 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-intron | ENST00000545252 | ENST00000377791 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-3UTR | ENST00000545252 | ENST00000602637 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-intron | ENST00000512111 | ENST00000377791 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-3UTR | ENST00000512111 | ENST00000602637 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-intron | ENST00000506274 | ENST00000377791 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
intron-3UTR | ENST00000506274 | ENST00000602637 | KLHL8 | chr4 | 88088395 | + | HIST1H2AC | chr6 | 26138694 | - |
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FusionProtFeatures for KLHL8_HIST1H2AC |
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Hgene | Tgene |
KLHL8 | HIST1H2AC |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin ligase complex required for The BCR(KLHL8) ubiquitinligase complex mediates ubiquitination and degradation of RAPSN.{ECO:0000269|PubMed:19158078}. | Core component of nucleosome. Nucleosomes wrap andcompact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KLHL8_HIST1H2AC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KLHL8_HIST1H2AC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLHL8_HIST1H2AC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLHL8_HIST1H2AC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |