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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19057

FusionGeneSummary for KLHL7_TMEM106B

check button Fusion gene summary
Fusion gene informationFusion gene name: KLHL7_TMEM106B
Fusion gene ID: 19057
HgeneTgene
Gene symbol

KLHL7

TMEM106B

Gene ID

55975

54664

Gene namekelch like family member 7transmembrane protein 106B
SynonymsCISS3|KLHL6|SBBI26HLD16
Cytomap

7p15.3

7p21.3

Type of geneprotein-codingprotein-coding
Descriptionkelch-like protein 7kelch-like 6kelch-like 7kelch/BTBtransmembrane protein 106B
Modification date2018052220180523
UniProtAcc

Q8IXQ5

Q9NUM4

Ensembl transtripts involved in fusion geneENST00000322231, ENST00000339077, 
ENST00000539124, ENST00000542558, 
ENST00000409689, ENST00000545443, 
ENST00000479288, ENST00000322275, 
ENST00000410047, ENST00000545771, 
ENST00000396668, ENST00000396667, 
ENST00000453686, 
Fusion gene scores* DoF score5 X 5 X 3=752 X 2 X 2=8
# samples 52
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: KLHL7 [Title/Abstract] AND TMEM106B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLHL7

GO:0016567

protein ubiquitination

21828050


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-14-0736-02AKLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000322231ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000322231ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-3UTRENST00000322231ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000339077ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000339077ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-3UTRENST00000339077ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000539124ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000539124ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-3UTRENST00000539124ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000542558ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000542558ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-3UTRENST00000542558ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000409689ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000409689ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-3UTRENST00000409689ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000545443ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-5UTRENST00000545443ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
5CDS-3UTRENST00000545443ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-5UTRENST00000479288ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-5UTRENST00000479288ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-3UTRENST00000479288ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-5UTRENST00000322275ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-5UTRENST00000322275ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-3UTRENST00000322275ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-5UTRENST00000410047ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-5UTRENST00000410047ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-3UTRENST00000410047ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-5UTRENST00000545771ENST00000396668KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-5UTRENST00000545771ENST00000396667KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+
intron-3UTRENST00000545771ENST00000453686KLHL7chr7

23191828

+TMEM106Bchr7

12254435

+

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FusionProtFeatures for KLHL7_TMEM106B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLHL7

Q8IXQ5

TMEM106B

Q9NUM4

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediatingubiquitination and subsequent degradation of substrate proteins.Probably mediates 'Lys-48'-linked ubiquitination.{ECO:0000269|PubMed:21828050}. Involved in dendrite morphogenesis and maintenance byregulating lysosomal trafficking via its interaction with MAP6.May act by inhibiting retrograde transport of lysosomes alongdendrites. Required for dendrite branching.{ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:24357581}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLHL7_TMEM106B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLHL7_TMEM106B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KLHL7CUL3, RBX1, KLHL7, UBC, MOV10, NXF1, NUP50, C9orf41, NR2C2, YWHAZ, CKAP5, NUP153, FERMT3, BOD1L1, MSRB3, KLHL6, ARIH1, SDC2, STAT5A, CEP44, GLI3TMEM106BBTNL8, CHMP2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLHL7_TMEM106B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLHL7_TMEM106B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLHL7C2751986RETINITIS PIGMENTOSA 421CTD_human;UNIPROT
TgeneTMEM106BC0751072Frontotemporal Lobar Degeneration1CTD_human