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Fusion gene ID: 19055 |
FusionGeneSummary for KLHL7_CRKL |
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Fusion gene information | Fusion gene name: KLHL7_CRKL | Fusion gene ID: 19055 | Hgene | Tgene | Gene symbol | KLHL7 | CRKL | Gene ID | 55975 | 1399 |
Gene name | kelch like family member 7 | CRK like proto-oncogene, adaptor protein | |
Synonyms | CISS3|KLHL6|SBBI26 | - | |
Cytomap | 7p15.3 | 22q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | kelch-like protein 7kelch-like 6kelch-like 7kelch/BTB | crk-like proteinv-crk avian sarcoma virus CT10 oncogene homolog-like | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | Q8IXQ5 | P46109 | |
Ensembl transtripts involved in fusion gene | ENST00000322231, ENST00000339077, ENST00000539124, ENST00000542558, ENST00000409689, ENST00000545443, ENST00000479288, ENST00000322275, ENST00000410047, ENST00000545771, | ENST00000354336, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 3 X 3=27 |
# samples | 5 | 3 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KLHL7 [Title/Abstract] AND CRKL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KLHL7 | GO:0016567 | protein ubiquitination | 21828050 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | D44954 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000322231 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
intron-3UTR | ENST00000339077 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
intron-3UTR | ENST00000539124 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
intron-3UTR | ENST00000542558 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
intron-3UTR | ENST00000409689 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
intron-3UTR | ENST00000545443 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
intron-3UTR | ENST00000479288 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
intron-3UTR | ENST00000322275 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
intron-3UTR | ENST00000410047 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
intron-3UTR | ENST00000545771 | ENST00000354336 | KLHL7 | chr7 | 23181797 | - | CRKL | chr22 | 21306542 | + |
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FusionProtFeatures for KLHL7_CRKL |
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Hgene | Tgene |
KLHL7 | CRKL |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediatingubiquitination and subsequent degradation of substrate proteins.Probably mediates 'Lys-48'-linked ubiquitination.{ECO:0000269|PubMed:21828050}. | May mediate the transduction of intracellular signals. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KLHL7_CRKL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KLHL7_CRKL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLHL7_CRKL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLHL7_CRKL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KLHL7 | C2751986 | RETINITIS PIGMENTOSA 42 | 1 | CTD_human;UNIPROT |
Tgene | CRKL | C0012236 | DiGeorge Syndrome | 1 | CTD_human |