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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19055

FusionGeneSummary for KLHL7_CRKL

check button Fusion gene summary
Fusion gene informationFusion gene name: KLHL7_CRKL
Fusion gene ID: 19055
HgeneTgene
Gene symbol

KLHL7

CRKL

Gene ID

55975

1399

Gene namekelch like family member 7CRK like proto-oncogene, adaptor protein
SynonymsCISS3|KLHL6|SBBI26-
Cytomap

7p15.3

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionkelch-like protein 7kelch-like 6kelch-like 7kelch/BTBcrk-like proteinv-crk avian sarcoma virus CT10 oncogene homolog-like
Modification date2018052220180522
UniProtAcc

Q8IXQ5

P46109

Ensembl transtripts involved in fusion geneENST00000322231, ENST00000339077, 
ENST00000539124, ENST00000542558, 
ENST00000409689, ENST00000545443, 
ENST00000479288, ENST00000322275, 
ENST00000410047, ENST00000545771, 
ENST00000354336, 
Fusion gene scores* DoF score5 X 5 X 3=753 X 3 X 3=27
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KLHL7 [Title/Abstract] AND CRKL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLHL7

GO:0016567

protein ubiquitination

21828050


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1D44954KLHL7chr7

23181797

-CRKLchr22

21306542

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000322231ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+
intron-3UTRENST00000339077ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+
intron-3UTRENST00000539124ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+
intron-3UTRENST00000542558ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+
intron-3UTRENST00000409689ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+
intron-3UTRENST00000545443ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+
intron-3UTRENST00000479288ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+
intron-3UTRENST00000322275ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+
intron-3UTRENST00000410047ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+
intron-3UTRENST00000545771ENST00000354336KLHL7chr7

23181797

-CRKLchr22

21306542

+

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FusionProtFeatures for KLHL7_CRKL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLHL7

Q8IXQ5

CRKL

P46109

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediatingubiquitination and subsequent degradation of substrate proteins.Probably mediates 'Lys-48'-linked ubiquitination.{ECO:0000269|PubMed:21828050}. May mediate the transduction of intracellular signals.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLHL7_CRKL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLHL7_CRKL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLHL7_CRKL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLHL7_CRKL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLHL7C2751986RETINITIS PIGMENTOSA 421CTD_human;UNIPROT
TgeneCRKLC0012236DiGeorge Syndrome1CTD_human