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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19054

FusionGeneSummary for KLHL7_BRD1

check button Fusion gene summary
Fusion gene informationFusion gene name: KLHL7_BRD1
Fusion gene ID: 19054
HgeneTgene
Gene symbol

KLHL7

BRD1

Gene ID

55975

23774

Gene namekelch like family member 7bromodomain containing 1
SynonymsCISS3|KLHL6|SBBI26BRL|BRPF1|BRPF2
Cytomap

7p15.3

22q13.33

Type of geneprotein-codingprotein-coding
Descriptionkelch-like protein 7kelch-like 6kelch-like 7kelch/BTBbromodomain-containing protein 1BR140-like proteinbromodomain and PHD finger-containing protein 2
Modification date2018052220180519
UniProtAcc

Q8IXQ5

O95696

Ensembl transtripts involved in fusion geneENST00000322231, ENST00000339077, 
ENST00000539124, ENST00000542558, 
ENST00000409689, ENST00000545443, 
ENST00000479288, ENST00000322275, 
ENST00000410047, ENST00000545771, 
ENST00000216267, ENST00000404034, 
ENST00000404760, ENST00000457780, 
ENST00000542442, ENST00000342989, 
ENST00000459821, 
Fusion gene scores* DoF score5 X 5 X 3=754 X 5 X 3=60
# samples 55
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLHL7 [Title/Abstract] AND BRD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLHL7

GO:0016567

protein ubiquitination

21828050

TgeneBRD1

GO:0043966

histone H3 acetylation

16387653


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T07017KLHL7chr7

23182025

+BRD1chr22

50167135

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000322231ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000322231ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000322231ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000322231ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000322231ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000322231ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000322231ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000339077ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000339077ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000339077ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000339077ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000339077ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000339077ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000339077ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000539124ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000539124ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000539124ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000539124ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000539124ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000539124ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000539124ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000542558ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000542558ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000542558ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000542558ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000542558ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000542558ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000542558ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000409689ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000409689ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000409689ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000409689ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000409689ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000409689ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000409689ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000545443ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000545443ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000545443ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000545443ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000545443ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000545443ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000545443ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000479288ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000479288ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000479288ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000479288ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000479288ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000479288ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000479288ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000322275ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000322275ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000322275ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000322275ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000322275ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000322275ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000322275ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000410047ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000410047ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000410047ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000410047ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000410047ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000410047ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000410047ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000545771ENST00000216267KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000545771ENST00000404034KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000545771ENST00000404760KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-3UTRENST00000545771ENST00000457780KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000545771ENST00000542442KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000545771ENST00000342989KLHL7chr7

23182025

+BRD1chr22

50167135

+
intron-intronENST00000545771ENST00000459821KLHL7chr7

23182025

+BRD1chr22

50167135

+

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FusionProtFeatures for KLHL7_BRD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLHL7

Q8IXQ5

BRD1

O95696

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediatingubiquitination and subsequent degradation of substrate proteins.Probably mediates 'Lys-48'-linked ubiquitination.{ECO:0000269|PubMed:21828050}. Component of the MOZ/MORF complex which has a histone H3acetyltransferase activity. {ECO:0000269|PubMed:16387653,ECO:0000269|PubMed:21880731}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLHL7_BRD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLHL7_BRD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for KLHL7_BRD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for KLHL7_BRD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLHL7C2751986RETINITIS PIGMENTOSA 421CTD_human;UNIPROT
TgeneBRD1C0036341Schizophrenia5PSYGENET
TgeneBRD1C0005586Bipolar Disorder4PSYGENET
TgeneBRD1C0010606Adenoid Cystic Carcinoma1CTD_human