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Fusion gene ID: 19052 |
FusionGeneSummary for KLHL5_UBE2K |
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Fusion gene information | Fusion gene name: KLHL5_UBE2K | Fusion gene ID: 19052 | Hgene | Tgene | Gene symbol | KLHL5 | UBE2K | Gene ID | 51088 | 3093 |
Gene name | kelch like family member 5 | ubiquitin conjugating enzyme E2 K | |
Synonyms | - | E2-25K|HIP2|HYPG|LIG|UBC1 | |
Cytomap | 4p14 | 4p14 | |
Type of gene | protein-coding | protein-coding | |
Description | kelch-like protein 5lymphocyte activation-associated protein | ubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqu | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q96PQ7 | P61086 | |
Ensembl transtripts involved in fusion gene | ENST00000261425, ENST00000508137, ENST00000504108, ENST00000359687, ENST00000381930, ENST00000261426, | ENST00000261427, ENST00000295963, ENST00000438068, ENST00000503368, ENST00000445950, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 3 X 3 X 3=27 |
# samples | 5 | 3 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KLHL5 [Title/Abstract] AND UBE2K [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | UBE2K | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 24882218 |
Tgene | UBE2K | GO:0010994 | free ubiquitin chain polymerization | 24882218 |
Tgene | UBE2K | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-VQ-A8PE-01A | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000261425 | ENST00000261427 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
5UTR-3CDS | ENST00000261425 | ENST00000295963 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
5UTR-3UTR | ENST00000261425 | ENST00000438068 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
5UTR-intron | ENST00000261425 | ENST00000503368 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
5UTR-intron | ENST00000261425 | ENST00000445950 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
5UTR-3CDS | ENST00000508137 | ENST00000261427 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
5UTR-3CDS | ENST00000508137 | ENST00000295963 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
5UTR-3UTR | ENST00000508137 | ENST00000438068 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
5UTR-intron | ENST00000508137 | ENST00000503368 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
5UTR-intron | ENST00000508137 | ENST00000445950 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3CDS | ENST00000504108 | ENST00000261427 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3CDS | ENST00000504108 | ENST00000295963 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3UTR | ENST00000504108 | ENST00000438068 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-intron | ENST00000504108 | ENST00000503368 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-intron | ENST00000504108 | ENST00000445950 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3CDS | ENST00000359687 | ENST00000261427 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3CDS | ENST00000359687 | ENST00000295963 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3UTR | ENST00000359687 | ENST00000438068 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-intron | ENST00000359687 | ENST00000503368 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-intron | ENST00000359687 | ENST00000445950 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3CDS | ENST00000381930 | ENST00000261427 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3CDS | ENST00000381930 | ENST00000295963 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3UTR | ENST00000381930 | ENST00000438068 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-intron | ENST00000381930 | ENST00000503368 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-intron | ENST00000381930 | ENST00000445950 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3CDS | ENST00000261426 | ENST00000261427 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3CDS | ENST00000261426 | ENST00000295963 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-3UTR | ENST00000261426 | ENST00000438068 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-intron | ENST00000261426 | ENST00000503368 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
intron-intron | ENST00000261426 | ENST00000445950 | KLHL5 | chr4 | 39046716 | + | UBE2K | chr4 | 39739040 | + |
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FusionProtFeatures for KLHL5_UBE2K |
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Hgene | Tgene |
KLHL5 | UBE2K |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KLHL5_UBE2K |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KLHL5_UBE2K |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KLHL5 | GABARAPL2, TK1, MAP1LC3B, SMN1, CUL3, FUS, MTNR1A | UBE2K | DSTYK, HTT, RNF2, UBE2I, DDX58, RNF125, RNF138, BFAR, UBOX5, RNF5, DTX3, MARCH7, SIAH1, TRIM27, RNF185, TRIM35, BIRC7, BIRC8, RNF4, TRIM34, RNF167, UHRF2, TRAF7, MKRN2, TRAIP, RING1, RNF41, MARCH3, RNF32, RNF114, LRSAM1, CBLC, DTX3L, DZIP3, MID1, MKRN3, TRIM39, RNF111, RNF144A, TRIM2, TRIM31, TRIM43, TRIM5, RBCK1, ITSN1, PRPF40A, CCNB1, DIABLO, BRCA1, UBC, CASP12, PIAS4, NUB1, NXF1, FZR1, NEDD4L, WWP2, ITCH, WDR1, WDR61, TXNDC17, TYMS, TXN, ANAPC11, IQCB1, BAG3, UBA1, TP53, MDM2, CDC6, PRRG4, REL, MIPOL1, DDI1, ZDHHC17, AMFR, BARD1, SENP1, MAP3K1, HNRNPA1, UBE2D2, RAB1A, TMEM189-UBE2V1, UBE2V1, UBE2N, RC3H2, TRIM63, SMURF1, CYHR1, ARL15, USP1, DLD |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLHL5_UBE2K |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLHL5_UBE2K |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KLHL5 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |