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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19052

FusionGeneSummary for KLHL5_UBE2K

check button Fusion gene summary
Fusion gene informationFusion gene name: KLHL5_UBE2K
Fusion gene ID: 19052
HgeneTgene
Gene symbol

KLHL5

UBE2K

Gene ID

51088

3093

Gene namekelch like family member 5ubiquitin conjugating enzyme E2 K
Synonyms-E2-25K|HIP2|HYPG|LIG|UBC1
Cytomap

4p14

4p14

Type of geneprotein-codingprotein-coding
Descriptionkelch-like protein 5lymphocyte activation-associated proteinubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqu
Modification date2018052220180523
UniProtAcc

Q96PQ7

P61086

Ensembl transtripts involved in fusion geneENST00000261425, ENST00000508137, 
ENST00000504108, ENST00000359687, 
ENST00000381930, ENST00000261426, 
ENST00000261427, ENST00000295963, 
ENST00000438068, ENST00000503368, 
ENST00000445950, 
Fusion gene scores* DoF score5 X 3 X 4=603 X 3 X 3=27
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KLHL5 [Title/Abstract] AND UBE2K [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE2K

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24882218

TgeneUBE2K

GO:0010994

free ubiquitin chain polymerization

24882218

TgeneUBE2K

GO:0070936

protein K48-linked ubiquitination

20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A8PE-01AKLHL5chr4

39046716

+UBE2Kchr4

39739040

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000261425ENST00000261427KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
5UTR-3CDSENST00000261425ENST00000295963KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
5UTR-3UTRENST00000261425ENST00000438068KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
5UTR-intronENST00000261425ENST00000503368KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
5UTR-intronENST00000261425ENST00000445950KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
5UTR-3CDSENST00000508137ENST00000261427KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
5UTR-3CDSENST00000508137ENST00000295963KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
5UTR-3UTRENST00000508137ENST00000438068KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
5UTR-intronENST00000508137ENST00000503368KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
5UTR-intronENST00000508137ENST00000445950KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3CDSENST00000504108ENST00000261427KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3CDSENST00000504108ENST00000295963KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3UTRENST00000504108ENST00000438068KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-intronENST00000504108ENST00000503368KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-intronENST00000504108ENST00000445950KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3CDSENST00000359687ENST00000261427KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3CDSENST00000359687ENST00000295963KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3UTRENST00000359687ENST00000438068KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-intronENST00000359687ENST00000503368KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-intronENST00000359687ENST00000445950KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3CDSENST00000381930ENST00000261427KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3CDSENST00000381930ENST00000295963KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3UTRENST00000381930ENST00000438068KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-intronENST00000381930ENST00000503368KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-intronENST00000381930ENST00000445950KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3CDSENST00000261426ENST00000261427KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3CDSENST00000261426ENST00000295963KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-3UTRENST00000261426ENST00000438068KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-intronENST00000261426ENST00000503368KLHL5chr4

39046716

+UBE2Kchr4

39739040

+
intron-intronENST00000261426ENST00000445950KLHL5chr4

39046716

+UBE2Kchr4

39739040

+

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FusionProtFeatures for KLHL5_UBE2K


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLHL5

Q96PQ7

UBE2K

P61086


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLHL5_UBE2K


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLHL5_UBE2K


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KLHL5GABARAPL2, TK1, MAP1LC3B, SMN1, CUL3, FUS, MTNR1AUBE2KDSTYK, HTT, RNF2, UBE2I, DDX58, RNF125, RNF138, BFAR, UBOX5, RNF5, DTX3, MARCH7, SIAH1, TRIM27, RNF185, TRIM35, BIRC7, BIRC8, RNF4, TRIM34, RNF167, UHRF2, TRAF7, MKRN2, TRAIP, RING1, RNF41, MARCH3, RNF32, RNF114, LRSAM1, CBLC, DTX3L, DZIP3, MID1, MKRN3, TRIM39, RNF111, RNF144A, TRIM2, TRIM31, TRIM43, TRIM5, RBCK1, ITSN1, PRPF40A, CCNB1, DIABLO, BRCA1, UBC, CASP12, PIAS4, NUB1, NXF1, FZR1, NEDD4L, WWP2, ITCH, WDR1, WDR61, TXNDC17, TYMS, TXN, ANAPC11, IQCB1, BAG3, UBA1, TP53, MDM2, CDC6, PRRG4, REL, MIPOL1, DDI1, ZDHHC17, AMFR, BARD1, SENP1, MAP3K1, HNRNPA1, UBE2D2, RAB1A, TMEM189-UBE2V1, UBE2V1, UBE2N, RC3H2, TRIM63, SMURF1, CYHR1, ARL15, USP1, DLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLHL5_UBE2K


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLHL5_UBE2K


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLHL5C0236736Cocaine-Related Disorders1CTD_human