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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1905

FusionGeneSummary for ANLN_EEPD1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANLN_EEPD1
Fusion gene ID: 1905
HgeneTgene
Gene symbol

ANLN

EEPD1

Gene ID

54443

80820

Gene nameanillin actin binding proteinendonuclease/exonuclease/phosphatase family domain containing 1
SynonymsFSGS8|Scraps|scraHSPC107
Cytomap

7p14.2

7p14.2

Type of geneprotein-codingprotein-coding
Descriptionanillinendonuclease/exonuclease/phosphatase family domain-containing protein 1
Modification date2018052320180519
UniProtAcc

Q9NQW6

Q7L9B9

Ensembl transtripts involved in fusion geneENST00000265748, ENST00000396068, 
ENST00000495714, 
ENST00000242108, 
ENST00000534978, 
Fusion gene scores* DoF score5 X 5 X 5=1254 X 3 X 3=36
# samples 54
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANLN [Title/Abstract] AND EEPD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANLN

GO:0000281

mitotic cytokinesis

10931866


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-6778-01AANLNchr7

36436028

+EEPD1chr7

36336602

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265748ENST00000242108ANLNchr7

36436028

+EEPD1chr7

36336602

+
In-frameENST00000265748ENST00000534978ANLNchr7

36436028

+EEPD1chr7

36336602

+
In-frameENST00000396068ENST00000242108ANLNchr7

36436028

+EEPD1chr7

36336602

+
In-frameENST00000396068ENST00000534978ANLNchr7

36436028

+EEPD1chr7

36336602

+
intron-3CDSENST00000495714ENST00000242108ANLNchr7

36436028

+EEPD1chr7

36336602

+
intron-3CDSENST00000495714ENST00000534978ANLNchr7

36436028

+EEPD1chr7

36336602

+

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FusionProtFeatures for ANLN_EEPD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANLN

Q9NQW6

EEPD1

Q7L9B9

Required for cytokinesis (PubMed:16040610). Essentialfor the structural integrity of the cleavage furrow and forcompletion of cleavage furrow ingression. Plays a role in blebassembly during metaphase and anaphase of mitosis(PubMed:23870127). May play a significant role in podocyte cellmigration (PubMed:24676636). {ECO:0000269|PubMed:10931866,ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454,ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138,ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANLNchr7:36436028chr7:36336602ENST00000265748+2241_45571125RegionNote=Required for ubiquitination
HgeneANLNchr7:36436028chr7:36336602ENST00000396068+2231_45571088RegionNote=Required for ubiquitination

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANLNchr7:36436028chr7:36336602ENST00000265748+224569_604571125Coiled coilOntology_term=ECO:0000255
HgeneANLNchr7:36436028chr7:36336602ENST00000396068+223569_604571088Coiled coilOntology_term=ECO:0000255
HgeneANLNchr7:36436028chr7:36336602ENST00000265748+224983_1107571125DomainPH
HgeneANLNchr7:36436028chr7:36336602ENST00000396068+223983_1107571088DomainPH
HgeneANLNchr7:36436028chr7:36336602ENST00000265748+2241_230571125RegionNote=Nuclear localization
HgeneANLNchr7:36436028chr7:36336602ENST00000265748+224730_1124571125RegionNote=Localization to the cleavage furrow
HgeneANLNchr7:36436028chr7:36336602ENST00000396068+2231_230571088RegionNote=Nuclear localization
HgeneANLNchr7:36436028chr7:36336602ENST00000396068+223730_1124571088RegionNote=Localization to the cleavage furrow
TgeneEEPD1chr7:36436028chr7:36336602ENST00000242108+5838_67438570DomainNote=HhH
TgeneEEPD1chr7:36436028chr7:36336602ENST00000534978+6938_67438570DomainNote=HhH


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FusionGeneSequence for ANLN_EEPD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANLN_EEPD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANLNTAF10, SH3KBP1, MEN1, LMNA, MARCH10, UBAP2L, ZWILCH, CRK, HIST1H2BG, NIN, ACTG1, ACTN4, ACTN1, AP2A1, AP2B1, APOB, BLMH, DST, CALM1, CALML3, CAMK2G, CAPZA1, CAPZA2, CAPZB, SEPT7, CFL1, AP2M1, CLIC1, CLTA, CLTB, CLTC, CPM, DAB2, DBN1, EEF1D, EPS15, FLII, FLNA, FLNB, FYN, NR3C1, ITPR3, ABLIM1, LMO7, LYN, MYO1B, MYH9, MYL6, MYLK, MYO1C, MYO1E, MYO5A, MYO5B, MYO6, PPP1R12A, PPP1R12B, SEPT2, PIK3C2A, PLEC, PPP1CA, PPP1CB, TWF1, SIPA1, FSCN1, SORD, SPTAN1, SPTBN1, SSFA2, ST5, SVIL, TCEA2, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, TPM4, CORO2A, YES1, LUZP1, PICALM, SORBS2, NUMB, CLINT1, ARHGAP11A, ARHGEF17, WDR1, ARPC5, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2, BASP1, MYL12A, SEPT9, TRIOBP, CIT, AKAP2, SYNPO, CEP162, AAK1, LIMCH1, SEPT6, MPRIP, COBL, SPECC1L, CORO1C, INTS7, PLEKHG3, RAI14, TES, ZBTB20, PACSIN3, TMOD3, LIMA1, GTSE1, MMGT1, MRPL16, UACA, ELP3, FEM1A, BMP2K, MYO5C, CORO1B, MICAL3, ARHGAP21, AFAP1, INF2, MRPL38, MYO19, ARPC5L, STON2, SSH2, NEXN, SPECC1, MISP, MYL6B, SEPT10, TPRN, MYO18A, SNW1, CDC5L, RHOA, CDH1, TRIM25EEPD1APP, CIAO1, FSD1, FYTTD1, TMEM185A, PCDHGC3, MED21, ISG20, GJB7, SDC1, TIGD5, NCSTN, RSBN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneANLNchr7:36436028chr7:36336602ENST00000265748+2241_155571125CD2AP
HgeneANLNchr7:36436028chr7:36336602ENST00000396068+2231_155571088CD2AP
HgeneANLNchr7:36436028chr7:36336602ENST00000265748+224231_676571125F-actin
HgeneANLNchr7:36436028chr7:36336602ENST00000396068+223231_676571088F-actin


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANLN_EEPD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANLN_EEPD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANLNC0032460Polycystic Ovary Syndrome1CTD_human
HgeneANLNC4014993FOCAL SEGMENTAL GLOMERULOSCLEROSIS 81UNIPROT