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Fusion gene ID: 1905 |
FusionGeneSummary for ANLN_EEPD1 |
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Fusion gene information | Fusion gene name: ANLN_EEPD1 | Fusion gene ID: 1905 | Hgene | Tgene | Gene symbol | ANLN | EEPD1 | Gene ID | 54443 | 80820 |
Gene name | anillin actin binding protein | endonuclease/exonuclease/phosphatase family domain containing 1 | |
Synonyms | FSGS8|Scraps|scra | HSPC107 | |
Cytomap | 7p14.2 | 7p14.2 | |
Type of gene | protein-coding | protein-coding | |
Description | anillin | endonuclease/exonuclease/phosphatase family domain-containing protein 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9NQW6 | Q7L9B9 | |
Ensembl transtripts involved in fusion gene | ENST00000265748, ENST00000396068, ENST00000495714, | ENST00000242108, ENST00000534978, | |
Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 4 X 3 X 3=36 |
# samples | 5 | 4 | |
** MAII score | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ANLN [Title/Abstract] AND EEPD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANLN | GO:0000281 | mitotic cytokinesis | 10931866 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-44-6778-01A | ANLN | chr7 | 36436028 | + | EEPD1 | chr7 | 36336602 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000265748 | ENST00000242108 | ANLN | chr7 | 36436028 | + | EEPD1 | chr7 | 36336602 | + |
In-frame | ENST00000265748 | ENST00000534978 | ANLN | chr7 | 36436028 | + | EEPD1 | chr7 | 36336602 | + |
In-frame | ENST00000396068 | ENST00000242108 | ANLN | chr7 | 36436028 | + | EEPD1 | chr7 | 36336602 | + |
In-frame | ENST00000396068 | ENST00000534978 | ANLN | chr7 | 36436028 | + | EEPD1 | chr7 | 36336602 | + |
intron-3CDS | ENST00000495714 | ENST00000242108 | ANLN | chr7 | 36436028 | + | EEPD1 | chr7 | 36336602 | + |
intron-3CDS | ENST00000495714 | ENST00000534978 | ANLN | chr7 | 36436028 | + | EEPD1 | chr7 | 36336602 | + |
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FusionProtFeatures for ANLN_EEPD1 |
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Hgene | Tgene |
ANLN | EEPD1 |
Required for cytokinesis (PubMed:16040610). Essentialfor the structural integrity of the cleavage furrow and forcompletion of cleavage furrow ingression. Plays a role in blebassembly during metaphase and anaphase of mitosis(PubMed:23870127). May play a significant role in podocyte cellmigration (PubMed:24676636). {ECO:0000269|PubMed:10931866,ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454,ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138,ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ANLN | chr7:36436028 | chr7:36336602 | ENST00000265748 | + | 2 | 24 | 1_45 | 57 | 1125 | Region | Note=Required for ubiquitination |
Hgene | ANLN | chr7:36436028 | chr7:36336602 | ENST00000396068 | + | 2 | 23 | 1_45 | 57 | 1088 | Region | Note=Required for ubiquitination |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ANLN | chr7:36436028 | chr7:36336602 | ENST00000265748 | + | 2 | 24 | 569_604 | 57 | 1125 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >ANLN | chr7:36436028 | chr7:36336602 | ENST00000396068 | + | 2 | 23 | 569_604 | 57 | 1088 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >ANLN | chr7:36436028 | chr7:36336602 | ENST00000265748 | + | 2 | 24 | 983_1107 | 57 | 1125 | Domain | PH |
Hgene | >ANLN | chr7:36436028 | chr7:36336602 | ENST00000396068 | + | 2 | 23 | 983_1107 | 57 | 1088 | Domain | PH |
Hgene | >ANLN | chr7:36436028 | chr7:36336602 | ENST00000265748 | + | 2 | 24 | 1_230 | 57 | 1125 | Region | Note=Nuclear localization |
Hgene | >ANLN | chr7:36436028 | chr7:36336602 | ENST00000265748 | + | 2 | 24 | 730_1124 | 57 | 1125 | Region | Note=Localization to the cleavage furrow |
Hgene | >ANLN | chr7:36436028 | chr7:36336602 | ENST00000396068 | + | 2 | 23 | 1_230 | 57 | 1088 | Region | Note=Nuclear localization |
Hgene | >ANLN | chr7:36436028 | chr7:36336602 | ENST00000396068 | + | 2 | 23 | 730_1124 | 57 | 1088 | Region | Note=Localization to the cleavage furrow |
Tgene | EEPD1 | chr7:36436028 | chr7:36336602 | ENST00000242108 | + | 5 | 8 | 38_67 | 438 | 570 | Domain | Note=HhH |
Tgene | EEPD1 | chr7:36436028 | chr7:36336602 | ENST00000534978 | + | 6 | 9 | 38_67 | 438 | 570 | Domain | Note=HhH |
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FusionGeneSequence for ANLN_EEPD1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANLN_EEPD1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ANLN | TAF10, SH3KBP1, MEN1, LMNA, MARCH10, UBAP2L, ZWILCH, CRK, HIST1H2BG, NIN, ACTG1, ACTN4, ACTN1, AP2A1, AP2B1, APOB, BLMH, DST, CALM1, CALML3, CAMK2G, CAPZA1, CAPZA2, CAPZB, SEPT7, CFL1, AP2M1, CLIC1, CLTA, CLTB, CLTC, CPM, DAB2, DBN1, EEF1D, EPS15, FLII, FLNA, FLNB, FYN, NR3C1, ITPR3, ABLIM1, LMO7, LYN, MYO1B, MYH9, MYL6, MYLK, MYO1C, MYO1E, MYO5A, MYO5B, MYO6, PPP1R12A, PPP1R12B, SEPT2, PIK3C2A, PLEC, PPP1CA, PPP1CB, TWF1, SIPA1, FSCN1, SORD, SPTAN1, SPTBN1, SSFA2, ST5, SVIL, TCEA2, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, TPM4, CORO2A, YES1, LUZP1, PICALM, SORBS2, NUMB, CLINT1, ARHGAP11A, ARHGEF17, WDR1, ARPC5, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2, BASP1, MYL12A, SEPT9, TRIOBP, CIT, AKAP2, SYNPO, CEP162, AAK1, LIMCH1, SEPT6, MPRIP, COBL, SPECC1L, CORO1C, INTS7, PLEKHG3, RAI14, TES, ZBTB20, PACSIN3, TMOD3, LIMA1, GTSE1, MMGT1, MRPL16, UACA, ELP3, FEM1A, BMP2K, MYO5C, CORO1B, MICAL3, ARHGAP21, AFAP1, INF2, MRPL38, MYO19, ARPC5L, STON2, SSH2, NEXN, SPECC1, MISP, MYL6B, SEPT10, TPRN, MYO18A, SNW1, CDC5L, RHOA, CDH1, TRIM25 | EEPD1 | APP, CIAO1, FSD1, FYTTD1, TMEM185A, PCDHGC3, MED21, ISG20, GJB7, SDC1, TIGD5, NCSTN, RSBN1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | ANLN | chr7:36436028 | chr7:36336602 | ENST00000265748 | + | 2 | 24 | 1_155 | 57 | 1125 | CD2AP |
Hgene | ANLN | chr7:36436028 | chr7:36336602 | ENST00000396068 | + | 2 | 23 | 1_155 | 57 | 1088 | CD2AP |
Hgene | ANLN | chr7:36436028 | chr7:36336602 | ENST00000265748 | + | 2 | 24 | 231_676 | 57 | 1125 | F-actin |
Hgene | ANLN | chr7:36436028 | chr7:36336602 | ENST00000396068 | + | 2 | 23 | 231_676 | 57 | 1088 | F-actin |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANLN_EEPD1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANLN_EEPD1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ANLN | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Hgene | ANLN | C4014993 | FOCAL SEGMENTAL GLOMERULOSCLEROSIS 8 | 1 | UNIPROT |