![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 19007 |
FusionGeneSummary for KLHDC4_SLC7A5 |
![]() |
Fusion gene information | Fusion gene name: KLHDC4_SLC7A5 | Fusion gene ID: 19007 | Hgene | Tgene | Gene symbol | KLHDC4 | SLC7A5 | Gene ID | 54758 | 8140 |
Gene name | kelch domain containing 4 | solute carrier family 7 member 5 | |
Synonyms | - | 4F2LC|CD98|D16S469E|E16|LAT1|MPE16 | |
Cytomap | 16q24.2 | 16q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | kelch domain-containing protein 4 | large neutral amino acids transporter small subunit 14F2 light chainCD98 light chainL-type amino acid transporter 1integral membrane protein E16sodium-independent neutral amino acid transporter LAT1solute carrier family 7 (amino acid transporter lig | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8TBB5 | Q01650 | |
Ensembl transtripts involved in fusion gene | ENST00000353170, ENST00000347925, ENST00000566349, ENST00000270583, | ENST00000565644, ENST00000261622, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: KLHDC4 [Title/Abstract] AND SLC7A5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-4Z-AA82-01A | KLHDC4 | chr16 | 87782279 | - | SLC7A5 | chr16 | 87871547 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000353170 | ENST00000565644 | KLHDC4 | chr16 | 87782279 | - | SLC7A5 | chr16 | 87871547 | - |
Frame-shift | ENST00000353170 | ENST00000261622 | KLHDC4 | chr16 | 87782279 | - | SLC7A5 | chr16 | 87871547 | - |
Frame-shift | ENST00000347925 | ENST00000565644 | KLHDC4 | chr16 | 87782279 | - | SLC7A5 | chr16 | 87871547 | - |
Frame-shift | ENST00000347925 | ENST00000261622 | KLHDC4 | chr16 | 87782279 | - | SLC7A5 | chr16 | 87871547 | - |
intron-3CDS | ENST00000566349 | ENST00000565644 | KLHDC4 | chr16 | 87782279 | - | SLC7A5 | chr16 | 87871547 | - |
intron-3CDS | ENST00000566349 | ENST00000261622 | KLHDC4 | chr16 | 87782279 | - | SLC7A5 | chr16 | 87871547 | - |
Frame-shift | ENST00000270583 | ENST00000565644 | KLHDC4 | chr16 | 87782279 | - | SLC7A5 | chr16 | 87871547 | - |
Frame-shift | ENST00000270583 | ENST00000261622 | KLHDC4 | chr16 | 87782279 | - | SLC7A5 | chr16 | 87871547 | - |
Top |
FusionProtFeatures for KLHDC4_SLC7A5 |
![]() |
Hgene | Tgene |
KLHDC4 | SLC7A5 |
Sodium-independent, high-affinity transport of largeneutral amino acids such as phenylalanine, tyrosine, leucine,arginine and tryptophan, when associated with SLC3A2/4F2hc.Involved in cellular amino acid uptake. Acts as an amino acidexchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3)and thyroxine (T4) across the cell membrane in tissues such asplacenta. Plays a role in neuronal cell proliferation(neurogenesis) in brain. Involved in the uptake of methylmercury(MeHg) when administered as the L-cysteine or D,L-homocysteinecomplexes, and hence plays a role in metal ion homeostasis andtoxicity. Involved in the cellular activity of small molecularweight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play animportant role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which inturn may play a key role in maintaining large neutral amino acidsas well as neurotransmitters in the neural retina. Acts as themajor transporter of tyrosine in fibroblasts. When associated withLAPTM4B, recruits SLC3A2 and SLC7A5 to lysosomes to promoteleucine uptake into these organelles and is required for mTORC1activation (PubMed:25998567). {ECO:0000269|PubMed:10049700,ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970,ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679,ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694,ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417,ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744,ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:18262359,ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for KLHDC4_SLC7A5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for KLHDC4_SLC7A5 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KLHDC4 | TERF1, KDM1A, SUV39H1, SUV39H2, CEP76, SHMT2, MOV10, NXF1, CROT, RPS19 | SLC7A5 | SLC3A2, ELAVL1, HNRNPU, NOS2, LGR4, IRAK1, TMEM17, TMEM216, NCSTN, TMEM63B, TUBA1C, MBOAT1, EGFR, CDC73, CYLD, TRIM25, TES |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for KLHDC4_SLC7A5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for KLHDC4_SLC7A5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SLC7A5 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | SLC7A5 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |