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Fusion gene ID: 19005 |
FusionGeneSummary for KLHDC4_CTGF |
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Fusion gene information | Fusion gene name: KLHDC4_CTGF | Fusion gene ID: 19005 | Hgene | Tgene | Gene symbol | KLHDC4 | CTGF | Gene ID | 54758 | 1490 |
Gene name | kelch domain containing 4 | connective tissue growth factor | |
Synonyms | - | CCN2|HCS24|IGFBP8|NOV2 | |
Cytomap | 16q24.2 | 6q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | kelch domain-containing protein 4 | connective tissue growth factorCCN family member 2IBP-8IGF-binding protein 8IGFBP-8hypertrophic chondrocyte-specific protein 24insulin-like growth factor-binding protein 8 | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q8TBB5 | P29279 | |
Ensembl transtripts involved in fusion gene | ENST00000353170, ENST00000347925, ENST00000566349, ENST00000270583, | ENST00000367976, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 2 X 2 X 1=4 |
# samples | 4 | 3 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/4*10)=2.90689059560852 | |
Context | PubMed: KLHDC4 [Title/Abstract] AND CTGF [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CTGF | GO:0045597 | positive regulation of cell differentiation | 20008146 |
Tgene | CTGF | GO:0046330 | positive regulation of JNK cascade | 20008146 |
Tgene | CTGF | GO:0051496 | positive regulation of stress fiber assembly | 20008146 |
Tgene | CTGF | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 20008146 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN482962 | KLHDC4 | chr16 | 87760459 | - | CTGF | chr6 | 132272292 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000353170 | ENST00000367976 | KLHDC4 | chr16 | 87760459 | - | CTGF | chr6 | 132272292 | - |
intron-3CDS | ENST00000347925 | ENST00000367976 | KLHDC4 | chr16 | 87760459 | - | CTGF | chr6 | 132272292 | - |
intron-3CDS | ENST00000566349 | ENST00000367976 | KLHDC4 | chr16 | 87760459 | - | CTGF | chr6 | 132272292 | - |
intron-3CDS | ENST00000270583 | ENST00000367976 | KLHDC4 | chr16 | 87760459 | - | CTGF | chr6 | 132272292 | - |
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FusionProtFeatures for KLHDC4_CTGF |
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Hgene | Tgene |
KLHDC4 | CTGF |
Major connective tissue mitoattractant secreted byvascular endothelial cells. Promotes proliferation anddifferentiation of chondrocytes. Mediates heparin- and divalentcation-dependent cell adhesion in many cell types includingfibroblasts, myofibroblasts, endothelial and epithelial cells.Enhances fibroblast growth factor-induced DNA synthesis.{ECO:0000269|PubMed:10614647, ECO:0000269|PubMed:12553878}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KLHDC4_CTGF |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KLHDC4_CTGF |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLHDC4_CTGF |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLHDC4_CTGF |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CTGF | C0023890 | Liver Cirrhosis | 3 | CTD_human |
Tgene | CTGF | C0034069 | Pulmonary Fibrosis | 3 | CTD_human;HPO |
Tgene | CTGF | C0024115 | Lung diseases | 2 | CTD_human |
Tgene | CTGF | C0235833 | Congenital diaphragmatic hernia | 2 | CTD_human |
Tgene | CTGF | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | CTGF | C0003504 | Aortic Valve Insufficiency | 1 | CTD_human |
Tgene | CTGF | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | CTGF | C0011616 | Contact Dermatitis | 1 | CTD_human |
Tgene | CTGF | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
Tgene | CTGF | C0018801 | Heart failure | 1 | CTD_human |
Tgene | CTGF | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | CTGF | C0021361 | Female infertility | 1 | CTD_human |
Tgene | CTGF | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
Tgene | CTGF | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CTGF | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | CTGF | C0033054 | Prenatal Exposure Delayed Effects | 1 | CTD_human |
Tgene | CTGF | C0036421 | Systemic Scleroderma | 1 | CTD_human |
Tgene | CTGF | C0524909 | Hepatitis B, Chronic | 1 | CTD_human |