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Fusion gene ID: 18989 |
FusionGeneSummary for KLF6_ARMC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLF6_ARMC4 | Fusion gene ID: 18989 | Hgene | Tgene | Gene symbol | KLF6 | ARMC4 | Gene ID | 1316 | 55130 |
| Gene name | Kruppel like factor 6 | armadillo repeat containing 4 | |
| Synonyms | BCD1|CBA1|COPEB|CPBP|GBF|PAC1|ST12|ZF9 | CILD23 | |
| Cytomap | 10p15.2 | 10p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Krueppel-like factor 6B-cell-derived protein 1GC-rich binding factorGC-rich sites-binding factor GBFKruppel-like zinc finger protein Zf9core promoter element-binding proteinproto-oncogene BCD1protooncogene B-cell derived 1suppression of tumorigeni | armadillo repeat-containing protein 4testis tissue sperm-binding protein Li 74n | |
| Modification date | 20180523 | 20180331 | |
| UniProtAcc | Q99612 | Q5T2S8 | |
| Ensembl transtripts involved in fusion gene | ENST00000497571, ENST00000542957, ENST00000173785, ENST00000469435, | ENST00000537576, ENST00000305242, ENST00000545014, ENST00000480504, ENST00000239715, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 3 X 4=48 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KLF6 [Title/Abstract] AND ARMC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KLF6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18755691 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-BP-4962-01A | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000497571 | ENST00000537576 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| In-frame | ENST00000497571 | ENST00000305242 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| In-frame | ENST00000497571 | ENST00000545014 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| 5CDS-intron | ENST00000497571 | ENST00000480504 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| 5CDS-intron | ENST00000497571 | ENST00000239715 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-3CDS | ENST00000542957 | ENST00000537576 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-3CDS | ENST00000542957 | ENST00000305242 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-3CDS | ENST00000542957 | ENST00000545014 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-intron | ENST00000542957 | ENST00000480504 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-intron | ENST00000542957 | ENST00000239715 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| 5UTR-3CDS | ENST00000173785 | ENST00000537576 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| 5UTR-3CDS | ENST00000173785 | ENST00000305242 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| 5UTR-3CDS | ENST00000173785 | ENST00000545014 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| 5UTR-intron | ENST00000173785 | ENST00000480504 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| 5UTR-intron | ENST00000173785 | ENST00000239715 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-3CDS | ENST00000469435 | ENST00000537576 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-3CDS | ENST00000469435 | ENST00000305242 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-3CDS | ENST00000469435 | ENST00000545014 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-intron | ENST00000469435 | ENST00000480504 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
| intron-intron | ENST00000469435 | ENST00000239715 | KLF6 | chr10 | 3822298 | - | ARMC4 | chr10 | 28196706 | - |
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FusionProtFeatures for KLF6_ARMC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLF6 | ARMC4 |
| Transcriptional activator (By similarity). Binds a GCbox motif. Could play a role in B-cell growth and development.{ECO:0000250}. | Ciliary protein that may be involved in a late step ofaxonemal outer dynein arm assembly. {ECO:0000269|PubMed:23849778}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KLF6 | chr10:3822298 | chr10:28196706 | ENST00000497571 | - | 3 | 4 | 200_224 | 266 | 284 | Zinc finger | C2H2-type 1 |
| Hgene | KLF6 | chr10:3822298 | chr10:28196706 | ENST00000497571 | - | 3 | 4 | 230_254 | 266 | 284 | Zinc finger | C2H2-type 2 |
| Tgene | >ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 828_867 | 831 | 1045 | Repeat | Note=ARM 6 |
| Tgene | >ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 871_910 | 831 | 1045 | Repeat | Note=ARM 7 |
| Tgene | >ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 912_951 | 831 | 1045 | Repeat | Note=ARM 8 |
| Tgene | >ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 953_992 | 831 | 1045 | Repeat | Note=ARM 9 |
| Tgene | >ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 994_1033 | 831 | 1045 | Repeat | Note=ARM 10 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KLF6 | chr10:3822298 | chr10:28196706 | ENST00000469435 | - | 1 | 2 | 200_224 | -60 | 282 | Zinc finger | C2H2-type 1 |
| Hgene | >KLF6 | chr10:3822298 | chr10:28196706 | ENST00000469435 | - | 1 | 2 | 230_254 | -60 | 282 | Zinc finger | C2H2-type 2 |
| Hgene | >KLF6 | chr10:3822298 | chr10:28196706 | ENST00000469435 | - | 1 | 2 | 260_282 | -60 | 282 | Zinc finger | C2H2-type 3 |
| Hgene | >KLF6 | chr10:3822298 | chr10:28196706 | ENST00000497571 | - | 3 | 4 | 260_282 | 266 | 284 | Zinc finger | C2H2-type 3 |
| Hgene | >KLF6 | chr10:3822298 | chr10:28196706 | ENST00000542957 | - | 1 | 3 | 200_224 | -89 | 238 | Zinc finger | C2H2-type 1 |
| Hgene | >KLF6 | chr10:3822298 | chr10:28196706 | ENST00000542957 | - | 1 | 3 | 230_254 | -89 | 238 | Zinc finger | C2H2-type 2 |
| Hgene | >KLF6 | chr10:3822298 | chr10:28196706 | ENST00000542957 | - | 1 | 3 | 260_282 | -89 | 238 | Zinc finger | C2H2-type 3 |
| Tgene | ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 484_523 | 831 | 1045 | Repeat | Note=ARM 1 |
| Tgene | ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 525_564 | 831 | 1045 | Repeat | Note=ARM 2 |
| Tgene | ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 622_661 | 831 | 1045 | Repeat | Note=ARM 3 |
| Tgene | ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 663_702 | 831 | 1045 | Repeat | Note=ARM 4 |
| Tgene | ARMC4 | chr10:3822298 | chr10:28196706 | ENST00000305242 | - | 15 | 20 | 746_785 | 831 | 1045 | Repeat | Note=ARM 5 |
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FusionGeneSequence for KLF6_ARMC4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KLF6_ENST00000497571_chr10_3822298_-_ARMC4_ENST00000537576_chr10_28196706_-_449aa MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILAREKKEESELKISSSPPEDTL ISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQLWGCVPGELPSPGKVRSGTS GKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRIID RLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVP >In-frame_KLF6_ENST00000497571_chr10_3822298_-_ARMC4_ENST00000305242_chr10_28196706_-_480aa MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILAREKKEESELKISSSPPEDTL ISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQLWGCVPGELPSPGKVRSGTS GKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRIID RLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVP LLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCITMHENGAVKLLLDMVGS >In-frame_KLF6_ENST00000497571_chr10_3822298_-_ARMC4_ENST00000545014_chr10_28196706_-_523aa MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILAREKKEESELKISSSPPEDTL ISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQLWGCVPGELPSPGKVRSGTS GKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRIID RLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVP LLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCITMHENGAVKTESRHVAR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KLF6_ENST00000497571_chr10_3822298_-_ARMC4_ENST00000537576_chr10_28196706_-_1347nt ATGGACGTGCTCCCCATGTGCAGCATCTTCCAGGAGCTCCAGATCGTGCACGAGACCGGCTACTTCTCGGCGCTGCCGTCTCTGGAGGAG TACTGGCAACAGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAG GAAGATCTGTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTC ATCAGCCCGAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCT CCCACGGCCAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCT TCTCCGGAACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCG GGGAAGCCAGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTT TACACCAAAAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGT TTTGCAAGAAGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGATAATTGAT CGCTTAGATGGAGTTCGTTTGTTGTGGTCCCTGCTGAAAAATCCTCACCCAGACGTGAAGGCCAGCGCAGCATGGGCACTCTGTCCATGC ATCAAAAATGCAAAGGATGCTGGGGAAATGGTTCGTTCCTTTGTTGGTGGTTTGGAACTTATTGTCAATTTACTGAAATCAGATAACAAA GAAGTTCTGGCAAGTGTATGTGCTGCCATTACCAACATAGCAAAAGATCAAGAAAATTTAGCTGTTATCACAGATCATGGAGTTGTTCCT TTATTGTCCAAACTGGCAAATACAAATAACAATAAATTGAGACATCATCTAGCAGAAGCTATTTCACGTTGCTGTATGTGGGGCAGGAAT AGAGTGGCCTTCGGTGAGCACAAAGCAGTGGCTCCACTAGTGCGTTATCTGAAATCAAATGACACCAACGTGCATCGGGCGACAGCTCAG >In-frame_KLF6_ENST00000497571_chr10_3822298_-_ARMC4_ENST00000305242_chr10_28196706_-_1440nt ATGGACGTGCTCCCCATGTGCAGCATCTTCCAGGAGCTCCAGATCGTGCACGAGACCGGCTACTTCTCGGCGCTGCCGTCTCTGGAGGAG TACTGGCAACAGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAG GAAGATCTGTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTC ATCAGCCCGAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCT CCCACGGCCAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCT TCTCCGGAACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCG GGGAAGCCAGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTT TACACCAAAAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGT TTTGCAAGAAGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGATAATTGAT CGCTTAGATGGAGTTCGTTTGTTGTGGTCCCTGCTGAAAAATCCTCACCCAGACGTGAAGGCCAGCGCAGCATGGGCACTCTGTCCATGC ATCAAAAATGCAAAGGATGCTGGGGAAATGGTTCGTTCCTTTGTTGGTGGTTTGGAACTTATTGTCAATTTACTGAAATCAGATAACAAA GAAGTTCTGGCAAGTGTATGTGCTGCCATTACCAACATAGCAAAAGATCAAGAAAATTTAGCTGTTATCACAGATCATGGAGTTGTTCCT TTATTGTCCAAACTGGCAAATACAAATAACAATAAATTGAGACATCATCTAGCAGAAGCTATTTCACGTTGCTGTATGTGGGGCAGGAAT AGAGTGGCCTTCGGTGAGCACAAAGCAGTGGCTCCACTAGTGCGTTATCTGAAATCAAATGACACCAACGTGCATCGGGCGACAGCTCAG GCCTTGTACCAACTCTCAGAAGACGCCGATAACTGCATCACCATGCATGAGAATGGTGCAGTAAAGCTTCTACTGGATATGGTTGGGTCC CCTGACCAGGATCTCCAGGAAGCTGCAGCTGGTTGTATATCCAATATCCGCAGGCTGGCTCTTGCTACAGAGAAGGCAAGATACACTTGA >In-frame_KLF6_ENST00000497571_chr10_3822298_-_ARMC4_ENST00000545014_chr10_28196706_-_1569nt ATGGACGTGCTCCCCATGTGCAGCATCTTCCAGGAGCTCCAGATCGTGCACGAGACCGGCTACTTCTCGGCGCTGCCGTCTCTGGAGGAG TACTGGCAACAGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAG GAAGATCTGTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTC ATCAGCCCGAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCT CCCACGGCCAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCT TCTCCGGAACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCG GGGAAGCCAGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTT TACACCAAAAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGT TTTGCAAGAAGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGATAATTGAT CGCTTAGATGGAGTTCGTTTGTTGTGGTCCCTGCTGAAAAATCCTCACCCAGACGTGAAGGCCAGCGCAGCATGGGCACTCTGTCCATGC ATCAAAAATGCAAAGGATGCTGGGGAAATGGTTCGTTCCTTTGTTGGTGGTTTGGAACTTATTGTCAATTTACTGAAATCAGATAACAAA GAAGTTCTGGCAAGTGTATGTGCTGCCATTACCAACATAGCAAAAGATCAAGAAAATTTAGCTGTTATCACAGATCATGGAGTTGTTCCT TTATTGTCCAAACTGGCAAATACAAATAACAATAAATTGAGACATCATCTAGCAGAAGCTATTTCACGTTGCTGTATGTGGGGCAGGAAT AGAGTGGCCTTCGGTGAGCACAAAGCAGTGGCTCCACTAGTGCGTTATCTGAAATCAAATGACACCAACGTGCATCGGGCGACAGCTCAG GCCTTGTACCAACTCTCAGAAGACGCCGATAACTGCATCACCATGCATGAGAATGGTGCAGTAAAGACAGAGTCTCGCCATGTCGCCAGG CTAGAGTGCAGTGACAACGATCTTGGCTCACTGCAACCTCCACCTCCCGGATTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGG GATTACAGCTTCTACTGGATATGGTTGGGTCCCCTGACCAGGATCTCCAGGAAGCTGCAGCTGGTTGTATATCCAATATCCGCAGGCTGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KLF6_ENST00000497571_chr10_3822298_-_ARMC4_ENST00000537576_chr10_28196706_-_1879nt GGCGGGGGCGGAGGGGGAGGCTGGCAGCGGAGCTTTGAATAGGGAAGTTTTGCAGGGGTTACGTTTGCAGTCAGTCCGGTGTTTGCAAAT ATTGTGTGGGCTCCGCGCGCTGCGGGCTGCGGGAGGGTCCGGCCGGGCGTCTCTGCGAGCCTGGAGTTTGCATGAAACTTTCACCTGCGC TCCGGGGAGACTTTCGGCTCCGGCTCCCACCGCGCGCCTCGCCGCCCTCGCGACCGCGGGCTCCGTCCAACCCGGCCCGACATGGACGTG CTCCCCATGTGCAGCATCTTCCAGGAGCTCCAGATCGTGCACGAGACCGGCTACTTCTCGGCGCTGCCGTCTCTGGAGGAGTACTGGCAA CAGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCTG TGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCCG AGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGCC AAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGAA CTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCCA GGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAAA AGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAGA AGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGATAATTGATCGCTTAGAT GGAGTTCGTTTGTTGTGGTCCCTGCTGAAAAATCCTCACCCAGACGTGAAGGCCAGCGCAGCATGGGCACTCTGTCCATGCATCAAAAAT GCAAAGGATGCTGGGGAAATGGTTCGTTCCTTTGTTGGTGGTTTGGAACTTATTGTCAATTTACTGAAATCAGATAACAAAGAAGTTCTG GCAAGTGTATGTGCTGCCATTACCAACATAGCAAAAGATCAAGAAAATTTAGCTGTTATCACAGATCATGGAGTTGTTCCTTTATTGTCC AAACTGGCAAATACAAATAACAATAAATTGAGACATCATCTAGCAGAAGCTATTTCACGTTGCTGTATGTGGGGCAGGAATAGAGTGGCC TTCGGTGAGCACAAAGCAGTGGCTCCACTAGTGCGTTATCTGAAATCAAATGACACCAACGTGCATCGGGCGACAGCTCAGGCCTTGTAC CAACTCTCAGAAGACGCCGATAACTGCATCACCATGCATGAGAATGGTGCAGTAAAGAAAAACATTTTTATCTCTTAGAAGAAATGACTA GAGTGAACCTCAAAACCTCATCTGCAAATTGACTCATGGATCCATAAATTCACTCCTGGACCCCAGTTGAGAACCCTGACCCTAAGGATT CTGAGCCTGCAAACCCTGGAGAAAAGTGGGGTTTGGCTGATCTCAGCTGGGCCAGGTGAGGATTAGCACCAGGTTGCAAGTAGATTCAAT >In-frame_KLF6_ENST00000497571_chr10_3822298_-_ARMC4_ENST00000305242_chr10_28196706_-_2045nt GGCGGGGGCGGAGGGGGAGGCTGGCAGCGGAGCTTTGAATAGGGAAGTTTTGCAGGGGTTACGTTTGCAGTCAGTCCGGTGTTTGCAAAT ATTGTGTGGGCTCCGCGCGCTGCGGGCTGCGGGAGGGTCCGGCCGGGCGTCTCTGCGAGCCTGGAGTTTGCATGAAACTTTCACCTGCGC TCCGGGGAGACTTTCGGCTCCGGCTCCCACCGCGCGCCTCGCCGCCCTCGCGACCGCGGGCTCCGTCCAACCCGGCCCGACATGGACGTG CTCCCCATGTGCAGCATCTTCCAGGAGCTCCAGATCGTGCACGAGACCGGCTACTTCTCGGCGCTGCCGTCTCTGGAGGAGTACTGGCAA CAGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCTG TGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCCG AGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGCC AAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGAA CTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCCA GGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAAA AGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAGA AGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGATAATTGATCGCTTAGAT GGAGTTCGTTTGTTGTGGTCCCTGCTGAAAAATCCTCACCCAGACGTGAAGGCCAGCGCAGCATGGGCACTCTGTCCATGCATCAAAAAT GCAAAGGATGCTGGGGAAATGGTTCGTTCCTTTGTTGGTGGTTTGGAACTTATTGTCAATTTACTGAAATCAGATAACAAAGAAGTTCTG GCAAGTGTATGTGCTGCCATTACCAACATAGCAAAAGATCAAGAAAATTTAGCTGTTATCACAGATCATGGAGTTGTTCCTTTATTGTCC AAACTGGCAAATACAAATAACAATAAATTGAGACATCATCTAGCAGAAGCTATTTCACGTTGCTGTATGTGGGGCAGGAATAGAGTGGCC TTCGGTGAGCACAAAGCAGTGGCTCCACTAGTGCGTTATCTGAAATCAAATGACACCAACGTGCATCGGGCGACAGCTCAGGCCTTGTAC CAACTCTCAGAAGACGCCGATAACTGCATCACCATGCATGAGAATGGTGCAGTAAAGCTTCTACTGGATATGGTTGGGTCCCCTGACCAG GATCTCCAGGAAGCTGCAGCTGGTTGTATATCCAATATCCGCAGGCTGGCTCTTGCTACAGAGAAGGCAAGATACACTTGAAATTTAAAT GGACATTACAAGCTATCAAATTCTACATGACACAGGACATGTCACTCCCATGGCCAGAAAGCCTAAATTGGGAAACAGTTGTTAGCAAAC CCTTTCAACCATCTAAATGAAAACACACAAATTGAAAATGCACAGAATGTTTTTCATCTGAAAATTGCATGGAGACTTTTGTTTCTATTT AATGTTTTCGAGATATGACATGTGATAAGATGGAAAGCCAATAAACCTGTGATAAGTTTCTAAGAATATGAGAATATACGTATATGATGT >In-frame_KLF6_ENST00000497571_chr10_3822298_-_ARMC4_ENST00000545014_chr10_28196706_-_2165nt GGCGGGGGCGGAGGGGGAGGCTGGCAGCGGAGCTTTGAATAGGGAAGTTTTGCAGGGGTTACGTTTGCAGTCAGTCCGGTGTTTGCAAAT ATTGTGTGGGCTCCGCGCGCTGCGGGCTGCGGGAGGGTCCGGCCGGGCGTCTCTGCGAGCCTGGAGTTTGCATGAAACTTTCACCTGCGC TCCGGGGAGACTTTCGGCTCCGGCTCCCACCGCGCGCCTCGCCGCCCTCGCGACCGCGGGCTCCGTCCAACCCGGCCCGACATGGACGTG CTCCCCATGTGCAGCATCTTCCAGGAGCTCCAGATCGTGCACGAGACCGGCTACTTCTCGGCGCTGCCGTCTCTGGAGGAGTACTGGCAA CAGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCTG TGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCCG AGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGCC AAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGAA CTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCCA GGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAAA AGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAGA AGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGATAATTGATCGCTTAGAT GGAGTTCGTTTGTTGTGGTCCCTGCTGAAAAATCCTCACCCAGACGTGAAGGCCAGCGCAGCATGGGCACTCTGTCCATGCATCAAAAAT GCAAAGGATGCTGGGGAAATGGTTCGTTCCTTTGTTGGTGGTTTGGAACTTATTGTCAATTTACTGAAATCAGATAACAAAGAAGTTCTG GCAAGTGTATGTGCTGCCATTACCAACATAGCAAAAGATCAAGAAAATTTAGCTGTTATCACAGATCATGGAGTTGTTCCTTTATTGTCC AAACTGGCAAATACAAATAACAATAAATTGAGACATCATCTAGCAGAAGCTATTTCACGTTGCTGTATGTGGGGCAGGAATAGAGTGGCC TTCGGTGAGCACAAAGCAGTGGCTCCACTAGTGCGTTATCTGAAATCAAATGACACCAACGTGCATCGGGCGACAGCTCAGGCCTTGTAC CAACTCTCAGAAGACGCCGATAACTGCATCACCATGCATGAGAATGGTGCAGTAAAGACAGAGTCTCGCCATGTCGCCAGGCTAGAGTGC AGTGACAACGATCTTGGCTCACTGCAACCTCCACCTCCCGGATTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGC TTCTACTGGATATGGTTGGGTCCCCTGACCAGGATCTCCAGGAAGCTGCAGCTGGTTGTATATCCAATATCCGCAGGCTGGCTCTTGCTA CAGAGAAGGCAAGATACACTTGAAATTTAAATGGACATTACAAGCTATCAAATTCTACATGACACAGGACATGTCACTCCCATGGCCAGA AAGCCTAAATTGGGAAACAGTTGTTAGCAAACCCTTTCAACCATCTAAATGAAAACACACAAATTGAAAATGCACAGAATGTTTTTCATC TGAAAATTGCATGGAGACTTTTGTTTCTATTTAATGTTTTCGAGATATGACATGTGATAAGATGGAAAGCCAATAAACCTGTGATAAGTT TCTAAGAATATGAGAATATACGTATATGATGTATTTTTAGTTCAGTGATGCTTTTGTATTTGTGGCGATTTTAATAAAAAGGATATGGCC |
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FusionGenePPI for KLF6_ARMC4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KLF6 | EHMT2, APOM, GTF3C1, PNO1, POLA2, KLF4, SP1, NR0B2, E2F1, HDAC3, NUFIP1, TAF9, FBL, NOP56, LCOR, APP, RUNX1, TRIM25 | ARMC4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLF6_ARMC4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLF6_ARMC4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KLF6 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | ARMC4 | C3809548 | CILIARY DYSKINESIA, PRIMARY, 23 | 1 | UNIPROT |
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