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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18988

FusionGeneSummary for KLF5_TMC4

check button Fusion gene summary
Fusion gene informationFusion gene name: KLF5_TMC4
Fusion gene ID: 18988
HgeneTgene
Gene symbol

KLF5

TMC4

Gene ID

688

147798

Gene nameKruppel like factor 5transmembrane channel like 4
SynonymsBTEB2|CKLF|IKLF-
Cytomap

13q22.1

19q13.42

Type of geneprotein-codingprotein-coding
DescriptionKrueppel-like factor 5(intestinal Kruppel-like factorBTE-binding protein 2GC box binding protein 2Klf5C isoformKruppel-like factor 5 (intestinal)basic transcription element binding protein 2colon krueppel-like factorcolon kruppel-like factorintestransmembrane channel-like protein 4testicular tissue protein Li 204
Modification date2018052720180523
UniProtAcc

Q13887

Q7Z404

Ensembl transtripts involved in fusion geneENST00000477333, ENST00000539231, 
ENST00000377687, 
ENST00000301187, 
ENST00000416963, ENST00000376591, 
ENST00000476013, 
Fusion gene scores* DoF score3 X 3 X 5=453 X 3 X 1=9
# samples 53
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KLF5 [Title/Abstract] AND TMC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLF5

GO:0045944

positive regulation of transcription by RNA polymerase II

16595680

HgeneKLF5

GO:0099156

cell-cell signaling via exosome

28408180

HgeneKLF5

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

28408180


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN418033KLF5chr13

73649913

+TMC4chr19

54664070

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000477333ENST00000301187KLF5chr13

73649913

+TMC4chr19

54664070

-
intron-3CDSENST00000477333ENST00000416963KLF5chr13

73649913

+TMC4chr19

54664070

-
intron-3CDSENST00000477333ENST00000376591KLF5chr13

73649913

+TMC4chr19

54664070

-
intron-intronENST00000477333ENST00000476013KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shitENST00000539231ENST00000301187KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shitENST00000539231ENST00000416963KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shitENST00000539231ENST00000376591KLF5chr13

73649913

+TMC4chr19

54664070

-
5CDS-intronENST00000539231ENST00000476013KLF5chr13

73649913

+TMC4chr19

54664070

-
In-frameENST00000377687ENST00000301187KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shitENST00000377687ENST00000416963KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shitENST00000377687ENST00000376591KLF5chr13

73649913

+TMC4chr19

54664070

-
5CDS-intronENST00000377687ENST00000476013KLF5chr13

73649913

+TMC4chr19

54664070

-

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FusionProtFeatures for KLF5_TMC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLF5

Q13887

TMC4

Q7Z404

Transcription factor that binds to GC box promoterelements. Activates the transcription of these genes. Probable ion channel. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLF5_TMC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KLF5_ENST00000377687_chr13_73649913_+_TMC4_ENST00000301187_chr19_54664070_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KLF5_ENST00000377687_chr13_73649913_+_TMC4_ENST00000301187_chr19_54664070_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_KLF5_ENST00000377687_chr13_73649913_+_TMC4_ENST00000301187_chr19_54664070_-_0nt


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FusionGenePPI for KLF5_TMC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLF5_TMC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLF5_TMC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLF5C0007137Squamous cell carcinoma1CTD_human
HgeneKLF5C0030297Pancreatic Neoplasm1CTD_human
HgeneKLF5C0036341Schizophrenia1PSYGENET
HgeneKLF5C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneKLF5C2936380Neointima1CTD_human