![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 18988 |
FusionGeneSummary for KLF5_TMC4 |
![]() |
Fusion gene information | Fusion gene name: KLF5_TMC4 | Fusion gene ID: 18988 | Hgene | Tgene | Gene symbol | KLF5 | TMC4 | Gene ID | 688 | 147798 |
Gene name | Kruppel like factor 5 | transmembrane channel like 4 | |
Synonyms | BTEB2|CKLF|IKLF | - | |
Cytomap | 13q22.1 | 19q13.42 | |
Type of gene | protein-coding | protein-coding | |
Description | Krueppel-like factor 5(intestinal Kruppel-like factorBTE-binding protein 2GC box binding protein 2Klf5C isoformKruppel-like factor 5 (intestinal)basic transcription element binding protein 2colon krueppel-like factorcolon kruppel-like factorintes | transmembrane channel-like protein 4testicular tissue protein Li 204 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q13887 | Q7Z404 | |
Ensembl transtripts involved in fusion gene | ENST00000477333, ENST00000539231, ENST00000377687, | ENST00000301187, ENST00000416963, ENST00000376591, ENST00000476013, | |
Fusion gene scores | * DoF score | 3 X 3 X 5=45 | 3 X 3 X 1=9 |
# samples | 5 | 3 | |
** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KLF5 [Title/Abstract] AND TMC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KLF5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16595680 |
Hgene | KLF5 | GO:0099156 | cell-cell signaling via exosome | 28408180 |
Hgene | KLF5 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 28408180 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN418033 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000477333 | ENST00000301187 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
intron-3CDS | ENST00000477333 | ENST00000416963 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
intron-3CDS | ENST00000477333 | ENST00000376591 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
intron-intron | ENST00000477333 | ENST00000476013 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
Frame-shift | ENST00000539231 | ENST00000301187 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
Frame-shift | ENST00000539231 | ENST00000416963 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
Frame-shift | ENST00000539231 | ENST00000376591 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
5CDS-intron | ENST00000539231 | ENST00000476013 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
In-frame | ENST00000377687 | ENST00000301187 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
Frame-shift | ENST00000377687 | ENST00000416963 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
Frame-shift | ENST00000377687 | ENST00000376591 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
5CDS-intron | ENST00000377687 | ENST00000476013 | KLF5 | chr13 | 73649913 | + | TMC4 | chr19 | 54664070 | - |
Top |
FusionProtFeatures for KLF5_TMC4 |
![]() |
Hgene | Tgene |
KLF5 | TMC4 |
Transcription factor that binds to GC box promoterelements. Activates the transcription of these genes. | Probable ion channel. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for KLF5_TMC4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_KLF5_ENST00000377687_chr13_73649913_+_TMC4_ENST00000301187_chr19_54664070_-_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_KLF5_ENST00000377687_chr13_73649913_+_TMC4_ENST00000301187_chr19_54664070_-_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_KLF5_ENST00000377687_chr13_73649913_+_TMC4_ENST00000301187_chr19_54664070_-_0nt |
Top |
FusionGenePPI for KLF5_TMC4 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for KLF5_TMC4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for KLF5_TMC4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KLF5 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | KLF5 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Hgene | KLF5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | KLF5 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | KLF5 | C2936380 | Neointima | 1 | CTD_human |