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Fusion gene ID: 18987 |
FusionGeneSummary for KLF5_SUPT16H |
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Fusion gene information | Fusion gene name: KLF5_SUPT16H | Fusion gene ID: 18987 | Hgene | Tgene | Gene symbol | KLF5 | SUPT16H | Gene ID | 688 | 11198 |
Gene name | Kruppel like factor 5 | SPT16 homolog, facilitates chromatin remodeling subunit | |
Synonyms | BTEB2|CKLF|IKLF | CDC68|FACTP140|SPT16|SPT16/CDC68 | |
Cytomap | 13q22.1 | 14q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | Krueppel-like factor 5(intestinal Kruppel-like factorBTE-binding protein 2GC box binding protein 2Klf5C isoformKruppel-like factor 5 (intestinal)basic transcription element binding protein 2colon krueppel-like factorcolon kruppel-like factorintes | FACT complex subunit SPT16FACT 140 kDa subunitchromatin-specific transcription elongation factor 140 kDa subunitfacilitates chromatin remodeling 140 kDa subunitfacilitates chromatin transcription complex subunit SPT16hSPT16suppressor of Ty 16 homolo | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q13887 | Q9Y5B9 | |
Ensembl transtripts involved in fusion gene | ENST00000477333, ENST00000539231, ENST00000377687, | ENST00000216297, ENST00000555943, | |
Fusion gene scores | * DoF score | 3 X 3 X 5=45 | 37 X 4 X 15=2220 |
# samples | 5 | 40 | |
** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(40/2220*10)=-2.47248777146274 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KLF5 [Title/Abstract] AND SUPT16H [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KLF5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16595680 |
Hgene | KLF5 | GO:0099156 | cell-cell signaling via exosome | 28408180 |
Hgene | KLF5 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 28408180 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-E7-A5KF-01A | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000477333 | ENST00000216297 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000477333 | ENST00000555943 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000539231 | ENST00000216297 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000539231 | ENST00000555943 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
5CDS-intron | ENST00000377687 | ENST00000216297 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
5CDS-intron | ENST00000377687 | ENST00000555943 | KLF5 | chr13 | 73651676 | + | SUPT16H | chr14 | 21829491 | - |
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FusionProtFeatures for KLF5_SUPT16H |
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Hgene | Tgene |
KLF5 | SUPT16H |
Transcription factor that binds to GC box promoterelements. Activates the transcription of these genes. | Component of the FACT complex, a general chromatinfactor that acts to reorganize nucleosomes. The FACT complex isinvolved in multiple processes that require DNA as a template suchas mRNA elongation, DNA replication and DNA repair. Duringtranscription elongation the FACT complex acts as a histonechaperone that both destabilizes and restores nucleosomalstructure. It facilitates the passage of RNA polymerase II andtranscription by promoting the dissociation of one histone H2A-H2Bdimer from the nucleosome, then subsequently promotes thereestablishment of the nucleosome following the passage of RNApolymerase II. The FACT complex is probably also involved inphosphorylation of 'Ser-392' of p53/TP53 via its association withCK2 (casein kinase II). {ECO:0000269|PubMed:10912001,ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006,ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704,ECO:0000269|PubMed:9836642}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KLF5_SUPT16H |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KLF5_SUPT16H |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KLF5 | SET, EP300, NFKB1, PRKCA, CREBBP, GTF2B, TBP, WWP1, ESR1, HDAC1, FBXW7, GSK3B, HDAC2, RARA, TRIM25, ESR2, SMURF2, WWTR1, ELAVL1, YAP1, SMAD2, RRBP1, SMAD4, SMAD3, ZBTB17, CTNNB1, SREBF1, SUMO1, UBE2I, NCOR2, NCOR1, PPARG, ANP32B, PARP1, TP53, GTF2E2, GTF2F2, ATXN3L, XPO1, ACTR5, RXRA, CEBPB, CEBPG, CSRP3, CEBPA, JUN, BAP1, HCFC1, OGT, ACTA2 | SUPT16H | BRCC3, PRKAA1, POLR1A, POLR1E, SSRP1, CHD1L, MCM4, PAF1, PARP1, H2AFX, MKL1, H3F3A, TRIM33, TAL1, CDK9, SUPT16H, MMS22L, TONSL, SMARCAD1, SREK1, SOX2, HDGF, ELAVL1, XRCC5, CUL3, CDK2, CAND1, FYTTD1, CSNK2A1, CSNK2B, SAP18, RTF1, LEO1, TOP1, DHX15, CTR9, IK, PRPF4B, SNRPD2, NCSTN, S100A9, HNRNPM, NHP2L1, DDX21, PRPF6, SF3A1, SNRPD1, PRPF3, ACIN1, EEF1A1, RBM25, MSH6, PRPF8, USP39, MSH2, PSIP1, CENPA, ESR1, FMNL1, VCP, PNKP, CD81, IGSF8, ICAM1, SRPK2, FTH1, QRICH1, RNF20, ATRX, HIST1H2AB, MOV10, NXF1, BRCA1, CUL7, OBSL1, EED, RNF2, BMI1, SUMO2, ABCE1, RPA4, SPIN2B, RPA2, SPIN1, TIPIN, RNF146, POLB, APLF, HIST1H2BA, MAFF, FBXW11, BRD3, CDK12, HMGB1, IWS1, NAP1L1, PES1, SRRM1, CDK11A, HMGB2, HMGB3, KRI1, TOP2B, ZC3H18, SFN, NTRK1, IFI16, MED4, EWSR1, CEP97, CNTROB, SPICE1, CEP164, DCTN1, POC1B, STIL, HIST1H3E, DAXX, HNRNPU, NPM1, RPL10, ETAA1, CENPQ, NF2, NANOG, UBR5, SBF1, HIST1H3A, MACROD1, H2AFY2, XPC, XRCC6, HIST1H4A, NAA40, WDR76, ALX3, TEAD2, L3MBTL1, CETN1, SIX2, POLL, RPA3, WRN, COX15, DLD, PDHA1, VDAC1, TRIM25, YAP1, MTF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLF5_SUPT16H |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLF5_SUPT16H |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KLF5 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | KLF5 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Hgene | KLF5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | KLF5 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | KLF5 | C2936380 | Neointima | 1 | CTD_human |