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Fusion gene ID: 18986 |
FusionGeneSummary for KLF5_PIBF1 |
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Fusion gene information | Fusion gene name: KLF5_PIBF1 | Fusion gene ID: 18986 | Hgene | Tgene | Gene symbol | KLF5 | PIBF1 | Gene ID | 688 | 10464 |
Gene name | Kruppel like factor 5 | progesterone immunomodulatory binding factor 1 | |
Synonyms | BTEB2|CKLF|IKLF | C13orf24|CEP90|JBTS33|PIBF | |
Cytomap | 13q22.1 | 13q21.33-q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | Krueppel-like factor 5(intestinal Kruppel-like factorBTE-binding protein 2GC box binding protein 2Klf5C isoformKruppel-like factor 5 (intestinal)basic transcription element binding protein 2colon krueppel-like factorcolon kruppel-like factorintes | progesterone-induced-blocking factor 1centrosomal protein of 90 kDa | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | Q13887 | Q8WXW3 | |
Ensembl transtripts involved in fusion gene | ENST00000477333, ENST00000539231, ENST00000377687, | ENST00000326291, ENST00000489922, | |
Fusion gene scores | * DoF score | 3 X 3 X 5=45 | 8 X 7 X 9=504 |
# samples | 5 | 10 | |
** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/504*10)=-2.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KLF5 [Title/Abstract] AND PIBF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KLF5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16595680 |
Hgene | KLF5 | GO:0099156 | cell-cell signaling via exosome | 28408180 |
Hgene | KLF5 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 28408180 |
Tgene | PIBF1 | GO:0031393 | negative regulation of prostaglandin biosynthetic process | 3863495 |
Tgene | PIBF1 | GO:0032695 | negative regulation of interleukin-12 production | 14634107 |
Tgene | PIBF1 | GO:0032733 | positive regulation of interleukin-10 production | 14634107 |
Tgene | PIBF1 | GO:0032815 | negative regulation of natural killer cell activation | 12516630 |
Tgene | PIBF1 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 16393965 |
Tgene | PIBF1 | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein | 16393965 |
Tgene | PIBF1 | GO:0042976 | activation of Janus kinase activity | 16393965 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CESC | TCGA-EK-A3GN-01A | KLF5 | chr13 | 73651676 | + | PIBF1 | chr13 | 73410241 | + |
TCGA | RV | ESCA | TCGA-LN-A4MQ-01A | KLF5 | chr13 | 73638021 | + | PIBF1 | chr13 | 73590007 | + |
TCGA | RV | LUSC | TCGA-MF-A522-01A | KLF5 | chr13 | 73651676 | + | PIBF1 | chr13 | 73410241 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000477333 | ENST00000326291 | KLF5 | chr13 | 73651676 | + | PIBF1 | chr13 | 73410241 | + |
intron-intron | ENST00000477333 | ENST00000489922 | KLF5 | chr13 | 73651676 | + | PIBF1 | chr13 | 73410241 | + |
intron-intron | ENST00000539231 | ENST00000326291 | KLF5 | chr13 | 73651676 | + | PIBF1 | chr13 | 73410241 | + |
intron-intron | ENST00000539231 | ENST00000489922 | KLF5 | chr13 | 73651676 | + | PIBF1 | chr13 | 73410241 | + |
5CDS-intron | ENST00000377687 | ENST00000326291 | KLF5 | chr13 | 73651676 | + | PIBF1 | chr13 | 73410241 | + |
5CDS-intron | ENST00000377687 | ENST00000489922 | KLF5 | chr13 | 73651676 | + | PIBF1 | chr13 | 73410241 | + |
intron-3CDS | ENST00000477333 | ENST00000326291 | KLF5 | chr13 | 73638021 | + | PIBF1 | chr13 | 73590007 | + |
intron-3UTR | ENST00000477333 | ENST00000489922 | KLF5 | chr13 | 73638021 | + | PIBF1 | chr13 | 73590007 | + |
Frame-shift | ENST00000539231 | ENST00000326291 | KLF5 | chr13 | 73638021 | + | PIBF1 | chr13 | 73590007 | + |
5CDS-3UTR | ENST00000539231 | ENST00000489922 | KLF5 | chr13 | 73638021 | + | PIBF1 | chr13 | 73590007 | + |
Frame-shift | ENST00000377687 | ENST00000326291 | KLF5 | chr13 | 73638021 | + | PIBF1 | chr13 | 73590007 | + |
5CDS-3UTR | ENST00000377687 | ENST00000489922 | KLF5 | chr13 | 73638021 | + | PIBF1 | chr13 | 73590007 | + |
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FusionProtFeatures for KLF5_PIBF1 |
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Hgene | Tgene |
KLF5 | PIBF1 |
Transcription factor that binds to GC box promoterelements. Activates the transcription of these genes. | Plays a role in ciliogenesis.{ECO:0000269|PubMed:26167768}. Isoform 1: Pericentriolar protein required to maintainmitotic spindle pole integrity (PubMed:21224392). Required for thecentrosomal accumulation of PCM1 and the recruitment of centriolarsatellite proteins such as BBS4. Via association with PCM1 may beinvolved in primary cilia formation (PubMed:23110211). Requiredfor CEP63 centrosomal localization and its interaction with WDR62.Together with CEP63 promotes centriole duplication. Promotes thecentrosomal localization of CDK2 (PubMed:26297806).{ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211,ECO:0000269|PubMed:26297806}. Isoform 4: The secreted form is a mediator ofprogesterone that by acting on the phospholipase A2 enzymeinterferes with arachidonic acid metabolism, induces a Th2 biasedimmune response, and by controlling decidual naturakl killer cells(NK) activity exerts an anti-abortive effect (PubMed:14634107,PubMed:3863495, PubMed:12516630). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. ActivatesSTAT6 and inhibits STAT4 phosphorylation. Signaling via a notidentified receptor seems to implicate IL4R and a GPI-anchoredprotein (PubMed:16393965, PubMed:25218441).{ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107,ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441,ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KLF5_PIBF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KLF5_PIBF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KLF5 | SET, EP300, NFKB1, PRKCA, CREBBP, GTF2B, TBP, WWP1, ESR1, HDAC1, FBXW7, GSK3B, HDAC2, RARA, TRIM25, ESR2, SMURF2, WWTR1, ELAVL1, YAP1, SMAD2, RRBP1, SMAD4, SMAD3, ZBTB17, CTNNB1, SREBF1, SUMO1, UBE2I, NCOR2, NCOR1, PPARG, ANP32B, PARP1, TP53, GTF2E2, GTF2F2, ATXN3L, XPO1, ACTR5, RXRA, CEBPB, CEBPG, CSRP3, CEBPA, JUN, BAP1, HCFC1, OGT, ACTA2 | PIBF1 | MAP3K2, APP, SAV1, SHMT2, NXF1, SLC25A41, PPP1R21, C17orf59, NTRK1, CEP63, KIAA0753, CCDC14, MED4, CEP290, CEP162, PCM1, SSX2IP, OFD1, CEP120, SPICE1, CEP128, CEP135, CEP89, CNTRL, NIN, ODF2, POC5, LCA5, SASS6, ITPKB, PCNT, FGFR1OP, MAPRE1, BORA, KIF7, PTPN22, TPTE2, TSNAXIP1, VAT1L, CPNE2, LRRCC1, EXOC3, PTPRQ, AHI1, EEA1, SNX27, ATP2B2, CEP131, SLC9A3R2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLF5_PIBF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLF5_PIBF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KLF5 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | KLF5 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Hgene | KLF5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | KLF5 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | KLF5 | C2936380 | Neointima | 1 | CTD_human |
Tgene | PIBF1 | C0000821 | Threatened abortion | 1 | CTD_human |