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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18985

FusionGeneSummary for KLF3_SCFD2

check button Fusion gene summary
Fusion gene informationFusion gene name: KLF3_SCFD2
Fusion gene ID: 18985
HgeneTgene
Gene symbol

KLF3

SCFD2

Gene ID

51274

152579

Gene nameKruppel like factor 3sec1 family domain containing 2
SynonymsBKLFSTXBP1L1
Cytomap

4p14

4q12

Type of geneprotein-codingprotein-coding
DescriptionKrueppel-like factor 3CACCC-box-binding protein BKLFKruppel-like factor 3 (basic)TEF-2basic Kruppel-like factorbasic krueppel-like factorbasic kruppel like factortranscript ch138sec1 family domain-containing protein 2syntaxin binding protein 1-like 1
Modification date2018052320180519
UniProtAcc

P57682

Q8WU76

Ensembl transtripts involved in fusion geneENST00000261438, ENST00000514033, 
ENST00000401642, ENST00000388940, 
Fusion gene scores* DoF score3 X 3 X 3=2710 X 8 X 10=800
# samples 311
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/800*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLF3 [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0WA-01AKLF3chr4

38691500

+SCFD2chr4

54011749

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261438ENST00000401642KLF3chr4

38691500

+SCFD2chr4

54011749

-
Frame-shiftENST00000261438ENST00000388940KLF3chr4

38691500

+SCFD2chr4

54011749

-
Frame-shiftENST00000514033ENST00000401642KLF3chr4

38691500

+SCFD2chr4

54011749

-
Frame-shiftENST00000514033ENST00000388940KLF3chr4

38691500

+SCFD2chr4

54011749

-

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FusionProtFeatures for KLF3_SCFD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLF3

P57682

SCFD2

Q8WU76

Binds to the CACCC box of erythroid cell-expressedgenes. May play a role in hematopoiesis (By similarity).{ECO:0000250}. May be involved in protein transport.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KLF3_SCFD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KLF3_SCFD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KLF3FHL3, CTBP2, KDM1A, SUV39H2, CTBP1, DVL3, TRAF2, EHMT2, LHX8, TRIM25SCFD2USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KLF3_SCFD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KLF3_SCFD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource