![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 18984 |
FusionGeneSummary for KLF3_HBG1 |
![]() |
Fusion gene information | Fusion gene name: KLF3_HBG1 | Fusion gene ID: 18984 | Hgene | Tgene | Gene symbol | KLF3 | HBG1 | Gene ID | 51274 | 3047 |
Gene name | Kruppel like factor 3 | hemoglobin subunit gamma 1 | |
Synonyms | BKLF | HBG-T2|HBGA|HBGR|HSGGL1|PRO2979 | |
Cytomap | 4p14 | 11p15.4 | |
Type of gene | protein-coding | protein-coding | |
Description | Krueppel-like factor 3CACCC-box-binding protein BKLFKruppel-like factor 3 (basic)TEF-2basic Kruppel-like factorbasic krueppel-like factorbasic kruppel like factortranscript ch138 | hemoglobin subunit gamma-1A-gamma globingamma A hemoglobingamma globingamma-1-globinhb F Agammahemoglobin gamma-1 chainhemoglobin gamma-a chainhemoglobin, gamma Ahemoglobin, gamma, regulator of | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P57682 | P69891 | |
Ensembl transtripts involved in fusion gene | ENST00000261438, ENST00000514033, | ENST00000330597, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 1=9 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KLF3 [Title/Abstract] AND HBG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AF116717 | KLF3 | chr4 | 38676413 | - | HBG1 | chr11 | 5275919 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000261438 | ENST00000330597 | KLF3 | chr4 | 38676413 | - | HBG1 | chr11 | 5275919 | - |
intron-intron | ENST00000514033 | ENST00000330597 | KLF3 | chr4 | 38676413 | - | HBG1 | chr11 | 5275919 | - |
Top |
FusionProtFeatures for KLF3_HBG1 |
![]() |
Hgene | Tgene |
KLF3 | HBG1 |
Binds to the CACCC box of erythroid cell-expressedgenes. May play a role in hematopoiesis (By similarity).{ECO:0000250}. | Gamma chains make up the fetal hemoglobin F, incombination with alpha chains. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for KLF3_HBG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for KLF3_HBG1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for KLF3_HBG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for KLF3_HBG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HBG1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | HBG1 | C0263454 | Chloracne | 1 | CTD_human |