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Fusion gene ID: 18983 |
FusionGeneSummary for KLF3_FAM114A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLF3_FAM114A1 | Fusion gene ID: 18983 | Hgene | Tgene | Gene symbol | KLF3 | FAM114A1 | Gene ID | 51274 | 92689 |
| Gene name | Kruppel like factor 3 | family with sequence similarity 114 member A1 | |
| Synonyms | BKLF | Noxp20 | |
| Cytomap | 4p14 | 4p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Krueppel-like factor 3CACCC-box-binding protein BKLFKruppel-like factor 3 (basic)TEF-2basic Kruppel-like factorbasic krueppel-like factorbasic kruppel like factortranscript ch138 | protein NOXP20nervous system over-expressed protein 20 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P57682 | Q8IWE2 | |
| Ensembl transtripts involved in fusion gene | ENST00000261438, ENST00000514033, | ENST00000515037, ENST00000358869, ENST00000513966, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 3 X 4=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KLF3 [Title/Abstract] AND FAM114A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-0797-01A | KLF3 | chr4 | 38682303 | + | FAM114A1 | chr4 | 38924391 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261438 | ENST00000515037 | KLF3 | chr4 | 38682303 | + | FAM114A1 | chr4 | 38924391 | + |
| In-frame | ENST00000261438 | ENST00000358869 | KLF3 | chr4 | 38682303 | + | FAM114A1 | chr4 | 38924391 | + |
| 5CDS-intron | ENST00000261438 | ENST00000513966 | KLF3 | chr4 | 38682303 | + | FAM114A1 | chr4 | 38924391 | + |
| In-frame | ENST00000514033 | ENST00000515037 | KLF3 | chr4 | 38682303 | + | FAM114A1 | chr4 | 38924391 | + |
| In-frame | ENST00000514033 | ENST00000358869 | KLF3 | chr4 | 38682303 | + | FAM114A1 | chr4 | 38924391 | + |
| 5CDS-intron | ENST00000514033 | ENST00000513966 | KLF3 | chr4 | 38682303 | + | FAM114A1 | chr4 | 38924391 | + |
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FusionProtFeatures for KLF3_FAM114A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLF3 | FAM114A1 |
| Binds to the CACCC box of erythroid cell-expressedgenes. May play a role in hematopoiesis (By similarity).{ECO:0000250}. | May play a role in neuronal cell development.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >FAM114A1 | chr4:38682303 | chr4:38924391 | ENST00000358869 | + | 7 | 15 | 343_367 | 315 | 564 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000261438 | + | 2 | 6 | 1_251 | 19 | 346 | Compositional bias | Note=Pro-rich |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000514033 | + | 2 | 4 | 1_251 | 19 | 233 | Compositional bias | Note=Pro-rich |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000261438 | + | 2 | 6 | 61_65 | 19 | 346 | Motif | Note=CTBP-binding motif |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000514033 | + | 2 | 4 | 61_65 | 19 | 233 | Motif | Note=CTBP-binding motif |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000261438 | + | 2 | 6 | 1_74 | 19 | 346 | Region | Note=Repressor domain |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000514033 | + | 2 | 4 | 1_74 | 19 | 233 | Region | Note=Repressor domain |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000261438 | + | 2 | 6 | 260_284 | 19 | 346 | Zinc finger | C2H2-type 1 |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000261438 | + | 2 | 6 | 290_314 | 19 | 346 | Zinc finger | C2H2-type 2 |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000261438 | + | 2 | 6 | 320_342 | 19 | 346 | Zinc finger | C2H2-type 3 |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000514033 | + | 2 | 4 | 260_284 | 19 | 233 | Zinc finger | C2H2-type 1 |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000514033 | + | 2 | 4 | 290_314 | 19 | 233 | Zinc finger | C2H2-type 2 |
| Hgene | >KLF3 | chr4:38682303 | chr4:38924391 | ENST00000514033 | + | 2 | 4 | 320_342 | 19 | 233 | Zinc finger | C2H2-type 3 |
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FusionGeneSequence for KLF3_FAM114A1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_KLF3_ENST00000261438_chr4_38682303_+_FAM114A1_ENST00000515037_chr4_38924391_+_268aa MLMFDPVPVKQEAMDPVSVVQSFLASLDGEKLELLKNDLISIKDIFAAKELENEENQEEQGLEEKGEEFARMLTELLFELHVAATPDKLN KAMKRAHDWVEEDQTVVSVDVAKVSEEETKKEEKEEKSQDPQEDKKEEKKTKTIEEVYMSSIESLAEVTARCIEQLHKVAELILHGQEEE >In-frame_KLF3_ENST00000261438_chr4_38682303_+_FAM114A1_ENST00000358869_chr4_38924391_+_268aa MLMFDPVPVKQEAMDPVSVVQSFLASLDGEKLELLKNDLISIKDIFAAKELENEENQEEQGLEEKGEEFARMLTELLFELHVAATPDKLN KAMKRAHDWVEEDQTVVSVDVAKVSEEETKKEEKEEKSQDPQEDKKEEKKTKTIEEVYMSSIESLAEVTARCIEQLHKVAELILHGQEEE >In-frame_KLF3_ENST00000514033_chr4_38682303_+_FAM114A1_ENST00000515037_chr4_38924391_+_268aa MLMFDPVPVKQEAMDPVSVVQSFLASLDGEKLELLKNDLISIKDIFAAKELENEENQEEQGLEEKGEEFARMLTELLFELHVAATPDKLN KAMKRAHDWVEEDQTVVSVDVAKVSEEETKKEEKEEKSQDPQEDKKEEKKTKTIEEVYMSSIESLAEVTARCIEQLHKVAELILHGQEEE >In-frame_KLF3_ENST00000514033_chr4_38682303_+_FAM114A1_ENST00000358869_chr4_38924391_+_268aa MLMFDPVPVKQEAMDPVSVVQSFLASLDGEKLELLKNDLISIKDIFAAKELENEENQEEQGLEEKGEEFARMLTELLFELHVAATPDKLN KAMKRAHDWVEEDQTVVSVDVAKVSEEETKKEEKEEKSQDPQEDKKEEKKTKTIEEVYMSSIESLAEVTARCIEQLHKVAELILHGQEEE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_KLF3_ENST00000261438_chr4_38682303_+_FAM114A1_ENST00000515037_chr4_38924391_+_804nt ATGCTCATGTTTGACCCAGTTCCTGTCAAGCAAGAGGCCATGGACCCTGTCTCAGTGGTTCAGTCATTTTTAGCATCACTTGATGGAGAG AAGCTGGAACTCTTAAAAAATGACCTAATTTCCATTAAAGACATCTTTGCAGCCAAAGAATTAGAGAATGAAGAAAATCAAGAAGAACAA GGCTTAGAAGAAAAGGGAGAAGAATTTGCTCGCATGCTTACAGAGCTTCTCTTTGAATTACATGTGGCGGCCACACCTGACAAACTCAAT AAGGCCATGAAGAGGGCTCATGACTGGGTGGAAGAGGATCAAACCGTGGTGTCAGTAGATGTGGCAAAAGTGTCCGAAGAAGAAACAAAG AAGGAAGAAAAGGAAGAGAAATCTCAAGACCCTCAAGAAGACAAAAAGGAGGAAAAGAAAACTAAGACCATAGAGGAAGTATACATGTCG TCCATTGAAAGTCTGGCGGAGGTAACAGCGCGCTGTATTGAGCAGCTTCATAAAGTAGCAGAATTAATTCTTCATGGACAAGAAGAGGAA AAACCAGCTCAGGACCAAGCAAAAGTTCTAATAAAATTAACTACTGCAATGTGCAATGAAGTGGCCTCTTTATCAAAGAAGTTTACGAAT TCTTTAACCACTGTTGGGAGCAACAAGAAGGCCGAGGTCCTTAACCCCATGATCAGTAGTGTATTGTTAGAGGGCTGCAACAGTACAACG >In-frame_KLF3_ENST00000261438_chr4_38682303_+_FAM114A1_ENST00000358869_chr4_38924391_+_804nt ATGCTCATGTTTGACCCAGTTCCTGTCAAGCAAGAGGCCATGGACCCTGTCTCAGTGGTTCAGTCATTTTTAGCATCACTTGATGGAGAG AAGCTGGAACTCTTAAAAAATGACCTAATTTCCATTAAAGACATCTTTGCAGCCAAAGAATTAGAGAATGAAGAAAATCAAGAAGAACAA GGCTTAGAAGAAAAGGGAGAAGAATTTGCTCGCATGCTTACAGAGCTTCTCTTTGAATTACATGTGGCGGCCACACCTGACAAACTCAAT AAGGCCATGAAGAGGGCTCATGACTGGGTGGAAGAGGATCAAACCGTGGTGTCAGTAGATGTGGCAAAAGTGTCCGAAGAAGAAACAAAG AAGGAAGAAAAGGAAGAGAAATCTCAAGACCCTCAAGAAGACAAAAAGGAGGAAAAGAAAACTAAGACCATAGAGGAAGTATACATGTCG TCCATTGAAAGTCTGGCGGAGGTAACAGCGCGCTGTATTGAGCAGCTTCATAAAGTAGCAGAATTAATTCTTCATGGACAAGAAGAGGAA AAACCAGCTCAGGACCAAGCAAAAGTTCTAATAAAATTAACTACTGCAATGTGCAATGAAGTGGCCTCTTTATCAAAGAAGTTTACGAAT TCTTTAACCACTGTTGGGAGCAACAAGAAGGCCGAGGTCCTTAACCCCATGATCAGTAGTGTATTGTTAGAGGGCTGCAACAGTACAACG >In-frame_KLF3_ENST00000514033_chr4_38682303_+_FAM114A1_ENST00000515037_chr4_38924391_+_804nt ATGCTCATGTTTGACCCAGTTCCTGTCAAGCAAGAGGCCATGGACCCTGTCTCAGTGGTTCAGTCATTTTTAGCATCACTTGATGGAGAG AAGCTGGAACTCTTAAAAAATGACCTAATTTCCATTAAAGACATCTTTGCAGCCAAAGAATTAGAGAATGAAGAAAATCAAGAAGAACAA GGCTTAGAAGAAAAGGGAGAAGAATTTGCTCGCATGCTTACAGAGCTTCTCTTTGAATTACATGTGGCGGCCACACCTGACAAACTCAAT AAGGCCATGAAGAGGGCTCATGACTGGGTGGAAGAGGATCAAACCGTGGTGTCAGTAGATGTGGCAAAAGTGTCCGAAGAAGAAACAAAG AAGGAAGAAAAGGAAGAGAAATCTCAAGACCCTCAAGAAGACAAAAAGGAGGAAAAGAAAACTAAGACCATAGAGGAAGTATACATGTCG TCCATTGAAAGTCTGGCGGAGGTAACAGCGCGCTGTATTGAGCAGCTTCATAAAGTAGCAGAATTAATTCTTCATGGACAAGAAGAGGAA AAACCAGCTCAGGACCAAGCAAAAGTTCTAATAAAATTAACTACTGCAATGTGCAATGAAGTGGCCTCTTTATCAAAGAAGTTTACGAAT TCTTTAACCACTGTTGGGAGCAACAAGAAGGCCGAGGTCCTTAACCCCATGATCAGTAGTGTATTGTTAGAGGGCTGCAACAGTACAACG >In-frame_KLF3_ENST00000514033_chr4_38682303_+_FAM114A1_ENST00000358869_chr4_38924391_+_804nt ATGCTCATGTTTGACCCAGTTCCTGTCAAGCAAGAGGCCATGGACCCTGTCTCAGTGGTTCAGTCATTTTTAGCATCACTTGATGGAGAG AAGCTGGAACTCTTAAAAAATGACCTAATTTCCATTAAAGACATCTTTGCAGCCAAAGAATTAGAGAATGAAGAAAATCAAGAAGAACAA GGCTTAGAAGAAAAGGGAGAAGAATTTGCTCGCATGCTTACAGAGCTTCTCTTTGAATTACATGTGGCGGCCACACCTGACAAACTCAAT AAGGCCATGAAGAGGGCTCATGACTGGGTGGAAGAGGATCAAACCGTGGTGTCAGTAGATGTGGCAAAAGTGTCCGAAGAAGAAACAAAG AAGGAAGAAAAGGAAGAGAAATCTCAAGACCCTCAAGAAGACAAAAAGGAGGAAAAGAAAACTAAGACCATAGAGGAAGTATACATGTCG TCCATTGAAAGTCTGGCGGAGGTAACAGCGCGCTGTATTGAGCAGCTTCATAAAGTAGCAGAATTAATTCTTCATGGACAAGAAGAGGAA AAACCAGCTCAGGACCAAGCAAAAGTTCTAATAAAATTAACTACTGCAATGTGCAATGAAGTGGCCTCTTTATCAAAGAAGTTTACGAAT TCTTTAACCACTGTTGGGAGCAACAAGAAGGCCGAGGTCCTTAACCCCATGATCAGTAGTGTATTGTTAGAGGGCTGCAACAGTACAACG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_KLF3_ENST00000261438_chr4_38682303_+_FAM114A1_ENST00000515037_chr4_38924391_+_1112nt CGCAGAGCGAGCGGCGCCGGCGTCATGTGACTGCCCGGAGTTGGTGCCAGGAGCCAGAGGGGAGCCAGGAGCGGAGCCGCGCGGAGCCGG GGCCCGAGCCGGAGCGCAGCGAGAGCGCCCGCCGCACGCGCGCCCGTCCCCGTCCCCTGCGGCCGCCAACGCCGCCCGGACTGGAGCCCT GACATTGCTGCGCTCGGGGGGCTCCAGGCAGCCCGTATCGGGGCCTTTATTTCTCGTCGGCGGCGCCCTGCACCGCGCCTCGCAAAGCCA AACACCAGAGCACCCTAGAAGGTTTAACTAAAAGAATGCTCATGTTTGACCCAGTTCCTGTCAAGCAAGAGGCCATGGACCCTGTCTCAG TGGTTCAGTCATTTTTAGCATCACTTGATGGAGAGAAGCTGGAACTCTTAAAAAATGACCTAATTTCCATTAAAGACATCTTTGCAGCCA AAGAATTAGAGAATGAAGAAAATCAAGAAGAACAAGGCTTAGAAGAAAAGGGAGAAGAATTTGCTCGCATGCTTACAGAGCTTCTCTTTG AATTACATGTGGCGGCCACACCTGACAAACTCAATAAGGCCATGAAGAGGGCTCATGACTGGGTGGAAGAGGATCAAACCGTGGTGTCAG TAGATGTGGCAAAAGTGTCCGAAGAAGAAACAAAGAAGGAAGAAAAGGAAGAGAAATCTCAAGACCCTCAAGAAGACAAAAAGGAGGAAA AGAAAACTAAGACCATAGAGGAAGTATACATGTCGTCCATTGAAAGTCTGGCGGAGGTAACAGCGCGCTGTATTGAGCAGCTTCATAAAG TAGCAGAATTAATTCTTCATGGACAAGAAGAGGAAAAACCAGCTCAGGACCAAGCAAAAGTTCTAATAAAATTAACTACTGCAATGTGCA ATGAAGTGGCCTCTTTATCAAAGAAGTTTACGAATTCTTTAACCACTGTTGGGAGCAACAAGAAGGCCGAGGTCCTTAACCCCATGATCA GTAGTGTATTGTTAGAGGGCTGCAACAGTACAACGTACATACAGGATGCCTTCCAGCTGCTGCTGCCTGTTCTGCAGGTCTCACATATCC >In-frame_KLF3_ENST00000261438_chr4_38682303_+_FAM114A1_ENST00000358869_chr4_38924391_+_3291nt CGCAGAGCGAGCGGCGCCGGCGTCATGTGACTGCCCGGAGTTGGTGCCAGGAGCCAGAGGGGAGCCAGGAGCGGAGCCGCGCGGAGCCGG GGCCCGAGCCGGAGCGCAGCGAGAGCGCCCGCCGCACGCGCGCCCGTCCCCGTCCCCTGCGGCCGCCAACGCCGCCCGGACTGGAGCCCT GACATTGCTGCGCTCGGGGGGCTCCAGGCAGCCCGTATCGGGGCCTTTATTTCTCGTCGGCGGCGCCCTGCACCGCGCCTCGCAAAGCCA AACACCAGAGCACCCTAGAAGGTTTAACTAAAAGAATGCTCATGTTTGACCCAGTTCCTGTCAAGCAAGAGGCCATGGACCCTGTCTCAG TGGTTCAGTCATTTTTAGCATCACTTGATGGAGAGAAGCTGGAACTCTTAAAAAATGACCTAATTTCCATTAAAGACATCTTTGCAGCCA AAGAATTAGAGAATGAAGAAAATCAAGAAGAACAAGGCTTAGAAGAAAAGGGAGAAGAATTTGCTCGCATGCTTACAGAGCTTCTCTTTG AATTACATGTGGCGGCCACACCTGACAAACTCAATAAGGCCATGAAGAGGGCTCATGACTGGGTGGAAGAGGATCAAACCGTGGTGTCAG TAGATGTGGCAAAAGTGTCCGAAGAAGAAACAAAGAAGGAAGAAAAGGAAGAGAAATCTCAAGACCCTCAAGAAGACAAAAAGGAGGAAA AGAAAACTAAGACCATAGAGGAAGTATACATGTCGTCCATTGAAAGTCTGGCGGAGGTAACAGCGCGCTGTATTGAGCAGCTTCATAAAG TAGCAGAATTAATTCTTCATGGACAAGAAGAGGAAAAACCAGCTCAGGACCAAGCAAAAGTTCTAATAAAATTAACTACTGCAATGTGCA ATGAAGTGGCCTCTTTATCAAAGAAGTTTACGAATTCTTTAACCACTGTTGGGAGCAACAAGAAGGCCGAGGTCCTTAACCCCATGATCA GTAGTGTATTGTTAGAGGGCTGCAACAGTACAACGTACATACAGGATGCCTTCCAGCTGCTGCTGCCTGTTCTGCAGGTCTCACATATCC AGACCAGTTGTTTGAAAGCACAGCCGTGACCTGGCCAGACTCCATCTAGTTAAAGGAGACAGCTGGCCGCCTTGCCTCAATATGTACCAT TTAAGGGGATGTTCTCTGTGCGCCTGGCCACAGACATCCATTTGAGGACACTACAAGCAATTTTGCACAGACAATATTGAGAATGCAAAT TTAGAGAGAGTTATCATTTCTCTCAATGTGTATAATTGTTTTTACAAACAATTGTGTTTTCTTTATGTTAATTTAAACTTACACAGCTTA TATTGAAAATTTCCTTTCATCTGAAATTTATTTACAAATATTCGTGTTCATTTTCCTGGTTAAGCATGCTATATTTAGAAACTCATGGGG AGACCTTAGACTTTTGTTTAATCCTTTATGTTTCAACCTTTAAATGTTCCATTCTTATAGTATTACTTTAAATCAATTCTAAAACTGAAC TTTGTTTTGTTACATAAATGTCGCAGGCAAAAATAACACTACTTATAGATTTTACCTATTATGGTAAAAAATAGGAACATATTGTCATTC TTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCGCCAGGCTGGAGTGCGTTGGCACAATCTCGGCTCACTGCAACCTCCGCCT CCTGGGTTCAATCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGTGTGCCACCACGCCCAGCCAATTTTTTTTGTATT TTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTG GGATTACAGGCTTGAGCCACCGCGCCCGGCCGGTCATTCATTCTTGCAACAAGCATTTATTGAGCACCTACTGTGTGCTCACAGTAAAGA AACGTGATCTTATCCCAGTAGAGGTAGATATTCTGAAAAAGAATAATTCTTAAACTGCTTAAAACAGGGGTCCCCACCCCCAGGCCACAG ACCAGTACCAGTCCGTGGCACTGGTTAGGAACCAGGCCACACAGCAGGGGGTGAGCGGTGGGTGAGTGAGCACAGCTTCATCTGTATTTA CAGCTGCTCCCCAGAGCTTGCATTACTGCCTGAGCTCTGCCTCCCGTCAGGTCAGCAGCAGCATTAGAGTCTCATGGGAGTGCGAACCCT GTTGTGAACTGCACATGCGAGGGATCTAGGTTGTGCACTCCTTATGAGAATCTAATGCCTGATGAATCTAATGCCTCATGATCTGAGGTT GAATAGCTTCGTGCCGAAACCATCCCCCACCCCCATCCCGCTACCCCGAGTCCGTGAAAAAATTGTCTTCCATGAAACCGGTCCCTGGTA CCAGAAAGGTTGGGGACCACTGGCTTAAAATACCAATAAATTTTTGAACCTTAAAAACTTTGAAGAACAAGGTAAATTGGTGTTTTATTT AATGTCCTACCCTTTAATTTGTTGCATTTTCCTATACTCTTTACACTATTTTATCCCAAACTATGTATATGAGGTGAAAATATATATGAA AAGGGATACTGAAGAATATTTAGTTTAAAATTAATTTCTTACGATCACGAGCACATGGTGGCATAATTACAAAGCTTGGAAGTATTCAAA TAGAAAATCAAAGGTGTTTCAATACAGTAGAATCCCAGGACTGCATTTTAAAATCGCCTCACAGATCACACTCGCTGGTGGCAAATATCA TCATCGTTGCTAAAGGACAGAAAATACTGATGTGTGTTTTAACTAACTGGTATATTGATCCATGGGAGGCTGCACAGAAGACCCTGCGGC CAGGAGGGGCATTGTCAGTGGCTGCTTCTCCTGAGCTCCACGCCTTCATTGCAGCTGCATGTTCGATACAATACACCTGCTTCACAGCCC CATGGACATCCCTACAGGTACTGTCATGTGAAGCCTTGCCTAGTAGTTCTCTCCAGGGCAAATGAAGCTCACAGTTTTGCAAGGTGGAAA CCTCTTATTCACATTTGCTTTGATTCCCCGATGGAGTAGACTGCCTTTGTTCCATACAGGCAAAGTAAGGATATTTTAATATCATCCTAC TTCTTATTAGCATTTCATTTGTCTATGTACTGTATTTCATTTGTATGTCTCCTGAAACATCCAAATAGAGAACATAAGAACACTTTATGT >In-frame_KLF3_ENST00000514033_chr4_38682303_+_FAM114A1_ENST00000515037_chr4_38924391_+_1111nt GCAGAGCGAGCGGCGCCGGCGTCATGTGACTGCCCGGAGTTGGTGCCAGGAGCCAGAGGGGAGCCAGGAGCGGAGCCGCGCGGAGCCGGG GCCCGAGCCGGAGCGCAGCGAGAGCGCCCGCCGCACGCGCGCCCGTCCCCGTCCCCTGCGGCCGCCAACGCCGCCCGGACTGGAGCCCTG ACATTGCTGCGCTCGGGGGGCTCCAGGCAGCCCGTATCGGGGCCTTTATTTCTCGTCGGCGGCGCCCTGCACCGCGCCTCGCAAAGCCAA ACACCAGAGCACCCTAGAAGGTTTAACTAAAAGAATGCTCATGTTTGACCCAGTTCCTGTCAAGCAAGAGGCCATGGACCCTGTCTCAGT GGTTCAGTCATTTTTAGCATCACTTGATGGAGAGAAGCTGGAACTCTTAAAAAATGACCTAATTTCCATTAAAGACATCTTTGCAGCCAA AGAATTAGAGAATGAAGAAAATCAAGAAGAACAAGGCTTAGAAGAAAAGGGAGAAGAATTTGCTCGCATGCTTACAGAGCTTCTCTTTGA ATTACATGTGGCGGCCACACCTGACAAACTCAATAAGGCCATGAAGAGGGCTCATGACTGGGTGGAAGAGGATCAAACCGTGGTGTCAGT AGATGTGGCAAAAGTGTCCGAAGAAGAAACAAAGAAGGAAGAAAAGGAAGAGAAATCTCAAGACCCTCAAGAAGACAAAAAGGAGGAAAA GAAAACTAAGACCATAGAGGAAGTATACATGTCGTCCATTGAAAGTCTGGCGGAGGTAACAGCGCGCTGTATTGAGCAGCTTCATAAAGT AGCAGAATTAATTCTTCATGGACAAGAAGAGGAAAAACCAGCTCAGGACCAAGCAAAAGTTCTAATAAAATTAACTACTGCAATGTGCAA TGAAGTGGCCTCTTTATCAAAGAAGTTTACGAATTCTTTAACCACTGTTGGGAGCAACAAGAAGGCCGAGGTCCTTAACCCCATGATCAG TAGTGTATTGTTAGAGGGCTGCAACAGTACAACGTACATACAGGATGCCTTCCAGCTGCTGCTGCCTGTTCTGCAGGTCTCACATATCCA >In-frame_KLF3_ENST00000514033_chr4_38682303_+_FAM114A1_ENST00000358869_chr4_38924391_+_3290nt GCAGAGCGAGCGGCGCCGGCGTCATGTGACTGCCCGGAGTTGGTGCCAGGAGCCAGAGGGGAGCCAGGAGCGGAGCCGCGCGGAGCCGGG GCCCGAGCCGGAGCGCAGCGAGAGCGCCCGCCGCACGCGCGCCCGTCCCCGTCCCCTGCGGCCGCCAACGCCGCCCGGACTGGAGCCCTG ACATTGCTGCGCTCGGGGGGCTCCAGGCAGCCCGTATCGGGGCCTTTATTTCTCGTCGGCGGCGCCCTGCACCGCGCCTCGCAAAGCCAA ACACCAGAGCACCCTAGAAGGTTTAACTAAAAGAATGCTCATGTTTGACCCAGTTCCTGTCAAGCAAGAGGCCATGGACCCTGTCTCAGT GGTTCAGTCATTTTTAGCATCACTTGATGGAGAGAAGCTGGAACTCTTAAAAAATGACCTAATTTCCATTAAAGACATCTTTGCAGCCAA AGAATTAGAGAATGAAGAAAATCAAGAAGAACAAGGCTTAGAAGAAAAGGGAGAAGAATTTGCTCGCATGCTTACAGAGCTTCTCTTTGA ATTACATGTGGCGGCCACACCTGACAAACTCAATAAGGCCATGAAGAGGGCTCATGACTGGGTGGAAGAGGATCAAACCGTGGTGTCAGT AGATGTGGCAAAAGTGTCCGAAGAAGAAACAAAGAAGGAAGAAAAGGAAGAGAAATCTCAAGACCCTCAAGAAGACAAAAAGGAGGAAAA GAAAACTAAGACCATAGAGGAAGTATACATGTCGTCCATTGAAAGTCTGGCGGAGGTAACAGCGCGCTGTATTGAGCAGCTTCATAAAGT AGCAGAATTAATTCTTCATGGACAAGAAGAGGAAAAACCAGCTCAGGACCAAGCAAAAGTTCTAATAAAATTAACTACTGCAATGTGCAA TGAAGTGGCCTCTTTATCAAAGAAGTTTACGAATTCTTTAACCACTGTTGGGAGCAACAAGAAGGCCGAGGTCCTTAACCCCATGATCAG TAGTGTATTGTTAGAGGGCTGCAACAGTACAACGTACATACAGGATGCCTTCCAGCTGCTGCTGCCTGTTCTGCAGGTCTCACATATCCA GACCAGTTGTTTGAAAGCACAGCCGTGACCTGGCCAGACTCCATCTAGTTAAAGGAGACAGCTGGCCGCCTTGCCTCAATATGTACCATT TAAGGGGATGTTCTCTGTGCGCCTGGCCACAGACATCCATTTGAGGACACTACAAGCAATTTTGCACAGACAATATTGAGAATGCAAATT TAGAGAGAGTTATCATTTCTCTCAATGTGTATAATTGTTTTTACAAACAATTGTGTTTTCTTTATGTTAATTTAAACTTACACAGCTTAT ATTGAAAATTTCCTTTCATCTGAAATTTATTTACAAATATTCGTGTTCATTTTCCTGGTTAAGCATGCTATATTTAGAAACTCATGGGGA GACCTTAGACTTTTGTTTAATCCTTTATGTTTCAACCTTTAAATGTTCCATTCTTATAGTATTACTTTAAATCAATTCTAAAACTGAACT TTGTTTTGTTACATAAATGTCGCAGGCAAAAATAACACTACTTATAGATTTTACCTATTATGGTAAAAAATAGGAACATATTGTCATTCT TTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCGCCAGGCTGGAGTGCGTTGGCACAATCTCGGCTCACTGCAACCTCCGCCTC CTGGGTTCAATCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGTGTGCCACCACGCCCAGCCAATTTTTTTTGTATTT TTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGG GATTACAGGCTTGAGCCACCGCGCCCGGCCGGTCATTCATTCTTGCAACAAGCATTTATTGAGCACCTACTGTGTGCTCACAGTAAAGAA ACGTGATCTTATCCCAGTAGAGGTAGATATTCTGAAAAAGAATAATTCTTAAACTGCTTAAAACAGGGGTCCCCACCCCCAGGCCACAGA CCAGTACCAGTCCGTGGCACTGGTTAGGAACCAGGCCACACAGCAGGGGGTGAGCGGTGGGTGAGTGAGCACAGCTTCATCTGTATTTAC AGCTGCTCCCCAGAGCTTGCATTACTGCCTGAGCTCTGCCTCCCGTCAGGTCAGCAGCAGCATTAGAGTCTCATGGGAGTGCGAACCCTG TTGTGAACTGCACATGCGAGGGATCTAGGTTGTGCACTCCTTATGAGAATCTAATGCCTGATGAATCTAATGCCTCATGATCTGAGGTTG AATAGCTTCGTGCCGAAACCATCCCCCACCCCCATCCCGCTACCCCGAGTCCGTGAAAAAATTGTCTTCCATGAAACCGGTCCCTGGTAC CAGAAAGGTTGGGGACCACTGGCTTAAAATACCAATAAATTTTTGAACCTTAAAAACTTTGAAGAACAAGGTAAATTGGTGTTTTATTTA ATGTCCTACCCTTTAATTTGTTGCATTTTCCTATACTCTTTACACTATTTTATCCCAAACTATGTATATGAGGTGAAAATATATATGAAA AGGGATACTGAAGAATATTTAGTTTAAAATTAATTTCTTACGATCACGAGCACATGGTGGCATAATTACAAAGCTTGGAAGTATTCAAAT AGAAAATCAAAGGTGTTTCAATACAGTAGAATCCCAGGACTGCATTTTAAAATCGCCTCACAGATCACACTCGCTGGTGGCAAATATCAT CATCGTTGCTAAAGGACAGAAAATACTGATGTGTGTTTTAACTAACTGGTATATTGATCCATGGGAGGCTGCACAGAAGACCCTGCGGCC AGGAGGGGCATTGTCAGTGGCTGCTTCTCCTGAGCTCCACGCCTTCATTGCAGCTGCATGTTCGATACAATACACCTGCTTCACAGCCCC ATGGACATCCCTACAGGTACTGTCATGTGAAGCCTTGCCTAGTAGTTCTCTCCAGGGCAAATGAAGCTCACAGTTTTGCAAGGTGGAAAC CTCTTATTCACATTTGCTTTGATTCCCCGATGGAGTAGACTGCCTTTGTTCCATACAGGCAAAGTAAGGATATTTTAATATCATCCTACT TCTTATTAGCATTTCATTTGTCTATGTACTGTATTTCATTTGTATGTCTCCTGAAACATCCAAATAGAGAACATAAGAACACTTTATGTA |
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FusionGenePPI for KLF3_FAM114A1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KLF3 | FHL3, CTBP2, KDM1A, SUV39H2, CTBP1, DVL3, TRAF2, EHMT2, LHX8, TRIM25 | FAM114A1 | AKT1S1, FAF1, PPAT, TLN1, HSPA4, N4BP1, RSU1, SEC24D, TARS, THUMPD3, RAB2A, SPG21, AGTRAP, RAB2B, CMTM5, TENC1, MIRLET7A1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLF3_FAM114A1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLF3_FAM114A1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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