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Fusion gene ID: 18977 |
FusionGeneSummary for KLF13_DTX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLF13_DTX2 | Fusion gene ID: 18977 | Hgene | Tgene | Gene symbol | KLF13 | DTX2 | Gene ID | 51621 | 113878 |
| Gene name | Kruppel like factor 13 | deltex E3 ubiquitin ligase 2 | |
| Synonyms | BTEB3|FKLF2|NSLP1|RFLAT-1|RFLAT1 | RNF58 | |
| Cytomap | 15q13.3 | 7q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Krueppel-like factor 13BTE-binding protein 3RANTES factor of late activated T lymphocytes-1basic transcription element binding protein 3novel Sp1-like zinc finger transcription factor 1transcription factor BTEB3transcription factor NSLP1 | probable E3 ubiquitin-protein ligase DTX2RING-type E3 ubiquitin transferase DTX2deltex 2, E3 ubiquitin ligasedeltex homolog 2deltex2hDTX2protein deltex-2ring finger protein 58zinc ion binding protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9Y2Y9 | Q86UW9 | |
| Ensembl transtripts involved in fusion gene | ENST00000307145, ENST00000560473, ENST00000500533, | ENST00000307569, ENST00000324432, ENST00000446600, ENST00000413936, ENST00000430490, ENST00000472426, ENST00000446820, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KLF13 [Title/Abstract] AND DTX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1425-01A | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000307145 | ENST00000307569 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| 5CDS-5UTR | ENST00000307145 | ENST00000324432 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| 5CDS-intron | ENST00000307145 | ENST00000446600 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| 5CDS-5UTR | ENST00000307145 | ENST00000413936 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| 5CDS-5UTR | ENST00000307145 | ENST00000430490 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| 5CDS-3UTR | ENST00000307145 | ENST00000472426 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| 5CDS-intron | ENST00000307145 | ENST00000446820 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-5UTR | ENST00000560473 | ENST00000307569 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-5UTR | ENST00000560473 | ENST00000324432 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-intron | ENST00000560473 | ENST00000446600 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-5UTR | ENST00000560473 | ENST00000413936 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-5UTR | ENST00000560473 | ENST00000430490 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-3UTR | ENST00000560473 | ENST00000472426 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-intron | ENST00000560473 | ENST00000446820 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-5UTR | ENST00000500533 | ENST00000307569 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-5UTR | ENST00000500533 | ENST00000324432 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-intron | ENST00000500533 | ENST00000446600 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-5UTR | ENST00000500533 | ENST00000413936 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-5UTR | ENST00000500533 | ENST00000430490 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-3UTR | ENST00000500533 | ENST00000472426 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
| intron-intron | ENST00000500533 | ENST00000446820 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
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FusionProtFeatures for KLF13_DTX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLF13 | DTX2 |
| Represses transcription by binding to the BTE site, aGC-rich DNA element, in competition with the activator SP1. Italso represses transcription by interacting with the corepressorSin3A and HDAC1. Activates RANTES expression in T-cells.{ECO:0000269|PubMed:11477107}. | Regulator of Notch signaling, a signaling pathwayinvolved in cell-cell communications that regulates a broadspectrum of cell-fate determinations. Probably acts both as apositive and negative regulator of Notch, depending on thedevelopmental and cell context. Mediates the antineural activityof Notch, possibly by inhibiting the transcriptional activationmediated by MATCH1. Functions as a ubiquitin ligase protein invitro, suggesting that it may regulate the Notch pathway via someubiquitin ligase activity. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KLF13_DTX2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KLF13_DTX2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KLF13 | SIN3A, CREBBP, SERPINH1, KAT2B, PCBD1, SREBF1, SREBF2, EP300, SH3KBP1, CHCHD10 | DTX2 | RBPMS, VSNL1, PLSCR1, RHOXF2, HPCAL4, NCS1, RFX6, TRIP13, UBE2D4, HPCAL1, NCALD, SFN, UBQLN4, MDC1, ARNT2, FHL2, GOLGA2, HDC, QARS, TRIP6, UBE2D1, UBE2D3, SUMO1, ABHD16A, SEC23B, FAM168A, STX12, SPAG8, SEC22A, SPG21, ALKBH4, EIF4ENIF1, TRIM54, PLEKHF2, C1orf94, RIMBP3, DTX2, GLYCTK, KLC3, KRTAP26-1, ZNF641, MCM2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLF13_DTX2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLF13_DTX2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KLF13 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | DTX2 | C0006118 | Brain Neoplasms | 1 | CTD_human |
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