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Fusion gene ID: 18977 |
FusionGeneSummary for KLF13_DTX2 |
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Fusion gene information | Fusion gene name: KLF13_DTX2 | Fusion gene ID: 18977 | Hgene | Tgene | Gene symbol | KLF13 | DTX2 | Gene ID | 51621 | 113878 |
Gene name | Kruppel like factor 13 | deltex E3 ubiquitin ligase 2 | |
Synonyms | BTEB3|FKLF2|NSLP1|RFLAT-1|RFLAT1 | RNF58 | |
Cytomap | 15q13.3 | 7q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | Krueppel-like factor 13BTE-binding protein 3RANTES factor of late activated T lymphocytes-1basic transcription element binding protein 3novel Sp1-like zinc finger transcription factor 1transcription factor BTEB3transcription factor NSLP1 | probable E3 ubiquitin-protein ligase DTX2RING-type E3 ubiquitin transferase DTX2deltex 2, E3 ubiquitin ligasedeltex homolog 2deltex2hDTX2protein deltex-2ring finger protein 58zinc ion binding protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9Y2Y9 | Q86UW9 | |
Ensembl transtripts involved in fusion gene | ENST00000307145, ENST00000560473, ENST00000500533, | ENST00000307569, ENST00000324432, ENST00000446600, ENST00000413936, ENST00000430490, ENST00000472426, ENST00000446820, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: KLF13 [Title/Abstract] AND DTX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-24-1425-01A | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000307145 | ENST00000307569 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
5CDS-5UTR | ENST00000307145 | ENST00000324432 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
5CDS-intron | ENST00000307145 | ENST00000446600 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
5CDS-5UTR | ENST00000307145 | ENST00000413936 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
5CDS-5UTR | ENST00000307145 | ENST00000430490 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
5CDS-3UTR | ENST00000307145 | ENST00000472426 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
5CDS-intron | ENST00000307145 | ENST00000446820 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-5UTR | ENST00000560473 | ENST00000307569 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-5UTR | ENST00000560473 | ENST00000324432 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-intron | ENST00000560473 | ENST00000446600 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-5UTR | ENST00000560473 | ENST00000413936 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-5UTR | ENST00000560473 | ENST00000430490 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-3UTR | ENST00000560473 | ENST00000472426 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-intron | ENST00000560473 | ENST00000446820 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-5UTR | ENST00000500533 | ENST00000307569 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-5UTR | ENST00000500533 | ENST00000324432 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-intron | ENST00000500533 | ENST00000446600 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-5UTR | ENST00000500533 | ENST00000413936 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-5UTR | ENST00000500533 | ENST00000430490 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-3UTR | ENST00000500533 | ENST00000472426 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
intron-intron | ENST00000500533 | ENST00000446820 | KLF13 | chr15 | 31619992 | + | DTX2 | chr7 | 76109738 | + |
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FusionProtFeatures for KLF13_DTX2 |
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Hgene | Tgene |
KLF13 | DTX2 |
Represses transcription by binding to the BTE site, aGC-rich DNA element, in competition with the activator SP1. Italso represses transcription by interacting with the corepressorSin3A and HDAC1. Activates RANTES expression in T-cells.{ECO:0000269|PubMed:11477107}. | Regulator of Notch signaling, a signaling pathwayinvolved in cell-cell communications that regulates a broadspectrum of cell-fate determinations. Probably acts both as apositive and negative regulator of Notch, depending on thedevelopmental and cell context. Mediates the antineural activityof Notch, possibly by inhibiting the transcriptional activationmediated by MATCH1. Functions as a ubiquitin ligase protein invitro, suggesting that it may regulate the Notch pathway via someubiquitin ligase activity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KLF13_DTX2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KLF13_DTX2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KLF13 | SIN3A, CREBBP, SERPINH1, KAT2B, PCBD1, SREBF1, SREBF2, EP300, SH3KBP1, CHCHD10 | DTX2 | RBPMS, VSNL1, PLSCR1, RHOXF2, HPCAL4, NCS1, RFX6, TRIP13, UBE2D4, HPCAL1, NCALD, SFN, UBQLN4, MDC1, ARNT2, FHL2, GOLGA2, HDC, QARS, TRIP6, UBE2D1, UBE2D3, SUMO1, ABHD16A, SEC23B, FAM168A, STX12, SPAG8, SEC22A, SPG21, ALKBH4, EIF4ENIF1, TRIM54, PLEKHF2, C1orf94, RIMBP3, DTX2, GLYCTK, KLC3, KRTAP26-1, ZNF641, MCM2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KLF13_DTX2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KLF13_DTX2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KLF13 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | DTX2 | C0006118 | Brain Neoplasms | 1 | CTD_human |